المؤلفون: Andrea Dalle Vedove, Giulia Cazzanelli, Jessica Corsi, Maria Sedykh, Vito Giuseppe D’Agostino, Amedeo Caflisch, Graziano Lolli

المصدر: ACS Bio & Med Chem Au, Vol 1, Iss 1, Pp 5-10 (2021)

مصطلحات موضوعية: Biology (General), QH301-705.5, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2694-2437

URL الوصول: https://doaj.org/article/8c4ffb7ac4c9479da3b9d1a394776eff

المؤلفون: Giulia Cazzanelli, Andrea Dalle Vedove, Giovanni Spagnolli, Luca Terruzzi, Enrica Colasurdo, Alberto Boldrini, Alexandros Patsilinakos, Mattia Sturlese, Alessandro Grottesi, Emiliano Biasini, Alessandro Provenzani, Alessandro Quattrone, Graziano Lolli

المساهمون: Cazzanelli, Giulia, Dalle Vedove, Andrea, Spagnolli, Giovanni, Terruzzi, Luca, Colasurdo, Enrica, Boldrini, Alberto, Patsilinakos, Alexandro, Sturlese, Mattia, Grottesi, Alessandro, Biasini, Emiliano, Provenzani, Alessandro, Quattrone, Alessandro, Lolli, Graziano

Relation: info:eu-repo/semantics/altIdentifier/pmid/38417111; info:eu-repo/semantics/altIdentifier/wos/WOS:001176223300001; journal:JOURNAL OF CHEMICAL INFORMATION AND MODELING; https://hdl.handle.net/11577/3525721; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85186483274

الاتاحة: https://hdl.handle.net/11577/3525721
https://doi.org/10.1021/acs.jcim.4c00051

المؤلفون: Andrea Dalle Vedove, Giulia Cazzanelli, Laurent Batiste, Jean-Rémy Marchand, Dimitrios Spiliotopoulos, Jessica Corsi, Vito Giuseppe D’Agostino, Amedeo Caflisch, Graziano Lolli

المساهمون: University of Zurich, Caflisch, Amedeo, Lolli, Graziano

المصدر: ACS Medicinal Chemistry Letters. 13:1434-1443

مصطلحات موضوعية: BAZ2A bromodomain, 1303 Biochemistry, Prostate cancer, 3002 Drug Discovery, BAZ2A bromodomain, Prostate cancer, Fragment growing, X-ray crystallography, Molecular docking, Binding assays, Organic Chemistry, 610 Medicine & health, Fragment growing, Biochemistry, Molecular docking, Drug Discovery, 10019 Department of Biochemistry, 570 Life sciences, biology, Binding assays, 1605 Organic Chemistry, X-ray crystallography

وصف الملف: ml2c00173.pdf - application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b542646d355aeeef41490b1c3531e2c
https://doi.org/10.1021/acsmedchemlett.2c00173

المؤلفون: Giulia Cazzanelli, Flávia Pereira, Sara Alves, Rita Francisco, Luísa Azevedo, Patrícia Dias Carvalho, Ana Almeida, Manuela Côrte-Real, Maria Oliveira, Cândida Lucas, Maria Sousa, Ana Preto

المصدر: Cells; Volume 7; Issue 2; Pages: 14

مصطلحات موضوعية: RAS proteins, S. cerevisiae, model, homologues, colorectal cancer, autophagy, KRAS

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cells7020014

الاتاحة: https://doi.org/10.3390/cells7020014

المؤلفون: Mariachiara, Micaelli, Andrea, Dalle Vedove, Linda, Cerofolini, Jacopo, Vigna, Denise, Sighel, Sara, Zaccara, Isabelle, Bonomo, Georgios, Poulentzas, Emanuele Filiberto, Rosatti, Giulia, Cazzanelli, Laura, Alunno, Romina, Belli, Daniele, Peroni, Erik, Dassi, Shino, Murakami, Samie R, Jaffrey, Marco, Fragai, Ines, Mancini, Graziano, Lolli, Alessandro, Quattrone, Alessandro, Provenzani

المصدر: ACS pharmacologytranslational science. 5(10)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::4bc91a5f7765aaa4f83c9890f6ba7a7a
https://pubmed.ncbi.nlm.nih.gov/36268123

المؤلفون: Cândida Lucas, Célia Ferreira, Giulia Cazzanelli, Ricardo Franco-Duarte, Joana Tulha

المصدر: Journal of Developmental Biology; Volume 4; Issue 4; Pages: 33

مصطلحات موضوعية: yeast, GUP, HHAT, morphogenesis, Hedgehog

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/jdb4040033

الاتاحة: https://doi.org/10.3390/jdb4040033

المؤلفون: Andrea Dalle Vedove, Francesca Zontab, Enrico Zanforlin, Nicola Demitri, Giovanni Ribaudo, Giulia Cazzanelli, Alberto Ongaro, Stefania Sarno, Giuseppe Zagotto, Roberto Battistutta, Maria Ruzzene, Graziano Lolli

المساهمون: Dalle Vedove, Andrea, Zontab, Francesca, Zanforlin, Enrico, Demitri, Nicola, Ribaudo, Giovanni, Cazzanelli, Giulia, Ongaro, Alberto, Sarno, Stefania, Zagotto, Giuseppe, Battistutta, Roberto, Ruzzene, Maria, Lolli, Graziano

وصف الملف: STAMPA

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000528271200002; volume:195; firstpage:.; lastpage:.; numberofpages:9; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11577/3335189; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85082868121

الاتاحة: http://hdl.handle.net/11577/3335189
https://doi.org/10.1016/j.ejmech.2020.112267

المؤلفون: Roberto Battistutta, Giovanni Ribaudo, Stefania Sarno, Andrea Dalle Vedove, Giuseppe Zagotto, Francesca Zonta, Graziano Lolli, Nicola Demitri, Alberto Ongaro, Maria Ruzzene, Giulia Cazzanelli, Enrico Zanforlin

مصطلحات موضوعية: Protein Conformation, Stereochemistry, Hinge, Pyrimidinones, Ring (chemistry), Jurkat Cells, Structure-Activity Relationship, Endocellular assay and mechanism of action, Protein kinase CK2, Thiadiazoles, Drug Discovery, Structural isomer, Side chain, Humans, Transferase, Chemical synthesis and structural characterization, Casein Kinase II, Protein Kinase Inhibitors, X-ray crystallography, Pharmacology, Kinase, Chemistry, Organic Chemistry, General Medicine, Molecular Docking Simulation, Drug Design

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37891d16707635691d74728a3c95264b
http://hdl.handle.net/11572/275324

المؤلفون: Selina Raguz, Ernesto Yagüe, Panagiotis Papoutsoglou, Yuan Zhou, Sabeena Rasul, Charles Coombes, Yunhui Hu, Nahal Masrour, Giulia Cazzanelli, Caroline Adams, Naina Patel

المساهمون: Cancer Research UK

المصدر: Biochemical Pharmacology. 85:186-196

مصطلحات موضوعية: medicine.medical_treatment, Pharmacology, Biochemistry, Topoisomerase II Inhibitors, Triple negative breast cancer, Pharmacology & Pharmacy, MULTIDRUG-RESISTANCE, DRUG, Poly-ADP-Ribose Binding Proteins, Promoter Regions, Genetic, Etoposide, Triple-negative breast cancer, Collateral sensitivity, P-GLYCOPROTEIN, CHEMOTHERAPY, Recombinant Proteins, APOPTOSIS, Neoplasm Proteins, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Female, 1115 Pharmacology and Pharmaceutical Sciences, MGMT, Life Sciences & Biomedicine, medicine.drug, EXPRESSION, Cyclin-Dependent Kinase Inhibitor p21, Antineoplastic Agents, Breast Neoplasms, Biology, Inhibitory Concentration 50, O(6)-Methylguanine-DNA Methyltransferase, Antigens, Neoplasm, Cell Line, Tumor, medicine, Humans, Doxorubicin, Cell Proliferation, Mitoxantrone, Carmustine, Chemotherapy, Science & Technology, IDENTIFICATION, Topoisomerase, G1 Phase, Cancer, TOP2A, Biological Transport, IN-VITRO, DNA Methylation, medicine.disease, GENE, ALPHA, DNA Topoisomerases, Type II, Drug Resistance, Neoplasm, biology.protein, Tumor Suppressor Protein p53

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263a9223df1802dc9f730b35ebaa420d
https://doi.org/10.1016/j.bcp.2012.10.020

المؤلفون: Sabeena Rasul, Yunhui Hu, Giulia Cazzanelli, Ben Hitchinson, Selina Raguz, R. Charles Coombes, Caroline Adams, Ernesto Yagüe

المساهمون: Cancer Research UK, Breast Cancer Research Trust, Breast Cancer Campaign

مصطلحات موضوعية: Cancer Research, Apoptosis Inhibitor, medicine.drug_class, PROTEINS, Cell, Apoptosis, Breast Neoplasms, Biology, Monoclonal antibody, medicine.disease_cause, Inhibitor of apoptosis, doxorubicin, PATHWAY, IAPS, inhibitors of apoptosis, Cell Line, Tumor, medicine, estrogen, TUMORIGENESIS, Humans, RNA, Small Interfering, GENE-EXPRESSION, Cell Proliferation, P53, Science & Technology, drug resistance, Antibiotics, Antineoplastic, tamoxifen, THERAPEUTIC TARGET, Intracellular Signaling Peptides and Proteins, Cancer, BREAST-CANCER CELLS, General Medicine, Cell cycle, medicine.disease, Caspase 9, Up-Regulation, medicine.anatomical_structure, Oncology, caspases, Drug Resistance, Neoplasm, Immunology, Cancer research, MCF-7 Cells, Female, Carcinogenesis, Life Sciences & Biomedicine, 1112 Oncology And Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9fa9cf4ca0919339da59d2d238a91a
http://hdl.handle.net/10044/1/31694

المؤلفون: Selina, Raguz, Caroline, Adams, Nahal, Masrour, Sabeena, Rasul, Panagiotis, Papoutsoglou, Yunhui, Hu, Giulia, Cazzanelli, Yuan, Zhou, Naina, Patel, Charles, Coombes, Ernesto, Yagüe

المصدر: Biochemical pharmacology. 85(2)

مصطلحات موضوعية: Cyclin-Dependent Kinase Inhibitor p21, G1 Phase, Antineoplastic Agents, Biological Transport, Breast Neoplasms, DNA Methylation, Carmustine, Recombinant Proteins, Neoplasm Proteins, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Inhibitory Concentration 50, O(6)-Methylguanine-DNA Methyltransferase, DNA Topoisomerases, Type II, Antigens, Neoplasm, Doxorubicin, Drug Resistance, Neoplasm, Cell Line, Tumor, Humans, Topoisomerase II Inhibitors, Female, Tumor Suppressor Protein p53, Poly-ADP-Ribose Binding Proteins, Promoter Regions, Genetic, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::fcd4c3c8a32ef3e4817a7dd10d7c8918
https://pubmed.ncbi.nlm.nih.gov/23122841

المؤلفون: Giulia Cazzanelli, Andrea Dalle Vedove, Giovanni Spagnolli, Luca Terruzzi, Enrica Colasurdo, Alberto Boldrini, Alexandros Patsilinakos, Mattia Sturlese, Alessandro Grottesi, Emiliano Biasini, Alessandro Provenzani, Alessandro Quattrone, Graziano Lolli

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Pharmacology, Cancer, Mental Health, Computational Biology, Biological Sciences not elsewhere classified, ythdf proteins contain, three family members, significant energetic barrier, offering new opportunities, interfering small molecules, altered balance detected, 6 , various cancers, crystallographic structures, computational studies, binding pocket, additional conformations

Relation: https://figshare.com/articles/journal_contribution/Pliability_in_the_m_sup_6_sup_A_Binding_Region_Extends_Druggability_of_YTH_Domains/25308554

الاتاحة: https://doi.org/10.1021/acs.jcim.4c00051.s001
https://figshare.com/articles/journal_contribution/Pliability_in_the_m_sup_6_sup_A_Binding_Region_Extends_Druggability_of_YTH_Domains/25308554

المؤلفون: Andrea Dalle Vedove (2632564), Giulia Cazzanelli (11569306), Jessica Corsi (11569309), Maria Sedykh (11569312), Vito Giuseppe D’Agostino (11257437), Amedeo Caflisch (230949), Graziano Lolli (1323711)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, soaking experiments using, resolution crystallographic studies, molecular docking campaign, competitive binding assays, 61 human bromodomains, baz2a bromodomain preincubated, baz2a bromodomain mutant, bromodomain adjacent, targeting baz2a, various cancers, two ligands, strong evidence, ray crystallography, increased affinity, fragment joining, crystal structure, close proximity, another ligand, also present

Relation: https://figshare.com/articles/journal_contribution/Identification_of_a_BAZ2A_Bromodomain_Hit_Compound_by_Fragment_Joining/16818055

الاتاحة: https://doi.org/10.1021/acsbiomedchemau.1c00016.s001

المؤلفون: Giulia Cazzanelli, Tiago Moreira, Suellen Ferro, João Azevedo-Silva, Eugénia Nogueira, Ana Preto

المصدر: CIÊNCIAVITAE

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5106ad91da66fe74219df5682c86ad78
https://www.eurekaselect.com/146965/chapter/colorectal-cancer-therapeutic-approaches%3A-from-classical-drugs-to-new-nanoparticle