المؤلفون: Sini Kinnunen, Mika Välimäki, Marja Tölli, Gerd Wohlfahrt, Rami Darwich, Hiba Komati, Mona Nemer, Heikki Ruskoaho

المصدر: PLoS ONE, Vol 10, Iss 12, p e0144145 (2015)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4671672?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/dd61662781cc4939b415bb3e5731d385

المؤلفون: Jarkko Huuskonen, Gerd Wohlfahrt, Matti Jauhiainen, Christian Ehnholm, Olle Teleman, Vesa M. Olkkonen

المصدر: Journal of Lipid Research, Vol 40, Iss 6, Pp 1123-1130 (1999)

مصطلحات موضوعية: HDL metabolism, lipid transfer proteins, homology modeling, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520335161; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/54d2c8e314584603a820d351cab79232

المؤلفون: Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J. Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Norbert Schmees, Kirstin Petersen

المصدر: Journal of Medicinal Chemistry. 66:3431-3447

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2d87f1f7a2f8fb4f1f0646d10e1712b2
https://doi.org/10.1021/acs.jmedchem.2c01933

المؤلفون: Mari Karimaa, Reetta Riikonen, Henna Kettunen, Päivi Taavitsainen, Meri Ramela, Marcin Chrusciel, Stefan Karlsson, Petteri Rummakko, Outi Simola, Gerd Wohlfahrt, Pasi Hakulinen, Annamari Vuorela, Heikki Joensuu, Tapio Utriainen, Karim Fizazi, Riikka Oksala

المصدر: Molecular Cancer Therapeutics. 21:1765-1776

مصطلحات موضوعية: Male, Cancer Research, Prostate, Adrenal Cortex Neoplasms, Hormones, Rats, Mice, Prostatic Neoplasms, Castration-Resistant, Disease Models, Animal, Dogs, Oncology, Humans, Animals, Cholesterol Side-Chain Cleavage Enzyme

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff128fc8cd26b2430750a17250799c6a
https://doi.org/10.1158/1535-7163.mct-22-0115

المؤلفون: Riikka Oksala, Karim Fizazi, Tapio Utriainen, Heikki Joensuu, Annamari Vuorela, Pasi Hakulinen, Gerd Wohlfahrt, Outi Simola, Petteri Rummakko, Stefan Karlsson, Marcin Chrusciel, Meri Ramela, Päivi Taavitsainen, Henna Kettunen, Reetta Riikonen, Mari Karimaa

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46051e52dfa8aaf74a566175a5384ef4
https://doi.org/10.1158/1535-7163.22523826

المؤلفون: Pekka J. Kallio, Murali Ramachandra, Nanduri Srinivas, Ravi K. Ujjinamatada, Subhendu Mukherjee, Samiulla Dhodheri, Thomas Anthony, Nagaraj Gowda, Rashmi Nair, Jiju Mani, Raghuveer K. Ramachandra, Kishore Narayanan, Shekar Chelur, Srinivasan Rajagopalan, Susanta Samajdar, Timo Korjamo, Riikka Oksala, Stefan Karlsson, Gerd Wohlfahrt, Tero Linnanen, Mari L. Björkman, Tarja Ikonen, Anu-Maarit Moilanen, Tim H. Holmström

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a4b40ece62b019671a48c99c70cd8b
https://doi.org/10.1158/1535-7163.22505722

المؤلفون: Pekka J. Kallio, Murali Ramachandra, Nanduri Srinivas, Ravi K. Ujjinamatada, Subhendu Mukherjee, Samiulla Dhodheri, Thomas Anthony, Nagaraj Gowda, Rashmi Nair, Jiju Mani, Raghuveer K. Ramachandra, Kishore Narayanan, Shekar Chelur, Srinivasan Rajagopalan, Susanta Samajdar, Timo Korjamo, Riikka Oksala, Stefan Karlsson, Gerd Wohlfahrt, Tero Linnanen, Mari L. Björkman, Tarja Ikonen, Anu-Maarit Moilanen, Tim H. Holmström

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b0ba784729eaeca665669c7e27a87040
https://doi.org/10.1158/1535-7163.c.6538162.v1

المؤلفون: Norbert Nagy, Kaisa Syrjänen, Piet Finckenberg, Gerd Wohlfahrt, Jouko Levijoki, Tuula Koskelainen, A. Koivisto, András Varró, Paul E. Miller, László Virág, Najah Abi-Gerges, Leena Otsomaa, Eero Mervaala, Andrea Ghetti, Hugh Chapman, Saara‐Elisa Peltokorpi, Aira Heikkilä, Norbert Jost, Guy Page, Julius Gy. Papp, Zsófia Kohajda

المساهمون: Medicum, Department of Pharmacology, Eero Mervaala / Principal Investigator

المصدر: British Journal of Pharmacology

مصطلحات موضوعية: 0301 basic medicine, Inotrope, Myocytes, Cardiac/metabolism, Sodium-Calcium Exchanger, Calcium/metabolism, NCX, Heart Ventricles, Sodium, hERG, sodium–calcium exchanger, Action Potentials, chemistry.chemical_element, Pharmacology, ORM-11372, 03 medical and health sciences, 0302 clinical medicine, Heart rate, Animals, Potency, positive inotropic effect, Myocytes, Cardiac, Ion channel, cardiac safety, ORM‐11372, Sodium-calcium exchanger, biology, Chemistry, Heart Ventricles/metabolism, Research Papers, Rats, Sodium/metabolism, 030104 developmental biology, biology.protein, Calcium, Rabbits, 3111 Biomedicine, 030217 neurology & neurosurgery, Ex vivo, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a59d209bbdf5c8135589cb2458da87f
https://doi.org/10.1111/bph.15257

المؤلفون: Meri Ramela, Reetta Riikonen, Riikka Oksala, Kati Rasanen, Mika Mustonen, Gerd Wohlfahrt, Mari Karimaa, Pirjo Vehmaan-Kreula, Petteri Rummakko

المصدر: Endocrine Abstracts.

مصطلحات موضوعية: Oncology, Therapeutic approach, medicine.medical_specialty, Prostate cancer, business.industry, Internal medicine, Cholesterol side-chain cleavage enzyme, Medicine, Castration resistant, business, medicine.disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::794fc70393858efddf2af009917f24c4
https://doi.org/10.1530/endoabs.63.p667

المؤلفون: Riikka Oksala, Reetta Riikonen, Kati Rasanen, Mari Karimaa, Pirjo Vehmaan-Kreula, Gerd Wohlfahrt, Petteri Rummakko, Meri Ramela, Mika Mustonen

المصدر: Journal of the Endocrine Society

مصطلحات موضوعية: Oncology, endocrine system, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Cholesterol side-chain cleavage enzyme, Steroid and Nuclear Receptors in Cancer and Physiology, Steroid Hormones and Receptors, Castration resistant, medicine.disease, Prostate cancer, Therapeutic approach, Internal medicine, medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e955843a9ffa55529a587b33b7dd6cd5
https://doi.org/10.1210/js.2019-sun-lb002

المؤلفون: Annamari Vuorela, Petteri Rummakko, Karim Fizazi, Riikka Oksala, Päivi Taavitsainen, Marcin Chrusciel, Mari Karimaa, Suvi Mansikka-Savolainen, Henna Kettunen, Outi Simola, Meri Ramela, Gerd Wohlfahrt

المصدر: Cancer Research. 81:1250-1250

مصطلحات موضوعية: Cancer Research, Chemistry, medicine.drug_class, medicine.medical_treatment, Steroid biosynthesis, Pharmacology, medicine.disease, Androgen, Steroid, Androgen deprivation therapy, Prostate cancer, Steroid hormone, Oncology, medicine, Testosterone, Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7e5f87cb99481938ff3775612c7dbef8
https://doi.org/10.1158/1538-7445.am2021-1250

المؤلفون: Samiulla D S, Shekar Chelur, Pathange Hemasankar, Mikko Myllymäki, Kavitha Nellore, Mahaboobi Jaleel, Naveen Kumar R, Prasad Yadlapalli, Aravind A B, Chandrasekhar Abbineni, Murali Ramachandra, Venkata Siva N. Reddy, Ramesh S. Senaiar, Susanta Samajdar, Subhendu Mukherjee, Saravanan Thiyagarajan, Raghavendra N R, Sivapriya Marappan, Gerd Wohlfahrt, Thomas Antony, Girish Aggunda Renukappa, Chandranath D. Naik, Asha Babu, Girish Daginakatte, Mamon Dey, Akhila Srinivas, Suraj T Gore

المصدر: Cancer Research. 81:1143-1143

مصطلحات موضوعية: Cancer Research, T cell, Cancer, Biology, medicine.disease, Bromodomain, Androgen receptor, HIF1A, medicine.anatomical_structure, Oncology, Cancer cell, Coactivator, biology.protein, Cancer research, medicine, CREB-binding protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::576694e462ade64801981b26dc54a029
https://doi.org/10.1158/1538-7445.am2021-1143

المؤلفون: Andreas Bender, Peteris Prusis, Qurrat Ul Ain, Gerd Wohlfahrt, Helena Henno, Lars-Olof Pietilä, Julian E. Fuchs, Vigneshwari Subramanian

المصدر: MedChemComm. 8:1037-1045

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Proteases, Protease, genetic structures, Visual interpretation, Chemistry, Ligand, medicine.medical_treatment, fungi, Organic Chemistry, Serine Protease Inhibitors, food and beverages, Pharmaceutical Science, Biochemistry, Serine, 03 medical and health sciences, 030104 developmental biology, Grind, Drug Discovery, medicine, Molecular Medicine, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547b8d3f8bd052f76d87cbd3b6e707d9
https://doi.org/10.1039/c6md00701e

المؤلفون: Avainash Kumar, Olli Törmäkangas, Susanta Samajdar, AB Aravind, Suraj Tgore, Subhendu Mukherjee, Nirbhay Kumar Tiwari, Girish Daginakatte, Anu Moilanen, Raghurami B Reddy, Laura Ravanti, Thomas Antony, Elina Mattila, Mari Björkman, Janith Mary Maben, Shekar Chelur, Mahaboobi Jaleel, Nvm Rao Bandaru, Akhila Srinivas, Indu Bansal, DS Samiulla, Rakesh P. Nankar, Kavitha Nellore, Chandrasekhar Abbineni, Chandranath D. Naik, Sanjeev Giri, Murali Ramachandra, Gerd Wohlfahrt, Naveen Kumar, Sivapriya Marappan

المصدر: Cancer Research. 80:1754-1754

مصطلحات موضوعية: Cancer Research, BRD4, Protein degradation, Prodrug, Pharmacology, Small molecule, In vitro, Bromodomain, chemistry.chemical_compound, Oncology, Mechanism of action, chemistry, medicine, medicine.symptom, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dac44ba72bb66c0059e6c8a84001aa4d
https://doi.org/10.1158/1538-7445.am2020-1754

المؤلفون: Shekar Chelur, Murali Ramachandra, Samiulla Dhodheri, Stefan Karlsson, Nanduri Srinivas, Thomas Anthony, Nagaraj Gowda, Kishore Narayanan, Tero Linnanen, Raghuveer Ramachandra, Tarja Ikonen, Jiju Mani, Susanta Samajdar, Ravi Kotrabasaiah Ujjinamatada, Srinivasan Rajagopalan, Timo Korjamo, Mari Björkman, Subhendu Mukherjee, Pekka Kallio, Rashmi Nair, Riikka Oksala, Gerd Wohlfahrt, Tim H. Holmström, Anu-Maarit Moilanen

المصدر: Molecular cancer therapeutics. 18(1)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, animal structures, Cell Survival, T-Lymphocytes, Programmed Cell Death 1 Receptor, CD8-Positive T-Lymphocytes, B7-H1 Antigen, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, In vivo, Cell Line, Tumor, Cytotoxic T cell, Animals, Humans, Phosphorylation, Carcinoma, Renal Cell, Protein Kinase Inhibitors, Cell Proliferation, Tube formation, Tumor microenvironment, Chemistry, Kinase, Receptors, Fibroblast Growth Factor, Xenograft Model Antitumor Assays, Kidney Neoplasms, Killer Cells, Natural, 030104 developmental biology, Receptors, Vascular Endothelial Growth Factor, Oncology, Cell culture, 030220 oncology & carcinogenesis, embryonic structures, Cancer research, Syngenic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef7dde209da91f1d77c8d247e665c2b
https://pubmed.ncbi.nlm.nih.gov/30301864

المؤلفون: Peteris Prusis, Henri Xhaard, Vigneshwari Subramanian, Gerd Wohlfahrt

المساهمون: Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Henri Xhaard / Principal Investigator, Computational Adme, Pharmaceutical Design and Discovery group, Drug Research Program

المصدر: MedChemComm. 7:1007-1015

مصطلحات موضوعية: 0301 basic medicine, DATABASE, Pharmaceutical Science, Computational biology, 3d descriptors, Machine learning, computer.software_genre, Biochemistry, 03 medical and health sciences, Drug Discovery, Kinome, Field based, Binding site, Interpretability, Pharmacology, Drug discovery, business.industry, Kinase, Ligand, Chemistry, Organic Chemistry, 030104 developmental biology, 317 Pharmacy, INHIBITOR SELECTIVITY, 1182 Biochemistry, cell and molecular biology, Molecular Medicine, Artificial intelligence, KINOME, business, computer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eacef3be7c090de37939c8d2e26aee4
https://doi.org/10.1039/c5md00556f

المؤلفون: Marion Weber-Boyvat, Jussi Jäntti, Vesa M. Olkkonen, Gerd Wohlfahrt, Nina Aro, Konstantin G. Chernov

المصدر: Traffic. 17:131-153

مصطلحات موضوعية: 0301 basic medicine, Fungal protein, Munc18 Proteins, Exocyst, Cell Biology, Plasma protein binding, Biology, Biochemistry, Exocytosis, Cell biology, 03 medical and health sciences, Bimolecular fluorescence complementation, 030104 developmental biology, Structural Biology, Genetics, Molecular Biology, Groove (engineering), SNARE complex assembly

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0741de383690ede3d051783f96d0c18c
https://doi.org/10.1111/tra.12349

المؤلفون: Karthikeyan Narasingapuram Arumugam, Jwala Nagaraj, DS Samiulla, Murali Ramachandra, Rajendra K. Palakurthy, Rajeev Goswami, Olli Törmäkangas, Anirudha Lakshminarasimhan, Narasimha Rao Krishnamurthy, Gerd Wohlfahrt, Anu Moilanen, Subhendu Mukherjee, Mahaboobi Jaleel, Anita R. Chacko

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:5309-5314

مصطلحات موضوعية: Indoles, Serine Proteinase Inhibitors, Pyridines, Stereochemistry, Hepsin, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Amidine, Mice, chemistry.chemical_compound, Cell Movement, Cyclohexanes, Cell Line, Tumor, Drug Discovery, Animals, Humans, Neoplasm Invasiveness, Molecular Biology, Serine protease, Indole test, biology, Chemistry, Aryl, Serine Endopeptidases, Organic Chemistry, Transmembrane protein, Molecular Docking Simulation, Cell culture, Microsomes, Liver, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11309c3bb66ab52d9329fa0c0ba4c60
https://doi.org/10.1016/j.bmcl.2015.09.042

المؤلفون: Rajeev Goswami, Subhendu Mukherjee, Gerd Wohlfahrt, Jwala Nagaraj, Krishnaprasad Subbarao, Chakshusmathi Ghadiyaram, Narasimha Rao Krishnamurthy, Leena Khare Satyam, Sreevalsam Gopinath, Hosahalli Subramanya, Murali Ramachandra

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:616-620

مصطلحات موضوعية: Male, Proteases, Serine Proteinase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Inflammation, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, Hydrolase, Serine, medicine, Animals, Matriptase, Molecular Biology, Serine protease, Binding Sites, biology, Serine Endopeptidases, Organic Chemistry, Cancer, medicine.disease, Amides, Molecular Docking Simulation, Kinetics, chemistry, biology.protein, Molecular Medicine, Hepatocyte growth factor, Growth inhibition, medicine.symptom, Half-Life, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af98eb705b94b9713c1a02f4738d18fb
https://doi.org/10.1016/j.bmcl.2014.12.008

المؤلفون: Jere Paavola, Vesa M. Olkkonen, Gerd Wohlfahrt, You Zhou

المصدر: Biochemical and Biophysical Research Communications. 446:675-680

مصطلحات موضوعية: Receptors, Steroid, Subfamily, Protein Conformation, Saccharomyces cerevisiae, ved/biology.organism_classification_rank.species, Biophysics, Danio, Glycerophospholipids, Fatty Acid-Binding Proteins, Biochemistry, 03 medical and health sciences, Phosphatidylinositol Phosphates, Animals, Humans, Gene family, Amino Acid Sequence, Model organism, Molecular Biology, OSBP, Zebrafish, Conserved Sequence, 030304 developmental biology, Genetics, 0303 health sciences, biology, ved/biology, 030302 biochemistry & molecular biology, Cell Biology, Zebrafish Proteins, Lipid Metabolism, biology.organism_classification, Protein Structure, Tertiary, Cell biology, Carrier Proteins, Oxysterol-binding protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2eaf0a4ec57c906279d4ea3c17a9bb
https://doi.org/10.1016/j.bbrc.2013.12.002