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1
المؤلفون: Robin D. Whittaker, Geoffrey A. Holdgate, Vivien Jacobs, M. Fennell, Laurent Francois Andre Hennequin, Judith A. Hargreaves, Brigitte Boyer, Alun Bermingham, Tim P. Green, Jon Curwen, Walter H.J. Ward, Allen Jack Mcqueen, Paul Elvin, Robert W. Wilkinson, Gerard Costello, Patrick Ple, Neil O. Carragher, D. Mark Hickinson, Barry R. Davies, Armelle Logie
المصدر: Green, T P, Fennell, M, Whittaker, R, Curwen, J, Jacobs, V, Allen, J, Logie, A, Hargreaves, J, Hickinson, D M, Wilkinson, R W, Elvin, P, Boyer, B, Carragher, N, Plé, P A, Bermingham, A, Holdgate, G A, Ward, W H J, Hennequin, L F, Davies, B R & Costello, G F 2009, ' Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530 ', Molecular Oncology, vol. 3, no. 3, pp. 248-261 . https://doi.org/10.1016/j.molonc.2009.01.002
مصطلحات موضوعية: Cancer Research, Transplantation, Heterologous, Administration, Oral, Mice, Nude, Antineoplastic Agents, Pharmacology, Metastasis, Mice, Rats, Nude, Clinical Trials, Phase II as Topic, In vivo, Cell Movement, Cell Line, Tumor, Genetics, medicine, Animals, Humans, Neoplasm Invasiveness, Benzodioxoles, Phosphorylation, Protein Kinase Inhibitors, Paxillin, Cell Proliferation, biology, Cell migration, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Neoplasm Proteins, Rats, Transplantation, src-Family Kinases, Oncology, Urinary Bladder Neoplasms, Tumor progression, Focal Adhesion Kinase 1, Papers, biology.protein, NIH 3T3 Cells, Quinazolines, Molecular Medicine, Neoplasm Transplantation, Proto-oncogene tyrosine-protein kinase Src
وصف الملف: application/pdf
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2
المصدر: Journal of Medicinal Chemistry. 34:181-189
مصطلحات موضوعية: Male, Agonist, Pyrrolidines, medicine.drug_class, Stereochemistry, Guinea Pigs, Analgesic, Molecular Conformation, Receptors, Opioid, mu, Mice, Inbred Strains, In Vitro Techniques, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Vas Deferens, X-Ray Diffraction, Acetamides, Drug Discovery, medicine, Animals, Moiety, Alkyl, chemistry.chemical_classification, Analgesics, Molecular Structure, Naloxone, Chemistry, Aryl, Muscle, Smooth, In vitro, Amino acid, Receptors, Opioid, Molecular Medicine, Female, Indicators and Reagents, Analgesia, Acetamide
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3
المؤلفون: Allen Jack Mcqueen, Jason Breed, Tim P. Green, Patrick Ple, Nicolas Warin, Rémy Morgentin, Richard A. Norman, Michael Fennell, Gerard Costello, Christine Lambert-van der Brempt, Annie Olivier, Ludovic Otterbein, Jon Curwen, Laurent Francois Andre Hennequin
المصدر: Journal of medicinal chemistry. 49(22)
مصطلحات موضوعية: Male, Models, Molecular, Chemical Phenomena, Stereochemistry, Transplantation, Heterologous, Mice, Nude, Antineoplastic Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Dogs, In vivo, Drug Discovery, Transferase, Animals, Humans, Neoplasm Invasiveness, Benzodioxoles, Enzyme Inhibitors, Cell Proliferation, ABL, biology, Chemistry, Kinase, Chemistry, Physical, 3T3 Cells, Protein-Tyrosine Kinases, Rats, Transplantation, src-Family Kinases, Solubility, Enzyme inhibitor, biology.protein, Quinazolines, Molecular Medicine, Thermodynamics, Female, Indicators and Reagents, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src
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4
المؤلفون: Michel Vautier, M. Fennell, Laurent Francois Andre Hennequin, Tim P. Green, Barlaam Bernard Christophe, Gerard Costello, Annie Olivier, Rémy Morgentin, Patrick Ple, Hervé Germain
المصدر: ChemInform. 37
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, High selectivity, Pharmaceutical Science, Pharmacology, Biochemistry, Chemical synthesis, CSK Tyrosine-Protein Kinase, Isomerism, Pharmacokinetics, Heterocyclic Compounds, Oral administration, Drug Discovery, Animals, Dosing, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, chemistry.chemical_classification, C-src kinase, Aniline Compounds, biology, Bicyclic molecule, Chemistry, Kinase, Cell growth, Organic Chemistry, General Medicine, Protein-Tyrosine Kinases, Rats, Kinetics, Enzyme, src-Family Kinases, Enzyme inhibitor, biology.protein, Quinazolines, Molecular Medicine, Signal transduction, Cell Division
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5
المؤلفون: Timothy Gerard Costello, K Harris, Laurence E. Mather, John R. Cormack, B LaFerlita, Michael Murphy
المصدر: British journal of anaesthesia. 94(6)
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, medicine, Humans, Anesthetics, Local, Craniotomy, Levobupivacaine, Bupivacaine, Epilepsy, Scalp, business.industry, Local anesthetic, Brain Neoplasms, Nerve Block, Perioperative, Middle Aged, Surgery, Blockade, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Epinephrine, Anesthesia, Female, business, medicine.drug
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6
المؤلفون: Brian Holloway, Georgina Speake, Gerard Costello
المصدر: Current opinion in pharmacology. 5(4)
مصطلحات موضوعية: Lung Neoplasms, Pharmacology, Erlotinib Hydrochloride, Gefitinib, Growth factor receptor, Carcinoma, Non-Small-Cell Lung, Drug Discovery, medicine, PTEN, Humans, Growth factor receptor inhibitor, Epidermal growth factor receptor, Organic Chemicals, Protein Kinase Inhibitors, Aniline Compounds, integumentary system, biology, Molecular Structure, ErbB Receptors, Cancer research, biology.protein, Aminoquinolines, Quinazolines, Erlotinib, Tyrosine kinase, medicine.drug
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7
المؤلفون: Christopher Hoy, Timothy Gerard Costello, John R. Cormack, Andrew J. Wyss, Michael Murphy, Karen Martin, Valena Braniff
المصدر: Journal of neurosurgical anesthesiology. 16(2)
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Dose, Adolescent, medicine.drug_class, medicine.medical_treatment, medicine, Humans, Ropivacaine, Anesthetics, Local, Wakefulness, Craniotomy, Aged, Aged, 80 and over, Scalp, Dose-Response Relationship, Drug, business.industry, Local anesthetic, Nerve Block, Middle Aged, Amides, Surgery, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Epinephrine, Anesthesia, Toxicity, Nerve block, Female, Neurology (clinical), business, medicine.drug
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8
المؤلفون: Patrick Ple, Gerard Costello, Tim P. Green, Michael Fennell, Allen Jack Mcqueen, Christine Lambert-van der Brempt, Laurent Francois Andre Hennequin, Jon Curwen
المصدر: Journal of medicinal chemistry. 47(4)
مصطلحات موضوعية: Models, Molecular, Antineoplastic Agents, Dioxoles, Receptor tyrosine kinase, CSK Tyrosine-Protein Kinase, Mice, Rats, Nude, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Neoplasm Invasiveness, Phosphorylation, Aniline Compounds, biology, Chemistry, Kinase insert domain receptor, 3T3 Cells, Protein-Tyrosine Kinases, Xenograft Model Antitumor Assays, Rats, src-Family Kinases, Biochemistry, Enzyme inhibitor, biology.protein, Quinazolines, Molecular Medicine, Tyrosine, Signal transduction, Tyrosine kinase, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase Src
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9Academic Journal
المؤلفون: Stephen Forbes, Robert Burke, Gerard Costello
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.112.5792; http://www.fig.net/pub/fig_2002/ts4-2/ts4_2_forbes_etal.pdf
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المؤلفون: L.F. Hennequin, Tim P. Green, Gerard Costello, P.A. Ple, Vivien Jacobs, R. Whittaker, Jon Curwen, M. Fennell, Allen Jack Mcqueen
المصدر: European Journal of Cancer Supplements. 2:109
مصطلحات موضوعية: Cancer Research, Tyrosine-protein kinase CSK, Oncology, Kinase, business.industry, Cancer research, Medicine, business, Src family, Proto-oncogene tyrosine-protein kinase Src
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11Academic Journal
المؤلفون: Timothy Gerard Costello
المصدر: Journal of Neurosurgical Anesthesiology; Apr2004, Vol. 16 Issue 2, p147-150, 4p
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12
المؤلفون: J. Edwin Saxton, Gerard Costello
المصدر: Tetrahedron. 42:6047-6069
مصطلحات موضوعية: chemistry.chemical_classification, Double bond, Stereochemistry, Alkaloid, Organic Chemistry, Total synthesis, Nuclear magnetic resonance spectroscopy, Biochemistry, chemistry.chemical_compound, Minovincine, chemistry, Drug Discovery, Lactam, Organic chemistry, Epimer
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13
المؤلفون: Whitby Richard J, Christopher Love, Philip J. Kocienski, David A. Roberts, Gerard Costello
المصدر: Tetrahedron. 45:3839-3848
مصطلحات موضوعية: chemistry.chemical_classification, Bicyclic molecule, Stereochemistry, Carboxylic acid, Organic Chemistry, Total synthesis, Alcohol, Biochemistry, Terpenoid, chemistry.chemical_compound, chemistry, Acetylene, Drug Discovery, Stereoselectivity, Diterpene
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14
المؤلفون: Heinz E. Moser, Albert Eschenmoser, Arthur Steiger, Anton Fliri, J. Schreiber, Gerard Costello
المصدر: Helvetica Chimica Acta. 69:1224-1262
مصطلحات موضوعية: chemistry.chemical_classification, Dipeptide, Stereochemistry, Organic Chemistry, Imine, Context (language use), Polymer, Random hexamer, Biochemistry, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Polynucleotide, Covalent bond, Amide, Drug Discovery, Polymer chemistry, Physical and Theoretical Chemistry
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15
المؤلفون: Gerard Costello, Clive Yeates, Richard J. Whitby, Philip J. Kocienski
المصدر: J. Chem. Soc., Chem. Commun.. :429-430
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Oxepane, Ketone, chemistry, Double bond, Bicyclic molecule, Stereochemistry, Diol, Molecular Medicine, Stereoselectivity, Ring (chemistry), Derivative (chemistry)
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16
المؤلفون: Gerard Costello, A. Sydney Bailey, Peter W. Scott, Gulam A. Bahadur
المصدر: Journal of the Chemical Society, Perkin Transactions 1. :2154
مصطلحات موضوعية: Indole test, chemistry.chemical_compound, chemistry, Side chain, Organic chemistry, Azide