المؤلفون: Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk, Eddine Saiah

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/e4e93d6c676242c793f6e0e9b9280186

المؤلفون: Sarah J. Mitchell, Alejandro Martin-Montalvo, Evi M. Mercken, Hector H. Palacios, Theresa M. Ward, Gelareh Abulwerdi, Robin K. Minor, George P. Vlasuk, James L. Ellis, David A. Sinclair, John Dawson, David B. Allison, Yongqing Zhang, Kevin G. Becker, Michel Bernier, Rafael de Cabo

المصدر: Cell Reports, Vol 6, Iss 5, Pp 836-843 (2014)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124714000655; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/4311e779c1b84073a91f71df14820ee9

المؤلفون: Elaine M. Quinet, Michael D. Basso, Anita R. Halpern, David W. Yates, Robert J. Steffan, Valerie Clerin, Christine Resmini, James C. Keith, Thomas J. Berrodin, Irene Feingold, Wenyan Zhong, Helen B. Hartman, Mark J. Evans, Stephen J. Gardell, Elizabeth DiBlasio-Smith, William M. Mounts, Edward R. LaVallie, Jay Wrobel, Ponnal Nambi, George P. Vlasuk

المصدر: Journal of Lipid Research, Vol 50, Iss 12, Pp 2358-2370 (2009)

مصطلحات موضوعية: cynomolgus monkey, dyslipidemia, fibroblast growth factor 19, hypertriglyceridemia, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520306593; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/ec0b71a6e2bf4790a3a5a3256e00f5d7

المؤلفون: James G Krueger, Mayte Suárez-Fariñas, Inna Cueto, Artemis Khacherian, Robert Matheson, Lawrence C Parish, Craig Leonardi, Denise Shortino, Akanksha Gupta, Jonathan Haddad, George P Vlasuk, Eric W Jacobson

المصدر: PLoS ONE, Vol 10, Iss 11, p e0142081 (2015)

مصطلحات موضوعية: Medicine, Science

Relation: http://europepmc.org/articles/PMC4640558?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/9e19d739bed14e038b7414b6243efab0

الاتاحة: https://doi.org/10.1371/journal.pone.0142081
https://doaj.org/article/9e19d739bed14e038b7414b6243efab0

المؤلفون: Hongying Yang, Wei Zhang, Heng Pan, Heidi G Feldser, Elden Lainez, Christine Miller, Stewart Leung, Zhong Zhong, Huizhen Zhao, Sharon Sweitzer, Thomas Considine, Thomas Riera, Vipin Suri, Brian White, James L Ellis, George P Vlasuk, Christine Loh

المصدر: PLoS ONE, Vol 7, Iss 9, p e46364 (2012)

مصطلحات موضوعية: Medicine, Science

Relation: http://europepmc.org/articles/PMC3460821?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/a56d628fd5a94f1da31e23a4f38bf9f6

الاتاحة: https://doi.org/10.1371/journal.pone.0046364
https://doaj.org/article/a56d628fd5a94f1da31e23a4f38bf9f6

المؤلفون: Vincenzo Libri, Andrew P Brown, Giulio Gambarota, Jonathan Haddad, Gregory S Shields, Helen Dawes, David J Pinato, Ethan Hoffman, Peter J Elliot, George P Vlasuk, Eric Jacobson, Martin R Wilkins, Paul M Matthews

المصدر: PLoS ONE, Vol 7, Iss 12, p e51395 (2012)

مصطلحات موضوعية: Medicine, Science

Relation: http://europepmc.org/articles/PMC3527451?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/45457f0e83024b468534bb0f4103a851

الاتاحة: https://doi.org/10.1371/journal.pone.0051395
https://doaj.org/article/45457f0e83024b468534bb0f4103a851

المؤلفون: Rebecca A. Shirk, George P. Vlasuk, Thromb Vasc Biol

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://atvb.ahajournals.org/content/27/9/1895.full.pdf.

مصطلحات موضوعية: Series Editor, Jeffrey I. Weitz

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.552.8083; http://atvb.ahajournals.org/content/27/9/1895.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.552.8083
http://atvb.ahajournals.org/content/27/9/1895.full.pdf

المؤلفون: Philip J. Rosenthal, Erick A. Goldman, Michael I. Weinhouse, George P. Vlasuk, Belinda J. Lee, Ajay Singh, Peggy Chiang, Scott J. Kemp

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://aac.asm.org/content/47/12/3810.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.616.9282; http://aac.asm.org/content/47/12/3810.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.616.9282
http://aac.asm.org/content/47/12/3810.full.pdf

المؤلفون: Catharine H. Duman, George P. Vlasuk, Taro Kato, Santosh Pothula, Rong-Jian Liu, Eddine Saiah, Seung Hahm, Ronald S. Duman, Rosemarie Terwilliger

المصدر: J Clin Invest

مصطلحات موضوعية: Male, 0301 basic medicine, Stimulation, mTORC1, Mechanistic Target of Rapamycin Complex 1, Blood–brain barrier, Synaptic Transmission, Rats, Sprague-Dawley, Synapse, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Premovement neuronal activity, Animals, Chronic stress, Prefrontal cortex, Heat-Shock Proteins, Mice, Knockout, Behavior, Animal, Chemistry, Depression, Brain-Derived Neurotrophic Factor, General Medicine, Antidepressive Agents, Rats, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Commentary, Antidepressant, biological phenomena, cell phenomena, and immunity, Neuroscience, Research Article, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bc335f8b180901f671e2f0efb2f1c7
https://europepmc.org/articles/PMC6546461/

المؤلفون: Emilie Giaime, George P. Vlasuk, Jessica J. Howell, Shomit Sengupta, Seung Hahm, David John O'neill, Eddine Saiah, Sridhar Narayan

المصدر: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: Male, 0301 basic medicine, Multiprotein complex, lcsh:Medicine, Administration, Oral, mTORC1, Mechanistic Target of Rapamycin Complex 1, Article, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Leucine, In vivo, Drug Discovery, Protein biosynthesis, Animals, Humans, RNA, Messenger, lcsh:Science, Transaminases, Neurons, chemistry.chemical_classification, Multidisciplinary, Activator (genetics), lcsh:R, Brain, Nuclear Proteins, Recombinant Proteins, In vitro, Cell biology, Amino acid, HEK293 Cells, 030104 developmental biology, chemistry, Drug Design, lcsh:Q, biological phenomena, cell phenomena, and immunity, 030217 neurology & neurosurgery, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6678722f6226c83bc4a70778e2d4d3
https://doi.org/10.1038/s41598-019-40693-5

المؤلفون: Robert Langer, John M. Maraganore, David P. Schenkein, Neil Warma, Chris Adams, Chip Clark, Mark Levin, William Rastetter, Bruce A Leicher, Nancy A Thornberry, Robert I Blum, Jonathan G Rosin, Kleanthis G Xanthopoulos, Timothy D. Harris, Jeff L Cleland, Robert Forrester, Nancy Simonian, Peter Barrett, Stephen Bloch, William J Rieflin, Brian M Gallagher, Lewis Rusty Williams, Doug Doerfler, Richard Ulevitch, David R. Liu, Andrew Levin, P. Grint, Nick J Simon, Pablo J Cagnoni, Daphne Zohar, Kush M Parmar, Guy Macdonald, Corey M McCann, Stelios Papadopoulos, Michael D Clayman, Diego Miralles, Paula Cobb, John Diekman, Jeremy M Levin, Amir Nashat, Samuel G Waksal, Rachel King, Sandford Sandy Zweifach, Gail J Maderis, Ankit Mahadevia, Heather Franklin, Cary G Pfeffer, Steven K Brauer, Akshay Vaishnaw, Clay B. Siegall, Howard Furst, Jonathan S Leff, William J Rutter, Dennis J. Purcell, Mary T Szela, J C Gutierrez-Ramos, Sean A McCarthy, Elizabeth Lr Donley, Yaron Werber, Doug E Williams, Christoph Westphal, Paul Sekhri, W Eddie Martucci, Jeb Keiper, John E Osborn, Simba Gill, Bassil Dahiyat, Steven H Holtzman, Annalisa Jenkins, Saurabh Saha, Matthew J. During, Camille Samuels, Mara G Aspinall, Chad Robins, Jason P Rhodes, Herve Hoppenot, Jeff Kaplan, Michael A Narachi, Amit Rakhit, Julia C Owens, Steve M Paul, Martin Varsavsky, Mark G. Currie, Rajeev Shah, Rob Perez, H. Stewart Parker, Jeff Stein, Leonard Patrick Gage, Perry Karsen, Joel F Martin, Bob More, Matthew Perry, James G McArthur, Gregory J Flesher, Martin Tolar, Andrew Schwab, James A Geraghty, Eric L Dobmeier, Brook Byers, Vanessa King, Mason W. Freeman, Larry Miller, Marco Taglietti, Jeff Albers, Neil A Exter, Michael W Bonney, Ron Cohen, Nick Leschly, Bruce L Booth, William J Newell, Peter Kolchinsky, Ryan J Watts, Paul Laikind, Andrew G. Myers, Cedric Francois, Stephen T Isaacs, Scott Koenig, Michel Vounatsos, Tuan Ha-Ngoc, Nicholas Galakatos, George P Vlasuk, Isaac Ciechanover, Jeff Kindler, Brian M. Cali, Matthew R Patterson, Kenneth I Moch, Tom Graney, Martin Babler, Jonathan J Fleming, Mark A Goldsmith, Daniel M Bradbury, John Mendlein, Mike Powell, Nessan Bermingham, Eric Elenko, H. Robert Horvitz, Yujiro Steve Hata, Mark Pruzanski, Faheem Hasnain, Henri A. Termeer, Maxine Gowen, Scott M Rocklage, Anne VanLent, Thomas Shenk, Leslie Henshaw, Jeff Jonker, Nina Kjellson, Deborah Dunsire, Zoe Barry, Ron C Renaud, Alex Martin, Uri Lopatin, George Scangos, Jean Kim, Kartik Ramamoorthi, Michael Rosenblatt, Nagesh K Mahanthappa, Harvey F. Lodish, Paul B Bolno, Wendell Wierenga, Atul Pande, Barry Greene, Alan Levy, Adrian Ad Rawcliffe, Wende S Hutton, C Geoffrey McDonough, Vicki L. Sato, Jean-Francois Formela, David V. Goeddel, Bill Haney, Rich Heyman, James E Audia, Ron Cooper, Nina Tandon, Brett Ahrens, Julian Adams, Peter Hecht, John J Lee, Stuart L. Schreiber, Laurence E Reid, Bernat Olle, Paul Hastings, John A. Scarlett, Michael Su, David Grayzel, Ted W Love, Arnold J. Levine, Gerhard Koenig, Thomas E Hughes, Jens W Eckstein, Wendy Nelson, Vikas Goyal

المصدر: Nature Biotechnology. 35:204-206

مصطلحات موضوعية: 0301 basic medicine, business.industry, media_common.quotation_subject, Population Dynamics, Immigration, Biomedical Engineering, Public Policy, Bioengineering, International trade, Emigration and Immigration, Applied Microbiology and Biotechnology, 03 medical and health sciences, 030104 developmental biology, Order (business), Political science, Humans, Molecular Medicine, business, Biotechnology, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2d10770c0eb9d17bb770366663a693
https://doi.org/10.1038/nbt.3824

المؤلفون: Oleg Kraydashenko, George P. Vlasuk, Peter J. Elliott, Arun K. Baksi, Ethan Hoffmann, Eric W. Jacobson, Jonathan Haddad, Alsu Zalevkaya, Roman Stets

المصدر: British Journal of Clinical Pharmacology. 78:69-77

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, business.industry, Insulin, medicine.medical_treatment, Type 2 Diabetes Mellitus, Type 2 diabetes, Placebo, medicine.disease, Metformin, Endocrinology, Pharmacokinetics, Tolerability, Internal medicine, medicine, Glucose homeostasis, Pharmacology (medical), business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::50926de29542c7ba78e50d0f5a40efb2
https://doi.org/10.1111/bcp.12327

المؤلفون: Kevin G. Becker, James L. Ellis, Rafael de Cabo, Sarah J. Mitchell, Hector H. Palacios, Evi M. Mercken, Maria Almeida, Yongqing Zhang, Ana P. Gomes, Michel Bernier, Robin K. Minor, Alejandro Martin-Montalvo, Joseph A. Baur, Morten Scheibye-Knudsen, Peter J. Elliott, Husam Khraiwesh, José A. González-Reyes, Jordan J Licata, José M. Villalba, Christoph H. Westphal, David A. Sinclair, George P. Vlasuk

المصدر: Aging Cell

مصطلحات موضوعية: Male, Aging, medicine.medical_specialty, Osteoporosis, Inflammation, Kaplan-Meier Estimate, healthspan, Biology, Heterocyclic Compounds, 2-Ring, Bone and Bones, Body Mass Index, Mice, 03 medical and health sciences, sirtuins, 0302 clinical medicine, Atrophy, Internal medicine, medicine, Animals, Humans, Survival analysis, 030304 developmental biology, Bone mineral, 0303 health sciences, Activator (genetics), muscle wasting, Original Articles, Cell Biology, medicine.disease, Survival Analysis, osteoporosis, Small molecule, Diet, Motor coordination, Mice, Inbred C57BL, Endocrinology, inflammation, Body Composition, medicine.symptom, lifespan, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3336defbf2d889fd9d57219b0417d1
https://doi.org/10.1111/acel.12220

المؤلفون: Eddine Saiah, George P. Vlasuk, Seong A. Kang, Stephanie N. Galda, Shomit Sengupta, Jessica J. Howell, Lisa Molz, David John O'neill, Sarah J. Mahoney, Andreas W. Machl, Seung Hahm, Casey J. Lumpkin

المصدر: Cell Chemical Biology. 26:1203-1213.e13

مصطلحات موضوعية: Proteomics, Glucose uptake, Clinical Biochemistry, Drug Evaluation, Preclinical, Glucose Transport Proteins, Facilitative, P70-S6 Kinase 1, Mechanistic Target of Rapamycin Complex 2, mTORC1, Mechanistic Target of Rapamycin Complex 1, 01 natural sciences, Biochemistry, mTORC2, Mice, Cell Line, Tumor, Drug Discovery, Animals, Humans, Phosphorylation, Molecular Biology, Mechanistic target of rapamycin, Protein kinase B, Cell Proliferation, Sirolimus, Pharmacology, biology, 010405 organic chemistry, Glucose transporter, High-Throughput Screening Assays, 0104 chemical sciences, Mice, Inbred C57BL, Glucose, Multiprotein Complexes, biology.protein, Molecular Medicine, GLUT1, biological phenomena, cell phenomena, and immunity, Proto-Oncogene Proteins c-akt, Signal Transduction, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e4e82f2a630644712668cbd876df78
https://doi.org/10.1016/j.chembiol.2019.05.009

المؤلفون: Peter S. Spector, Allan S. Jaffe, Eugene Braunwald, James T. Willerson, Steven R. Bergmann, Desire Collen, Robert Roberts, Philip A. Ludbrook, Robert L. Frye, David J. Schneider, George P. Vlasuk, Elizabeth Sobel Avera, RJ Kirk

المصدر: Experimental Biology and Medicine. 238:1101-1115

مصطلحات موضوعية: Societies, Scientific, Cardiovascular Diseases, Diabetes Mellitus, Art history, Tribute, Sobel operator, Sociology, History, 20th Century, Periodicals as Topic, History, 21st Century, General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6418c2cdc1b5842f47f2907835b289
https://doi.org/10.1177/1535370213505824

المؤلفون: Jill C. Milne, Angela Tornblom, Jean Bemis, Jeremy S. Disch, George P. Vlasuk, Peter Elliot, Amy V. Lynch, Robert B. Perni, Pui Yee Ng, James L. Ellis, Akanksha Gupta, Christopher Oalmann, Joseph J. Nunes, J. Joshua Smith, Kristina Kriksciukaite, Michael R. Jirousek, Marie Yeager, Vipin Suri, David P. Carney, Meghan Duncan, Jeffrey Song, Siva Lavu, Thomas V. Riera, Chi B. Vu

المصدر: Letters in Drug Design & Discovery. 10:793-797

مصطلحات موضوعية: Chemistry, Activator (genetics), Drug Discovery, Pharmaceutical Science, Molecular Medicine, Computational biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d0097b909e7a83a1c2a6561804d09532
https://doi.org/10.2174/15701808113100990021

المؤلفون: Taylor Lg Doyle, Jeremy S. Disch, George P. Vlasuk, Christine Loh, Ana P. Gomes, Basil P. Hubbard, Jun Li, James L. Ellis, Sean M. Armour, David A. Sinclair, Quinn Lu

المصدر: Cell Cycle. 12:2233-2240

مصطلحات موضوعية: endocrine system diseases, medicine.drug_class, Carbazoles, Carboxamide, Plasma protein binding, Biology, Substrate Specificity, Sirtuin 1, Genes, Reporter, Report, Cell Line, Tumor, medicine, Humans, Protein Interaction Domains and Motifs, Binding site, Luciferases, Molecular Biology, Adaptor Proteins, Signal Transducing, Regulation of gene expression, Binding Sites, food and beverages, Acetylation, Cell Biology, Cell biology, Histone Deacetylase Inhibitors, enzymes and coenzymes (carbohydrates), Gene Expression Regulation, Biochemistry, biology.protein, lipids (amino acids, peptides, and proteins), NAD+ kinase, Signal transduction, Protein Processing, Post-Translational, hormones, hormone substitutes, and hormone antagonists, Protein Binding, Signal Transduction, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328cfea700e565ebf3e3f620c1e7ab12
https://doi.org/10.4161/cc.25268

المؤلفون: Ghotas Evindar, Frank T. Coppo, George P. Vlasuk, Eli Schuman, Charles A. Blum, Cheney Mao, Lei Jin, Han Dai, Robert B. Perni, Jianghe Deng, Svetlana L. Belyanskaya, Todd L. Graybill, John W. Cuozzo, Leah Aquilani, Jeremy S. Disch, Cynthia H. Chiu, Siva Lavu, Kenneth E Lind

المصدر: Journal of Medicinal Chemistry. 56:3666-3679

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, medicine.drug_class, Carboxamide, SIRT2, chemistry.chemical_compound, Sirtuin 2, Sirtuin 1, Sirtuin 3, Drug Discovery, medicine, Humans, Sirtuins, biology, Nicotinamide, Drug discovery, Active site, Small molecule, Pyrimidines, chemistry, Biochemistry, Sirtuin, biology.protein, Molecular Medicine, NAD+ kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d930b58d521e3aa0dbb27bc20c5fe4
https://doi.org/10.1021/jm400204k

المؤلفون: Paolo Sassone-Corsi, Yasukazu Nakahata, Giuseppe Astarita, George P. Vlasuk, Danuta E. Mossakowska, James L. Ellis, Marina M. Bellet, Emma Watts, Ken Edwards, Marlene Cervantes, Mohamed Boudjelal, Christine Loh

المصدر: Proceedings of the National Academy of Sciences. 110:3333-3338

مصطلحات موضوعية: Transcription, Genetic, endocrine system diseases, Knockout, Circadian clock, CLOCK Proteins, Enzyme Activators, Biology, Heterocyclic Compounds, 4 or More Rings, Cell Line, Mice, Enzyme activator, Sirtuin 1, Genetic, Heterocyclic Compounds, Sirtuins, Animals, Humans, Circadian rhythm, Mice, Knockout, Multidisciplinary, ARNTL Transcription Factors, Activator (genetics), Epigenetic, food and beverages, Biological Sciences, 4 or More Rings, NAD, Chromatin, Circadian Rhythm, enzymes and coenzymes (carbohydrates), Metabolism, Gene Expression Regulation, Liver, Biochemistry, biology.protein, NAD+ kinase, biological phenomena, cell phenomena, and immunity, Transcription, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7098d65ad72857e379b9671115ac1e0e
https://doi.org/10.1073/pnas.1214266110

المؤلفون: James L. Ellis, Abdulrahman Chahin, Johannes M. Freudenberg, Abdullah Chahin, Yong Li, Vipin Suri, John E. Palardy, Steven M. Opal, Michelle Yamamoto, George P. Vlasuk, Noubar Kessimian, Nicholas A. Parejo

المصدر: Shock (Augusta, Ga.). 45(4)

مصطلحات موضوعية: Transcription, Genetic, Peritonitis, Critical Care and Intensive Care Medicine, medicine.disease_cause, Proinflammatory cytokine, Sepsis, Mice, Sirtuin 1, Streptococcal Infections, Streptococcus pneumoniae, medicine, Animals, Anilides, biology, Activator (genetics), business.industry, Bacterial pneumonia, medicine.disease, Immunity, Innate, Enzyme Activation, Disease Models, Animal, Thiazoles, Immunology, Sirtuin, Pneumococcal pneumonia, Emergency Medicine, biology.protein, Female, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbde4ee95e4c9915cabfdd8ff55baf75
https://pubmed.ncbi.nlm.nih.gov/26974318