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1
المؤلفون: Scott A. Miller, George M. Derbin, Sherif Badawy, Munir A. Hussain, Fang Zhao
المصدر: Journal of Pharmaceutical Sciences. 101:3526-3530
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Chemistry, Pharmaceutical, Electrospray ionization, Pharmaceutical Science, chemistry.chemical_element, Antineoplastic Agents, Protonation, Oxygen Isotopes, Cleavage (embryo), Catalysis, Hydrolysis, Drug Stability, Liquid chromatography–mass spectrometry, Technology, Pharmaceutical, Organic chemistry, Chromatography, High Pressure Liquid, Chromatography, Reverse-Phase, Alanine, Triazines, Chemistry, Water, Hydrogen-Ion Concentration, Degradation (geology), Spectrophotometry, Ultraviolet, Acids, Carbon
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2
المؤلفون: Ligang Qian, Carl Thibeault, Amrita Kamath, Barri Wautlet, Alain Martel, George L. Trainor, Punit Marathe, Celia D’Arienzo, Benjamin J. Henley, Steven Mortillo, Donna D. Wei, Robert Jeyaseelan, Ravindra W. Tejwani, John T. Hunt, Louis J. Lombardo, Rejean Ruel, Yueping Zhang, Zhen-Wei Cai, Joseph Fargnoli, Arvind Mathur, Alexandre L'Heureux, Joel C. Barrish, Rajeev S. Bhide, George M. Derbin
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:2985-2989
مصطلحات موضوعية: ERG1 Potassium Channel, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Angiogenesis Inhibitors, Biochemistry, Chemical synthesis, Cell Line, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Growth factor receptor, In vivo, Drug Discovery, Animals, Humans, Pyrroles, Molecular Biology, Mice, Inbred BALB C, Bicyclic molecule, biology, Triazines, Chemistry, Organic Chemistry, Protein-Tyrosine Kinases, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Ether-A-Go-Go Potassium Channels, In vitro, Enzyme inhibitor, Drug Design, biology.protein, Cytochrome P-450 CYP3A Inhibitors, Molecular Medicine, Tyrosine kinase, Isopropyl
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3
المؤلفون: Celia D’Arienzo, Daniel W. Kukral, Stephanie Barbosa, Steve Mortillo, John T. Hunt, Lawrence Wu, Punit Marathe, George M. Derbin, Joseph Fargnoli, Yong-Zheng Zhang, Robert M. Borzilleri, Joel C. Barrish, Zhongping Shi, Jeffrey A. Robl, Robert Jeyaseelan, Rajeev S. Bhide, Ligang Qian, Donna D. Wei, Junying Fan, Amrita Kamath, Xiaoping Zheng, Zhen-Wei Cai, Louis J. Lombardo, Barri Wautlet
المصدر: Journal of Medicinal Chemistry. 51:1976-1980
مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Fibroblast growth factor receptor 1, Kinase insert domain receptor, Prodrug, Chemical synthesis, stomatognathic diseases, chemistry.chemical_compound, Brivanib alaninate, Growth factor receptor, In vivo, Enzyme inhibitor, Drug Discovery, biology.protein, Molecular Medicine
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4
المؤلفون: Sherif Badawy, Krishnaswamy Srinivas Raghavan, Yan Xu, Ajit S. Narang, Qingmei Ye, Antonio Ramirez, Frank Rinaldi, Dhaval Patel, George M. Derbin, Maria Vincent, John R. Crison, Aaron P. Yamniuk, Yande Huang, Michael Galella, Balvinder S. Vig
المصدر: Pharmaceutical Research.
مصطلحات موضوعية: Models, Molecular, Absorption (pharmacology), Magnetic Resonance Spectroscopy, Chemistry, Pharmaceutical, Inorganic chemistry, Administration, Oral, Pharmaceutical Science, Buffers, Calorimetry, Intestinal absorption, chemistry.chemical_compound, Dynamic light scattering, Humans, Surface Tension, Computer Simulation, Pharmacology (medical), Colloids, Particle Size, Solubility, Pharmacology, Supersaturation, Alanine, Aqueous solution, Triazines, Chemistry, Organic Chemistry, Hydrogen-Ion Concentration, Bioavailability, Brivanib alaninate, Intestinal Absorption, Molecular Medicine, Biotechnology
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5
المؤلفون: Blisse Vakkalagadda, Steven Zhang, Kevin N. Heller, Teresa Has, Vikram Roongta, Christoph Matthias Ahlers, Stephanie M Dorizio, Jong-Soon Park, George M. Derbin
المصدر: Journal of clinical pharmacology. 52(9)
مصطلحات موضوعية: Adult, Male, Vascular Endothelial Growth Factor A, Receptor, ErbB-2, Cmax, Biological Availability, Pharmacology, Food-Drug Interactions, Pharmacokinetics, Piperidines, Dry skin, medicine, Humans, Pharmacology (medical), Pyrroles, Adverse effect, Meal, Cross-Over Studies, business.industry, Triazines, digestive, oral, and skin physiology, Middle Aged, Bioavailability, ErbB Receptors, stomatognathic diseases, Diarrhea, Tolerability, Food, Female, medicine.symptom, business
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6
المؤلفون: Bogdan Sleczka, Hongjian Zhang, R. Marcus Fancher, George M. Derbin, Richard Rockar, Punit Marathe
المصدر: Journal of pharmaceutical sciences. 100(7)
مصطلحات موضوعية: Male, Time Factors, Drug Evaluation, Preclinical, Pharmaceutical Science, Ph dependent, Administration, Oral, Absorption (skin), Pharmacology, Beagle, Injections, Intramuscular, Dogs, Pharmacokinetics, medicine, Animals, Gastrostomy, Gastric Juice, Chemistry, Stomach, digestive, oral, and skin physiology, Fasting, Hydrogen-Ion Concentration, Famotidine, Dietary Fats, Pentagastrin, medicine.anatomical_structure, Intestinal Absorption, Pharmaceutical Preparations, Gastric Mucosa, Models, Animal, Canine model, medicine.drug
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7
المؤلفون: Robert Jeyaseelan, Steve Mortillo, Joseph Fargnoli, Rajeev S. Bhide, Ligang Qian, George M. Derbin, John T. Hunt, Punit Marathe, Louis J. Lombardo, Amrita Kamath, Xiaoping Zheng, John S. Tokarski, Daniel W. Kukral, Robert M. Borzilleri, Barri Wautlet, Joel C. Barrish, Celia D’Arienzo
المصدر: Journal of medicinal chemistry. 49(13)
مصطلحات موضوعية: Models, Molecular, Umbilical Veins, Stereochemistry, Administration, Oral, Aminopyridines, Mice, Nude, Angiogenesis Inhibitors, In Vitro Techniques, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Non-competitive inhibition, Growth factor receptor, Aminothiazole, Drug Discovery, Animals, Humans, Kinase activity, Benzamide, Cell Proliferation, Binding Sites, biology, Chemistry, Endothelial Cells, Kinase insert domain receptor, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Rats, Vascular endothelial growth factor, Macaca fascicularis, Thiazoles, Enzyme inhibitor, biology.protein, Molecular Medicine, Endothelium, Vascular
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8
المؤلفون: Steven Mortillo, Donna D. Wei, Daniel W. Kukral, Viral Vyas, Arvind Mathur, Stephanie Barbosa, Laurence I. Wu, John T. Hunt, Zhen-Wei Cai, Soong-Hoon Kim, Robert Jeyaseelan, Kenneth J. Leavitt, Sam T. Chao, Joseph Fargnoli, Joel C. Barrish, Ligang Qian, Amrita Kamath, Punit Marathe, Xiaoping Zheng, Barri Wautlet, Yong-Zheng Zhang, Leslie Leith, Louis J. Lombardo, Celia D’Arienzo, George M. Derbin, Rajeev S. Bhide, Robert M. Borzilleri, Aberra Fura
المصدر: Journal of medicinal chemistry. 49(7)
مصطلحات موضوعية: Stereochemistry, Transplantation, Heterologous, Mice, Nude, Angiogenesis Inhibitors, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Humans, Prodrugs, Pyrroles, Triazine, Mice, Inbred BALB C, Alanine, Triazines, Stereoisomerism, Prodrug, Vascular Endothelial Growth Factor Receptor-2, In vitro, Brivanib alaninate, chemistry, Alkoxy group, Molecular Medicine, Drug Screening Assays, Antitumor, Neoplasm Transplantation, Methyl group