المؤلفون: Strieder-Barboza, Clarissa, Flesher, Carmen G., Geletka, Lynn M., Eichler, Tad, Akinleye, Olukemi, Ky, Alexander, Ehlers, Anne P., Lumeng, Carey N., O’Rourke, Robert W.

المساهمون: National Institutes of Health, Veterans Affairs

المصدر: Adipocyte ; volume 11, issue 1, page 665-675 ; ISSN 2162-3945 2162-397X

الاتاحة: http://dx.doi.org/10.1080/21623945.2022.2154112
https://www.tandfonline.com/doi/pdf/10.1080/21623945.2022.2154112

المؤلفون: Russo, Lucia, Muir, Lindsey, Geletka, Lynn, Delproposto, Jennifer, Baker, Nicki, Flesher, Carmen, O'Rourke, Robert, Lumeng, Carey N.

المساهمون: University of Michigan Medical School and the Department of Pediatrics and Pulmonary Medicine and the Department of Surgery

المصدر: Molecular Metabolism ; volume 39, page 100983 ; ISSN 2212-8778

الاتاحة: http://dx.doi.org/10.1016/j.molmet.2020.100983
https://api.elsevier.com/content/article/PII:S2212877820300570?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2212877820300570?httpAccept=text/plain

المؤلفون: Muir, Lindsey A., Baker, Nicki A., Washabaugh, Alexandra R., Neeley, Christopher K., Flesher, Carmen G., DelProposto, Jennifer B., Geletka, Lynn M., Ghaferi, Amir A., Finks, Jonathan F., Singer, Kanakadurga, Varban, Oliver A., Lumeng, Carey N., O'Rourke, Robert W.

المصدر: Adipocyte ; volume 6, issue 2, page 134-140 ; ISSN 2162-3945 2162-397X

الاتاحة: http://dx.doi.org/10.1080/21623945.2017.1287639
https://www.tandfonline.com/doi/pdf/10.1080/21623945.2017.1287639

المؤلفون: Cho, Kae Won, Zamarron, Brian F., Muir, Lindsey A., Singer, Kanakadurga, Porsche, Cara E., DelProposto, Jennifer B., Geletka, Lynn, Meyer, Kevin A., O’Rourke, Robert W., Lumeng, Carey N.

المصدر: The Journal of Immunology ; volume 197, issue 9, page 3650-3661 ; ISSN 0022-1767 1550-6606

الاتاحة: https://doi.org/10.4049/jimmunol.1600820
https://journals.aai.org/jimmunol/article-pdf/197/9/3650/1423584/1600820.pdf

المؤلفون: Singer, Kanakadurga, Maley, Nidhi, Mergian, Taleen, DelProposto, Jennifer, Cho, Kae Won, Zamarron, Brian F., Martinez-Santibanez, Gabriel, Geletka, Lynn, Muir, Lindsey, Wachowiak, Phillip, Demirjian, Chaghig, Lumeng, Carey N.

المساهمون: National Institutes of Health

المصدر: Journal of Biological Chemistry ; volume 290, issue 21, page 13250-13262 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1074/jbc.m114.634568
https://api.elsevier.com/content/article/PII:S0021925820336887?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021925820336887?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1074/jbc.M114.634568

المؤلفون: Cho, Kae Won, Morris, David L., DelProposto, Jennifer L., Geletka, Lynn, Zamarron, Brian, Martinez-Santibanez, Gabriel, Meyer, Kevin A., Singer, Kanakadurga, O’Rourke, Robert W., Lumeng, Carey N.

المصدر: Cell Reports ; volume 9, issue 2, page 605-617 ; ISSN 2211-1247

الاتاحة: http://dx.doi.org/10.1016/j.celrep.2014.09.004
https://api.elsevier.com/content/article/PII:S2211124714007724?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S2211124714007724?httpAccept=text/xml

المؤلفون: Singer, Kanakadurga, DelProposto, Jennifer, Lee Morris, David, Zamarron, Brian, Mergian, Taleen, Maley, Nidhi, Cho, Kae Won, Geletka, Lynn, Subbaiah, Perla, Muir, Lindsey, Martinez-Santibanez, Gabriel, Nien-Kai Lumeng, Carey

المساهمون: National Institutes of Health, American Diabetes Association, National Institutes of Health, United States Training Grant, Janette Ferrantino Investigator Award from the Department of Pediatrics

المصدر: Molecular Metabolism ; volume 3, issue 6, page 664-675 ; ISSN 2212-8778

الاتاحة: http://dx.doi.org/10.1016/j.molmet.2014.06.005
https://api.elsevier.com/content/article/PII:S2212877814001239?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2212877814001239?httpAccept=text/plain

المؤلفون: Geletka, Lynn, Chen, Baoshan, Nuss, Donald, Suzuki, Nobuhiro, Parsley, Todd

المصدر: dsRNA Genetic Elements ; page 145-163 ; ISBN 9780849322051 9781420039122

الاتاحة: http://dx.doi.org/10.1201/9781420039122.ch6
http://www.crcnetbase.com/doi/pdf/10.1201/9781420039122.ch6

المؤلفون: Lumeng, Carey N., Liu, Jianhua, Geletka, Lynn, Delaney, Colin, Delproposto, Jennifer, Desai, Anjali, Oatmen, Kelsie, Martinez-Santibanez, Gabriel, Julius, Annabelle, Garg, Sanjay, Yung, Raymond L.

المصدر: The Journal of Immunology ; volume 187, issue 12, page 6208-6216 ; ISSN 0022-1767 1550-6606

الاتاحة: https://doi.org/10.4049/jimmunol.1102188
https://journals.aai.org/jimmunol/article-pdf/187/12/6208/1344174/1102188.pdf

المؤلفون: Westcott, Daniel J., DelProposto, Jennifer B., Geletka, Lynn M., Wang, Tianyi, Singer, Kanakadurga, Saltiel, Alan R., Lumeng, Carey N.

المصدر: Journal of Experimental Medicine ; volume 206, issue 13, page 3143-3156 ; ISSN 1540-9538 0022-1007

الاتاحة: http://dx.doi.org/10.1084/jem.20091333
https://rupress.org/jem/article-pdf/206/13/3143/1910707/jem_20091333.pdf

المؤلفون: Chiang, Shian-Huey, Bazuine, Merlijn, Lumeng, Carey N., Geletka, Lynn M., Mowers, Jonathan, White, Nicole M., Ma, Jing-Tyan, Zhou, Jie, Qi, Nathan, Westcott, Dan, Delproposto, Jennifer B., Blackwell, Timothy S., Yull, Fiona E., Saltiel, Alan R.

المصدر: Cell ; volume 138, issue 5, page 961-975 ; ISSN 0092-8674

الاتاحة: http://dx.doi.org/10.1016/j.cell.2009.06.046
https://api.elsevier.com/content/article/PII:S0092867409007934?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0092867409007934?httpAccept=text/plain

المؤلفون: Zamarron, Brian F., Porsche, Cara E., Luan, Danny, Lucas, Hannah R., Mergian, Taleen A., Martinez‐santibanez, Gabriel, Cho, Kae Won, DelProposto, Jennifer L., Geletka, Lynn M., Muir, Lindsey A., Singer, Kanakadurga, Lumeng, Carey N.

مصطلحات موضوعية: Endocrinology, Health Sciences

وصف الملف: application/pdf

Relation: Zamarron, Brian F.; Porsche, Cara E.; Luan, Danny; Lucas, Hannah R.; Mergian, Taleen A.; Martinez‐santibanez, Gabriel; Cho, Kae Won; DelProposto, Jennifer L.; Geletka, Lynn M.; Muir, Lindsey A.; Singer, Kanakadurga; Lumeng, Carey N. (2020). "Weight Regain in Formerly Obese Mice Hastens Development of Hepatic Steatosis Due to Impaired Adipose Tissue Function." Obesity (6): 1086-1097.; https://hdl.handle.net/2027.42/155467; Obesity; Miller RS, Becker KG, Prabhu V, Cooke DW. Adipocyte gene expression is altered in formerly obese mice and as a function of diet composition. J Nutr 2008; 138: 1033 - 1038.; Power C, Thomas C. Changes in BMI, duration of overweight and obesity, and glucose metabolism: 45 years of follow- up of a birth cohort. Diabetes Care 2011; 34: 1986 - 1991.; Cancello R, Zulian A, Gentilini D, et al. Permanence of molecular features of obesity in subcutaneous adipose tissue of ex- obese subjects. Int J Obes (Lond) 2013; 37: 867 - 873.; Magkos F, Fraterrigo G, Yoshino J, et al. Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. Cell Metab 2016; 23: 591 - 601.; Kratz M, Hagman DK, Kuzma JN, et al. Improvements in glycemic control after gastric bypass occur despite persistent adipose tissue inflammation. Obesity (Silver Spring) 2016; 24: 1438 - 1445.; Zamarron BF, Mergian TA, Cho KW, et al. Macrophage proliferation sustains adipose tissue inflammation in formerly obese mice. Diabetes 2017; 66: 392 - 406.; Jung DY, Ko HJ, Lichtman EI, et al. Short- term weight loss attenuates local tissue inflammation and improves insulin sensitivity without affecting adipose inflammation in obese mice. Am J Physiol Endocrinol Metab 2013; 304: E964 - E976.; Schmitz J, Evers N, Awazawa M, et al. Obesogenic memory can confer long- term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss. Mol Metab 2016; 5: 328 - 339.; Kalupahana NS, Voy BH, Saxton AM, Moustaid- Moussa N. Energy- restricted high- fat diets only partially improve markers of systemic and adipose tissue inflammation. Obesity (Silver Spring) 2011; 19: 245 - 254.; Martinez- Santibanez G, Cho KW, Lumeng CN. Imaging white adipose tissue with confocal microscopy. Methods Enzymol 2014; 537: 17 - 30.; Lee YH, Petkova AP, Granneman JG. Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab 2013; 18: 355 - 367.; Lee YH, Petkova AP, Mottillo EP, Granneman JG. In vivo identification of bipotential adipocyte progenitors recruited by β3- adrenoceptor activation and high- fat feeding. Cell Metab 2012; 15: 480 - 491.; Torti FM, Torti SV, Larrick JW, Ringold GM. Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta. J Cell Biol 1989; 108: 1105 - 1113.; Hu Y, Bhupathiraju SN, de Koning L, Hu FB. Duration of obesity and overweight and risk of type 2 diabetes among US women. Obesity (Silver Spring) 2014; 22: 2267 - 2273.; Lotta LA, Gulati P, Day FR, et al. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet 2017; 49: 17 - 26.; Keophiphath M, Achard V, Henegar C, Rouault C, Clement K, Lacasa D. Macrophage- secreted factors promote a profibrotic phenotype in human preadipocytes. Mol Endocrinol 2009; 23: 11 - 24.; Gustafson B, Smith U. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3- L1 preadipocytes. J Biol Chem 2006; 281: 9507 - 9516.; Bilkovski R, Schulte DM, Oberhauser F, et al. Adipose tissue macrophages inhibit adipogenesis of mesenchymal precursor cells via wnt- 5a in humans. Int J Obes (Lond) 2011; 35: 1450 - 1454.; Bing C. Is interleukin- 1β a culprit in macrophage- adipocyte crosstalk in obesity? Adipocyte 2015; 4: 149 - 152.; Gagnon A, Foster C, Landry A, Sorisky A. The role of interleukin 1β in the anti- adipogenic action of macrophages on human preadipocytes. J Endocrinol 2013; 217: 197 - 206.; Petersen RK, Jorgensen C, Rustan AC, et al. Arachidonic acid- dependent inhibition of adipocyte differentiation requires PKA activity and is associated with sustained expression of cyclooxygenases. J Lipid Res 2003; 44: 2320 - 2330.; Weinstock A, Brown EJ, Garabedian ML, et al. Single- cell RNA sequencing of visceral adipose tissue leukocytes reveals that caloric restriction following obesity promotes the accumulation of a distinct macrophage population with features of phagocytic cells [published online July 19, 2019]. Immunometabolism 2019; 1. doi: https://doi.org/10.20900/immunometab20190008; Strissel KJ, Stancheva Z, Miyoshi H, et al. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 2007; 56: 2910 - 2918.; Sattar N, Forrest E, Preiss D. Non- alcoholic fatty liver disease. BMJ 2014; 349: g4596. doi: https://doi.org/10.1136/bmj.g4596; Barbosa- da- Silva S, da Silva NC, Aguila MB, Mandarim- de- Lacerda CA. Liver damage is not reversed during the lean period in diet- induced weight cycling in mice. Hepatol Res 2014; 44: 450 - 459.; Clement K, Viguerie N, Poitou C, et al. Weight loss regulates inflammation- related genes in white adipose tissue of obese subjects. FASEB J 2004; 18: 1657 - 1669.; Steckhan N, Hohmann CD, Kessler C, Dobos G, Michalsen A, Cramer H. Effects of different dietary approaches on inflammatory markers in patients with metabolic syndrome: a systematic review and meta- analysis. Nutrition 2016; 32: 338 - 348.; Franz MJ, Boucher JL, Rutten- Ramos S, VanWormer JJ. Lifestyle weight- loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review and meta- analysis of randomized clinical trials. J Acad Nutr Diet 2015; 115: 1447 - 1463.; Soleymani T, Daniel S, Garvey WT. Weight maintenance: challenges, tools and strategies for primary care physicians. Obes Rev 2016; 17: 81 - 93.; Puzziferri N, Roshek TB 3rd, Mayo HG, Gallagher R, Belle SH, Livingston EH. Long- term follow- up after bariatric surgery: a systematic review. JAMA 2014; 312: 934 - 942.; Karmali S, Brar B, Shi X, Sharma AM, de Gara C, Birch DW. Weight recidivism post- bariatric surgery: a systematic review. Obes Surg 2013; 23: 1922 - 1933.; Mackie GM, Samocha- Bonet D, Tam CS. Does weight cycling promote obesity and metabolic risk factors? Obes Res Clin Pract 2017; 11: 131 - 139.; Mehta T, Smith DL Jr, Muhammad J, Casazza K. Impact of weight cycling on risk of morbidity and mortality. Obes Rev 2014; 15: 870 - 881.; Stevens VL, Jacobs EJ, Sun J, et al. Weight cycling and mortality in a large prospective US study. Am J Epidemiol 2012; 175: 785 - 792.; Vergnaud AC, Bertrais S, Oppert JM, et al. Weight fluctuations and risk for metabolic syndrome in an adult cohort. Int J Obes (Lond) 2008; 32: 315 - 321.; Zhang H, Tamakoshi K, Yatsuya H, et al. Long- term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men. Circ J 2005; 69: 13 - 18.; Neamat- Allah J, Barrdahl M, Husing A, et al. Weight cycling and the risk of type 2 diabetes in the EPIC- Germany cohort. Diabetologia 2015; 58: 2718 - 2725.; Sea MM, Fong WP, Huang Y, Chen ZY. Weight cycling- induced alteration in fatty acid metabolism. Am J Physiol Regul Integr Comp Physiol 2000; 279: R1145 - R1155.; Kochan Z, Karbowska J, Swierczynski J. The effects of weight cycling on serum leptin levels and lipogenic enzyme activities in adipose tissue. J Physiol Pharmacol 2006; 57 ( Suppl 6 ): 115 - 127.; Fried SK, Hill JO, Nickel M, DiGirolamo M. Prolonged effects of fasting- refeeding on rat adipose tissue lipoprotein lipase activity: influence of caloric restriction during refeeding. J Nutr 1983; 113: 1861 - 1869.; Schofield SE, Parkinson JR, Henley AB, Sahuri- Arisoylu M, Sanchez- Canon GJ, Bell JD. Metabolic dysfunction following weight cycling in male mice. Int J Obes (Lond) 2017; 41: 402 - 411.; Barbosa- da- Silva S, Fraulob- Aquino JC, Lopes JR, Mandarim- de- Lacerda CA, Aguila MB. Weight cycling enhances adipose tissue inflammatory responses in male mice. PLoS One 2012; 7: e39837. doi: https://doi.org/10.1371/journal.pone.0039837; Anderson EK, Gutierrez DA, Kennedy A, Hasty AH. Weight cycling increases T- cell accumulation in adipose tissue and impairs systemic glucose tolerance. Diabetes 2013; 62: 3180 - 3188.

الاتاحة: https://hdl.handle.net/2027.42/155467
https://doi.org/10.1002/oby.22788

المؤلفون: Parsley, Todd B., Chen, Baoshan, Geletka, Lynn M., Nuss, Donald L.

المصدر: Eukaryotic Cell ; volume 1, issue 3, page 401-413 ; ISSN 1535-9778 1535-9786

الاتاحة: http://dx.doi.org/10.1128/ec.1.3.401-413.2002
https://journals.asm.org/doi/pdf/10.1128/EC.1.3.401-413.2002

المؤلفون: Chen, Baoshan, Geletka, Lynn M., Nuss, Donald L.

المصدر: Journal of Virology ; volume 74, issue 16, page 7562-7567 ; ISSN 0022-538X 1098-5514

الاتاحة: http://dx.doi.org/10.1128/jvi.74.16.7562-7567.2000
https://journals.asm.org/doi/pdf/10.1128/JVI.74.16.7562-7567.2000

المؤلفون: Suzuki, Nobuhiro, Geletka, Lynn M., Nuss, Donald L.

المصدر: Journal of Virology ; volume 74, issue 16, page 7568-7577 ; ISSN 0022-538X 1098-5514

الاتاحة: http://dx.doi.org/10.1128/jvi.74.16.7568-7577.2000
https://journals.asm.org/doi/pdf/10.1128/JVI.74.16.7568-7577.2000

المؤلفون: Muir, Lindsey A., Kiridena, Samadhi, Griffin, Cameron, DelProposto, Jennifer B., Geletka, Lynn, Martinez‐santibañez, Gabriel, Zamarron, Brian F., Lucas, Hannah, Singer, Kanakadurga, O’ Rourke, Robert W., Lumeng, Carey N.

مصطلحات موضوعية: adipose tissue dendritic cell, obesity, adipocyte, foam cell, apoptosis, Microbiology and Immunology, Health Sciences

وصف الملف: application/pdf

Relation: Muir, Lindsey A.; Kiridena, Samadhi; Griffin, Cameron; DelProposto, Jennifer B.; Geletka, Lynn; Martinez‐santibañez, Gabriel; Zamarron, Brian F.; Lucas, Hannah; Singer, Kanakadurga; O’ Rourke, Robert W.; Lumeng, Carey N. (2018). "Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages." Journal of Leukocyte Biology 103(4): 615-628.; http://hdl.handle.net/2027.42/142947; Journal of Leukocyte Biology; Jenkins SJ, Ruckerl D, Thomas GD, et al. Ilâ 4 directly signals tissueâ resident macrophages to proliferate beyond homeostatic levels controlled by csfâ 1. J Exp Med. 2013; 210: 2477 â 2491.; Reilly SM, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017; 11: 90.; Singer K, DelProposto J, Morris Le, et al. Dietâ induced obesity promotes myelopoiesis in hematopoietic stem cells. Mol Metab. 2014;3:664â 675.; Cho KW, Zamarron BF, Muir LA, et al. Adipose tissue dendritic cells are independent contributors to obesityâ induced inflammation and insulin resistance. J Immunol. 2016; 197: 3650 â 3661.; Pamir N, Liu NC, Irwin A, et al. Granulocyte/macrophage colonyâ stimulating factorâ dependent dendritic cells restrain lean adipose tissue expansion. J Biol Chem. 2015; 290: 14656 â 14667.; Cho KW, Morris DL, DelProposto JL, et al. An MHC IIâ dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesityâ induced inflammation. Cell Rep. 2014; 9: 605 â 617.; Shapiro H, Pecht T, Shacoâ Levy R, et al. Adipose tissue foam cells are present in human obesity. J Clin Endocrinol Metab. 2013; 98: 1173 â 1181.; Jenkins SJ, Ruckerl D, Cook PC, et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of th2 inflammation. Science. 2011; 332: 1284 â 1288.; Zamarron BF, Mergian TA, Cho KW, et al. Macrophage proliferation sustains adipose tissue inflammation in formerly obese mice. Diabetes. 2017; 66: 392 â 406.; Hill AA, Andersonâ Baucum EK, Kennedy AJ, Webb CD, Yull FE, Hasty AH. Activation of nfâ κb drives the enhanced survival of adipose tissue macrophages in an obesogenic environment. Mol Metab. 2015; 4: 665 â 677.; Winer S, Chan Y, Paltser G, et al. Normalization of obesityâ associated insulin resistance through immunotherapy. Nat Med. 2009; 15: 921 â 929.; Feuerer M, Herrero L, Cipolletta D, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009; 15: 930 â 939.; Nishimura S, Manabe I, Nagasaki M, et al. Cd8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009; 15: 914 â 920.; Ji Y, Sun S, Xia S, Yang L, Li X, Qi L. Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukinâ 4. J Biol Chem. 2012; 287: 24378 â 24386.; Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011; 121: 2111 â 2117.; Braune J, Weyer U, Hobusch C, et al. Ilâ 6 regulates m2 polarization and local proliferation of adipose tissue macrophages in obesity. J Immunol. 2017; 198: 2927 â 2934.; Yoshida H, Watanabe H, Ishida A, et al. Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of highâ fat dietâ induced obesity. Biochem Biophys Res Commun. 2014; 454: 95 â 101.; Tardelli M, Zeyda K, Morenoâ Viedma V, et al. Osteopontin is a key player for local adipose tissue macrophage proliferation in obesity. Mol Metab. 2016; 5: 1131 â 1137.; Chapman J, Miles PD, Ofrecio JM, et al. Osteopontin is required for the early onset of high fat dietâ induced insulin resistance in mice. PLoS One. 2010; 5: e13959.; Zheng C, Yang Q, Cao J, et al. Local proliferation initiates macrophage accumulation in adipose tissue during obesity. Cell Death Dis. 2016; 31: 54.; Kim JI, Huh JY, Sohn JH, et al. Lipidâ overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Mol Cell Biol. 2015; 35: 1686 â 1699.; Wensveen FM, Jelencic V, Valentic S, et al. Nk cells link obesityâ induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015; 16: 376.; Aouadi M, Vangala P, Yawe JC, et al. Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance. Am J Physiol Endocrinol Metab. 2014; 307: E374 â E383.; Kosteli A, Sugaru E, Haemmerle G, et al. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest. 2010; 120: 3466 â 3479.; Nguyen MT, Favelyukis S, Nguyen AK, et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via tollâ like receptors 2 and 4 and jnkâ dependent pathways. J Biol Chem. 2007; 282: 35279 â 35292.; Bourlier V, Zakaroffâ Girard A, Miranville A, et al. Remodeling phenotype of human subcutaneous adipose tissue macrophages. Circulation. 2008; 117: 806 â 815.; Lee YH, Petkova AP, Granneman JG. Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab. 2013; 18: 355 â 367.; Parlee SD, Lentz SI, Mori H, MacDougald OA. Quantifying size and number of adipocytes in adipose tissue. Methods Enzymol. 2014; 537: 93 â 122.; Wang QA, Tao C, Gupta RK, Scherer PE. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med. 2013; 19: 1338 â 1344.; Gutierrez DA, Kennedy A, Orr JS, et al. Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of ccr2â deficient mice delays improvements in insulin sensitivity. Diabetes. 2011; 60: 2820 â 2829.; Mulder P, Morrison MC, Wielinga PY, van Duyvenvoorde W, Kooistra T, Kleemann R. Surgical removal of inflamed epididymal white adipose tissue attenuates the development of nonâ alcoholic steatohepatitis in obesity. Int J Obes. 2016; 40: 675 â 684.; Unger RH, Scherer PE. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab. 2010; 21: 345 â 352.; Ohman MK, Wright AP, Wickenheiser KJ, Luo W, Eitzman DT. Visceral adipose tissue and atherosclerosis. Curr Vasc Pharmacol. 2009; 7: 169 â 179.; Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112: 1796 â 1808.; Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesityâ related insulin resistance. J Clin Invest. 2003; 112: 1821 â 1830.; Morris DL, Singer K, Lumeng CN. Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states. Curr Opin Clin Nutr Metab Care. 2011; 14: 341 â 346.; Weisberg SP, Hunter D, Huber R, et al. Ccr2 modulates inflammatory and metabolic effects of highâ fat feeding. J Clin Invest. 2006; 116: 115 â 124.; Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117: 175 â 184.; Wentworth JM, Naselli G, Brown WA, et al. Proâ inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes. 2010; 59: 1648 â 1656.; Prieur X, Mok CY, Velagapudi VR, et al. Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and m2/m1 polarization in obese mice. Diabetes. 2011; 60: 797 â 809.; Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. Ablation of CD11câ positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 2008; 8: 301 â 309.; Xu X, Grijalva A, Skowronski A, van Eijk M, Serlie MJ, Ferrante AW. Obesity activates a program of lysosomalâ dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab. 2013; 18: 816 â 830.; Odegaard JI, Ricardoâ Gonzalez RR, Goforth MH, et al. Macrophageâ specific ppargamma controls alternative activation and improves insulin resistance. Nature. 2007; 447: 1116 â 1120.; Kang K, Reilly SM, Karabacak V, et al. Adipocyteâ derived th2 cytokines and myeloid ppardelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008; 7: 485 â 495.; Odegaard JI, Ricardoâ Gonzalez RR, Red Eagle A, et al. Alternative m2 activation of kupffer cells by ppardelta ameliorates obesityâ induced insulin resistance. Cell Metab. 2008; 7: 496 â 507.; Nawaz A, Aminuddin A, Kado T, et al. CD206+ m2â like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun. 2017; 8: 017 â 00231.; Spencer M, Yaoâ Borengasser A, Unal R, et al. Adipose tissue macrophages in insulinâ resistant subjects are associated with collagen vi and fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab. 2010; 299: E1016 â E1027.; Shaul ME, Bennett G, Strissel KJ, Greenberg AS, Obin MS. Dynamic, m2â like remodeling phenotypes of CD11c+ adipose tissue macrophages during highâ fat dietâ induced obesity in mice. Diabetes. 2010; 59: 1171 â 1181.; Amano S, Cohen JessicaL, Vangala P, et al. Local proliferation of macrophages contributes to obesityâ associated adipose tissue inflammation. Cell Metabolism. 2014; 19: 162 â 171.; Haase J, Weyer U, Immig K, et al. Local proliferation of macrophages in adipose tissue during obesityâ induced inflammation. Diabetologia. 2014; 57: 562 â 571.; Lee YS, Li P, Huh JY, et al. Inflammation is necessary for longâ term but not shortâ term highâ fat dietâ induced insulin resistance. Diabetes. 2011; 60: 2474 â 2483.; Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during dietâ induced obesity. Diabetes. 2007; 56: 16 â 23.; Morris DL, Oatmen KE, Wang T, DelProposto JL, Lumeng CN. Cx3cr1 deficiency does not influence trafficking of adipose tissue macrophages in mice with dietâ induced obesity. Obesity. 2012; 20: 1189 â 1199.

الاتاحة: http://hdl.handle.net/2027.42/142947
https://doi.org/10.1002/JLB.3HI1017-422R

المؤلفون: Muir, Lindsey A., Neeley, Christopher K., Meyer, Kevin A., Baker, Nicki A., Brosius, Alice M., Washabaugh, Alexandra R., Varban, Oliver A., Finks, Jonathan F., Zamarron, Brian F., Flesher, Carmen G., Chang, Joshua S., DelProposto, Jennifer B., Geletka, Lynn, Martinez‐santibanez, Gabriel, Kaciroti, Niko, Lumeng, Carey N., O'Rourke, Robert W.

مصطلحات موضوعية: Endocrinology, Health Sciences

وصف الملف: application/pdf

Relation: Muir, Lindsey A.; Neeley, Christopher K.; Meyer, Kevin A.; Baker, Nicki A.; Brosius, Alice M.; Washabaugh, Alexandra R.; Varban, Oliver A.; Finks, Jonathan F.; Zamarron, Brian F.; Flesher, Carmen G.; Chang, Joshua S.; DelProposto, Jennifer B.; Geletka, Lynn; Martinez‐santibanez, Gabriel; Kaciroti, Niko; Lumeng, Carey N.; O'Rourke, Robert W. (2016). "Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity." Obesity 24(3): 597-605.; http://hdl.handle.net/2027.42/117485; Obesity; Lacasa D, Taleb S, Keophiphath M, Miranville A, Clement K. Macrophageâ secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 2007; 148: 868 â 877.; Dankel SN, Svärd J, Matthä S, et al. COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. Obesity (Silver Spring) 2014; 22: 1807 â 1813.; Divoux A, Tordjman J, le Lacasa D, et al. Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes 2010; 59L 2817 â 2825.; Spencer M, Yaoâ Borengasser A, Unal R, et al. Adipose tissue macrophages in insulinâ resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab 2010; 299: E1016 â E1027.; Bourlier V, Sengenès C, Zakaroffâ Girard A, et al. TGFbeta family members are key mediators in the induction of myofibroblast phenotype of human adipose tissue progenitor cells by macrophages. PLoS One 2012; 7: e31274.; Henegar C, Tordjman J, Achard V, et al. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol 2008; 9: R14.; Vila IK, Badin PM, Marques MA, et al. Immune cell Tollâ like receptor 4 mediates the development of obesityâ and endotoxemiaâ associated adipose tissue fibrosis. Cell Rep 2014; 7: 1116 â 1129.; Halberg N, Khan T, Trujillo ME, et al. Hypoxiaâ inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 2009; 29: 4467 â 4483.; Jiang C, Qu A, Matsubara T, et al. Disruption of hypoxiaâ inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in highâ fat dietâ fed mice. Diabetes 2011; 60: 2484 â 2495.; Sun K, Park J, Gupta OT, et al. Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. Nat Commun 2014; 5: 3485.; Abdennour M, Reggio S, Le Naour G, et al. Association of adipose tissue and liver fibrosis with tissue stiffness in morbid obesity: links with diabetes and BMI loss after gastric bypass. J Clin Endocrinol Metab 2014; 99: 898 â 907.; Lackey DE, Burk DH, Ali MR, et al. Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity. Am J Physiol Endocrinol Metab 2014; 306: E233 â E246.; Kim SM, Lun M, Wang M, et al. Loss of white adipose hyperplastic potential is associated with enhanced susceptibility to insulin resistance. Cell Metab 2014; 20: 1049 â 1058.; Isakson P, Hammarstedt A, Gustafson B, Smith U. Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factorâ alpha, and inflammation. Diabetes 2009; 58: 1550 â 1557.; Hauner H, Wabitsch M, Pfeiffer EF. Differentiation of adipocyte precursor cells from obese and nonobese adult women and from different adipose tissue sites. Horm Metab Res Suppl 1988; 19: 35 â 39.; Maumus M, Sengenès C, Decaunes P, et al. Evidence of in situ proliferation of adult adipose tissueâ derived progenitor cells: influence of fat mass microenvironment and growth. J Clin Endocrinol Metab 2008; 93: 4098 â 4106.; Tchoukalova YD, Votruba SB, Tchkonia T, Giorgadze N, Kirkland JL, Jensen MD. Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc Natl Acad Sci USA 2010; 107: 18226 â 18231.; Tchkonia T, Giorgadze N, Pirtskhalava T, et al. Fat depotâ specific characteristics are retained in strains derived from single human preadipocytes. Diabetes 2006; 55: 2571 â 2578.; Drolet R, Richard C, Sniderman AD, et al. Hypertrophy and hyperplasia of abdominal adipose tissues in women. Int J Obes (Lond) 2008; 32: 283 â 291.; O'Rourke RW, White AE, Metcalf MD, et al. Hypoxiaâ induced inflammatory cytokine secretion in human adipose tissue stromovascular cells. Diabetologia 2011; 54: 1480 â 1490.; Lee YH, Petkova AP, Granneman JG. Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab 2013; 18: 355 â 367.; Sengenès C, Lolmède K, Zakaroffâ Girard A, Busse R, Bouloumié A. Preadipocytes in the human subcutaneous adipose tissue display distinct features from the adult mesenchymal and hematopoietic stem cells. J Cell Physiol 2005; 205: 114 â 122.; O'Connell J, Lynch L, Cawood TJ, et al. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS One 2010; 5: e9997.; Wood IS, de Heredia FP, Wang B, Trayhurn P. Cellular hypoxia and adipose tissue dysfunction in obesity. Proc Nutr Soc 2009; 68: 370 â 377.; Goossens GH, Bizzarri A, Venteclef N, et al. Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation 2011; 124: 67 â 76.; Peng H, Sarwar Z, Yang XP, et al. Profibrotic role for interleukinâ 4 in cardiac remodeling and dysfunction. Hypertension 2015; 66: 582 â 589. 20.; Yan J, Zhang Z, Yang J, Mitch WE, Wang Y. JAK3/STAT6 stimulates bone marrowâ derived fibroblast activation in renal fibrosis. J Am Soc Nephrol 2015; pii: ASN.2014070717. [Epub ahead of print].; Lu J, Shi J, Li M, et al. Activation of AMPK by metformin inhibits TGFâ βâ induced collagen production in mouse renal fibroblasts. Life Sci 2015; 127: 59 â 65.; Zhang W, Wu R, Zhang F, et al. Thiazolidinediones improve hepatic fibrosis in rats with nonâ alcoholic steatohepatitis by activating the adenosine monophosphateâ activated protein kinase signalling pathway. Clin Exp Pharmacol Physiol 2012; 39: 1026 â 1033.; Johannsen DL, Tchoukalova Y, Tam C, et al. Effect of 8 weeks of overfeeding on ectopic fat deposition and insulin sensitivity: testing the adipose tissue expandability hypothesis. Diabetes Care 2014; 37: 2789 â 2797.; Arner E, Westermark PO, Spalding KL, et al. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 2010; 59: 105 â 109.; Cotillard A, Poitou C, Torcivia A, et al. Adipocyte size threshold matters: link with risk of type 2 diabetes and improved insulin resistance after gastric bypass. J Clin Endocrinol Metab 2014; 99: E1466 â E1470.; Erikssonâ Hogling D, Andersson DP, Bäckdahl J, et al. Adipose tissue morphology predicts improved insulin sensitivity following moderate or pronounced weight loss. Int J Obes (Lond) 2015; 39: 893 â 898.; Landgraf K, Rockstroh D, Wagner IV, et al. Evidence of early alterations in adipose tissue biology and function and its association with obesityâ related inflammation and insulin resistance in children. Diabetes 2014; 64: 1249 â 1261.; Rydén M, Andersson DP, Bergström IB, Arner P. Adipose tissue and metabolic alterations: regional differences in fat cell size and number matter, but differently: a crossâ sectional study. J Clin Endocrinol Metab 2014; 99: E1870 â E1876.; Veilleux A, Caronâ Jobin M, Noël S, Laberge PY, Tchernof A. Visceral adipocyte hypertrophy is associated with dyslipidemia independent of body composition and fat distribution in women. Diabetes 2011; 60: 1504 â 1511.

الاتاحة: http://hdl.handle.net/2027.42/117485
https://doi.org/10.1002/oby.21377

المؤلفون: Muir, Lindsey A., Neeley, Christopher K., Meyer, Kevin A., Baker, Nicki A., Brosius, Alice M., Washabaugh, Alexandra R., Varban, Oliver A., Finks, Jonathan F., Zamarron, Brian F., Flesher, Carmen G., Chang, Joshua S., DelProposto, Jennifer B., Geletka, Lynn, Martinez-Santibanez, Gabriel, Kaciroti, Niko, Lumeng, Carey N., O'Rourke, Robert W.

المصدر: Obesity (Silver Spring, Md.). 24(3)

مصطلحات موضوعية: Male, Hyperplasia, Subcutaneous Fat, Bariatric Surgery, Hypertrophy, Middle Aged, Fibrosis, Article, Adipose Tissue, Diabetes Mellitus, Type 2, Adipocytes, Humans, Female, Obesity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9c1e4d12b6eeeffedeb74dc07e73f395
https://pubmed.ncbi.nlm.nih.gov/26965380

المؤلفون: Zamarron, Brian F., Mergian, Taleen A., Kae Won Cho, Martinez-Santibanez, Gabriel, Luan, Danny, Singer, Kanakadurga, DelProposto, Jennifer L., Geletka, Lynn M., Muir, Lindsey A., Lumeng, Carey N., Cho, Kae Won

المصدر: Diabetes; Feb2017, Vol. 66 Issue 2, p392-406, 15p, 8 Graphs

مصطلحات موضوعية: MACROPHAGES, CELL proliferation, ADIPOSE tissues, OVERWEIGHT persons, LABORATORY mice, WEIGHT loss, HIGH-fat diet, HEALTH, ANIMAL experimentation, BODY weight, CELL physiology, DIET, FLOW cytometry, FLUORESCENT antibody technique, GLUCOSE tolerance tests, IMMUNOBLOTTING, IMMUNOHISTOCHEMISTRY, INFLAMMATION, INSULIN, INTERFERONS, INTERLEUKIN-1, MICE, OBESITY, PROTEINS, RESEARCH funding, T cells, TUMOR necrosis factors, GENE expression profiling

المؤلفون: Morris, David L., Kae Won Cho, DelProposto, Jennifer L., Oatmen, Kelsie E., Geletka, Lynn M., Martinez-Santibanez, Gabriel, Singer, Kanakadurga, Lumeng, Carey N.

المصدر: Diabetes; Aug2013, Vol. 62 Issue 8, p2762-2772, 11p, 3 Color Photographs, 4 Graphs

مصطلحات موضوعية: ADIPOSE tissues, MACROPHAGES, T cells, OBESITY, CD4 antigen, ANTIGEN presenting cells, INTERFERONS, MAJOR histocompatibility complex, PHYSIOLOGY