نتائج البحث - "Gavory, Gerald"

1

Academic Journal

USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF

المؤلفون: Jurisic, Anamarija, Sung, Pei-Ju, Wappett, Mark, Daubriac, Julien, Lobb, Ian T, Kung, Wei-Wei, Crawford, Nyree, Page, Natalie, Cassidy, Eamon, Feutren-Burton, Stephanie, Rountree, J S Shane, Helm, Matthew D, O'Dowd, Colin R, Kennedy, Richard D, Gavory, Gerald, Cranston, Aaron N, Longley, Daniel B, Jacq, Xavier, Harrison, Timothy

المصدر: Jurisic , A , Sung , P-J , Wappett , M , Daubriac , J , Lobb , I T , Kung , W-W , Crawford , N , Page , N , Cassidy , E , Feutren-Burton , S , Rountree , J S S , Helm , M D , O'Dowd , C R , Kennedy , R D , Gavory , G , Cranston , A N , Longley , D B , Jacq , X & Harrison , T 2024 , ' USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by ....

مصطلحات موضوعية: Humans, Vascular Endothelial Growth Factor A, Immune Checkpoint Inhibitors/pharmacology, Ubiquitin-Specific Peptidase 7, Neoplasms, Neovascularization, Pathologic/drug therapy, Fibroblasts/metabolism, Tumor Microenvironment, CCAAT-Enhancer-Binding Proteins/pharmacology, Ubiquitin-Protein Ligases/pharmacology, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://pure.qub.ac.uk/en/publications/5fa479d6-0aa5-4450-8240-97d4b9bc1e29
https://doi.org/10.1002/ctm2.1648
https://pureadmin.qub.ac.uk/ws/files/584466100/Downblast.pdf

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2

Academic Journal

Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma.

المؤلفون: Stevenson, Leanne, Cairns, Lauren, Li, Xiaodun, Jammula, Sriganesh, Taylor, Harriet, Douglas, Rosalie, McCabe, Niamh, Gavory, Gerald, Jacq, Xavier, Fitzgerald, Rebecca C., Kennedy, Richard D., Harrison, Timothy, Turkington, Richard C.

المصدر: Scientific Reports; 12/30/2024, Vol. 14 Issue 1, p1-14, 14p

مصطلحات موضوعية: CELL death, WESTERN countries, CELL survival, CELL lines, SURVIVAL rate

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3

Academic Journal

Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development

المؤلفون: Page, Natalie, Wappett, Mark, O'Dowd, Colin R., O'Rourke, Martin, Gavory, Gerald, Zhang, Lixin, Rountree, J. S. Shane, Jordan, Linda, Barker, Oliver, Gibson, Hayley, Boyd, Caroline, Feutren-Burton, Stephanie, McLean, Estelle, Trevitt, Graham, Harrison, Timothy

المصدر: Page , N , Wappett , M , O'Dowd , C R , O'Rourke , M , Gavory , G , Zhang , L , Rountree , J S S , Jordan , L , Barker , O , Gibson , H , Boyd , C , Feutren-Burton , S , McLean , E , Trevitt , G & Harrison , T 2022 , ' Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development ' , Scientific Reports , vol. 12 , 15715 . https://doi.org/10.1038/s41598-022-20208-5

مصطلحات موضوعية: Tamoxifen, Angiogenesis Inhibitors, Serine, Phosphatidylinositol 3-Kinases - metabolism, Isoenzymes, Proto-Oncogene Proteins c-akt - metabolism, Threonine, Protein Kinase Inhibitors - pharmacology - therapeutic use, Humans

وصف الملف: application/pdf

الاتاحة: https://pure.qub.ac.uk/en/publications/149e3246-450d-4699-80a2-2dd83dead1c9
https://doi.org/10.1038/s41598-022-20208-5
https://pureadmin.qub.ac.uk/ws/files/379179592/Identification_and_development_of_a_subtype_selective_allosteric_AKT_inhibitor_suitable_for_clinical_development.pdf

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4

Academic Journal

Identification and structure-guided development of pyrimidinone based USP7 inhibitors

المؤلفون: O'Dowd, Colin R., Helm, Matthew D., Rountree, J. S. Shane, Flasz, Jakub T., Arkoudis, Elias, Miel, Hugues, Hewitt, Peter R., Jordan, Linda, Barker, Oliver, Hughes, Caroline, Rozycka, Ewelina, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Fuetren-Burton, Stephanie, Dvorkin, Scarlett, Gavory, Gerald, Harrison, Timothy

المصدر: O'Dowd , C R , Helm , M D , Rountree , J S S , Flasz , J T , Arkoudis , E , Miel , H , Hewitt , P R , Jordan , L , Barker , O , Hughes , C , Rozycka , E , Cassidy , E , McClelland , K , Odrzywol , E , Page , N , Fuetren-Burton , S , Dvorkin , S , Gavory , G & Harrison , T 2018 , ' Identification and structure-guided development of pyrimidinone based USP7 inhibitors ' , ACS Medicinal Chemistry Letters ....

وصف الملف: application/pdf

الاتاحة: https://pure.qub.ac.uk/en/publications/2f45280f-2e3b-4155-98fd-e3d8efc69242
https://doi.org/10.1021/acsmedchemlett.7b00512
https://pureadmin.qub.ac.uk/ws/files/147621355/Identification_and_Structure_Guided_Development_of_Pyrimidinone_Based_USP7_Inhibitors.pdf

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5

Academic Journal

Identification and Characterization of Dual Inhibitors of the USP25/ 28 Deubiquitinating Enzyme Subfamily

المصدر: Wrigley , J D , Gavory , G , Simpson , I , Preston , M , Plant , H , Bradley , J , Goeppert , A U , Rozycka , E , Davies , G , Walsh , J , Valentine , A , McClelland , K , Odrzywol , K E , Renshaw , J , Boros , J , Tart , J , Leach , L , Nowak , T , Ward , R A , Harrison , T & Andrews , D M 2017 , ' Identification and Characterization of Dual Inhibitors of the ....

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://pure.qub.ac.uk/en/publications/58debcb9-1bd8-4e20-88a2-a14b7e3ed675
https://doi.org/10.1021/acschembio.7b00334
https://pureadmin.qub.ac.uk/ws/files/138563496/Wriglies.pdf

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6

Academic Journal

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

المؤلفون: Gavory, Gerald, O'Dowd, Colin, Helm, Matthew D., Flasz, Jakub, Arkoudis, Elias, Dossang, Anthony, Hughes, Caroline, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Barker, Oliver, Miel, Hugues, Harrison, Timothy

المصدر: Gavory , G , O'Dowd , C , Helm , M D , Flasz , J , Arkoudis , E , Dossang , A , Hughes , C , Cassidy , E , McClelland , K , Odrzywol , E , Page , N , Barker , O , Miel , H & Harrison , T 2017 , ' Discovery and characterization of highly potent and selective allosteric USP7 inhibitors ' , Nature Chemical Biology , vol. 14 , pp. 118-125 . https://doi.org/10.1038/nchembio.2528

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://pure.qub.ac.uk/en/publications/e7597a0f-932a-40c7-93ad-632aa359463e
https://doi.org/10.1038/nchembio.2528
https://pureadmin.qub.ac.uk/ws/files/138886374/DisCombined.pdf

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7

Academic Journal

Identification of a new RNA{middle dot}RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation

المؤلفون: Ren, Xiaojun, Gavory, Gérald, Li, Haitao, Ying, Liming, Klenerman, David, Balasubramanian, Shankar

مصطلحات موضوعية: Articles

وصف الملف: text/html

Relation: http://nar.oxfordjournals.org/cgi/content/short/31/22/6509; http://dx.doi.org/10.1093/nar/gkg871

الاتاحة: http://nar.oxfordjournals.org/cgi/content/short/31/22/6509
https://doi.org/10.1093/nar/gkg871

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8

Academic Journal

Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro

المؤلفون: Gavory, Gérald, Farrow, Mark, Balasubramanian, Shankar

مصطلحات موضوعية: Articles

وصف الملف: text/html

Relation: http://nar.oxfordjournals.org/cgi/content/short/30/20/4470; http://dx.doi.org/10.1093/nar/gkf575

الاتاحة: http://nar.oxfordjournals.org/cgi/content/short/30/20/4470
https://doi.org/10.1093/nar/gkf575

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9

Conference

Mebendazole: A candidate FDA approved drug for repurposing in leukaemia

المؤلفون: Matchett, Kyle B., Grishagin, Ivan V., Kettyle, Laura M., Gavory, Gerald, Harrison, Timothy, Mills, Ken, Thompson, Alexander

المصدر: Matchett , K B , Grishagin , I V , Kettyle , L M , Gavory , G , Harrison , T , Mills , K & Thompson , A 2016 , ' Mebendazole: A candidate FDA approved drug for repurposing in leukaemia ' , XXXVI World Congress International Society of Haematology , Glasgow , United Kingdom , 18/04/2016 - 21/04/2016 pp. 121-122 .

الاتاحة: https://pure.qub.ac.uk/en/publications/f6e7daf9-2404-42a8-bcda-33e3bd888ccf

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