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1
المؤلفون: Donald Nelson, Gary G. Chicchi, James Dellureficio, Ravi P. Nargund, Peter H. Dobbelaar, Liangqin Guo, Kwei-Lan Tsao, Janet S. Kerr, Bei Zhang, Zhong Lai, Patricia R. Bunting, Shrenik K. Shah, Raman K. Bakshi, Qingmei Hong, Hongbo Qi, Guillermo Fernandez, Mikhail Reibarkh, Qing Shao, Quang Truong, Koppara Samuel, Jian Liu, Sylvia Volksdorf, Zhixiong Ye, Yun-Ping Zhou, Margaret Wu, Cai Li, Stan Mitelman, Andrew D. Howard, Wu Du, Maria E. Trujillo, George J. Eiermann, Shuwen He, Vijay Bhasker G. Reddy, Tianying Jian, Pierre Morissette, Patrick Fitzgerald, Dorina Trusca, Sharon Tong, William K. Hagmann
المصدر: ACS Medicinal Chemistry Letters. 5:748-753
مصطلحات موضوعية: biology, business.industry, Organic Chemistry, hERG, Antagonist, In vitro toxicology, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, QT interval, Somatostatin, Drug Discovery, biology.protein, Medicine, cardiovascular diseases, Receptor, business, Antagonism
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2
المؤلفون: David Wilson, Bindhu V. Karanam, Mona Purcell, Maria Madeira, Gary G. Chicchi, Jianming Bao, Liza Gantert, Robert J. DeVita, Huagang Lu, Wai-Si Eng, Sander G. Mills, Richard G. Ball, Andrew J. Kassick, Peter Lin, Sanjeev Kumar, Jaime Lynn Bunda, George A. Doss, Kwei-Lan C. Tsao, Jacquelyn J. Cook, Xinchun Tong, Richard Tschirret-Guth, Jinlong Jiang, Koppara Samuel, Richard Hargreaves, Hong Wang, Donald F. Hora
المصدر: Journal of Medicinal Chemistry. 56:5940-5948
مصطلحات موضوعية: Trifluoromethyl, CYP3A4, Chemistry, Stereochemistry, Glucuronidation, chemistry.chemical_compound, Drug Discovery, medicine, Molecular Medicine, Potency, NK1 receptor antagonist, Once daily dosing, Short duration, Aprepitant, medicine.drug
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3
المؤلفون: Gary G. Chicchi, Jennifer R. Kosinski, Alessandro Pocai, George J. Eiermann, Julie Lao, Aleksandr Petrov, Xiaobing Du, Xiaolan Shen
المصدر: American Journal of Physiology-Endocrinology and Metabolism. 303:E265-E271
مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Biology, Carbohydrate metabolism, Glucagon-Like Peptide-1 Receptor, Mice, chemistry.chemical_compound, Glucagon-Like Peptide 1, Physiology (medical), Internal medicine, Receptors, Glucagon, medicine, Animals, Insulin, Glucose tolerance test, Peptide analog, medicine.diagnostic_test, Glucose Tolerance Test, Glucose clamp technique, Glucagon-like peptide-1, Mice, Inbred C57BL, Oxyntomodulin, Glucose, Endocrinology, chemistry, Glucose Clamp Technique, Glucagon receptor
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4
المؤلفون: Ranabir SinhaRoy, Gary G. Chicchi, Mark D. Erion, Nancy A. Thornberry, Jonathan Day, George J. Eiermann, Alessandro Pocai, Jas Gidda, Matthias H. Tschöp, Richard D. DiMarchi, David L. Smiley, Donald J. Marsh, Vasily M. Gelfanov, Paul E. Carrington
المصدر: Biopolymers. 98:443-450
مصطلحات موضوعية: Blood Glucose, Male, Agonist, medicine.medical_specialty, Aminoisobutyric Acids, medicine.drug_class, Molecular Sequence Data, Glycogenolysis, Biophysics, Mice, Obese, Peptide, CHO Cells, Transfection, Biochemistry, Glucagon, Glucagon-Like Peptide-1 Receptor, Biomaterials, Mice, Structure-Activity Relationship, Cricetulus, Glucagon-Like Peptide 1, Cricetinae, Internal medicine, Weight Loss, Cyclic AMP, Receptors, Glucagon, medicine, Animals, Humans, Histidine, Amino Acid Sequence, Receptor, chemistry.chemical_classification, Organic Chemistry, General Medicine, Glucagon-like peptide-1, Amino acid, Mice, Inbred C57BL, Glucose, Endocrinology, Amino Acid Substitution, chemistry, Hyperglycemia, Proteolysis, PEGylation, Anti-Obesity Agents, Glucagon receptor
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5
المؤلفون: Wai-Si Eng, Xinchun Tong, Richard Tschirret-Guth, Song Zheng, Gary G. Chicchi, Geoge A. Doss, Koppara Samuel, Richard Hargreaves, Terence G. Hamill, Marc M. Kurtz, Robert J. DeVita, Sanjeev Kumar, Alan Wheeldon, Emma J. Carlson, Alana Upthagrove, Jaime Lynn Bunda, Stephen Krause, Jinlong Jiang, Christine Ryan, Sander G. Mills, Donald Burns, Kwei-Lan C. Tsao
المصدر: Journal of Medicinal Chemistry. 52:3039-3046
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Morpholines, Administration, Oral, Stereoisomerism, CHO Cells, Isoindoles, Chemical synthesis, Inhibitory Concentration 50, chemistry.chemical_compound, Cricetulus, Neurokinin-1 Receptor Antagonists, Cricetinae, Drug Discovery, medicine, Animals, Humans, Antiemetic, Drug Interactions, Enzyme Inhibitors, Aprepitant, Trifluoromethyl, Antagonist, Brain, Receptor antagonist, Macaca mulatta, chemistry, Molecular Medicine, NK1 receptor antagonist, medicine.drug
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6
المؤلفون: Peter Lin, Gary G. Chicchi, Julie A. DeMartino, Neil Collinson, Marc M. Kurtz, Susan Boyce, Robert J. DeVita, Alan Wheeldon, Jonathan R. Young, Stephen Moore, Emma J. Carlson, Kwei-Lan C. Tsao, Sander G. Mills, Karen Townson, George A. Doss, Gregori J. Morriello, Nadia M.J. Rupniak
المصدر: Bioorganic & Medicinal Chemistry. 16:2156-2170
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydroxylation, Methylation, Biochemistry, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, Neurokinin-1 Receptor Antagonists, In vivo, Drug Discovery, Humans, Urea, Pyrroles, Molecular Biology, Molecular Structure, Bicyclic molecule, Chemistry, Organic Chemistry, Diastereomer, Stereoisomerism, Penetration (firestop), Receptors, Neurokinin-1, Bridged Bicyclo Compounds, Heterocyclic, Amides, In vitro, Lactam, Epoxy Compounds, Molecular Medicine
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7
المؤلفون: Janet Kerr, Gary G. Chicchi, Margaret Wu, Cai Li, Shuwen He, Vijay Bhasker G. Reddy, Sharon Tong, William K. Hagmann, Patrick Fitzgerald, Guillermo Fernandez, Andrew D. Howard, Tianying Jian, Zhe Feng, Raman K. Bakshi, Dorina Trusca, Peter H. Dobbelaar, Donald Nelson, Mikhail Reibarkh, Qing Shao, Liangqin Guo, Yun-Ping Zhou, Ravi P. Nargund, Kwei-Lan Tsao, Edward C. Sherer, Stan Mitelman, Pierre Morissette, Maria E. Trujillo, Quang Truong, Zhixiong Ye, James D. Dellureficio, Hongbo Qi, Melissa Lin, Shrenik K. Shah, Sylvia Volksdorf, Jian Liu, Qingmei Hong, Koppara Samuel, Alexander Pasternak, George J. Eiermann, Patricia B. Bunting, Wu Du, Bei B. Zhang
المصدر: Bioorganicmedicinal chemistry letters. 26(6)
مصطلحات موضوعية: QTC PROLONGATION, congenital, hereditary, and neonatal diseases and abnormalities, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, 010402 general chemistry, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Humans, cardiovascular diseases, Receptors, Somatostatin, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, 0104 chemical sciences, Rats, biology.protein, Molecular Medicine, Antagonism, Carbolines
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8
المؤلفون: Anka G. Ehrhardt, Karen H. Dingley, Nam Fung Kar, Harold B. Wood, Gary G. Chicchi, Ping Liu, Timothy J. Kowalski, Cheng Zhu, Viktor Hornak, Joe Lamberson, Morgan Woods, Jenna L. Terebetski, Margaret van Heek, Joie Garfunkle, Christopher Moyes, Michael W. Miller, Zhiyong Hu, Byron G. DuBois, Andrea Woods, Ravi P. Nargund, Joyce Powell, Gino Salituro, Jianmei Pang, Louis-Charles Campeau, Yuping Zhu, David N. Hunter, Scott D. Edmondson, Toru Seo, Fez Ujjainwalla, Ling Kang, Andrew Stamford
مصطلحات موضوعية: Type ii diabetes, GPR119, Orally active, In vivo, Chemistry, Organic Chemistry, Drug Discovery, Potency, Gpr119 agonist, Pharmacology, Biochemistry, Combinatorial chemistry
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9
المؤلفون: Xiaodong Yang, Guoqiang Jiang, Emma R. Parmee, Songnian Lin, James R. Tata, Gary G. Chicchi, Laurie Tota, Bei B. Zhang, Maria E. Trujillo, Corey Miller, Fengqi Zhang, Edward J. Brady, Alka Bansal, Sajjad A. Qureshi, Gino Salituro
المصدر: Bioorganicmedicinal chemistry letters. 25(19)
مصطلحات موضوعية: medicine.medical_specialty, Indazoles, Indoles, Clinical Biochemistry, Pharmaceutical Science, Mice, Obese, CHO Cells, Pyrazole, Biochemistry, Glucagon, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cricetulus, Pharmacokinetics, Internal medicine, Diabetes mellitus, Drug Discovery, medicine, Receptors, Glucagon, Animals, Humans, Molecular Biology, Indole test, Indazole, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, medicine.disease, In vitro, Rats, Endocrinology, chemistry, Molecular Medicine, Glucagon receptor
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10
المؤلفون: Kwei-Lan Tsao, Derun Li, Liangqing Guo, Richard G. Ball, Zhicai Wu, David X. Yang, Gary G. Chicchi, William K. Hagmann, Quang Tuang, Dorina Trusca, Yang Yu, Shuwen He, Qingmei Hong, Ravi P. Nargund, Edward C. Sherer, Yun-Ping Zhou, Zhong Lai, Andrew D. Howard
المصدر: Bioorganicmedicinal chemistry letters. 25(17)
مصطلحات موضوعية: Agonist, medicine.drug_class, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Biochemistry, Methylamines, Structure-Activity Relationship, Drug Discovery, medicine, Somatostatin receptor 3, Molecular Medicine, Humans, Receptors, Somatostatin, Antagonism, Molecular Biology
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11
المؤلفون: Jason M, Elliott, Robert W, Carling, Gary G, Chicchi, James, Crawforth, Peter H, Hutson, A Brian, Jones, Sarah, Kelly, Rose, Marwood, Georgina, Meneses-Lorente, Elena, Mezzogori, Fraser, Murray, Michael, Rigby, Inmaculada, Royo, Michael G N, Russell, Duncan, Shaw, Bindi, Sohal, Kwei Lan, Tsao, Brian, Williams
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5752-5756
مصطلحات موضوعية: Neurotransmitter Agents, Dose-Response Relationship, Drug, Organic Chemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Receptors, Neurokinin-3, CHO Cells, Fluorine, Biochemistry, Piperazines, Structure-Activity Relationship, Hydrazines, Cricetinae, Drug Discovery, Quinolines, Tumor Cells, Cultured, Animals, Molecular Medicine, Molecular Biology
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12
المؤلفون: Gary G. Chicchi, Paul E. Finke, Joseph M. Metzger, Dorothy Levorse, Malcolm MacCoss, Margaret A. Cascieri, D. Euan MacIntyre, Laura C. Meurer, Kwei-Lan Tsao, Sharon Sadowski, Sander G. Mills
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:4497-4503
مصطلحات موضوعية: Molecular Structure, Tertiary amine, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Cyclopentanes, Receptors, Neurokinin-1, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Neurokinin-1 Receptor Antagonists, Solubility, chemistry, Morpholine, Drug Discovery, Humans, Molecular Medicine, Molecule, Structure–activity relationship, Cyclopentane, Molecular Biology
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13
المؤلفون: Janusz Jozef Kulagowski, Gary G. Chicchi, Clare London, Alan Wheeldon, Ian Thomas Huscroft, Emma J. Carlson, Marc M. Kurtz, Piotr Raubo
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:2008-2012
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, hERG, Substituent, Pharmaceutical Science, Ether, CHO Cells, Medicinal chemistry, Biochemistry, Chemical synthesis, Bridged Bicyclo Compounds, chemistry.chemical_compound, Benzyl ether, Neurokinin-1 Receptor Antagonists, In vivo, Cricetinae, Drug Discovery, Side chain, Animals, Humans, Receptor, Molecular Biology, Octane, Aza Compounds, biology, Organic Chemistry, General Medicine, Ether-A-Go-Go Potassium Channels, chemistry, Cyclization, biology.protein, Molecular Medicine, NK1 receptor antagonist, Selectivity
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14
المؤلفون: Gary G. Chicchi, Janusz Jozef Kulagowski, Piotr Raubo
المصدر: Synlett. :271-274
مصطلحات موضوعية: chemistry.chemical_compound, Heptane, Bicyclic molecule, Diene, Chemistry, Ligand, Stereochemistry, Organic Chemistry, Stereoselectivity, Metathesis, Ring (chemistry), Acyclic diene metathesis
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15
المؤلفون: Gary G. Chicchi, Barry R. Cunningham, Michelle K. Clements, Marc M. Kurtz, Ruiping Wang, Qingyun Liu, Christopher P. Austin, Margaret A. Cascieri
المصدر: Gene. 296:205-212
مصطلحات موضوعية: Male, Molecular Sequence Data, Peptide, Substance P, CHO Cells, Biology, Cleavage (embryo), Binding, Competitive, Mice, Radioligand Assay, chemistry.chemical_compound, Cricetinae, Tachykinins, Databases, Genetic, Genetics, medicine, Animals, Humans, heterocyclic compounds, Amino Acid Sequence, Protein Precursors, Receptor, Gene, Receptors, Tachykinin, B cell, chemistry.chemical_classification, Dose-Response Relationship, Drug, Sequence Homology, Amino Acid, Gene Expression Profiling, Receptors, Neurokinin-3, Receptors, Neurokinin-2, General Medicine, Receptors, Neurokinin-1, Peptide Fragments, Rats, Gene expression profiling, medicine.anatomical_structure, chemistry, Biochemistry, Female, Tachykinin receptor, Sequence Alignment
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16
المؤلفون: Madhumeeta J Dhar, Lorraine Malkowitz, Kevin T. Chapman, Kang Cheng, Steven M. Hutchins, Stephen G. Pacholok, Christopher A. Willoughby, Keith G. Rosauer, Gary G. Chicchi, David H. Weinberg, Sharon Sadowski, Smita Patel, Jerry Di Salvo
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:93-96
مصطلحات موضوعية: Indoles, Stereochemistry, G protein, medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Receptors, Cell Surface, Carboxamide, Ligands, Binding, Competitive, Biochemistry, Chemical synthesis, Structure-Activity Relationship, GTP-Binding Proteins, Drug Discovery, medicine, Combinatorial Chemistry Techniques, Humans, Amines, Receptor, Molecular Biology, Receptors, Tachykinin, G protein-coupled receptor, Bicyclic molecule, Chemistry, Ligand, Organic Chemistry, Amides, Receptors, Serotonin, Molecular Medicine, Receptors, Chemokine, Amine gas treating
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17
المؤلفون: Yang Yu, Gary G. Chicchi, Frederick Wong, Janet S. Kerr, Sharon Tong, Zhe Feng, Guillermo Fernandez, Edward C. Sherer, Kwei-Lan Tsao, Qing Shao, Bei B. Zhang, Yun-Ping Zhou, Pierre Morissette, Shuwen He, Shrenik K. Shah, Vijay Bhasker G. Reddy, Liangqin Guo, Ravi P. Nargund, Margaret Wu, Cai Li, Zhixiong Ye, Alexander Pasternak, George J. Eiermann, Patricia R. Bunting, Hongbo Qi, Michele Pachanski, Stan Mitelman, Maria E. Trujillo, Quang Truong, Maria Madiera, Andrew D. Howard, Donald Nelson, Qingmei Hong, Zhong Lai, Yue Feng, Bindhu V. Karanam, Jian Liu, Koppara Samuel, Wu Du, William K. Hagmann, Tianying Jian, Dorina Trusca, Sylvia Volksdorf, Peter H. Dobbelaar
المصدر: ACS medicinal chemistry letters. 6(5)
مصطلحات موضوعية: business.industry, Murine model, Organic Chemistry, Drug Discovery, Antagonist, Qtc interval prolongation, medicine, Type 2 diabetes, Glucose excursion, Pharmacology, medicine.disease, business, Biochemistry
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18
المؤلفون: Angela Williams, Mark Peter Ridgill, Gary G. Chicchi, Christopher John Swain, Jason Matthew Elliott, Marc M. Kurtz, Nicola Szeto, Denise Morrison, Alan P. Watt, Duncan Shaw
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:3031-3034
مصطلحات موضوعية: Indoles, Metabolic Clearance Rate, Stereochemistry, Neurokinin A, Clinical Biochemistry, Drug Evaluation, Preclinical, Substituent, Administration, Oral, Biological Availability, Pharmaceutical Science, Biochemistry, Piperazines, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Cricetinae, Amide, Drug Discovery, Animals, Structure–activity relationship, Moiety, Molecular Biology, Indole test, Aryl, Organic Chemistry, Amides, Rats, Piperazine, chemistry, Molecular Medicine, Lead compound
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19
المؤلفون: Gary G. Chicchi, Mark Peter Ridgill, Gregory John Hollingworth, Angela Williams, W. Rycroft, Kwei-Lan Tsao, Christopher John Swain, Kevin Dinnell, Jason Matthew Elliott, Madhumeeta J Dhar, Marc M. Kurtz
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1237-1240
مصطلحات موضوعية: Indoles, Nitrogen, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Molecular Conformation, Substituent, Pharmaceutical Science, chemistry.chemical_element, Electrons, Carboxamide, CHO Cells, Substance P, Binding, Competitive, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Neurokinin-1 Receptor Antagonists, Cricetinae, Drug Discovery, medicine, Animals, Molecular Biology, Indole test, Behavior, Animal, Bicyclic molecule, Aryl, Organic Chemistry, Recombinant Proteins, chemistry, Molecular Medicine, Gerbillinae, Selectivity, Palladium
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20
المؤلفون: Margaret A. Cascieri, Malcolm MacCoss, Gary G. Chicchi, Gregory E. Koch, Sharon Sadowski, Stephen E. de Laszlo, Candice Hacker, E. Ber, William K. Hagmann, Pasquale P. Vicario, Donna Louizides
المصدر: Journal of Biological Chemistry. 274:8694-8697
مصطلحات موضوعية: Agonist, endocrine system, Cations, Divalent, Pyridines, medicine.drug_class, Glucagon-Like Peptides, CHO Cells, Biochemistry, Glucagon, Glucagon-Like Peptide-1 Receptor, Hormone Antagonists, Cricetinae, Receptors, Glucagon, medicine, Animals, Humans, Pyrroles, Receptor, Molecular Biology, Glucagon-like peptide 1 receptor, Molecular Structure, Chemistry, digestive, oral, and skin physiology, Cell Biology, Enzyme Activation, Transmembrane domain, Mutation, Peptides, Glucagon receptor family, Glucagon receptor, hormones, hormone substitutes, and hormone antagonists, Adenylyl Cyclases, Protein Binding