المؤلفون: Gareth WALDRON, Michael SUTTON, Nicola REGAN, Takuma HARADA, 原田 拓真

المصدر: Annual Meeting of the Japanese Society of Toxicology. 2010, :358

المؤلفون: David C. Pryde, Brian E. Marron, Peter J. Cox, C. J. Markworth, Joseph S. Warmus, Christopher William West, David Printzenhoff, S. McMurray, Stupple Paul Anthony, Zhixin Lin, Nigel Alan Swain, Mark L. Chapman, C. E. Payne, Ryoichi Suzuki, Gareth Waldron

المصدر: MedChemComm. 8:1255-1267

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Chemistry, Organic Chemistry, Pharmaceutical Science, Ether, Biochemistry, Combinatorial chemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Pharmacokinetics, Voltage sensor, Drug Discovery, Molecular Medicine, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::686aba00c31c3db790fd73e2323a9e86
https://doi.org/10.1039/c7md00131b

المؤلفون: Michelle Tran-Dubé, Bruce M. Bechle, Michelle Kraus, Ciarán N. Cronin, Kim James, Joseph S. Warmus, Fen Wang, Jianmin Sun, Indrawan James Mcalpine, Sacha Ninkovic, Jianwei Bian, Samantha Elizabeth Greasley, Neil J. Flanagan, Matthew Corbett, Rebecca Dias, Andrews Mark David, Asako Nagata, John F. Braganza, Linda Kitching, David C. Blakemore, Eric Johnson, Sarah Elizabeth Skerratt, Kiyoyuki Omoto, Sharan K. Bagal, Jingrong Jean Cui, James Bilsland, Peter J. Bungay, Rachel L. Grimley, Stephanie Scales, Gareth Waldron

المصدر: Journal of medicinal chemistry. 61(15)

مصطلحات موضوعية: 0301 basic medicine, animal structures, Protein Conformation, Pyridines, Pain, Tropomyosin receptor kinase B, Neurotrophin-3, Pharmacology, Tropomyosin receptor kinase A, Ligands, 030226 pharmacology & pharmacy, Tropomyosin receptor kinase C, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, Animals, Humans, Tissue Distribution, Protein Kinase Inhibitors, Brain-derived neurotrophic factor, biology, Chemistry, Receptor Protein-Tyrosine Kinases, Rats, Molecular Docking Simulation, 030104 developmental biology, Nerve growth factor, nervous system, Solubility, Trk receptor, biology.protein, Molecular Medicine, Neurotrophin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f470c72f1e1c68f507f99de2c39e1f77
https://pubmed.ncbi.nlm.nih.gov/29944371

المؤلفون: Michelle Kraus, James Bilsland, Neil J. Flanagan, Gareth Waldron, Linda Kitching, Indrawan James Mcalpine, Peter J. Bungay, Jingrong Jean Cui, David Fengas, Rachel L. Grimley, Joseph S. Warmus, Ciarán N. Cronin, Samantha Elizabeth Greasley, Philip J Clarke, David C. Blakemore, Asako Nagata, Eric Johnson, Sharan K. Bagal, Rebecca Dias, Kiyoyuki Omoto, Matthew Corbett

المصدر: Journal of medicinal chemistry. 62(1)

مصطلحات موضوعية: animal structures, Allosteric regulation, Drug Evaluation, Preclinical, Tropomyosin receptor kinase B, Neurotrophin-3, Tropomyosin receptor kinase A, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, 01 natural sciences, Tropomyosin receptor kinase C, 03 medical and health sciences, Structure-Activity Relationship, Allosteric Regulation, Drug Discovery, Animals, Humans, Protein Isoforms, Amino Acid Sequence, Receptor, trkA, Protein Kinase Inhibitors, 030304 developmental biology, Brain-derived neurotrophic factor, 0303 health sciences, Binding Sites, biology, Chemistry, 0104 chemical sciences, High-Throughput Screening Assays, Protein Structure, Tertiary, Rats, 010404 medicinal & biomolecular chemistry, Nerve growth factor, nervous system, Cancer research, biology.protein, Microsomes, Liver, Molecular Medicine, Pyrazoles, Sequence Alignment, Neurotrophin, Half-Life, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783bc10c50e46e9fccee1aeb733dbfb1
https://pubmed.ncbi.nlm.nih.gov/29672039

المؤلفون: Russell Jones, Inaki Morao, Colin Robinson, Stupple Paul Anthony, Susan Cole, David G. Brown, Karl Richard Gibson, Angus N. R. Nedderman, Gareth Waldron, Sarah Elizabeth Skerratt, James Bilsland, Andrews Mark David, Kiyoyuki Omoto, Peter J. Bungay, Kimberly Skinner, Sharan K. Bagal, Thomas Ryckmans

المصدر: Journal of medicinal chemistry. 59(22)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Druggability, Pain, Quantitative Structure-Activity Relationship, Neurotrophin-3, Pharmacology, 01 natural sciences, Receptor tyrosine kinase, 03 medical and health sciences, Drug Discovery, medicine, Humans, Pyrroles, Protein Kinase Inhibitors, Brain-derived neurotrophic factor, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chronic pain, medicine.disease, 0104 chemical sciences, 030104 developmental biology, Nerve growth factor, Pyrimidines, nervous system, Trk receptor, QD431, biology.protein, Molecular Medicine, Protein Kinases, Neurotrophin

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a752fa27ce219afd09077598d1a3a87e
https://pubmed.ncbi.nlm.nih.gov/27766865

المؤلفون: Mark Holbrook, Matthew J. Winter, William S. Redfern, Jean-Pierre Valentin, Paul Butler, Gareth Waldron, Rob Wallis

المصدر: Journal of Pharmacological and Toxicological Methods. 58:110-117

مصطلحات موضوعية: Pharmacology, animal structures, Drug-Related Side Effects and Adverse Reactions, biology, Drug discovery, Safety pharmacology, fungi, Toxicology, Bioinformatics, biology.organism_classification, Risk Assessment, Data science, Predictive Value of Tests, Larva, Paradigm shift, Mammalian cell, Toxicity Tests, Animals, Economics, Pharmaceutical, Zebrafish, Biotechnology industry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fc0b2e6ef8276f6f6da789a23d79ac
https://doi.org/10.1016/j.vascn.2008.05.006

المؤلفون: Paul Goldsmith, Stephane Berghmans, Iain Gardner, Frances M. Richards, Gillian Kimber, W.K. Alderton, Alan Geoffrey Roach, Angeleen Fleming, Paul Butler, Gareth Waldron, Zoe Golder

المصدر: Journal of Pharmacological and Toxicological Methods. 58:59-68

مصطلحات موضوعية: Time Factors, animal structures, Drug-Related Side Effects and Adverse Reactions, ved/biology.organism_classification_rank.species, Drug Evaluation, Preclinical, Pharmacology, Toxicology, Species Specificity, In vivo, Toxicity Tests, Animals, Humans, Adverse effect, Model organism, Zebrafish, Vision, Ocular, biology, Drug discovery, ved/biology, Safety pharmacology, fungi, Heart, biology.organism_classification, Gastrointestinal Tract, Pharmaceutical Preparations, Larva, Models, Animal, Toxicity, Optomotor response

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d1a4071d95a6718043b74d05b63cb7
https://doi.org/10.1016/j.vascn.2008.05.130

المؤلفون: Derek Leishman, Gareth Waldron

المصدر: Voltage-Gated Ion Channels as Drug Targets, Volume 29

مصطلحات موضوعية: Materials science, Nanotechnology, Patch clamp, Communication channel, Planar patch clamp

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5ffbe3c86bd2e9fcc334996970b3e63c
https://doi.org/10.1002/3527608141.ch4

المؤلفون: Christine Williams, Gareth Waldron, Claire Margaret Wood

المصدر: Drug Discovery Today. 9:434-441

مصطلحات موضوعية: Pharmacology, Patch-Clamp Techniques, Computer science, Drug discovery, Biomedical Technology, Nanotechnology, Computational biology, Ion Channels, Drug Design, Drug Discovery, Animals, Patch clamp, Throughput (business), Ion channel

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8dfcc1d170044ce53cf6002668cc768
https://doi.org/10.1016/s1359-6446(04)03064-8

المؤلفون: Arun Sridhar, Jacques Hamon, Joanne Bowes, Gareth Waldron, Andrew J. Brown, Steven Whitebread, Wolfgang Jarolimek

المصدر: Nature reviews. Drug discovery. 11(12)

مصطلحات موضوعية: Pharmacology, Drug, Knowledge management, Drug Industry, Drug-Related Side Effects and Adverse Reactions, business.industry, Drug discovery, Market Withdrawal, Collaborative knowledge, media_common.quotation_subject, General Medicine, medicine.disease, Risk Assessment, Biotechnology, Drug Discovery, medicine, Profiling (information science), Attrition, Business, Drug industry, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60147374fbba939fa1e41cb273d5aab8
https://pubmed.ncbi.nlm.nih.gov/23197038

المؤلفون: Margaret Falconer, Gareth Waldron, Wilma Keighley, Gill Congrave, Sandha Surah-Narwal, Giuseppe Ciaramella, Fiona Smith, Paul Hayter, Peter Haddock, Zhen Liu, Andreas Sewing

المصدر: Journal of biomolecular screening. 7(5)

مصطلحات موضوعية: 0301 basic medicine, Patch-Clamp Techniques, High-throughput screening, Drug Evaluation, Preclinical, Nanotechnology, 01 natural sciences, Biochemistry, Ion Channels, Analytical Chemistry, Ion, 03 medical and health sciences, Automation, Fluorescence Resonance Energy Transfer, Throughput (business), Ion channel, Fluorescent Dyes, Chemistry, Reproducibility of Results, Fluorescence, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Förster resonance energy transfer, Molecular Medicine, Core system, Biotechnology, Primary screening

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c1bf2a4f332224981f7f0353fece00
https://pubmed.ncbi.nlm.nih.gov/14599362

المؤلفون: Stella Chime, Gareth Waldron, Richard J. Newman, Andy N. Mead

المصدر: Journal of Pharmacological and Toxicological Methods. 64:e24-e25

مصطلحات موضوعية: Pharmacology, Cognition, Toxicology, Psychology, Cognitive psychology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0dc4d4985861e5257c05910a98fecdd8
https://doi.org/10.1016/j.vascn.2011.03.088

المؤلفون: Amy Warr, Cathleen Hsu, Richard Newman, Suzanne Shires, Andy N. Mead, Karen Tse, Gareth Waldron

المصدر: Journal of Pharmacological and Toxicological Methods. 68:e8

مصطلحات موضوعية: Pharmacology, Beam walking, Intrinsic activity, GABAA receptor, Chemistry, Subtype selective, Toxicology, Selectivity, Drug discrimination

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::27057c39a0ddc723d148e3e2dde388a6
https://doi.org/10.1016/j.vascn.2013.01.038

المؤلفون: Karen Tse, Richard J. Newman, Gareth Waldron

المصدر: Journal of Pharmacological and Toxicological Methods. 62:e39

مصطلحات موضوعية: Pharmacology, business.industry, Safety pharmacology, Medicine, Computational biology, Toxicology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::095b0b7672eeeb07749513d267feb601
https://doi.org/10.1016/j.vascn.2010.11.133

المؤلفون: Jill Steidl-Nichols, Xian Chen, Sunny Z. Sun, Gareth Waldron, Bernard Fermini, Richard Newman, Karen Tse

المصدر: Journal of Pharmacological and Toxicological Methods. 62:e8

مصطلحات موضوعية: Pharmacology, business.industry, Hippocampal slice, Convulsion, Medicine, medicine.symptom, Toxicology, business, Neuroscience, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::76c7016a33beece5f5e9ec12bcf6e6f5
https://doi.org/10.1016/j.vascn.2010.11.025

المؤلفون: Richard Newman, Gareth Waldron, Karen Y. Tse, Tanya Knight

المصدر: Journal of Pharmacological and Toxicological Methods. 62:e21

مصطلحات موضوعية: Pharmacology, Pathology, medicine.medical_specialty, Beam walking, Chemistry, GABAA receptor, Biophysics, medicine, Toxicology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8d7d4fbfbed9234cf717816ae47d1de0
https://doi.org/10.1016/j.vascn.2010.11.070

المؤلفون: Mark Holbrook, Rob Wallis, Will S. Redfern, Jean-Pierre Valentin, Matthew J. Winter, Paul Butler, Gareth Waldron

المصدر: Journal of Pharmacological and Toxicological Methods. 62:e22

مصطلحات موضوعية: Pharmacology, biology, business.industry, Safety pharmacology, Medicine, Toxicology, biology.organism_classification, business, Neuroscience, Zebrafish

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2d172f3d116d2e45a982024e9cf1c796
https://doi.org/10.1016/j.vascn.2010.11.075

المؤلفون: Gareth Waldron

المصدر: Toxicology Letters. 189:S8

مصطلحات موضوعية: business.industry, Safety pharmacology, Medicine, General Medicine, Pharmacology, Toxicology, business, Drug Dependency

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3896307eead2135c812218b217f92384
https://doi.org/10.1016/j.toxlet.2009.06.168

المؤلفون: A. Alexandrou, Michael R. Sutton, Gareth Waldron, N. Regan

المصدر: Journal of Pharmacological and Toxicological Methods. 58:158

مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, business.industry, Internal medicine, Cardiology, medicine, Toxicology, business, QT interval

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e1f9b9c722e118b04ea2c8731c272894
https://doi.org/10.1016/j.vascn.2008.05.053