المؤلفون: Verbeeren, Jens, Teixeira, Joana, Garcia, Susana M. D. A.

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: Rna-binding proteins, In-vivo, Gene-expression, Mbnl proteins, Nuclear foci, Localization, Alignment, Target, Identification, Sequestration, Genetics, developmental biology, physiology

وصف الملف: application/pdf

Relation: We are grateful to the CGC, funded by NIH Office of Research Infrastructure Programs (P40 OD010440), which provided some of the strains. We also thank the laboratories of Drs. Brendan Battersby and Olli Matilainen for sharing reagents, and Dr. Mikko Frilander for critical reading of the manuscript.; Verbeeren , J , Teixeira , J & Garcia , S M D A 2023 , ' The Muscleblind-like protein MBL-1 regulates microRNA expression in Caenorhabditis elegans through an evolutionarily conserved autoregulatory mechanism ' , PLoS Genetics , vol. 19 , no. 12 , e1011109 . https://doi.org/10.1371/journal.pgen.1011109; ORCID: /0000-0002-1638-7575/work/152346295; http://hdl.handle.net/10138/570478; 56199c20-8976-4542-90a9-252e539a7485; 001130039200002

الاتاحة: http://hdl.handle.net/10138/570478

المؤلفون: Verbeeren, Jens, Teixeira, Joana, Garcia, Susana M. D. A.

المساهمون: Hart, Anne C., Academy of Finland, Ella ja Georg Ehrnroothin Säätiö, Instrumentariumin Tiedesäätiö, Suomen Kulttuurirahasto

المصدر: PLOS Genetics ; volume 19, issue 12, page e1011109 ; ISSN 1553-7404

الاتاحة: http://dx.doi.org/10.1371/journal.pgen.1011109
https://dx.plos.org/10.1371/journal.pgen.1011109

المؤلفون: Matilainen, Olli, Ribeiro, Ana R. S., Verbeeren, Jens, Cetinbas, Murat, Sood, Heini, Sadreyev, Ruslan, Garcia, Susana M. D. A.

المساهمون: Molecular and Integrative Biosciences Research Programme, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: Muscleblind splicing factor, C. elegans, lifespan, p38 MAPK, PMK-1, ATF-1, SKN-1, mitochondrial stress, INNATE IMMUNE-RESPONSES, MITOCHONDRIAL DYSFUNCTION, FACTOR SKN-1, KINASE, RNA, MAPK, PROTEINS, PATHWAY, STRESS, EXPRESSION, Genetics, developmental biology, physiology

وصف الملف: application/pdf

Relation: Valtion perusrahoitus/hankkeet; Finlands Akademi; The Garcia Laboratory is supported by the Academy of Finland Project Funding (309173) and by the Institute of Biotechnology, University of Helsinki. O.M. is supported by the University of Helsinki 3-year grant and by the Institute of Biotechnology. J.V. and H.S. were supported by the Academy of Finland Project Funding (309173). A.R.S.R. was supported by AICEP, Portuguese Trade & Investment Agency, Project Inov Contacto Program, 2019-international internships. R.I.S. is supported by NIH NIDDK P30DK040561.; Matilainen , O , Ribeiro , A R S , Verbeeren , J , Cetinbas , M , Sood , H , Sadreyev , R & Garcia , S M D A 2021 , ' Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1 ' , Genetics , vol. 219 , no. 2 , 114 . https://doi.org/10.1093/genetics/iyab114; ORCID: /0000-0002-1638-7575/work/103232829; http://hdl.handle.net/10138/342444; bd13ef99-1a9c-4bf3-a62d-a3d414c8e02d; 000708515000011

الاتاحة: http://hdl.handle.net/10138/342444

المؤلفون: Braun, Maya, Shoshani, Shachar, Teixeira, Joana, Shtern, Anna Mellul, Miller, Maya, Granot, Zvi, Fischer, Sylvia E. J., Garcia, Susana M. D. A., Tabach, Yuval

المساهمون: Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: MYOTONIC-DYSTROPHY PATIENTS, DOUBLE-STRANDED-RNA, TRINUCLEOTIDE-REPEAT, CAENORHABDITIS-ELEGANS, MITOCHONDRIAL-DNA, EPIGENETIC MEMORY, TRIPLET REPEAT, INTERFERENCE, GENE, IDENTIFICATION, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: We thank Prof. Gary Ruvkun, Massachusetts General Hospital and Harvard Medical School, for his com-ments on the project. We also thank Prof. Igor Ulitsky and Prof. Eran Hornstein at the Weizmann Institute of Science for reviewing the manuscript. This work was supported by the Israel Science Foundation (grant number 1591/19) . J.T. was supported by the Academy of Finland Project Funding (grant number 309173/17) .; Braun , M , Shoshani , S , Teixeira , J , Shtern , A M , Miller , M , Granot , Z , Fischer , S E J , Garcia , S M D A & Tabach , Y 2022 , ' Asymmetric inheritance of RNA toxicity in C. elegans expressing CTG repeats ' , iScience , vol. 25 , no. 5 , 104246 . https://doi.org/10.1016/j.isci.2022.104246; ORCID: /0000-0002-1638-7575/work/113990065; http://hdl.handle.net/10138/344129; ddd14c88-798e-49e4-a63f-02fba4ed8d35; 000795545500008

الاتاحة: http://hdl.handle.net/10138/344129

المؤلفون: Teixeira, Joana, Harju, Anu-Mari, Othman, Alaa, Eriksson, Ove, Battersby, Brendan J, Garcia, Susana M D A

المساهمون: Phillips, C, Academy of Finland Project Funding, University of Helsinki Internal Funding, Otto A. Malm Foundation, AICEP, Portuguese and European funds, Sigrid Juselius Foundation

المصدر: GENETICS ; ISSN 1943-2631

الاتاحة: https://doi.org/10.1093/genetics/iyae208
https://academic.oup.com/genetics/advance-article-pdf/doi/10.1093/genetics/iyae208/61286386/iyae208.pdf

المؤلفون: Matilainen, Olli, Ribeiro, Ana R S, Verbeeren, Jens, Cetinbas, Murat, Sood, Heini, Sadreyev, Ruslan I, Garcia, Susana M D A

المساهمون: Academy of Finland Project Funding, Institute of Biotechnology, University of Helsinki, Institute of Biotechnology, NIH, NIDDK

المصدر: Genetics ; volume 219, issue 2 ; ISSN 1943-2631

الاتاحة: https://doi.org/10.1093/genetics/iyab114
http://academic.oup.com/genetics/advance-article-pdf/doi/10.1093/genetics/iyab114/39721351/iyab114.pdf
https://academic.oup.com/genetics/article-pdf/219/2/iyab114/41535511/iyab114.pdf

المؤلفون: Matilainen, Olli Juhani, Bou Sleiman, Maroun, Moral Quiros, Pedro, Garcia, Susana M. D. A., Auwerx, Johan

المصدر: http://infoscience.epfl.ch/record/299739.

Relation: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE105036; http://infoscience.epfl.ch/record/299739

الاتاحة: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE105036
http://infoscience.epfl.ch/record/299739

المؤلفون: Matilainen, Olli, Sleiman, Maroun S. Bou, Quiros, Pedro M., Garcia, Susana M. D. A., Auwerx, Johan

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: UNFOLDED PROTEIN RESPONSE, LIFE-SPAN EXTENSION, HEAT-SHOCK PROTEINS, GENE-EXPRESSION, C-ELEGANS, CAENORHABDITIS-ELEGANS, LONGEVITY, DAF-16, INNATE, YEAST, Biomedicine

وصف الملف: application/pdf

Relation: O.M is supported by FEBS long-term fellowship. P.M.Q. was supported by a long-term fellowship from EMBO (ALTF 480-2014). This work is supported by grants from the Ecole Polytechnique Federale de Lausanne, the Swiss National Science Foundation (31003A-140780), the AgingX program of the Swiss Initiative for Systems Biology (51RTP0-151019), and the NIH (R01AG043930). The authors thank Carina Holmberg and Pierre Gonczy for sharing reagents and Laurent Mouchiroud and Vincenzo Sorrentino for assistance with the experiments. Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440).; Matilainen , O , Sleiman , M S B , Quiros , P M , Garcia , S M D A & Auwerx , J 2017 , ' The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress ' , Nature Communications , vol. 8 , 1818 . https://doi.org/10.1038/s41467-017-01903-8; ORCID: /0000-0002-1638-7575/work/52697401; http://hdl.handle.net/10138/232835; 870be9fa-5502-40ec-bd5b-99980631840a; 85035815644; 000416399400004

الاتاحة: http://hdl.handle.net/10138/232835

المؤلفون: Matilainen, Olli, Sleiman, Maroun S. Bou, Quiros, Pedro M., Garcia, Susana M. D. A., Auwerx, Johan

المصدر: Nature Communications ; volume 8, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-017-01903-8
https://www.nature.com/articles/s41467-017-01903-8.pdf
https://www.nature.com/articles/s41467-017-01903-8

المؤلفون: Matilainen, Olli, Ribeiro, Ana R. S., Cetinbas, Murat, Sadreyev, Ruslan I., Garcia, Susana M. D. A.

المصدر: SSRN Electronic Journal ; ISSN 1556-5068

الاتاحة: http://dx.doi.org/10.2139/ssrn.3569543

المؤلفون: Garcia, Susana M. D. A., Tabach, Yuval, Lourenço, Guinevere F., Armakola, Maria, Ruvkun, Gary

مصطلحات موضوعية: CUG repeats, myotonic dystrophy, DM1, RNA toxicity, repeat disorders, nonsense-mediated decay

وصف الملف: application/pdf

Relation: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125460/pdf/; Nature structural & molecular biology; Garcia, Susana M. D. A., Yuval Tabach, Guinevere F. Lourenço, Maria Armakola, and Gary Ruvkun. 2014. “Identification of genes in trinucleotide repeat RNA toxicity pathways in C. elegans.” Nature structural & molecular biology 21 (8): 712-720. doi:10.1038/nsmb.2858. http://dx.doi.org/10.1038/nsmb.2858.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:14065573

الاتاحة: http://nrs.harvard.edu/urn-3:HUL.InstRepos:14065573
https://doi.org/10.1038/nsmb.2858

المؤلفون: Zhang, Chi, Montgomery, Taiowa A, Fischer, Sylvia E J, Garcia, Susana M D A, Riedel, Christian G, Fahlgren, Noah, Sullivan, Christopher M, Carrington, James C, Ruvkun, Gary

المصدر: Zhang , C , Montgomery , T A , Fischer , S E J , Garcia , S M D A , Riedel , C G , Fahlgren , N , Sullivan , C M , Carrington , J C & Ruvkun , G 2012 , ' The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification ' , Current Biology , vol. 22 , no. 10 , pp. 881-90 . https://doi.org/10.1016/j.cub.2012.04.011

مصطلحات موضوعية: Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, RNA Interference, RNA, Double-Stranded, Small Interfering, RNA-Binding Proteins, RNA-Induced Silencing Complex

الاتاحة: https://hdl.handle.net/11370/3268e08a-10f4-45e0-8567-bf282eeb51e7
https://research.rug.nl/en/publications/3268e08a-10f4-45e0-8567-bf282eeb51e7
https://doi.org/10.1016/j.cub.2012.04.011

المؤلفون: Garcia, Susana M D A, Tabach, Yuval, Lourenço, Guinevere F, Armakola, Maria, Ruvkun, Gary

المصدر: Nature Structural & Molecular Biology; Aug2014, Vol. 21 Issue 8, p712-720, 9p

مصطلحات موضوعية: CAENORHABDITIS elegans, IDENTIFICATION, GENE expression, RNA, TRINUCLEOTIDE repeats, TOXICOLOGY, MYOTONIA atrophica, TUMOR suppressor genes

المؤلفون: Matilainen, Olli, Ribeiro, Ana R S, Verbeeren, Jens, Cetinbas, Murat, Sood, Heini, Sadreyev, Ruslan I, Garcia, Susana M D A

المصدر: Genetics; October 2021, Vol. 219 Issue: 2