المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/figure/Pedigrees_of_the_two_independent_families_with_Bilallelic_Germline_i_MSH3_i_-Mutations_/17094881

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s001

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/figure/Single_nucleotide_variant_profile_of_MSH3-deficient_adenomas_and_sporadic_adenomas_HGCA_/17094884

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s002

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/dataset/1_9_single_base_substitution_mutational_signatures_of_all_nine_polyps_using_deconstructSigs_/17094887

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s003

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/figure/Variant_features_of_MSH3-deficient_adenomas_including_silent_variants_/17094896

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s006

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/figure/Indel_pattern_in_MSH3-deficient_adenomas_and_sporadic_adenomas_HGCA_/17094893

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s005

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/dataset/Result_of_pathway_analysis_/17094905

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s009

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/figure/Variant_c_1303delA_in_the_gene_i_ACVR2A_i_/17094899

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s007

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/dataset/Somatic_CNVs_detected_in_polyps_from_patient_1661_2_/17094911

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s011

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/figure/Fractions_of_indels_and_SNVs_in_MSH3-deficient_adenomas_and_HGCA_/17094914

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.g001

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/dataset/Somatic_variants_of_candidate_driver_genes_in_MSH3-deficient_adenomas_/17094902

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s008

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/dataset/Somatic_variants_identified_in_MSH3-deficient_adenomas_/17094908

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.s010

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/figure/Insertion_and_deletion_mutational_signatures_of_MSH3-deficient_adenomas_/17094917

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.g002

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/figure/Analysis_and_comparison_of_i_APC_i_variants_in_MSH3-deficient_adenomas_and_other_sources_/17094920

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.g003

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/figure/Distribution_of_affected_candidate_driver_genes_of_MSH3-related_tumourigenesis_across_all_nine_adenomas_/17094923

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.g004

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/dataset/Most_promising_candidate_driver_genes_of_MSH3-related_tumourigenesis_/17094929

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.t002

المؤلفون: Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic

Relation: https://figshare.com/articles/dataset/Characteristics_of_colorectal_polyps_from_patients_with_i_MSH3_i_-related_adenomatous_polyposis_investigated_via_whole_exome_sequencing_/17094926

الاتاحة: https://doi.org/10.1371/journal.pone.0259185.t001