المؤلفون: Yu Wai Chen, Wai-Po Kong, Kwok-Yin Wong

المصدر: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2602-2612 (2023)

مصطلحات موضوعية: AlphaFold 2, ColabFold, Gromacs, CHARMM-GUI membrane builder, CHARMM36 force field, Transmembrane proteins, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037023001526; https://doaj.org/toc/2001-0370

URL الوصول: https://doaj.org/article/f86fa9d9863447ae968db1c3178d5ffe

المؤلفون: Kreiter, Jürgen (University of Veterinary Medicine Vienna), Pohl, Elena E. (University of Veterinary Medicine Vienna), Vazdar, Mario (University of Chemistry and Technology Prague), Bardakji, Sarah (University of Veterinary Medicine Vienna), Škulj, Sanja (University of Veterinary Medicine Vienna), Brkljača, Zlatko (Rudjer Bošković Institute)

المصدر: International Journal of Molecular Sciences 24(18) (2023)

مصطلحات موضوعية: Mitochondrial Adp/Atp Carrier, Gui Membrane-Builder, Molecular-Dynamics, H+ Transport, Uncoupling Proteins, Flip-Flop, Saccharomyces-Cerevisiae, Purine Nucleotides, Proton Transport, Binding

وصف الملف: application/pdf

Relation: isPartOf:https://phaidra.vetmeduni.ac.at/o:605[Open Access Publications]; https://phaidra.vetmeduni.ac.at/o:2514

الاتاحة: https://doi.org/10.3390/ijms241813701
https://phaidra.vetmeduni.ac.at/o:2514

المؤلفون: Kupke, Thomas, Götz, Rabea M., Richter, Florian M., Beck, Rainer, Lolicato, Fabio, Nickel, Walter, Hopf, Carsten, Brügger, Britta

المساهمون: Department of Physics

مصطلحات موضوعية: Gui membrane-builder, Proteolysis protease, Gene-product, Pdz domains, Tnf-alpha, Cleavage, Yael, Region, S2p, Degs, Physical sciences

وصف الملف: application/pdf

Relation: Kupke , T , Götz , R M , Richter , F M , Beck , R , Lolicato , F , Nickel , W , Hopf , C & Brügger , B 2023 , ' In vivo characterization of the bacterial intramembrane-cleaving protease RseP using the heme binding tag-based assay iCliPSpy ' , Communications Biology , vol. 6 , no. 1 , 287 . https://doi.org/10.1038/s42003-023-04654-z; http://hdl.handle.net/10138/357722; 2a42a55a-bdf0-4500-8f91-a1526ce47c50; 85150665894; 000952993800008

الاتاحة: http://hdl.handle.net/10138/357722

المؤلفون: Salomaa, Siiri, Miihkinen, Mitro, Kremneva, Elena, Paatero, Ilkka, Lilja, Johanna, Jacquemet, Guillaume, Vuorio, Joni, Antenucci, Lina, Kogan, Konstantin, Nia, Fatemeh Hassani, Hollos, Patrik, Isomursu, Aleksi, Vattulainen, Ilpo, Coffey, Eleanor T., Kreienkamp, Hans-Juergen, Lappalainen, Pekka, Ivaska, Johanna

المساهمون: Institute of Biotechnology, Department of Physics, Doctoral Programme in Biomedicine, Doctoral Programme in Chemistry and Molecular Sciences, Doctoral Programme in Integrative Life Science, Doctoral Programme in Materials Research and Nanosciences, Biosciences, Pekka Lappalainen / Principal Investigator

مصطلحات موضوعية: POSTSYNAPTIC DENSITY PROTEINS, GUI MEMBRANE-BUILDER, INTEGRIN ACTIVATION, MUTATIONS, ADHESION, FAMILY, DOMAIN, TALIN, BRAIN, INDIVIDUALS, Physical sciences

وصف الملف: application/pdf

Relation: We thank the Cell Imaging and Cytometry and the Zebrafish Core facilities (Turku Bioscience Centre, University of Turku and A degrees bo Akademi University) and University of Turku Central Animal Laboratory, all supported by Biocenter Finland, for services in imaging and animal experiments. CSC -IT Center for Science is acknowledged for computing resources. We thank P. Laasola, J. Siivonen, and V. Pollari for technical help, G. Bruno for initial work on the N52R mutation, and H. Hamidi for editing of the manuscript and illustrations. I. Barsukov, J. Pouwels, P. Hotulainen, and the Ivaska lab are acknowledged for important suggestions, feedback, and stimulating discussions. This study has been supported by an ERC CoG grant 615258 (J.I.), the Academy of Finland (J.I., G.J., E.T.C., P.L., and I.V.), the Finnish Cancer Foundation (J.I., P.L., and I.V.), the Sigrid Juselius Foundation (J.I., G.J., and I.V.), and grants from Deutscher Akademischer Austauschdienst (DAAD) (to F.H.N.), Deutsche Forschungsgemeinschaft (DFG) (KR 1321/9-1; to H.-J.K.), and the Human Frontier Science Program (project no. RGP0059/2019 to I.V.). S.I.S. has been supported by the Svenska Kulturfonden, Finnish Cultural Foundation, University of Turku Foundation, and Maud Kuistila Memorial Foundation. S.I.S. and M.M. have been supported by University of Turku Drug Research Doctoral Programme, J.L. by Turku Doctoral Programme of Molecular Medicine, and A.I. by Turku Doctoral Programme in Molecular Life Sciences.; Salomaa , S , Miihkinen , M , Kremneva , E , Paatero , I , Lilja , J , Jacquemet , G , Vuorio , J , Antenucci , L , Kogan , K , Nia , F H , Hollos , P , Isomursu , A , Vattulainen , I , Coffey , E T , Kreienkamp , H-J , Lappalainen , P & Ivaska , J 2021 , ' SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling ' , Current Biology , vol. 31 , no. 22 , pp. 4956-+ . https://doi.org/10.1016/j.cub.2021.09.022; ORCID: /0000-0003-3270-9391/work/105285231; ORCID: /0000-0001-7408-3214/work/105286814; http://hdl.handle.net/10138/350903; 522ad92b-6f6e-416d-a10e-31b4adef750b; 000730117100007

الاتاحة: http://hdl.handle.net/10138/350903

المؤلفون: Galemou Yoga, Etienne, Parey, Kristian, Djurabekova, Amina, Haapanen, Outi, Siegmund, Karin, Zwicker, Klaus, Sharma, Vivek, Zickermann, Volker, Angerer, Heike

المساهمون: Materials Physics, Department of Physics, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: GUI MEMBRANE-BUILDER, MOLECULAR-DYNAMICS, CRYSTAL-STRUCTURE, UBIQUINONE BINDING, 49-KDA SUBUNIT, CRYO-EM, CHARMM, PROTEIN, OXIDOREDUCTASE, ORIENTATION, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: Valtion perusrahoitus/hankkeet; The authors thank I. Dikic for institutional support at Medical School, Institute of Biochemistry II, Frankfurt am Main and they thank W. Kuhlbrandt for institutional support and o. Yildiz and J. F. Castillo-Hernandez for computational support at the MPI of Biophysics. The authors wish to acknowledge CSC-IT Center for Science, Finland, for computational resources, including Pilot Grand Challenge projects complexIty (puhti supercomputer) and complexIty2 (mahti supercomputer). They also acknowledge PRACE for awarding us access to MareNostrum at Barcelona Supercomputing Center (BSC), Spain and to Marconi100 at CINECA, Italy. This work was supported by the Deutsche Forschungsgemeinschaft (grant AN 1080/3-1 to H.A. and ZI 552/4-2 to V.Z.). V.S. acknowledges research funding from the Academy of Finland (294652), the University of Helsinki, the Magnus Ehrnrooth Foundation and the Sigrid Juselius Foundation. O.H. acknowledges research funds from the CHEMS doctoral school of the University of Helsinki. EM data were collected and processed at the cryo-EM facility of the MPI of Biophysics, funded by the Max Planck Society.; Galemou Yoga , E , Parey , K , Djurabekova , A , Haapanen , O , Siegmund , K , Zwicker , K , Sharma , V , Zickermann , V & Angerer , H 2020 , ' Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I ' , Nature Communications , vol. 11 , no. 1 , 6008 . https://doi.org/10.1038/s41467-020-19778-7; ORCID: /0000-0002-8838-3151/work/86487789; http://hdl.handle.net/10138/324006; ff5a4f52-47cb-42d6-b28e-5e7d6709d5c8; 000596012700012

الاتاحة: http://hdl.handle.net/10138/324006

المؤلفون: Purhonen, Janne, Grigorjev, Vladislav, Ekiert, Robert, Aho, Noora, Rajendran, Jayasimman, Pietras, Rafal, Truve, Katarina, Wikström, Mårten, Sharma, Vivek, Osyczka, Artur, Fellman, Vineta, Kallijärvi, Jukka

المساهمون: STEMM - Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Research Programs Unit, Department of Physics, Institute of Biotechnology, Materials Physics, Clinicum, HUS Children and Adolescents, Children's Hospital

مصطلحات موضوعية: IRON-SULFUR PROTEIN, CYTOCHROME BC(1) COMPLEX, GUI MEMBRANE-BUILDER, RESPIRATORY-CHAIN, CRYSTAL-STRUCTURE, GRACILE SYNDROME, MUTATIONS, GENERATION, DYNAMICS, DISEASE, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: Valtion perusrahoitus/hankkeet; We thank Dr. Saara Tegelberg, Eva Hansson, Elisa Altay, Rishi Banerjee, and Meharji Arumilli for technical assistance. We thank Dr. Arkadiusz Borek and Dr. Patryk Kuleta for assistance in characterizing the enzymatic activities of the bacterial complexes and Outi Haapanen for help with ubiquinone topology and parameters. The Center for Scientific Computing, Finland is acknowledged for computing time. This study was supported by grants from Academy of Finland (grant 259296 to V.F., grant 294652 to V.S., grant 311031 to N.A.), Swedish Research Council (grant 521-2011-3877 to V.F.), Finnish Physicians' Society (to V.F.), Foundation for Pediatric Research in Finland (to V.F.), Folkhalsan Research Center (to V.F. and J.K.), Magnus Ehrnrooth Foundation (to V.F. and V.S.), University of Helsinki (to V.S.), Sigrid Juselius Foundation (to V.S.), and National Science Centre, Poland (Maestro grant 2015/18/A/NZ1/00046 to A.O.).; Purhonen , J , Grigorjev , V , Ekiert , R , Aho , N , Rajendran , J , Pietras , R , Truve , K , Wikström , M , Sharma , V , Osyczka , A , Fellman , V & Kallijärvi , J 2020 , ' A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice ' , Nature Communications , vol. 11 , no. 1 , 322 . https://doi.org/10.1038/s41467-019-14201-2; ORCID: /0000-0002-8838-3151/work/70951302; ORCID: /0000-0003-3773-7025/work/70951990; ORCID: /0000-0002-7527-4415/work/85518554; http://hdl.handle.net/10138/313076; aadb2f5b-3cbb-42b4-aa65-2f1b9ea6a401; 000511912200012

الاتاحة: http://hdl.handle.net/10138/313076

المؤلفون: Thomas Kupke, Rabea M. Götz, Florian M. Richter, Rainer Beck, Fabio Lolicato, Walter Nickel, Carsten Hopf, Britta Brügger

المساهمون: Department of Physics

المصدر: Communications Biology. 6

مصطلحات موضوعية: Gene-product, Yael, Degs, Medicine (miscellaneous), Pdz domains, Tnf-alpha, S2p, 114 Physical sciences, General Biochemistry, Genetics and Molecular Biology, Gui membrane-builder, Region, Proteolysis protease, General Agricultural and Biological Sciences, Cleavage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ff551fc4b22ca39a0ccaceefa7cce3
https://doi.org/10.1038/s42003-023-04654-z

المؤلفون: Haapanen, Outi, Djurabekova, Amina, Sharma, Vivek

المساهمون: Department of Physics, Institute of Biotechnology

مصطلحات موضوعية: Physical sciences, redox chemistry, proton transport, electron transport, density functional calculations, molecular dynamics, cell respiration, GUI MEMBRANE-BUILDER, MOLECULAR-DYNAMICS, CRYSTAL-STRUCTURE, UBIQUINONE BINDING, CORRELATION-ENERGY, BOUND UBIQUINONE, MECHANISM, SUBUNIT, CHARMM, REDUCTION

وصف الملف: application/pdf

Relation: Valtion perusrahoitus/hankkeet; Haapanen , O , Djurabekova , A & Sharma , V 2019 , ' Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I ' , Frontiers in Chemistry , vol. 7 , 221 . https://doi.org/10.3389/fchem.2019.00221; RIS: urn:C768B1110F96B5E8D69BA5E13274DE84; ORCID: /0000-0002-8838-3151/work/56838520; http://hdl.handle.net/10138/301185; d4fdac04-1357-4241-b8fa-0d43f08a1612; 000463921400001

الاتاحة: http://hdl.handle.net/10138/301185

المؤلفون: Karhu, Lasse, Magarkar, Aniket, Bunker, Alex, Xhaard, Henri

المساهمون: Division of Pharmaceutical Chemistry and Technology, Division of Pharmaceutical Biosciences, Drug Research Program, Pharmaceutical biophysics group, Pharmaceutical Design and Discovery group, Henri Xhaard / Principal Investigator

مصطلحات موضوعية: Chemical sciences, PROTEIN-COUPLED RECEPTOR, GUI MEMBRANE-BUILDER, STRUCTURAL BASIS, ALLOSTERIC MODULATION, FORCE-FIELD, MODEL, OX1, CHOLESTEROL, MECHANISM, PEPTIDES

وصف الملف: application/pdf

Relation: Karhu , L , Magarkar , A , Bunker , A & Xhaard , H 2019 , ' Determinants of Orexin Receptor Binding and Activation—A Molecular Dynamics Study ' , Journal of Physical Chemistry B , vol. 123 , no. 12 , pp. 2609-2622 . https://doi.org/10.1021/acs.jpcb.8b10220; RIS: urn:315FF15231D80DAD70633C0DCB3E7232; ORCID: /0000-0002-1236-9513/work/56834736; ORCID: /0000-0001-6432-8580/work/56838033; http://hdl.handle.net/10138/301182; 3956caa3-f9e2-45bc-9573-f02784c51513; 85063393166; 000463116700003

الاتاحة: http://hdl.handle.net/10138/301182

المؤلفون: Noora Aho, Mårten Wikström, Vladislav Grigorjev, Vineta Fellman, Vivek Sharma, Janne Purhonen, Artur Osyczka, Robert Ekiert, Jukka Kallijärvi, Rafał Pietras, Katarina Truvé, Jayasimman Rajendran

المساهمون: STEMM - Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Research Programs Unit, Department of Physics, Institute of Biotechnology, Materials Physics, Clinicum, HUS Children and Adolescents, Children's Hospital

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications

مصطلحات موضوعية: DYNAMICS, epistasis, Male, 0301 basic medicine, Non-Mendelian inheritance, Mitochondrial Diseases, Metabolic disorders, Respiratory chain, General Physics and Astronomy, DISEASE, mitokondriotaudit, Electron Transport Complex III, Mice, 0302 clinical medicine, energy metabolism, CRYSTAL-STRUCTURE, IRON-SULFUR PROTEIN, lcsh:Science, Mice, Knockout, Genetics, mitokondrio-DNA, Multidisciplinary, CYTOCHROME BC(1) COMPLEX, Cytochrome b, Cytochromes b, Mitochondria, 3. Good health, Female, RESPIRATORY-CHAIN, GRACILE SYNDROME, henkiinjääminen, Oxidation-Reduction, Mitochondrial DNA, Mitochondrial disease, Science, Congenic, Molecular Dynamics Simulation, Biology, DNA, Mitochondrial, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, aineenvaihduntahäiriöt, medicine, metabolic disorders, Animals, MUTATIONS, Epistasis, Genetic, Energy metabolism, General Chemistry, Cytochrome b Group, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Coenzyme Q – cytochrome c reductase, Epistasis, 1182 Biochemistry, cell and molecular biology, ATPases Associated with Diverse Cellular Activities, lcsh:Q, GUI MEMBRANE-BUILDER, koe-eläinmallit, Metabolism, Inborn Errors, 030217 neurology & neurosurgery, GENERATION, Molecular Chaperones

وصف الملف: application/pdf; fulltext

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0ee8976c7e6c7bef1293e37bef5de9
https://doaj.org/article/3779b9d3fc13415ab6b4e35cb40df347

المؤلفون: Bavnhøj, Laust, Paulsen, Peter Aasted, Flores-Canales, Jose C., Schiøtt, Birgit, Pedersen, Bjørn Panyella

المصدر: Bavnhøj , L , Paulsen , P A , Flores-Canales , J C , Schiøtt , B & Pedersen , B P 2021 , ' Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H + symporter STP10 ' , Nature Plants , vol. 7 , no. 10 , pp. 1409-1419 . https://doi.org/10.1038/s41477-021-00992-0

مصطلحات موضوعية: CRYSTAL-STRUCTURE, DYNAMICS, ELECTROSTATICS, EXPRESSION, FORCE-FIELD, GENES, GUI MEMBRANE-BUILDER, HEXOSE TRANSPORTER, IDENTIFICATION, PROTEIN-SEQUENCE

الاتاحة: https://pure.au.dk/portal/en/publications/7bd3cf1a-657b-4914-9919-0384644eb127
https://doi.org/10.1038/s41477-021-00992-0
http://www.scopus.com/inward/record.url?scp=85115410884&partnerID=8YFLogxK

المؤلفون: Jose C. Flores-Canales, Laust Bavnhøj, Bjørn Panyella Pedersen, Peter Aasted Paulsen, Birgit Schiøtt

المصدر: Bavnhøj, L, Paulsen, P A, Flores-Canales, J C, Schiøtt, B & Pedersen, B P 2021, ' Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H + symporter STP10 ', Nature Plants, vol. 7, no. 10, pp. 1409-1419 . https://doi.org/10.1038/s41477-021-00992-0
Nature plants 7(10), 1409-1419 (2021). doi:10.1038/s41477-021-00992-0

مصطلحات موضوعية: DYNAMICS, EXPRESSION, GENES, Glucose uptake, Plant Science, PROTEIN-SEQUENCE, Arabidopsis, Arabidopsis thaliana, Monosaccharide, CRYSTAL-STRUCTURE, chemistry.chemical_classification, IDENTIFICATION, biology, Chemistry, food and beverages, biology.organism_classification, Plant cell, HEXOSE TRANSPORTER, Apoplast, ddc:580, Biochemistry, ELECTROSTATICS, Symporter, FORCE-FIELD, GUI MEMBRANE-BUILDER, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07e54deda89c6e08d110897279752d3

المؤلفون: Etienne Galemou Yoga, Kristian Parey, Amina Djurabekova, Outi Haapanen, Karin Siegmund, Klaus Zwicker, Vivek Sharma, Volker Zickermann, Heike Angerer

المساهمون: Materials Physics, Department of Physics, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)

مصطلحات موضوعية: Science, 49-KDA SUBUNIT, PROTEIN, CRYO-EM, UBIQUINONE BINDING, MOLECULAR-DYNAMICS, 1182 Biochemistry, cell and molecular biology, lcsh:Q, GUI MEMBRANE-BUILDER, CRYSTAL-STRUCTURE, OXIDOREDUCTASE, ORIENTATION, lcsh:Science, CHARMM

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::15f9df98d0bd5fc2ca266ede696f4849
http://hdl.handle.net/10138/324006

المؤلفون: Fatemeh Hassani Nia, Guillaume Jacquemet, Siiri I Salomaa, Hans-Jürgen Kreienkamp, Elena Kremneva, Ilpo Vattulainen, Joni Vuorio, Eleanor T. Coffey, Patrik Hollos, Konstantin Kogan, Lina Antenucci, Johanna Ivaska, Aleksi Isomursu, Pekka Lappalainen, Ilkka Paatero, Johanna Lilja, Mitro Miihkinen

المساهمون: Institute of Biotechnology, Department of Physics, Doctoral Programme in Biomedicine, Doctoral Programme in Chemistry and Molecular Sciences, Doctoral Programme in Integrative Life Science, Doctoral Programme in Materials Research and Nanosciences, Biosciences, Pekka Lappalainen / Principal Investigator

المصدر: Current Biology. 31:4956-4970.e9

مصطلحات موضوعية: Scaffold protein, Integrins, Dendritic spine, Integrin, Nerve Tissue Proteins, macromolecular substances, GTPase, ADHESION, Cell morphology, 114 Physical sciences, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, DOMAIN, TALIN, BRAIN, Actin, Biological Phenomena, 030304 developmental biology, 0303 health sciences, biology, INTEGRIN ACTIVATION, MUTATIONS, Microfilament Proteins, rap1 GTP-Binding Proteins, Actins, POSTSYNAPTIC DENSITY PROTEINS, FAMILY, Cell biology, INDIVIDUALS, Crosstalk (biology), biology.protein, GUI MEMBRANE-BUILDER, Rap1, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9e2c7e2acd67c42aed91dc31274cb8
https://doi.org/10.1016/j.cub.2021.09.022

المؤلفون: Outi Haapanen, Amina Djurabekova, Vivek Sharma

المساهمون: Department of Physics, Institute of Biotechnology

المصدر: Frontiers in Chemistry, Vol 7 (2019)
Frontiers in Chemistry

مصطلحات موضوعية: MECHANISM, Proton, BOUND UBIQUINONE, Protonation, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, 114 Physical sciences, lcsh:Chemistry, Molecular dynamics, Quinone binding, redox chemistry, cell respiration, Proton transport, CRYSTAL-STRUCTURE, electron transport, Original Research, Ubiquinone binding, Chemistry, General Chemistry, CORRELATION-ENERGY, 021001 nanoscience & nanotechnology, Electron transport chain, molecular dynamics, 0104 chemical sciences, UBIQUINONE BINDING, REDUCTION, lcsh:QD1-999, Chemical physics, MOLECULAR-DYNAMICS, Coenzyme Q – cytochrome c reductase, density functional calculations, SUBUNIT, GUI MEMBRANE-BUILDER, proton transport, 0210 nano-technology, CHARMM

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10439decc7069a583fbac40e606d359
http://hdl.handle.net/10138/301185

المؤلفون: Hans-Jürgen Apell, Minwoo Han, Qiucen Jiang, Alvaro Garcia, Ronald J. Clarke, Himanshu Khandelia, Flemming Cornelius

المصدر: Jiang, Q, Garcia, A, Han, M, Cornelius, F, Apell, H J, Khandelia, H & Clarke, R J 2017, ' Electrostatic Stabilization Plays a Central Role in Autoinhibitory Regulation of the Na +,K +-ATPase ', Biophysical Journal, vol. 112, no. 2, pp. 288-299 . https://doi.org/10.1016/j.bpj.2016.12.008
Jiang, Q, Garcia, A, Han, M, Cornelius, F, Apell, H-J, Khandelia, H & Clarke, R J 2017, ' Electrostatic Stabilization Plays a Central Role in Autoinhibitory Regulation of the Na+,K+-ATPase ', Biophysical Journal, vol. 112, no. 2, pp. 288-299 . https://doi.org/10.1016/j.bpj.2016.12.008

مصطلحات موضوعية: 0301 basic medicine, PARTICLE MESH EWALD, Protein Conformation, Swine, ATPase, 01 natural sciences, SODIUM-POTASSIUM PUMP, P-TYPE ATPASES, Adenosine Triphosphate, Guoy-Chapman theory, CRYSTAL-STRUCTURE, Channels and Transporters, Phosphorylation, KIDNEY OUTER MEDULLA, buffer effects, chemistry.chemical_classification, 010304 chemical physics, biology, Chemistry, ADDITIVE FORCE-FIELD, Membrane, eosin, fluorescence, Sodium-Potassium-Exchanging ATPase, ALPHA-SUBUNIT, ionic strength, Stereochemistry, Protein subunit, Static Electricity, Kinetics, Biophysics, Molecular Dynamics Simulation, 03 medical and health sciences, ddc:570, 0103 physical sciences, Animals, PROTEIN-KINASE-C, Na+/K+-ATPase, Osmolar Concentration, 030104 developmental biology, Enzyme, MOLECULAR-DYNAMICS, Ionic strength, biology.protein, GUI MEMBRANE-BUILDER, 030403 - Characterisation of Biological Macromolecules [FoR], stopped-flow kinetics

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee9c8d156e4fa59b9da3015cb7f9e5c
https://doi.org/10.1016/j.bpj.2016.12.008

المؤلفون: Aniket Magarkar, Alex Bunker, Henri Xhaard, Lasse Karhu

المساهمون: Division of Pharmaceutical Chemistry and Technology, Division of Pharmaceutical Biosciences, Drug Research Program, Pharmaceutical biophysics group, Pharmaceutical Design and Discovery group, Henri Xhaard / Principal Investigator

المصدر: The Journal of Physical Chemistry. B

مصطلحات موضوعية: STRUCTURAL BASIS, MECHANISM, Agonist, medicine.drug_class, Protein Conformation, 116 Chemical sciences, Allosteric regulation, Molecular Dynamics Simulation, 010402 general chemistry, 01 natural sciences, ALLOSTERIC MODULATION, Article, chemistry.chemical_compound, Molecular dynamics, Orexin Receptors, 0103 physical sciences, Materials Chemistry, medicine, Humans, Amino Acid Sequence, OX1, Physical and Theoretical Chemistry, Receptor, POPC, Orexins, Binding Sites, 010304 chemical physics, CHOLESTEROL, Suvorexant, Antagonist, Water, PEPTIDES, Azepines, Triazoles, Orexin receptor, 0104 chemical sciences, 3. Good health, Surfaces, Coatings and Films, PROTEIN-COUPLED RECEPTOR, MODEL, chemistry, FORCE-FIELD, Biophysics, GUI MEMBRANE-BUILDER, Orexin Receptor Antagonists, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6c43fe302b15665ece82e87358536b
https://pubmed.ncbi.nlm.nih.gov/30786708

المؤلفون: Purhonen, J., Grigorjev, V., Ekiert, R., Aho, N., Rajendran, J., Pietras, R., Truvé, Katarina, Wikstrom, M., Sharma, V., Osyczka, A., Fellman, V., Kallijarvi, J.

المصدر: Nature Communications. 11(1)

مصطلحات موضوعية: Cell and Molecular Biology, Cell- och molekylärbiologi, iron-sulfur protein, cytochrome bc(1) complex, gui membrane-builder, respiratory-chain, crystal-structure, gracile syndrome, mutations, generation, dynamics, disease, Science & Technology - Other Topics

URL الوصول: https://gup.ub.gu.se/publication/290984

المؤلفون: Soohyung Park (1325910), Yeol Kyo Choi (3913363), Seonghoon Kim (1559083), Jumin Lee (1372398), Wonpil Im (79057)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, two previous studies, preferentially extended laterally, art delivery system, small interfering rna, new lipid types, membrane builder <, existing lipid types, lipids also relaxes, realistic lnp patch, rational lnp design, cationic lipids fit, cationic lipids due, gui membrane builder, gains tremendous interest, ), containing lnp membranes, ionizable cationic lipids, without genetic drugs, cationic lipids, genetic drugs,

Relation: https://figshare.com/articles/journal_contribution/CHARMM-GUI_Membrane_Builder_for_Lipid_Nanoparticles_with_Ionizable_Cationic_Lipids_and_PEGylated_Lipids/16652955

الاتاحة: https://doi.org/10.1021/acs.jcim.1c00770.s001