المؤلفون: Bohan Chen, Zubia Alam, Yan Ge, Lance Dworkin, Rujun Gong

المصدر: Frontiers in Physiology, Vol 13 (2022)

مصطلحات موضوعية: glomerular pathobiology, melanocortin 5 receptor, podocytopathy, GSK3β (glycogen synthase kinase 3β), puromycin aminonucleoside nephrosis, Physiology, QP1-981

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2022.887641/full; https://doaj.org/toc/1664-042X

URL الوصول: https://doaj.org/article/ab4aa8bad78d4198aa55226d4c80e969

المؤلفون: Hao Wang, Lei Wang, Keyi Jia, Yu Liu, Sha Zhao, Wei Li, Caicun Zhou, Minlin Jiang, Bin Chen, Yayi He

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)

مصطلحات موضوعية: Genome instability, PD-L1, programmed death ligand 1, BRCA, breast cancer susceptibility gene, ICI, immune checkpoint inhibitor, medicine.medical_treatment, MUTYH, MutY homolog, cGAS, cyclic GMP–AMP synthase, Review, DNA damage response, Malignant transformation, ORR, objective response rate, PCR, polymerase chain reaction, 0302 clinical medicine, SCNAs, somatic copy number alterations, FDA, United State Food and Drug Administration, Cancer immunotherapy, MGMT, O6-methylguanine methyltransferase, PD-1, RB1, retinoblastoma 1, General Pharmacology, Toxicology and Pharmaceutics, BER, base excision repair, RAD51C, RAD51 homolog C, 0303 health sciences, TME, tumor microenvironment, TP53, tumor protein P53, cGAS–STING, MSI, microsatellite instability, TRIF, Toll-interleukin 1 receptor domain-containing adaptor inducing INF-β, PFS, progression-free survival, STAT, signal transducer and activator of transcription, NEK1, NIMA-related kinase 1, Tumor microenvironment, PALB2, partner and localizer of BRCA2, RSR, replication stress response, 030220 oncology & carcinogenesis, Immunotherapy, PARP, poly-ADP ribose polymerase, JAK, Janus kinase, IHC, immunohistochemistry, Genomic instability, PD-L1, DSBs, double-strand breaks, DNA repair, DNA damage, CHK1, checkpoint kinase 1, IRF1, interferon regulatory factor 1, MLH1, MutL homolog 1, RM1-950, MMR, mismatch repair, STING, stimulator of interferon genes, Biology, MNT, MAX network transcriptional repressor, DDR, DNA damage response, MSH2/6, MutS protein homologue-2/6, OS, overall survival, RPA, replication protein A, 03 medical and health sciences, GSK3β, glycogen synthase kinase 3β, NER, nucleotide excision repair, NSCLC, non-small cell lung cancer, MyD88, myeloid differentiation factor 88, ssDNA, single-stranded DNA, medicine, DAMP, damage-associated molecular patterns, DR, direct repair, 030304 developmental biology, BAP1, BRCA1-associated protein 1, BRAF, v-RAF murine sarcoma viral oncogene homologue B, TLR4, Toll-like receptor 4, Cancer, NGS, next generation sequencing, ATM, ataxia-telangiectasia mutated, NIMA, never-in-mitosis A, medicine.disease, CHEK, cell-cycle checkpoint kinase, PD-1, programmed death 1, MAD1, mitotic arrest deficient-like 1, body regions, IFNγ, interferon gamma, TILs, tumor-infiltrating lymphocytes, TBK1, TANK-binding kinase 1, ATR, ataxia telangiectasia and Rad3 related, Cancer research, NHEJ, nonhomologous end-joining, Therapeutics. Pharmacology, HMGB1, high mobility group box-1, HRR, homologous recombination repair, XRCC4, X-ray repair cross complementing protein 4, TMB, tumor mutational burden

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe73202674a833d134ec811bcbf7332
https://doi.org/10.1016/j.apsb.2021.01.003

المؤلفون: Supriyo Bhatticharya, Weidong Hu, Patty Wong, Alonso Tapia, John E. Shively, Teresa Hong, Karine Bagramyan, Markus Kalkum

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: inorganic chemicals, ITAM, immunoreceptor tyrosine activation motif, Consensus site, macromolecular substances, Biochemistry, environment and public health, Dephosphorylation, ITIM, immunoreceptor tyrosine inhibitory motif, Antigens, CD, GSK3β, glycogen synthase kinase 3β, Humans, PKA, Protein kinase A, NMR, nuclear magnetic resonance, Molecular Biology, CEACAM1, Protein kinase C, beta Catenin, Glycogen Synthase Kinase 3 beta, Kinase, Chemistry, molecular modeling, GSK3β, Cell Biology, MS, β-catenin, Cyclic AMP-Dependent Protein Kinases, NMR, Cell biology, enzymes and coenzymes (carbohydrates), Phosphorylation, bacteria, PKA, protein kinase A, CEACAM1, carcinoembryonic antigen-related cell adhesion molecule-1, Signal transduction, Cell Adhesion Molecules, Proto-oncogene tyrosine-protein kinase Src, Protein Binding, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccb9ee3a38831296650a9c6f5b494c4
https://pubmed.ncbi.nlm.nih.gov/34656562

المؤلفون: Raju V. S. Rajala

المصدر: Journal of Lipid Research, Vol 62, Iss, Pp 100041-(2021)
Journal of Lipid Research

مصطلحات موضوعية: 0301 basic medicine, PI(3,4) P2, phosphatidylinositol 3,4-bisphosphate, IGF, insulin-like growth factor, PIKfyve, FYVE-type zinc finger containing phosphoinositide kinase, 030204 cardiovascular system & hematology, Phosphatidylinositols, Biochemistry, PDGF, platelet-derived growth factor, chemistry.chemical_compound, PTP1B, protein tyrosine phosphatase 1B, 0302 clinical medicine, Endocrinology, SHIP, Src homology 2 domain-containing inositol polyphosphate 5-phosphatase, phosphoinositide binding proteins, PI(4,5)P2, phosphatidylinositol 4,5-bisphosphate, biology, Grb14, growth factor receptor-bound protein 14, phosphoinositide kinases, PI(5)P, phosphatidylinositol 5-phosphate, PIPK, phosphatidylinositol phosphate kinase, PITP, phosphatidylinositol transfer protein, Cell biology, Pleckstrin homology domain, PI4K, phosphatidylinositol 4-kinase, OCRL, oculocerebrorenal syndrome of Lowe, Phosphatidylinositol 4,5-bisphosphate, PI(3)P, phosphatidylinositol 3-phosphate, IR, insulin receptor, PI(3,5)P2, phosphatidylinositol 3,5-bisphosphate, VDAC, voltage-dependent anion channel, IRS, insulin receptor substrate, lipids (amino acids, peptides, and proteins), PIP, phosphatidylinositol phosphate, IP3, inositol triphosphate, light activation, PI3K, phosphoinositide 3-kinase, SH2, Src homology 2, CNTF, ciliary neurotrophic factor, TRP, transient receptor potential, Thematic Review Series: Seeing 2020: Lipids and Lipid-Soluble Molecules in the Eye, musculoskeletal diseases, Phosphatidylinositol 3,5-bisphosphate, RPE, retinal pigment epithelium, CNGA1, cyclic nucleotidegated channel subunit α1, PH, pleckstrin homology, Vps, vacuolar protein sorting, mTOR, mammalian target of rapamycin, QD415-436, PI, phosphatidylinositol, Phosphoinositide Phosphatases, INPP5, inositol polyphosphate 5-phosphatase, 03 medical and health sciences, FYCO1, FYVE and coiled-coil domain autophagy adaptor 1, PLC, phospholipase C, GSK3β, glycogen synthase kinase 3β, PKC, protein kinase C, ROS, rod outer segment, Phosphatidylinositol 5-phosphate, GPCR, G protein-coupled receptor, CNG, cyclic nucleotide-gated, Phosphoinositide 3-kinase, Phosphatidylinositol (3,4,5)-trisphosphate, Phosphatidylinositol 3-phosphate, fungi, PI(4)P, phosphatidylinositol 4-phosphate, Thematic Review Series, phosphoinositide phosphatases, Cell Biology, PTEN, phosphatase and tensin homolog, PI(3,4,5)P2, phosphatidylinositol 3,4,5-trisphosphate, body regions, 030104 developmental biology, chemistry, biology.protein, EPO, erythropoietin, RA, Ras-associating

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad76a0de070275a6dd0bb666e2b0f8c
http://www.sciencedirect.com/science/article/pii/S0022227521000213

المؤلفون: Measho Abreha, Allan I. Levey, Shamsideen A. Ojelade, Duc M. Duong, Zachary T. McEachin, Gary J. Bassell, Eric B. Dammer, Nicholas T. Seyfried, James J. Lah, Joshua M. Shulman, Marla Gearing

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Male, 0301 basic medicine, FTD, frontotemporal dementia, Alzheimer’s disease (AD), Biochemistry, Frontotemporal dementia and parkinsonism linked to chromosome 17, IMAC, immobilized metal affinity chromatography, TANK-binding kinase 1, neurofibrillary tangles (NFTs), posttranslational modification (PTM), CDK5, cyclin dependent kinase 5, Corticobasal degeneration, Protein Interaction Maps, co-IP, co-immunoprecipitation, ERG, electroretinogram, FTDP-17, familial frontotemporal dementia and parkinsonism linked to chromosome 17, FA, formic acid, Gene knockdown, Kinase, LFQ, label-free quantitation, Neurodegeneration, IP, immunoprecipitation, ALS, amyotrophic lateral sclerosis, CAMK, calcium/calmodulin-dependent protein kinase, Cell biology, Tauopathies, co-immunoprecipitation (co-IP), Mitogen-activated protein kinase, Phosphorylation, Drosophila, Female, Tauopathy, Research Article, CBD, corticobasal degeneration, FDR, false discovery rate, tau Proteins, Protein Serine-Threonine Kinases, Biology, AD, Alzheimer’s disease, TFA, trifluoroacetic acid, 03 medical and health sciences, Alzheimer Disease, GSK3β, glycogen synthase kinase 3β, medicine, Animals, Humans, mass spectrometry (MS), IκB kinase (IKK), Molecular Biology, TANK-binding kinase 1 (TBK1), NFT, neurofibrillary tangle, microtubule-associated protein tau (MAPT), GO, gene ontology, familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), 030102 biochemistry & molecular biology, Cyclin-dependent kinase 5, Neurofibrillary tangle, Cell Biology, Aβ, amyloid-β, medicine.disease, In vitro, HCD, higher-energy collision dissociation, HEK293 Cells, 030104 developmental biology, MS, mass spectrometry, DTT, dithiothreitol, TBK1, TANK-binding kinase 1, biology.protein, PTM, posttranslational modification, IAA, iodoacetamide, MAPK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f79bdc687578d84246e18e1f234fa5
https://doi.org/10.1101/2020.06.17.157552

المؤلفون: Si-Chi Xu, Qi-Zhu Tang, Sha-Sha Wang, Zhen-Guo Ma, Yu-Pei Yuan, Xin Zhang

المصدر: EBioMedicine
EBioMedicine, Vol 18, Iss C, Pp 179-187 (2017)

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, β-MHC, (β-myosin heavy chain), PI3K, (phosphatidylinositol-3-kinase), Cardiac fibrosis, lcsh:Medicine, BW, (body weight), chemistry.chemical_compound, Mice, 0302 clinical medicine, Piperidines, GSK-3, Transforming Growth Factor beta, Cytochrome P-450 Enzyme Inhibitors, AKT, (protein kinase B), Anilides, LVIDd, (left ventricle end-diastolic internal diameter), PPAR-γ, (peroxisome proliferator activated receptor-γ), RNA, Small Interfering, ISO, (isoprenaline), Myofibroblasts, Cells, Cultured, lcsh:R5-920, Angiotensin II, MAPK, (mitogen-activated protein kinases), Cell Differentiation, Heart, General Medicine, α-SMA, (α-smooth muscle actin), 030220 oncology & carcinogenesis, Piperine, TL, (tibial length), AMPKα, (AMP­activated protein kinase α), HW, (heart weight), RNA Interference, lcsh:Medicine (General), Research Paper, Signal Transduction, medicine.medical_specialty, PPAR-γ, Polyunsaturated Alkamides, GSK3β, (glycogen synthase kinase 3β), Biology, Cardiac fibroblast, General Biochemistry, Genetics and Molecular Biology, BNP, (brain natriuretic peptide), FS, (fractional shortening), 03 medical and health sciences, Alkaloids, Internal medicine, medicine, Animals, ERK, (extracellular signal-regulated kinase), Benzodioxoles, Protein kinase A, Protein kinase B, PI3K/AKT/mTOR pathway, Glycogen Synthase Kinase 3 beta, AKT, Myocardium, lcsh:R, Isoproterenol, Fibroblasts, medicine.disease, Fibrosis, GAPDH, (glyceraldehyde 3-phosphate dehydrogenase), AB, (aortic banding), ANP, (atrial natriuretic peptide), Mice, Inbred C57BL, PPAR gamma, 030104 developmental biology, Endocrinology, chemistry, PE, (phenylephrine), CF, (cardiac fibroblast), TGF-β, (transforming growth factor-β), Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ada4a8515da60f9e4b290d6176c8f4c
http://europepmc.org/articles/PMC5405163

المؤلفون: Lars Stechemesser, Eva Rohde, Wolfgang Patsch, Simon Auer, Daniel Weghuber, Elmar Aigner, Elisabeth Haschke-Becher, Stephan Zandanell, Bernhard Paulweber, Thomas K. Felder, Sebastian K. Eder, David Niederseer, Andrej Wagner, Alexandra Feldman, Ursula Huber-Schönauer, Michael Strasser, Christian Datz, Sandra Ruhaltinger, Christoph Grabmer

المساهمون: University of Zurich, Aigner, Elmar

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 1, Pp 38-47 (2017)

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, BMI, body mass index, AST, aspartate aminotransferase, Type 2 diabetes, 1307 Cell Biology, PC, phosphatidylcholine, IR, insulin resistance, HOMA-IR, homeostatic model assessment-insulin resistance, GGT, gamma-glutamyl transpeptidase, Homeostasis, Iron overload, Glucose homeostasis, PC_E, plasmalogens, Metabolic Syndrome, TNF, tumor necrosis factor, biology, PEMT, phosphatidylethanolamine N-methyltransferase, Middle Aged, DIOS, dysmetabolic iron overload syndrome, HDL, high density lipoproteins, 10209 Clinic for Cardiology, CRP, C-reactive protein, Female, Original Article, MetS, metabolic syndrome, −Fe, without iron overload, Adult, Akt/PKB, Akt/protein kinase B, lcsh:Internal medicine, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, GNMT, glycine N-methyltransferase, Iron, 610 Medicine & health, GLUT1, glucose transporter 1, Carbohydrate metabolism, WHO, World Health Organization, LDL, low density lipoproteins, 03 medical and health sciences, Insulin resistance, GSK3β, glycogen synthase kinase 3β, ALT, alanine aminotransferase, VLDL, very low-densitylipoproteins, Internal medicine, T2D, type 2 diabetes mellitus, 1312 Molecular Biology, medicine, Humans, Metabolomics, Obesity, lcsh:RC31-1245, Molecular Biology, HIF1α, hypoxia-inducible factor 1α, RBC, red blood count, CDP, Cytidinediphosphat, MRI, magnet resonance imaging, +Fe, with iron overload, FoxO1, forkhead transcription factor O1, Sarcosine, Cell Biology, Glucose Tolerance Test, Phlebotomy, medicine.disease, WHR, waist hip ratio, IL, interleukin, Ferritin, Cross-Sectional Studies, Glucose, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Ferritins, biology.protein, Citrulline, GLUT1, Hyperferritinemia, Insulin Resistance, Metabolic syndrome, PCOS, polycystic ovary syndrome, oGTT, oral glucose tolerance test

وصف الملف: 1-s2.0-S2212877816302095-main.pdf - application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae81e4d845b080c0c9735c73057cb1b6
https://doi.org/10.1016/j.molmet.2016.10.006

المؤلفون: Ping Li, Baolin Liu, Meng-Ru Sun, Yi Li, Hua Yang, Hui-Min Zhu, Yu-Fan Feng, Yu-Chen Li, Xiao-Tian Liu

المصدر: Redox Biology
Redox Biology, Vol 38, Iss, Pp 101771-(2021)

مصطلحات موضوعية: 0301 basic medicine, Sod2, superoxide dismutase 2, OXPHOS, oxidative phosphorylation, Clinical Biochemistry, PGC-1α, Biochemistry, CPT-1, carnitine palmitoyltransferase-1, NAO, nonyl acridine orange, Mice, 0302 clinical medicine, MCU, mitochondrial calcium uniporter, Songorine, OCR, oxygen consumption rate, NRF1, lcsh:QH301-705.5, HO-1, heme oxygenase-1, chemistry.chemical_classification, Cardioprotection, lcsh:R5-920, Kelch-Like ECH-Associated Protein 1, Organelle Biogenesis, NAC, n-acetylcysteine, Chemistry, ORAI1, TFAM, mitochondrial transcription factor A, respiratory system, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Cell biology, Septic cardiomyopathy, NRVMs, neonatal rat ventricular myocytes, LPS, lipopolysaccharide, NRF1, nuclear respiratory factor-1, lcsh:Medicine (General), Research Paper, NF-E2-Related Factor 2, ETC, electron transport chain, TCA, tricarboxylic acid, ARE, antioxidant response element, Oxidative phosphorylation, Nrf2, 03 medical and health sciences, ROS, reactive oxygen species, Alkaloids, Mitochondrial biogenesis, GSK3β, glycogen synthase kinase 3β, Sepsis, Animals, Reactive oxygen species, CRAC, calcium release-activated calcium, ECAR, extracellular acidification rate, Nrf2, NF-E2-p45-related factor 2, Organic Chemistry, TFAM, KEAP1, mtDNA, mitochondrial DNA, 030104 developmental biology, lcsh:Biology (General), 3-MA, 3-methyladenine, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfbaa40881ff4417c6f9c6683fa36d6
https://doi.org/10.1016/j.redox.2020.101771

المؤلفون: Hsu, En-Chi, Kulp, Samuel K., Huang, Han-Li, Tu, Huang-Ju, Salunke, Santosh B., Sullivan, Nicholas J., Sun, Duxin, Wicha, Max S., Shapiro, Charles L., Chen, Ching-Shih

المصدر: Neoplasia (New York, N.Y.)

مصطلحات موضوعية: DAPT, N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester, Blotting, Western, NCT, nicastrin, Fluorescent Antibody Technique, Breast Neoplasms, Mice, SCID, Protein Serine-Threonine Kinases, Caveolae, Real-Time Polymerase Chain Reaction, Article, Gene Expression Regulation, Enzymologic, Immunoenzyme Techniques, Mice, Membrane Microdomains, GSK3β, glycogen synthase kinase 3β, Mice, Inbred NOD, Tumor Cells, Cultured, Animals, Humans, Immunoprecipitation, RNA, Messenger, NICD, Notch intracellular domain, RNA, Small Interfering, IL-6, interleukin-6, TNBC, triple negative breast cancer, PEN-2, presenilin enhancer 2, Receptors, Notch, Interleukin-6, Reverse Transcriptase Polymerase Chain Reaction, CSC, cancer stem cell, ILK, integrin-linked kinase, Gene Expression Regulation, Neoplastic, PS1, presenilin-1, embryonic structures, OCTG, n-octyl d-glucopyranoside, Neoplastic Stem Cells, Female, DAPI, 4',6-diamidino-2-phenylindole, Amyloid Precursor Protein Secretases, PI3K, phosphoinositide 3-kinase, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::438a8df04965f10f62abbb6ef37caaef
http://europepmc.org/articles/PMC4719004

المؤلفون: Zimmermann, Kristin, Baldinger, Johannes, Mayerhofer, Barbara, Atanasov, Atanas G., Dirsch, Verena M., Heiss, Elke H.

المصدر: Free Radical Biology & Medicine

مصطلحات موضوعية: WT, wild type, AMPK, ACC, acetyl-CoA carboxylase, HO-1, heme oxygenase 1, DMSO, dimethyl sulfoxide, AMP-Activated Protein Kinases, Biochemistry, environment and public health, Mice, UPR, unfolded protein response, OCR, oxygen consumption rate, MEF, Propiophenones, AMPK, AMP-activated kinase, GSSG, oxidized glutathione, Xanthohumol, respiratory system, Maf, small musculoaponeurotic fibrosarcoma, Flow Cytometry, Mitochondria, ER stress, TAK, transforming growth factor β-activated kinase, Oxidation-Reduction, Signal Transduction, PERK, GSH, glutathione (reduced), LKB1, NF-E2-Related Factor 2, Blotting, Western, HO-1, ARE, antioxidant response element, mTOR, mammalian target of rapamycin, βTrcP1, β-transducin-repeat containing protein 1, Real-Time Polymerase Chain Reaction, CHO, Chinese hamster ovary, Article, Nrf2, ER, endoplasmic reticulum, Keap1, Kelch-like ECH-associated protein, LKB1, liver kinase B1, ROS, reactive oxygen species, GSK3β, glycogen synthase kinase 3β, Physiology (medical), Animals, MEF, mouse embryonic fibroblasts, Flavonoids, Hrd1, synoviolin/Hrd1 (HMG-CoA reductase degradation)-ubiquitin ligase, PERK, protein kinase RNA-like endoplasmic reticulum kinase, Nrf2, nuclear factor E2-related factor 2, Membrane Proteins, CaMKK, calcium calmodulin-dependent kinase kinase, Receptor Cross-Talk, NADPH, nicotinamide adenine dinucleotide phosphate, Fibroblasts, Oxidative Stress, DCF, dichlorofluorescein, Unfolded Protein Response, FCS, fetal calf serum, XN/Xn, xanthohumol, Reactive Oxygen Species, Heme Oxygenase-1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::01c7c1ba0c732b3c1aa080d2b6d563e4
http://europepmc.org/articles/PMC4568300

المؤلفون: Antonio Rodríguez-Sinovas, David Garcia-Dorado, Marisol Ruiz-Meana, Ignasi Barba

المصدر: Journal of Molecular and Cellular Cardiology

مصطلحات موضوعية: 0301 basic medicine, Succinate, Succinic Acid, Ischemia/reperfusion injury, 030204 cardiovascular system & hematology, 0302 clinical medicine, MCU, mitochondrial calcium uniporter, Hexokinase, Bcl-xL, B-cell lymphoma-extra large, PCr, phosphocreatine, ANT, adenine nucleotide translocase, Bak, Bcl-2 homologous antagonist/killer, MitoPY1, Mitochondria Peroxy-Yellow 1, CrP, creatine phosphate, Heart, LS, light scattering, Bcl-2, B cell lymphoma 2, Mitochondria, NCLX, Na+/Ca2+ exchanger, Bid, BH3 interacting-domain death agonist, Anesthesia, Reperfusion Injury, BCECF, 2′,7′-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein, pmf, proton motive force, VDAC, voltage-dependent anion channel, OMM, outer mitochondrial membrane, Cardiology and Cardiovascular Medicine, CsA, cyclosporine A, IMM, inner mitochondrial membrane, Bax, Bcl-2-like protein 4, medicine.medical_specialty, mPTP, mitochondrial permeability transition pore, Cyp-D, cyclophilin D, Mdivi-1, mitochondrial division inhibitor 1, Article, 03 medical and health sciences, ROS, reactive oxygen species, GSK3β, glycogen synthase kinase 3β, PO1, Peroxy-Orange 1, SOD, superoxide dismutase, medicine, Humans, Molecular Biology, Drp1, dynamin-related protein 1, business.industry, IR, ischemia/reperfusion, 5-cH2DCFDA, 5-carboxy-2′,7′dichlorodihydrofluorescein diacetate, Succinates, IP, ischemic preconditioning, HK, hexokinase, REF, reverse electron flow, medicine.disease, Permeability transition pore, PKCε, protein kinase Cε, Surgery, Critical appraisal, 030104 developmental biology, G-6-P, glucose-6-phosphate, Calcium, IF1, ATP synthase inhibitor factor 1, business, Reactive oxygen species, Reperfusion injury, DHE, dihydroethidium, CK, creatine kinase, Bad, Bcl-2-associated death promoter

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634c2fd43b4e26a7f7a1dfc2fc12acd4
https://pubmed.ncbi.nlm.nih.gov/28689004

المؤلفون: Ettcheto Arriola, Miren, Sánchez-López, E. (Elena), Pons, Laura, Busquets Figueras, Oriol, Olloquequi González, Jordi, Beas Zárate, Carlos, Pallàs i Llibería, Mercè, 1964, García López, María Luisa, Auladell i Costa, M. Carme, Folch, Jaume, Camins Espuny, Antoni

المساهمون: Universitat de Barcelona

المصدر: Redox Biology, Vol 13, Iss C, Pp 345-352 (2017)
Redox Biology
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona

مصطلحات موضوعية: GFAP, Glial Fibrillary Acidic Protein, ADAM10, Disintegrin and metalloproteinase domain-containing protein 10, MAPK, Mitogen-activated protein kinase, BACE1, β-secretase 1, CDK5, Cyclin-dependent kinase 5, Ibuprofen, IBU, Ibuprofen, Hippocampus, Mitocondris, PFA, Paraformaldehide, PPARγ, Peroxisome proliferator-activated receptor-γ, Amyloid beta-Protein Precursor, Mice, Cognition, DXI, Dexibuprofen, APPSwe/PS1dE9, Aspartic Acid Endopeptidases, Proto-Oncogene Proteins c-abl, PKA, Protein kinase A, lcsh:QH301-705.5, lcsh:R5-920, DI, Discrimination index, Brain, Drugs, COX-1, Cyclooxygenase-1, NORT, Novel object recognition test, IDE, Insulin-degrading enzyme, Memory impairment, Alzheimer's disease, Mitochondria, TNF-α, Tumor necrosis factor, Neuroprotective Agents, pTAU, Phospho-TAU, SYP, Synaptophysin, Female, AD, Alzheimer's disease, lcsh:Medicine (General), Hippocampus (Brain), Medicaments, Research Paper, Signal Transduction, APP/PS1, APPswe/PS1dE9, NSAIDs, Non-steroidal anti-inflammatory drugs, Hipocamp (Cervell), NFĸβ, Nuclear factor kappa beta, c-ABL, Abelson non-receptor tyrosine kinase, tau Proteins, COX-2, Cyclooxygenase-2, Alzheimer Disease, Cyclins, GSK3β, Glycogen synthase kinase 3β, Aβ, Amyloid beta, Presenilin-1, Animals, Insulin receptors, Tumor Necrosis Factor-alpha, Cyclin-Dependent Kinase 5, Receptors d'insulina, Phosphoproteins, iNOS, Inducible nitric oxide synthase, Mice, Inbred C57BL, Dexibuprofen, MWM, Morris water maze, Malaltia d'Alzheimer, lcsh:Biology (General), nNOS, Neuronal Nitric Oxide Synthase, Amyloid Precursor Protein Secretases, TAU, Carrier Proteins, APP, Amyloid precursor protein, NFTs, Neurofibrillary tangles, WT, Wild type, Insulin receptor

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eeb03ed861896c8e278a922a0d33b70d
http://hdl.handle.net/2445/118847

المؤلفون: Eduardo N. Chini, Carlos Escande, Claudia Cs S. Chini, Veronica Nin

المصدر: Biochemical Journal

مصطلحات موضوعية: HFD, high-fat diet, Small interfering RNA, viruses, Circadian clock, Regulator, HDAC, histone deacetylase, Biochemistry, RAR-related orphan receptor alpha, Mice, 0302 clinical medicine, FL, full-length, RNA, Small Interfering, Mice, Knockout, HA, haemagglutinin, 0303 health sciences, DMEM, Dulbecco's modified Eagle's medium, Rev-erbα, Protein Stability, ARNTL Transcription Factors, Deleted in Breast Cancer 1 (DBC1), Circadian Rhythm, Cell biology, CLOCK, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, Plasmids, Signal Transduction, Research Article, ER, oestrogen receptor, Biology, Protein degradation, Transfection, Cell Line, Alas1, δ-aminolaevulinic acid synthase 1, HEK, human embryonic kidney, 03 medical and health sciences, FBS, fetal bovine serum, GSK3β, glycogen synthase kinase 3β, Circadian Clocks, DBC1, Deleted in Breast Cancer 1, Animals, Humans, LZ, leucine zipper, RNA, Messenger, Circadian rhythm, Molecular Biology, Adaptor Proteins, Signal Transducing, 030304 developmental biology, KO, knockout, BMAL1, PGC-1α, peroxisome-proliferator-activated receptor γ co-activator 1α, Cell Biology, MEF, mouse embryonic fibroblast, WT, wild-type, Molecular biology, Protein Structure, Tertiary, circadian, Gene Expression Regulation, Nuclear receptor, siRNA, small interfering RNA, Nuclear Receptor Subfamily 1, Group D, Member 1, AR, androgen receptor, NCoR, nuclear receptor co-repressor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a608ac30f926e77de0d0ee2a8b77e28
https://doi.org/10.1042/bj20121085

المؤلفون: Partha Krishnamurthy, Hemantkumar Chavan, Hong-Min Ni, Jibiao Li, John Y.L. Chiang, Yifeng Ding, Tiangang Li, Yifeng Wang, Wen-Xing Ding, David J. Matye

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 245-260 (2017)

مصطلحات موضوعية: 0301 basic medicine, FC, free cholesterol, SREBP, sterol response element binding protein, medicine.medical_specialty, mTOR, the nutrient sensing mechanistic target of rapamycin, medicine.drug_class, Autolysosome, Sterol O-acyltransferase, CQ, chloroquine, LMP, lysosome membrane permeabilization, Biology, Cholesterol 7 alpha-hydroxylase, CE, cholesterol ester, PI, phosphatidylinositol, ACAT, acyl-CoA:cholesterol acyltransferase, ER, endoplasmic reticulum, 03 medical and health sciences, S6, tibosomal protein S6, GSK3β, glycogen synthase kinase 3β, Internal medicine, medicine, LC3, microtubule-associated protein 1A/1B-light chain 3, lcsh:RC799-869, HMGCR, HMG-CoA reductase, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, Cholestyramine, Original Research, Hepatology, Bile acid, Autophagy, Gastroenterology, DIO, diet-induced obesity, 4EBP-1, eukaryotic translation initiation factor 4E-binding protein 1, CYP7A1, cholesterol 7α-hydroxylase, LDLR, low-density lipoprotein receptor, mRNA, messenger RNA, Cell biology, Fatty Liver, 030104 developmental biology, Endocrinology, Cholesterol, HMG-CoA reductase, PM, plasma membrane, biology.protein, ChTM, cholestyramine, lipids (amino acids, peptides, and proteins), lcsh:Diseases of the digestive system. Gastroenterology, Nuclear Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03458c30ea64c5f0a2a0ae5b34c10cc

المؤلفون: Kailainathan, Sumangali, Piers, Thomas M., Yi, Jee Hyun, Choi, Seongmin, Fahey, Mark S., Borger, Eva, Gunn-Moore, Frank J., O’Neill, Laurie, Lever, Michael, Whitcomb, Daniel J., Cho, Kwangwook, Allen, Shelley J.

المساهمون: University of St Andrews. School of Biology, University of St Andrews. Institute of Behavioural and Neural Sciences, University of St Andrews. Biomedical Sciences Research Complex

المصدر: Kailainathan, S, Piers, T M, Yi, J H, Choi, S, Fahey, M S, Borger, E, Gunn-Moore, F J, O'Neill, L, Lever, M, Whitcomb, D J, Cho, K & Allen, S J 2016, ' Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) ', Pharmacological Research, vol. 104, pp. 97-107 . https://doi.org/10.1016/j.phrs.2015.12.008
Kailainathan, S, Piers, T M, Yi, J H, Choi, S M, Fahey, M S, Borger, E, Gunn-Moore, F J, O'Neill, L, Lever, M, Whitcomb, D J, Cho, K & Allen, S J 2016, ' Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) ', Pharmacological Research, vol. 104, pp. 97-107 . https://doi.org/10.1016/j.phrs.2015.12.008
Kailainathan, S, Piers, T M, Yi, J H, Choi, S, Fahey, M S, Borger, E, Gunn-Moore, F J, O'Neill, L, Lever, M, Whitcomb, D J, Cho, K & Allen, S J 2016, ' Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) ', Pharmacological Research, vol. 104, no. 0, pp. 97-107 . https://doi.org/10.1016/j.phrs.2015.12.008
Pharmacological Research

مصطلحات موضوعية: Male, DIV, days in vitro, IPTG, isopropyl β-D-1-thiogalactopyranoside, Long-Term Potentiation, LD, luminal domain, chemical compounds studied in this article, Hippocampus, Mice, LTP, long-term potentiation, NAD, nicotinamide adenine dinucleotide, binding kinetics, CD, circular dichroism, ANOVA, analysis of variance, Cells, Cultured, Membrane Potential, Mitochondrial, Neurons, Pro-brain-derived neurotrophic factor (proBDNF), Neuronal Plasticity, LDH, lactate dehydrogenase, neurotrophin receptor, TrkB, tyrosine kinase B, fEPSP, field excitatory postsynaptic potentials, Neurotrophin receptors, SNP, single nucleotide polymorphism, Recombinant Proteins, aCSF, artificial cerebrospinal fluid, PMS, phenazinemethosulfate, Chemical compounds studied in this article, BDNF, brain-derived neurotrophic factor, Val66Met polymorphism, JC-1 dye, 5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide, neurotrophin receptors, RM, LTD, long-term depression, NDAS, SPR, surface plasmon resonance, tau Proteins, QH426 Genetics, AD, Alzheimer’s disease, Article, SDG 3 - Good Health and Well-being, GSK3β, glycogen synthase kinase 3β, Animals, Humans, p75NTR, pan-neurotrophin receptor, FCR, furin cleavage-resistant, Protein Precursors, Rats, Wistar, QH426, ComputingMethodologies_COMPUTERGRAPHICS, Pharmacology, PONDR, predictor of naturally disordered regions, Glycogen Synthase Kinase 3 beta, Polymorphism, Genetic, L-Lactate Dehydrogenase, Brain-Derived Neurotrophic Factor, Long-term depression (LTD), ECD, extracellular domain, TrkBIg2, TrkB immunoglobulin-like domain 2, WT, wild-type, SDS PAGE, sodium dodecyl sulfate polyacrylamide electrophoresis, RM Therapeutics. Pharmacology, long-term depression (LTD), Binding kinetics, DTT, dithiothreitol, s.e.m., standard error of mean, Synapses, RU, response units

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f16825268b801b7410012eba9db69263
https://hdl.handle.net/20.500.11820/4c394466-7f86-4195-98e2-7f20d1ae3435

المؤلفون: Yi Ju Wu, Hsuan Chia Chang, Yu Chih Pan, Xiao Wen Wang, Shen Liang Chen, Han Feng Teng

المصدر: Bioscience Reports, Vol 35, Iss 2, p e00180 (2015)
Bioscience Reports

مصطلحات موضوعية: muscle, PAX3, lcsh:Life, lcsh:QR1-502, SKM, skeletal muscle, MyoD, Biochemistry, PBST, PBS containing 0.5% Tween 20, lcsh:Microbiology, CMB, confluent myoblast, P6P, proximal 6 kb promoter, Myotome, DE, distal enhancer, Paired Box Transcription Factors, Wnt Signaling Pathway, PRR, proximal regulatory region, Genetics, qRT-PCR, quantitative reverse transcription–PCR, DMEM, Dulbecco's modified Eagle's medium, TRE, T3-response element, Myogenesis, Wnt signaling pathway, PAX7 Transcription Factor, HRP, horseradish peroxidase, Wnt3a, Fgf, fibroblast growth factor, dpc, day(s) postcoitum, musculoskeletal system, Cell biology, medicine.anatomical_structure, JNK, c-Jun N-terminal kinase, embryonic structures, MYF5, Myogenic Regulatory Factor 5, myogenesis, WRE, Wnt-response element, animal structures, Biophysics, T3, 3,3′,5-tri-iodothyronine, Gapdh, glyceraldehyde-3-phosphate dehydrogenase, Biology, Response Elements, Cell Line, HEK, human embryonic kidney, GSK3β, glycogen synthase kinase 3β, Wnt3A Protein, Shh, Sonic Hedgehog, medicine, Humans, MRF, myogenic regulatory factor, Molecular Biology, PAX3 Transcription Factor, MyoD Protein, Original Paper, LEF, lymphoid enhancer factor, HEK 293 cells, Cell Biology, β-catenin, Pax7, NFAT, nuclear factor of activated T-cells, lcsh:QH501-531, DRR, distal regulatory region, TKE, thymidine kinase promoter and enhancer, Gene Expression Regulation, MT, myotube, Myogenic regulatory factors, BAC, bacterial artificial chromosome, MAPK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adaba77f83726e776c8908b600accdd5
http://www.bioscirep.org/bsr/035/e180/bsr035e180.htm

المؤلفون: Jia Yu, David M. Virshup

المصدر: Bioscience Reports, Vol 34, Iss 5, p e00142 (2014)
Bioscience Reports

مصطلحات موضوعية: LEF, lymphoid enhancer-binding factor, lcsh:Life, lcsh:QR1-502, Review Article, COP, coat protein complex, Fibroblast growth factor, Proto-Oncogene Mas, Biochemistry, lcsh:Microbiology, Mice, Epidermal growth factor, Neoplasms, CK1α, casein kinase 1 α, WNT1, Sonic hedgehog, Wnt Signaling Pathway, RSPO, R-Spondin, Receptors, Notch, adenomatous polyposis coli, Wnt signaling pathway, LRP6, LRP5, APC, adenomatous polyposis coli, CTD, C-terminal domain, FDH, focal dermal hypoplasia, Cell biology, Signalling, BAR, Bin-Amphiphysin-Rvs, CBP, CREB (cAMP response element-binding)-binding protein, planar cell polarity (PCP), animal structures, Biophysics, PCP, planar cell polarity, Wnt1 Protein, Protein Serine-Threonine Kinases, Biology, LRP, lipoprotein receptor-related protein, Wnt, Ror2, receptor tyrosine kinase-like orphan receptor 2, GSK3β, glycogen synthase kinase 3β, Animals, Humans, Hedgehog Proteins, Hippo Signaling Pathway, ER, endoplasmic reticulum FAP, familial adenomatous polyposis, NTD, N-terminal domain, Molecular Biology, CRD, cysteine-rich domain, TCF, T cell-specific factor, Epidermal Growth Factor, PORCN, protein Porcupine, SNX-1, sorting nexin-1, Cell Biology, Fibroblast Growth Factors, lcsh:QH501-531, sFRP, secreted Frizzled-related protein, swim, Wingless-interacting molecule, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ac3f889e7d13de835fecd65af3f5d0
https://doi.org/10.1042/bsr20140119

المؤلفون: David J. Porteous, Nicholas J. Bradshaw

المصدر: Bradshaw, N J & Porteous, D J 2012, ' DISC1-binding proteins in neural development, signalling and schizophrenia ', Neuropharmacology, vol. 62, no. 3, pp. 1230-41 . https://doi.org/10.1016/j.neuropharm.2010.12.027
Neuropharmacology

مصطلحات موضوعية: Scaffold protein, BACE1, β-site APP-cleaving enzyme-1, PCM1, Pericentriolar material 1, PSD, Post-synaptic density, Neurodevelopment, FEZ1, Fasciculation and elongation protein zeta 1, 0302 clinical medicine, PDE4B, CEP290, Centrosomal protein 290 kDa, Copy-number variation, NDE1, Nuclear distribution factor E homologue 1 or Nuclear distribution element 1, 0303 health sciences, LEF/TCF, Lymphoid enhancer factor/T cell factor, biology, Kal7, Kalirin-7, LIS1, Lissencephaly 1, ATF4, Activating transcription factor 4, PACAP, Pituitary adenylate cyclase-activating polypeptide, DISC1, Schizophrenia, Signalling, Synapse, Association studies, 3. Good health, GluR, Glutamate receptor, PDE4, Phosphodiesterase 4, CRE, cAMP response element, Neural development, Signal Transduction, CNV, Copy number variation, Neurogenesis, Schizophrenia (object-oriented programming), Nerve Tissue Proteins, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, PCNT, Pericentrin, GSK3β, Glycogen synthase kinase 3β, Animals, Humans, DBZ, DISC1-binding zinc finger, DISC1, Disrupted in schizophrenia 1, 030304 developmental biology, Pharmacology, BBS4, Bardet–Biedl syndrome 4, NDEL1, PI3 K, Phosphatidylinositiol 3-kinase, Rac1, Ras-related C3 botulinum toxin substrate 1, TNIK, Traf2 and Nck interacting kinase, mTOR, Mammalian target of rapamycin, Dixdc1, Dishevelled-axin domain containing-1, TNIK, NRG, Neuregulin, biology.protein, Carrier Proteins, APP, Amyloid precursor protein, Neuroscience, NDEL1, NDE-like 1, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2484878371787d3d5cd23355557c79
https://www.pure.ed.ac.uk/ws/files/8426775/DISC1_binding_proteins_in_neural_development_signalling_and_schizophrenia.pdf

المؤلفون: Rebecca J. Burkhalter, Maria V. Barbolina, M. Sharon Stack

المصدر: Biochemical Journal

مصطلحات موضوعية: Dkk, Dickkopf, endocrine system diseases, T-cell factor/lipoprotein receptor-related (Tcf/Lef), Review Article, medicine.disease_cause, Biochemistry, 0302 clinical medicine, LPAR, LPA receptor, Tumor Microenvironment, COX2,cyclo-oxygenase 2, SFRP, secreted Fzd-related protein, ET, endothelin, Fzd, Frizzled, TGF, transforming growth factor, beta Catenin, ETAR, ET type A receptor, Ovarian Neoplasms, 0303 health sciences, Tcf, T-cell factor, MCA, multi-cellular aggregate, Wnt signaling pathway, LRP5, APC, adenomatous polyposis coli, VEGF, vascular endothelial growth factor, female genital diseases and pregnancy complications, 3. Good health, ILK, integrin-linked kinase, Lef, lymphoid enhancer factor, MMP, matrix metalloproteinase, ovarian cancer, 030220 oncology & carcinogenesis, EGFR, EGF receptor, Female, Signal transduction, NF-κB, nuclear factor κB, endothelin, EOC, epithelial ovarian carcinoma, LPA, lysophosphatidic acid, PI3K, phosphoinositide 3-kinase, Signal Transduction, PTEN, phosphatase and tensin homologue deleted on chromosome 10, VEGFR, vascular EGFR, Beta-catenin, integrin, Integrin, Biology, IGF-1, insulin-like growth factor-1, Models, Biological, CTGF, connective tissue growth factor, LRP, lipoprotein receptor-related protein, 03 medical and health sciences, Wnt, GSK3β, glycogen synthase kinase 3β, medicine, Humans, Molecular Biology, 030304 developmental biology, GPCR, G-protein-coupled receptor, EGF, epidermal growth factor, Tumor microenvironment, IDAX, inhibitor of the Dvl and Axin complex, ETBR, ET type B receptor, Cell Biology, β-catenin, medicine.disease, Dvl, Dishevelled 1, microenvironment, IL, interleukin, Wnt Proteins, E-cadherin, epithelial cadherin, Immunology, biology.protein, Cancer research, WIF-1, Wnt-inhibitory factor 1, FRAT1, frequently rearranged in advanced T-cell lymphomas 1, Carcinogenesis, Ovarian cancer, lysophosphatidic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78227cf9ee2595792ebf0003fba19151
https://pubmed.ncbi.nlm.nih.gov/21668411