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المؤلفون: Siying Zhu, Matthew S. Tremblay, Sean B. Joseph, Seung Hyuk Choi, Mitch Hull, Weijun Shen, Valeria Marrocco, Sijia Li, Marta Diez Cunado, Ana M. Gamo, Tuan Tran, Jason Roland, Arnab K. Chatterjee, Qiangwei Fu, Van Nguyen-Tran, Nikki Rogers
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3983-3993 (2021)مصطلحات موضوعية: TG, thapsigargin, Cell signaling, ATF4, activating transcription factor 4, IKKβ, inhibitor of nuclear factor kappa-B kinase subunit beta, PERK, PKR-like ER kinase, XBP1, X-box-binding protein 1, OGTT, oral glucose tolerance test, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Unfolded protein response, 0302 clinical medicine, UPR, unfolded protein response, GLuc, Gaussia luciferase, Chaperones, Protein biosynthesis, IL1β, interleukin 1β, General Pharmacology, Toxicology and Pharmaceutics, uHTS, ultra-high throughput screening, IRE1, inositol requiring enzyme 1α/β, 0303 health sciences, ASGR, asialoglycoprotein receptor 1, biology, Chemistry, Small molecules, Diabetes, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, ATF6, activating transcription factor 6α/β, β cells, i.p., intraperitoneal, Cell biology, Liver, 030220 oncology & carcinogenesis, T1/2D, type1/2 diabetes, Tm, tunicamycin, Protein folding, Original Article, ER stress, NASH, nonalcoholic steatohepatitis, INFγ, interferon gamma, TNFα, tumor necrosis factor alpha, RM1-950, GRPRP94, glucose-regulated protein 94, ER, endoplasmic reticulum, 03 medical and health sciences, SP1/2, serine protease1/2, GRP78, 78-kDa glucose-regulated protein, BID, twice a day, Pancreas, 030304 developmental biology, Reporter gene, Nod, non-obese diabetic, Activator (genetics), Endoplasmic reticulum, Metabolic diseases, Chaperone (protein), EGFP-VSVG, enhanced green fluorescence protein-vesicular stomatitis virus ts045 G protein, GSIS, glucose stimulated insulin secretion, biology.protein, Asialoglycoprotein receptor, Therapeutics. Pharmacology, CLuc, Cypridina luciferase, ERP72, endoplasmic reticulum proteins 72
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المؤلفون: Johanna McChord, Katharina Ganss, Christian Krautz, Sebastian Hempel, Klaus-Peter Knoch, Michele Solimena, Robert Grützmann, Philippe Ravassard, Kamal Chowdhury, Jürgen Weitz, Stephan Kersting, Christian Pilarsky, Hassan Mziaut, Steffen Wolk, Georg Henniger
المساهمون: Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Max-Planck-Institut für Biophysikalische Chemie - Max Planck Institute for Biophysical Chemistry [Göttingen], Max-Planck-Gesellschaft, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
المصدر: Molecular metabolism
Molecular metabolism, Elsevier, 2020, 31, pp.150-162. ⟨10.1016/j.molmet.2019.11.012⟩
Molecular Metabolism, Vol 31, Iss, Pp 150-162 (2020)
Molecular Metabolism
Mol. Metab. 31, 150-162 (2020)مصطلحات موضوعية: Male, 0301 basic medicine, Pten, phosphatase and tensin homolog, Pi3k, phosphatidylinositol-4,5-bisphosphate 3-kinase, Apoptosis, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], miR-132, microRNA 132, miR-132, Creb, cAMP response element-binding protein, BrdU, bromodeoxyuridine, Mice, 0302 clinical medicine, Insulin-Secreting Cells, miRNA, microRNA, Raf, rapidly accelerated fibrosarcoma, Cells, Cultured, Mice, Knockout, Gene knockdown, Forkhead Box Protein O3, FOXO3, Original Article, β cell regeneration, Beta cell, Signal Transduction, lcsh:Internal medicine, Cell Survival, T2D, type 2 diabetes, 030209 endocrinology & metabolism, Biology, Fgfr3, fibroblast growth factor receptor 3, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, RT-PCR, reverse transcription polymerase chain reaction, Pancreatectomy, Nras, neuroblastoma RAS viral oncogene homolog, Downregulation and upregulation, Pten/Akt/Foxo3a, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], microRNA, Animals, Humans, PTEN, Gnb, G protein subunit beta, lcsh:RC31-1245, Molecular Biology, Protein kinase B, Gnb1, G protein subunit beta 1, IPA, Ingenuity Pathway Analysis, Cell Proliferation, Mir-132, Beta Cell Regeneration, Pten/akt/foxo3a, pHH3, phosphohistone H3, Mapk1, mitogen-activated protein kinase 1, PTEN Phosphohydrolase, Cell Biology, LCM, laser capture microscopy, Mice, Inbred C57BL, MicroRNAs, HEK293 Cells, 030104 developmental biology, Ras, rat sarcoma, Pik3r1, phosphoinositide-3 kinase regulatory subunit 1, Akt, protein kinase B, Cancer research, biology.protein, Foxo3a, Forkhead box O3a, Sos1, Son of Sevenless homolog 1, Proto-Oncogene Proteins c-akt
وصف الملف: application/pdf; application/zip
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المؤلفون: Katleen Lemaire, Abhijit Babaji Shinde, Stefan Vinckier, Frans Schuit, Ritesh K. Baboota, Marc Fransen, Paul P. Van Veldhoven, Myriam Baes
المصدر: Molecular Metabolism, Vol 22, Iss, Pp 71-83 (2019)
Molecular Metabolismمصطلحات موضوعية: Male, Islet, medicine.medical_specialty, Programmed cell death, HFD, high-fat diet, lcsh:Internal medicine, Peroxisome-Targeting Signal 1 Receptor, medicine.medical_treatment, DEGs, differentially expressed genes, Mice, Transgenic, Apoptosis, Peroxisome, IPITT, intraperitoneal insulin tolerance test, LPC, lysophoshatidylcholine, GSIS, glucose-stimulated insulin secretion, Mice, ROS, reactive oxygen species, GSEA, gene set enrichment analysis, Internal medicine, Insulin-Secreting Cells, medicine, Peroxisomes, KEGG, Kyoto encyclopedia of genes and genomes, Animals, Receptor, TEM, transmission electron microscopy, lcsh:RC31-1245, Molecular Biology, Beta oxidation, Mice, Knockout, PCA, principal component analysis, Chemistry, Peroxisomal matrix, Insulin, Diabetes, Cell Biology, Metabolism, Ctrl, control, β-cell, Endocrinology, High-fat diet, IPGTT, intraperitoneal glucose tolerance test, Original Article, Homeostasis
وصف الملف: Print-Electronic
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المؤلفون: Alanis Perez, Varun Bahl, Klaus H. Kaestner, Catherine Lee May, Benjamin Glaser
المصدر: Molecular Metabolism, Vol 49, Iss, Pp 101193-(2021)
Molecular Metabolismمصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, T2D, Type 2 Diabetes Mellitus, HFD, high-fat diet, EdU, Ethynyl deoxyuridine, medicine.medical_treatment, Gck∗, Gck mutant allele containing ins454A activating mutation, CreERT2, tamoxifen-inducible Cre recombinase-estrogen receptor fusion protein, Mice, 0302 clinical medicine, Insulin-Secreting Cells, Insulin Secretion, Glucokinase, Insulin, Glucose homeostasis, Glycolysis, Internal medicine, geography.geographical_feature_category, Chemistry, Glucagon secretion, Fasting, Islet, Original Article, Female, medicine.medical_specialty, 030209 endocrinology & metabolism, Diet, High-Fat, Glucagon, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, GSGS, α-mutGCK, GckLoxPGck∗/LoxPGck∗ Gcg-CreERT2, Hyperinsulinism, Glucose Intolerance, GCK, wild-type glucokinase gene, medicine, Animals, Molecular Biology, GCG, glucagon, geography, α-Cell, GCK, CgA, Chromogranin A, Cell Biology, RC31-1245, Glucose, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Glucagon-Secreting Cells, GSGS, glucose-suppression of glucagon secretion, GKAs, glucokinase activators, Hyperglucagonemia
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المؤلفون: Nada Mohamed, Ting Zhang, Justin Molitoris, Krishna Prasadan, Mohamed Saleh, Yan Wang, Anuradha Sehrawat, Ranjeet Kalsi, Madison Thomas, George K. Gittes
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: insulin secretion, HFD, high-fat diet, medicine.medical_treatment, glucose metabolism, Smad2 Protein, Carbohydrate metabolism, Diet, High-Fat, SMAD transcription factor, TGF-β, transforming growth factor-beta, Biochemistry, transforming growth factor beta (TGF-β), BrdU, bromodeoxyuridine, ER, endoplasmic reticulum, GSIS, glucose-stimulated insulin secretion, Mice, Downregulation and upregulation, PPX, partial pancreatectomy, Diabetes mellitus, Insulin-Secreting Cells, medicine, Animals, Molecular Biology, IPITT, intraperitoneal insulin tolerance testing, Mice, Knockout, biology, Chemistry, Cell growth, smad2-βKO, deletion of smad2 protein in ins1cre, smad2fx/fx, Insulin, RIP, rat insulin promoter, Type 2 Diabetes Mellitus, Cell Biology, Transforming growth factor beta, T2DM, type 2 diabetes mellitus, medicine.disease, β-cell, Cell biology, Hyperglycemia, HOMA-IR, homeostatic model assessment–estimated insulin resistance, biology.protein, Signal transduction, HbA1c, glycated hemoglobin, RT-PCR, real-time PCR, IHC, immunohistochemistry, Signal Transduction, Research Article
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المؤلفون: Carlos Castaño, Gema Alcarraz-Vizán, Marcelina Párrizas, Sara de Pablo, Júlia Rodríguez-Comas, Joan-Marc Servitja, Mario Vallejo, Antonio Fernández-Pérez, Sara Ramírez, Daniela Díaz-Catalán, Anna Novials, Marc Claret
المساهمون: Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Generalitat de Catalunya, Comisión Nacional de Investigación Científica y Tecnológica (Chile), Centro Esther Koplowitz, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (España)
المصدر: Molecular Metabolism
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Metabolism, Vol 53, Iss, Pp 101251-(2021)مصطلحات موضوعية: 0301 basic medicine, Leptin, Male, T2D, Type 2 diabetes, Type 2 diabetes, TMEM27, Transmembrane protein 27, Mice, 0302 clinical medicine, Hyperinsulinemia, Glucose homeostasis, Aspartic Acid Endopeptidases, Internal medicine, biology, Insulin secretion, BACE2, High-fat diet, BACE1, β-site APP-cleaving enzyme 1, Original Article, AD, Alzheimer's disease, medicine.medical_specialty, HFD, High-fat diet, CD, Chow diet, Neuropeptide, 030209 endocrinology & metabolism, GSIS, Glucose stimulated insulin secretion, hIAPP, human islet amyloid polypeptide, Mice, Transgenic, 03 medical and health sciences, Insulin resistance, β-cell proliferation, medicine, Animals, Obesity, BACE2, β-site APP-cleaving enzyme 2, Molecular Biology, business.industry, BKO, BACE2 knock-out, Cell Biology, medicine.disease, RC31-1245, Diet, Insulin receptor, 030104 developmental biology, Endocrinology, biology.protein, Amyloid Precursor Protein Secretases, business, WT, Wild type
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المؤلفون: Abdullateef Isiaka Alagbonsi, Sheu Oluwadare Sulaiman, Abdul-Musawwir Alli-Oluwafuyi, Mayowa Adewale Iyanda, T.M. Salman
المصدر: Metabolism Open
Metabolism Open, Vol 10, Iss, Pp 100092-(2021)مصطلحات موضوعية: medicine.medical_specialty, G6P, Glucose-6-phosphate, IMGU, Insulin-mediated glucose uptake, GLUT, Glucose transporter, Physiology, medicine.medical_treatment, SEM, Standard error of mean, Ethyl acetate, Stimulation, QD415-436, TCA, Tricarboxylic acid cycle, Biochemistry, G6Pase, Glucose-6-phosphatase, Glucoregulatory enzymes, GSIS, glucose-stimulated insulin secretion, chemistry.chemical_compound, HRP, Horseradish Peroxidase, HClO4, Perchloric acid, KOH, Potassium hydroxide, Internal medicine, Lactate dehydrogenase, medicine, QP1-981, Insulin, Glycolysis, G6PD, Glucose-6-phosphate dehydrogenase, Saline, EATO, Ethyl acetate TO fraction, Plasma glucose, LDH, Lactate dehydrogenase, ANOVA, Analysis of Variance, Telfairia occidentalis, Glycogen, MCT, Monocarboxylate transporters, General Medicine, NAD, Nicotinamide adenine dinucleotide, Original Research Paper, GCK, Glucokinase, Metabolic pathway, TO, Telfairia occidentalis, Endocrinology, ELISA, Enzyme-linked immunosorbent assay, chemistry, Glucose metabolites, NHTO, N-hexane TO fraction, ATP, Adenosine triphosphate
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المصدر: Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101267-(2021)
Molecular Metabolism, 53مصطلحات موضوعية: 0301 basic medicine, Regulator, 030209 endocrinology & metabolism, Apoptosis, EMT TF, EMT transcription factor, T2D, type 2 diabetes, Biology, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, Mice, iPSC, induced pluripotent stem cells, 0302 clinical medicine, UPR, unfolded protein response, Downregulation and upregulation, Insulin-Secreting Cells, microRNA, Insulin Secretion, miRNA, microRNA, Glucose homeostasis, Animals, Islet aggregation, Epithelial–mesenchymal transition, Molecular Biology, Internal medicine, Cells, Cultured, Proinsulin, Mice, Knockout, Zinc Finger E-box-Binding Homeobox 1, Cell Biology, Endoplasmic Reticulum Stress, RC31-1245, Double-negative feedback loop, Cell biology, β-cell dedifferentiation, Epithelial-to-mesenchymal transition, ER stress, MET, mesenchymal-to-epithelial transition, MicroRNAs, 030104 developmental biology, Tg, thapsigargin, Unfolded protein response, Original Article, T1D, type 1 diabetes, EMT, epithelial-to-mesenchymal transition
وصف الملف: application/application/pdf
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المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Leptin, medicine.medical_treatment, A Kinase Anchor Proteins, AMP-Activated Protein Kinases, Biochemistry, chemistry.chemical_compound, Adenosine Triphosphate, AMP-activated protein kinase, KATP Channels, Adipocyte, Insulin-Secreting Cells, Insulin Secretion, Fluorescence Resonance Energy Transfer, Glucose homeostasis, Homeostasis, Insulin, Phosphorylation, AC, adenylyl cyclase, biology, Chemistry, Calcineurin, Cell biology, protein kinase A (PKA), Protein Transport, A-kinase anchoring protein (AKAP), hormones, hormone substitutes, and hormone antagonists, Research Article, Signal Transduction, ATP-sensitive potassium channel, NMDAR, N-methyl-D-aspartate receptor, PP2B, protein phosphatase 2B, Primary Cell Culture, AKAP, A-kinase anchoring protein, Calcium-Calmodulin-Dependent Protein Kinase Kinase, FRET, fluorescence resonance energy transfer, Cell Line, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, medicine, Humans, Protein kinase A, Molecular Biology, cyclic AMP (cAMP), 030102 biochemistry & molecular biology, Cell Membrane, Actin remodeling, Cell Biology, Cyclic AMP-Dependent Protein Kinases, CaMKKβ, calcium/calmodulin-dependent kinase kinase β, AMPK, AMP-activated protein kinase, 030104 developmental biology, Glucose, fluorescence resonance energy transfer (FRET), biology.protein, PKA, protein kinase A
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المؤلفون: Kyle S. McCommis, Jerry R. Colca, Dakota R. Kamm, Laura N. Healy, Martin C. Sharpe, Kelly D. Pyles
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Male, insulin secretion, medicine.medical_treatment, GLP-1RA, glucagon-like peptide-1 receptor agonist, DMSO, dimethyl sulfoxide, Biochemistry, Mice, Non-alcoholic Fatty Liver Disease, AST, aspartate transaminase, insulin resistance, Nonalcoholic fatty liver disease, Hyperinsulinemia, Insulin, DMEM, Dulbecco's modified Eagle's medium, diabetes, Fatty liver, NASH, RIP, rat insulin promoter, NEFA, nonesterified fatty acid, hyperinsulinemia, Drug Therapy, Combination, Female, TZD, thiazolidinedione, NASH, nonalcoholic steatohepatitis, MPC, mitochondrial pyruvate carrier, medicine.drug, Research Article, medicine.medical_specialty, Veh, vehicle solution, ALT, alanine transaminase, TAG, triacylglyceride, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, Insulin resistance, Diabetes mellitus, Internal medicine, NAFLD, medicine, Animals, Hypoglycemic Agents, TBST, Tris-buffered saline with Tween-20, Molecular Biology, Glucagon-like peptide 1 receptor, 030102 biochemistry & molecular biology, Liraglutide, business.industry, nutritional and metabolic diseases, Acetophenones, Cell Biology, medicine.disease, beta cell, Mice, Inbred C57BL, PPARγ, peroxisome proliferator-activated receptor γ, 030104 developmental biology, Endocrinology, Lira, liraglutide, Thiazolidinediones, NAFLD, nonalcoholic fatty liver disease, business, metabolism
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المؤلفون: Andrew T. Nelson, Dionicio Siegel, Pratik Aryal, Rucha Patel, Barbara B. Kahn, Jennifer Lee, Alan Saghatelian, Ismail Syed
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100108-(2021)مصطلحات موضوعية: Male, Glucose uptake, OAHSA, oleic acid hydroxy stearic acid, SAHSA, stearic acid hydroxy stearic acid, Biochemistry, Palmitic acid, BMDC, bone marrow–derived dendritic cell, chemistry.chemical_compound, Endocrinology, 9-OAHPA, 9-oleic acid hydroxy palmitic acid, Insulin Secretion, Palmitoleic acid, chemistry.chemical_classification, Molecular Structure, diabetes, CEL, carboxyl ester lipase, Esters, Stereoisomerism, WAT, white adipose tissue, Middle Aged, macrophages, POHSA, palmitoleic acid hydroxy stearic acid, LPS, lipopolysaccharide, Female, Stearic acid, 9-PAHPA, 9-palmitic acid hydroxy palmitic acid, Research Article, Adult, insulin, QD415-436, fatty acids, lipids, GSIS, glucose-stimulated insulin secretion, adipocytes/obesity, HSA, hydroxy stearic acid, PAHSA, palmitic acid hydroxy stearic acid, Free fatty acid receptor 1, Humans, stereoisomers, Fatty acid, Cell Biology, Metabolism, GSIS, Oleic acid, GPR40, G protein–coupled receptor 40, Glucose, chemistry, BMDM, bone marrow–derived macrophage, inflammation, FAHFA, fatty acid esters of hydroxy fatty acid, GPCR, G protein–coupled receptor, metabolism
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المؤلفون: Bernard Thorens, Michele Solimena, Christian Klose, Jürgen Weitz, Florence Mehl, Jessica Denom, Ana Rodriguez Sanchez-Archidona, Clara Roujeau, Mark Ibberson, Christophe Magnan, Marko Barovic, Céline Cruciani-Guglielmacci, Kai Simons, Nadim Kassis, Leonore Wigger, Marius Distler, Justine Lallement
المصدر: Molecular Metabolism
Molecular metabolism, vol. 54, pp. 101355
Molecular Metabolism, Vol 54, Iss, Pp 101355-(2021)مصطلحات موضوعية: Male, PC, phosphatidylcholines, HFD, high-fat diet, T2D, Type 2 diabetes, medicine.medical_treatment, PITPNC1, Type 2 diabetes, Transcriptome, Mice, AUC, area under the curve, LPC, lysophosphatidylcholines, 0302 clinical medicine, Insulin-Secreting Cells, Gene expression, Insulin Secretion, Internal medicine, Cells, Cultured, 0303 health sciences, Mice, Inbred BALB C, geography.geographical_feature_category, Chol, cholesterol, OXPHOS, Oxidative phosphorylation, ABHD6, Islet, Cell biology, Mice, Inbred DBA, TAGs, triacylglycerols, VDR, vitamin D receptor, Original Article, Sphingomyelin, Systems biology, medicine.drug, LDL, low-density lipoproteins, β-cell function, 030209 endocrinology & metabolism, Biology, GSIS, glucose-stimulated insulin secretion, ER, endoplasmic reticulum, 03 medical and health sciences, SMs, sphingomyelins, WGCNA, weighted gene co-expression network analysis, GO, Gene Ontology, medicine, KEGG, Kyoto encyclopedia of genes and genomes, Animals, Humans, Lpl, lipoprotein lipase, Carnitine, PI, phosphatidylinositols, Molecular Biology, Triglycerides, 030304 developmental biology, geography, PCA, principal component analysis, HDL, high-density lipoproteins, Insulin, RC, regular chow, Cell Biology, medicine.disease, RC31-1245, CE, cholesteryl esters, Mice, Inbred C57BL, Biomarkers/blood, Biomarkers/metabolism, Glucose/metabolism, Insulin-Secreting Cells/metabolism, Triglycerides/blood, Triglycerides/metabolism, Biomarkers, Triacylglycerols, Glucose
وصف الملف: application/pdf
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المؤلفون: James Cantley, Dorit Samocha-Bonet, P. Tess Whitworth, Daniel J. Fazakerley, David E. James, Lindsay E. Wu, Trevor J. Biden, Nigel Turner
المساهمون: Fazakerley, Daniel [0000-0001-8241-2903], Apollo - University of Cambridge Repository
المصدر: Molecular Metabolism
مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, BMI, body mass index, FABP4, SILAC, stable-isotope labelling by amino acids in cell culture, Adipokine, T2D, type 2 diabetes, Type 2 diabetes, Biology, cAMP, cyclic-AMP, Brief Communication, Fatty acid-binding protein, GSIS, glucose-stimulated insulin secretion, chemistry.chemical_compound, Insulin resistance, Internal medicine, Adipocyte, Insulin receptor substrate, medicine, Obesity, Molecular Biology, IBMX, 3-Isobutyl-1-methylxanthine, NEFA, non-esterified fatty acid, Insulin, Insulin secretion, Beta-cell, Cell Biology, medicine.disease, Endocrinology, chemistry, ELISA, enzyme-linked immunosorbant assay, Beta cell
وصف الملف: application/pdf
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المؤلفون: Graeme Milligan, Daniele Bolognini, Domonkos Dedeo
المصدر: Current Opinion in Endocrine and Metabolic Research
مصطلحات موضوعية: 0301 basic medicine, Cell type, Endocrinology, Diabetes and Metabolism, IgG, immunoglobulin G, SCG, superior cervical ganglion, enteroendocrine, ILC3, type 3 innate lymphoid cell, 030209 endocrinology & metabolism, Enteroendocrine cell, Biology, IgA, immunoglobulin A, Article, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, immune cells, 0302 clinical medicine, Immune system, G protein-coupled receptors, DREADD, Designer Receptor Exclusively Activated by Designer Drug, PYY, peptide YY, pancreas, GLP-1, glucagon-like peptide 1, BAFF, B-cell activating factor, Receptor, KO, knock-out, G protein-coupled receptor, Short-chain fatty acid, FFA2, ALDH1A2, aldehyde dehydrogenase 1 family member, Short chain fatty acids, FFA3, CMTB, 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide, HFD, high-fat-diet, Cell biology, 030104 developmental biology, SCFA, short-chain fatty acid, GTT, glucose tolerance test, PNS, peripheral nervous system, PA, (S)-2-(4-chlorophenyl)-3,3-dimethyl-N-(5-phenylthiazol-2-yl)butanamide, Fermentation, SCA, small carboxylic acid, Homeostasis
وصف الملف: application/pdf
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المؤلفون: Mercè Obach, Gema Alcarraz-Vizán, Júlia Rodríguez-Comas, Juan Moreno-Vedia, Anna Novials, Raquel Horrillo, Joan-Marc Servitja, Montserrat Costa, Carlos Castaño, Daniela Díaz-Catalán, Sara de Pablo, Anna Mestre
المصدر: Molecular Metabolism, Vol 37, Iss, Pp 100984-(2020)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, T2D, Type 2 diabetes, Macrophage, medicine.medical_treatment, Apoptosis, Mice, 0302 clinical medicine, Insulin-Secreting Cells, IAPP, Insulin Secretion, Glucose homeostasis, Insulin, DIC, Dissociated islet cell, geography.geographical_feature_category, Chemistry, AAT, Alpha1-antitrypsin, Islet, Islet Amyloid Polypeptide, Islet inflammation, medicine.anatomical_structure, Alpha1-antitrypsin, PDX1, Original Article, medicine.symptom, β-Cell, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Amyloid, lcsh:Internal medicine, GSIS, Glucose-stimulated insulin secretion, 030209 endocrinology & metabolism, Inflammation, Mice, Transgenic, Proinflammatory cytokine, 03 medical and health sciences, Islets of Langerhans, hIAPP, Human islet amyloid polypeptide, Internal medicine, Glucose Intolerance, medicine, Animals, Humans, lcsh:RC31-1245, Molecular Biology, MФ, Macrophage, geography, Pancreatic islets, Macrophages, Cell Biology, Glucose Tolerance Test, hIAPP-Tg, Human islet amyloid polypeptide transgenic (mouse), Disease Models, Animal, 030104 developmental biology, Endocrinology, Glucose, Diabetes Mellitus, Type 2, alpha 1-Antitrypsin, IL-1Ra, Interleukin-1 receptor antagonist
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المؤلفون: Emily M. Overway, Karin J. Bosma, Derek P. Claxton, James K. Oeser, Kritika Singh, Lindsay B. Breidenbach, Hassane S. Mchaourab, Lea K. Davis, Richard M. O'Brien
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Blood Glucose, insulin secretion, FBG, fasting blood glucose, glucose metabolism, single-nucleotide polymorphism (SNP), MAF, minor allele frequency, Polymorphism, Single Nucleotide, GWAS, genome-wide association studies, Biochemistry, G6Pase, glucose-6-phosphatase, enzyme degradation, ER, endoplasmic reticulum, GSIS, glucose-stimulated insulin secretion, Mice, G6PC, glucose-6-phosphatase catalytic subunit, ORF, open reading frame, EHR, electronic health record, Animals, AA, amino acid, Molecular Biology, glucose-6-phosphatase, islet, HRP, horseradish peroxidase, Fasting, Cell Biology, WT, wild-type, GSD1a, glycogen storage disease type 1a, SNP, single-nucleotide polymorphism, Research Article
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المؤلفون: Over Cabrera, James Ficorilli, Janice Shaw, Felipe Echeverri, Frank Schwede, Oleg G. Chepurny, Colin A. Leech, George G. Holz
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: endocrine system, insulin secretion, OGTT, oral glucose tolerance test, GcgR, glucagon receptor, GRA, GcgR antagonist, T2D, type 2 diabetes, Biochemistry, Glucagon-Like Peptide-1 Receptor, GSIS, glucose-stimulated insulin secretion, Islets of Langerhans, Mice, CM, conditioned medium, Glucagon-Like Peptide 1, cAMP, Animals, Insulin, Molecular Biology, islet, digestive, oral, and skin physiology, Cell Biology, Glucagon, SES, standard extracellular saline, Rats, Mice, Inbred C57BL, Glucose, Diabetes Mellitus, Type 2, IVGTT, intravenous glucose tolerance test, AUC, area-under-the-curve, BSA, bovine serum albumin, GLP-1, hormones, hormone substitutes, and hormone antagonists, Research Article, GLP-1R, glucagon-like peptide-1 receptor
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المؤلفون: Daniel J. Horan, Hyun Cheol Roh, Aaron C. Ericsson, Surabhi D. Abhyankar, Natalie D. Stull, Xiaocheng C. Dong, Alexander G. Robling, Hongxia Ren, Robert N. Bone, Austin M. Reilly, Shijun Yan, Jason M. Conley, Carmella Evans-Molina, Menghao Huang
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: insulin receptor (INSR), HFD, high-fat diet, OGTT, oral glucose tolerance test, medicine.medical_treatment, Glucose uptake, ROI, region of interest, Type 2 diabetes, Biochemistry, type 2 diabetes (T2DM), Insr, insulin receptor, Mice, insulin resistance, Hyperinsulinemia, Insulin, glucose transporter type 4 (GLUT4), Mice, Knockout, Glucose Transporter Type 4, diabetes, biology, GLUT4, glucose transporter type 4, GIRKO, GLUT4 promoter-driven insulin receptor knockout, FFPE, formalin-fixed paraffin-embedded, IPGTT, intraperitoneal glucose tolerance test, LPS, lipopolysaccharide, MIRKO, muscle-Insr-KO, Research Article, medicine.medical_specialty, glucose metabolism, T2D, type 2 diabetes, Diet, High-Fat, GSIS, glucose-stimulated insulin secretion, Insulin resistance, Diabetes mellitus, Internal medicine, Glucose Intolerance, medicine, Animals, Molecular Biology, micro-CT, micro-computed tomography, NCD, normal chow diet, business.industry, VLDL, very-low-density lipoprotein, nutritional and metabolic diseases, DIO, diet-induced obesity, Cell Biology, medicine.disease, Mice, Inbred C57BL, FIRKO, fat-Insr-KO, Insulin receptor, Endocrinology, Diabetes Mellitus, Type 2, Hyperglycemia, biology.protein, diet, business, metabolism, GLUT4
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المؤلفون: Hindrik Mulder
المصدر: Molecular Metabolism, Vol 6, Iss 9, Pp 1040-1051 (2017)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, endocrine system diseases, POLRMT, eQTL, Expression quantitative trait locus, medicine.medical_treatment, TEFM, Mitochondrial transcription elongation factor, Cell, Review, TFB1M, Transcription factor B1 mitochondrial, Disease, Mitochondrion, KATP, ATP-dependent K+-channel, POLRMT, Mitochondrial RNA polymerase, PPARγ, Peroxisome proliferator-activated receptor-γ, Insulin-Secreting Cells, Insulin, Genetics, ICDc, Cytosolic isocitrate dehydrogenase, Genome-wide association study (GWAS), Insulin secretion, OXPHOS, Oxidative phosphorylation, ATGL, adipocyte triglyceride lipase, Mitochondria, DNA-Binding Proteins, medicine.anatomical_structure, TCA, Tricarboxylic acid, Islets, PGC, Peroxisome proliferator-activated receptor-γ co-activator, Glycolysis, GWAS, Genome-wide association study, PRC, PGC1-related coactivator, β-Cell, TFB2M, Transcription factor B2 mitochondrial, lcsh:Internal medicine, TFAM, Transcription factor A mitochondrial, GSIS, Glucose-stimulated insulin secretion, SNP, Single Nucleotide Polymorphism, Biology, CYTB, Cytochrome b, SUR1, Sulphonylurea receptor-1, HSL, Hormone-sensitive lipase, MTERF, Mitochondrial transcription termination factor, Mitochondrial Proteins, COX, Cytochrome c oxidase, 03 medical and health sciences, NRF, Nuclear respiratory factor, medicine, Animals, Humans, Genetic Predisposition to Disease, Expression quantitative trait locus (eQTL), NSUN4, NOP2/Sun RNA methyltransferase family member 4, SENP1, Sentrin/SUMO-specific protease-1, lcsh:RC31-1245, GDH, Glutamate dehydrogenase, Molecular Biology, Transcription factor, TFB1M, ND, NADH dehydrogenase, nutritional and metabolic diseases, Methyltransferases, Cell Biology, TFAM, PDH, pyruvate dehydrogenase, Oxidative Stress, 030104 developmental biology, Diabetes Mellitus, Type 2, PC, Pyruvate carboxylase, POLγ, DNA polymerase-γ, ERR-α, Estrogen-related receptor-α, T2D, Type 2 Diabetes, AMPK, AMP-dependent protein kinase, Genome-Wide Association Study, Transcription Factors
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المؤلفون: Kristin L. Hunt, Bo Xiang, Michael B. Wheeler, Michael Jonasson, Steven Cooper, Nivedita Seshadri, Vernon W. Dolinsky, Christine A. Doucette
المصدر: Molecular Metabolism, Vol 6, Iss 7, Pp 760-769 (2017)
Molecular Metabolismمصطلحات موضوعية: Male, WT, wild type, 0301 basic medicine, T2D, Type 2 diabetes, LG, Low glucose, Cell, Endogeny, Ucp2-βKO, β cell-specific Ucp2 knockout, Mice, Insulin-Secreting Cells, MIN6, Mouse insulinoma 6, Gene expression, Insulin, Cells, Cultured, geography.geographical_feature_category, Glucose-stimulated insulin secretion, Glucose tolerance, Islet, β cells, Circadian Rhythm, medicine.anatomical_structure, ZT, Zeitgeber time, medicine.medical_specialty, endocrine system, lcsh:Internal medicine, Pancreatic islets, GSIS, Glucose-stimulated insulin secretion, HG, High glucose, Biology, Brief Communication, Exocytosis, UCP2, Uncoupling protein 2, Cell Line, 03 medical and health sciences, Downregulation and upregulation, Internal medicine, medicine, Zeitgeber, Animals, lcsh:RC31-1245, Molecular Biology, i.p.GTT, intraperitoneal glucose tolerance test, geography, Wild type, Cell Biology, Uncoupling protein 2, Mice, Inbred C57BL, Glucose, 030104 developmental biology, Endocrinology, Ins2-cre, Ins2 promoter-driven cre recombinase