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المؤلفون: Pingping Luo, Rui Zhang, Qian Yu, George L. Tipoe, Ming Zheng, Xiaoming Sun, Yingxia Liu, Jia Xiao, Wei Li, Hong Zhang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 668-679 (2021)مصطلحات موضوعية: Alcoholic liver disease, INSR, insulin receptor, TCF/LEF, T-cell factor/lymphoid enhancer factor, AST, aspartate aminotransferase, Pharmacology, TSA, thermal shift assay, 0302 clinical medicine, WAT, white adipose tissues, HSL, hormone sensitive lipase, FFA, free fatty acids, MTT, 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide, General Pharmacology, Toxicology and Pharmaceutics, NF-κB, nuclear factor kappa B, RER, respiratory exchange ratio, 0303 health sciences, LRP6, low-density lipoprotein receptor related protein 6, TNF, tumor necrosis factor, NAS, NAFLD activity score, biology, TG, triglyceride, Chemistry, NIAAA, National Institute on Alcohol Abuse and Alcoholism, Liver cell, CYP2E1, cytochrome P450 2E1, 030220 oncology & carcinogenesis, LDLR, low-density lipoprotein receptor, NRF2, nuclear factor erythroid 2-related factor 2, IRS, insulin receptor substrate, GTT, glucose tolerance test, Original Article, medicine.symptom, Safety, IRTK, insulin receptor tyrosine kinase, GSK3β, glycogen synthase kinase 3 beta, NAFLD, non-alcoholic fatty liver disease, ALD, alcoholic liver disease, SREBP-1c, sterol regulatory element-binding protein 1c, Inflammation, SPR, surface plasmon resonance, AMPK, adenosine 5′-monophosphate (AMP)-activated protein kinase, SAMC, S-allylmercaptocysteine, 03 medical and health sciences, ADIPOQ, adiponectin, Insulin resistance, ORF, open reading frame, PA, palmitate acid, ALT, alanine aminotransferase, medicine, CPT1, carnitine palmitoyltransferase I, IRS-1, GRB14, growth factor receptor-bound protein 14, Protein kinase B, 030304 developmental biology, ATGL, adipose triglyceride lipase, PPARα, peroxisome proliferator-activated receptor alpha, AKT, lcsh:RM1-950, ALDH2, aldehyde dehydrogenase 2, GSK3β, Lipid metabolism, medicine.disease, S-Allylmercaptocysteine, WT, wild-type, IL, interleukin, TC, total cholesterol, Insulin receptor, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, biology.protein, NAC, N-acetyl-cysteine, Steatosis, IGF-1, insulin-like growth factors-1
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المؤلفون: Raju V. S. Rajala
المصدر: Journal of Lipid Research, Vol 62, Iss, Pp 100041-(2021)
Journal of Lipid Researchمصطلحات موضوعية: 0301 basic medicine, PI(3,4) P2, phosphatidylinositol 3,4-bisphosphate, IGF, insulin-like growth factor, PIKfyve, FYVE-type zinc finger containing phosphoinositide kinase, 030204 cardiovascular system & hematology, Phosphatidylinositols, Biochemistry, PDGF, platelet-derived growth factor, chemistry.chemical_compound, PTP1B, protein tyrosine phosphatase 1B, 0302 clinical medicine, Endocrinology, SHIP, Src homology 2 domain-containing inositol polyphosphate 5-phosphatase, phosphoinositide binding proteins, PI(4,5)P2, phosphatidylinositol 4,5-bisphosphate, biology, Grb14, growth factor receptor-bound protein 14, phosphoinositide kinases, PI(5)P, phosphatidylinositol 5-phosphate, PIPK, phosphatidylinositol phosphate kinase, PITP, phosphatidylinositol transfer protein, Cell biology, Pleckstrin homology domain, PI4K, phosphatidylinositol 4-kinase, OCRL, oculocerebrorenal syndrome of Lowe, Phosphatidylinositol 4,5-bisphosphate, PI(3)P, phosphatidylinositol 3-phosphate, IR, insulin receptor, PI(3,5)P2, phosphatidylinositol 3,5-bisphosphate, VDAC, voltage-dependent anion channel, IRS, insulin receptor substrate, lipids (amino acids, peptides, and proteins), PIP, phosphatidylinositol phosphate, IP3, inositol triphosphate, light activation, PI3K, phosphoinositide 3-kinase, SH2, Src homology 2, CNTF, ciliary neurotrophic factor, TRP, transient receptor potential, Thematic Review Series: Seeing 2020: Lipids and Lipid-Soluble Molecules in the Eye, musculoskeletal diseases, Phosphatidylinositol 3,5-bisphosphate, RPE, retinal pigment epithelium, CNGA1, cyclic nucleotidegated channel subunit α1, PH, pleckstrin homology, Vps, vacuolar protein sorting, mTOR, mammalian target of rapamycin, QD415-436, PI, phosphatidylinositol, Phosphoinositide Phosphatases, INPP5, inositol polyphosphate 5-phosphatase, 03 medical and health sciences, FYCO1, FYVE and coiled-coil domain autophagy adaptor 1, PLC, phospholipase C, GSK3β, glycogen synthase kinase 3β, PKC, protein kinase C, ROS, rod outer segment, Phosphatidylinositol 5-phosphate, GPCR, G protein-coupled receptor, CNG, cyclic nucleotide-gated, Phosphoinositide 3-kinase, Phosphatidylinositol (3,4,5)-trisphosphate, Phosphatidylinositol 3-phosphate, fungi, PI(4)P, phosphatidylinositol 4-phosphate, Thematic Review Series, phosphoinositide phosphatases, Cell Biology, PTEN, phosphatase and tensin homolog, PI(3,4,5)P2, phosphatidylinositol 3,4,5-trisphosphate, body regions, 030104 developmental biology, chemistry, biology.protein, EPO, erythropoietin, RA, Ras-associating