-
1Academic Journal
المؤلفون: Francesco De Pascali, Aylin Hanyaloglu, Frederic Jean-Alphonse, Francesco Potì, Eric Reiter
المصدر: Frontiers in Endocrinology, Vol 15 (2024)
مصطلحات موضوعية: endocrine system, GPCRs (G protein-coupled receptors), gonadotropin receptors, pharmacoperones, ketogenic diet, prostaglandin E (PGE2) 2, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
وصف الملف: electronic resource
-
2Academic Journal
المؤلفون: Davide Sala, Peter W. Hildebrand, Jens Meiler
المصدر: Frontiers in Molecular Biosciences, Vol 10 (2023)
مصطلحات موضوعية: AlphaFold, GPCRs (G-protein-coupled receptors), kinases, structure prediction, protein function, Biology (General), QH301-705.5
وصف الملف: electronic resource
-
3Academic Journal
المؤلفون: Leslie Salas-Estrada, Bianca Fiorillo, Marta Filizola
المصدر: Frontiers in Endocrinology, Vol 13 (2022)
مصطلحات موضوعية: GPCRs (G protein-coupled receptors), metadynamics, molecular dynamics simulation, machine learning, enhanced sampling, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
وصف الملف: electronic resource
-
4News
المؤلفون: De Pascali, Francesco, Hanyaloglu, Aylin, Jean-Alphonse, Frederic, Potì, Francesco, Reiter, Eric
المصدر: Department of Biochemistry and Molecular Biology Faculty Papers
مصطلحات موضوعية: endocrine system, GPCRs (G protein-coupled receptors), gonadotropin receptors, pharmacoperones, ketogenic diet, prostaglandin E (PGE2) 2, Receptors, G-Protein-Coupled, Signal Transduction, Biochemistry, Endocrinology
وصف الملف: application/pdf
Relation: https://jdc.jefferson.edu/bmpfp/252; https://jdc.jefferson.edu/context/bmpfp/article/1253/viewcontent/Pharmacology_of_endocrine_related_GPCRs.pdf
-
5Academic Journal
المؤلفون: Joanna Filipowska, Nagesha G. Kondegowda, Nancy Leon-Rivera, Sangeeta Dhawan, Rupangi C. Vasavada
المصدر: Frontiers in Endocrinology, Vol 13 (2022)
مصطلحات موضوعية: LGR4, GPCRs (G protein-coupled receptors), Wnt signaling, RANKL (Receptor Activator for Nuclear Factor k B Ligand), inflammation, NFκB - Nuclear Factor κB, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
وصف الملف: electronic resource
-
6Academic Journal
المؤلفون: Beatriz Bueschbell, Prashiela Manga, Anke C. Schiedel
المصدر: Frontiers in Molecular Biosciences, Vol 9 (2022)
مصطلحات موضوعية: orphan receptors, GPCRs (G protein-coupled receptors), GPR143, ocular albinism type 1 (OA1), melanosome, intracellular GPCR, Biology (General), QH301-705.5
وصف الملف: electronic resource
-
7Academic Journal
المؤلفون: Abigail Pearce, Theo Redfern-Nichols, Matthew Harris, David R. Poyner, Mark Wigglesworth, Graham Ladds
المصدر: Frontiers in Physiology, Vol 13 (2022)
مصطلحات موضوعية: GPCRs (G protein-coupled receptors), signalling bias, CLR, β-arrestins, RAMPs, internalisation, Physiology, QP1-981
وصف الملف: electronic resource
-
8Academic JournalDetermining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias.
المؤلفون: Pearce, Abigail, Redfern-Nichols, Theo, Harris, Matthew, Poyner, David R, Wigglesworth, Mark, Ladds, Graham
المصدر: nlmid: 101549006 ; essn: 1664-042X
مصطلحات موضوعية: CLR, GPCRs (G protein-coupled receptors), GRK (G protein receptor kinase), RAMPs, internalisation, signalling bias, β-arrestins
وصف الملف: application/pdf
-
9
المؤلفون: Hariharan, Ashwini, Weir, Nick, Robertson, Colin, He, Liqun, Betsholtz, Christer, Longden, Thomas A.
المصدر: Frontiers in Cellular Neuroscience. 14
مصطلحات موضوعية: pericytes, ion channels, GPCRs (G protein coupled receptors), neurovascular coupling (NVC), cerebral blood flow (CBF), K-ATP channels, brain metabolism
وصف الملف: electronic
-
10
المؤلفون: Maryam S. Vasefi, Claire Alexander
المصدر: IBRO Neuroscience Reports, Vol 11, Iss, Pp 88-102 (2021)
IBRO Neuroscience Reportsمصطلحات موضوعية: CBD, Cannabidiol, GPCRs, G-Protein Coupled Receptors, PET, Positron Emission Tomography, DRN, Dorsal Raphe Nucleus, CB2R, Cannabinoid Receptor Type 2, Cannabidiol, Traumatic Stress, Prefrontal cortex, 5-HT, Serotonin, General Neuroscience, 5-HT2AR, 5-HT Receptor Type 2 A, Glutamate receptor, PTSD, PFC, Prefrontal Cortex, ERK1/2, Extracellular Signal-Related Kinases Type 1 or Type 2, medicine.anatomical_structure, GABAergic, NMDAR, N-Methyl-D-aspartate Receptors, CB1R, Cannabinoid Receptor Type 1, psychological phenomena and processes, medicine.drug, RC321-571, mPFC, Medial Prefrontal Cortex, Serotonin, Neurosciences. Biological psychiatry. Neuropsychiatry, SSNRI, Selective Norepinephrine Reuptake Inhibitor, Amygdala, behavioral disciplines and activities, Article, Dorsal raphe nucleus, 2-AG, 2-arachidonoylglycerol, medicine, fMRI, Functional Magnetic Resonance Imaging, SSRI, Selective Serotonin Reuptake Inhibitor, PFC, DRN and Raphe, business.industry, PTSD, Post-Traumatic Stress Disorder, GABA, Gamma-Aminobutyric Acid, medicine.disease, COVID-19, SARS-CoV-2, digestive system diseases, AEA, Anandamide, nervous system, Extinction (neurology), 5-HT1AR, 5-HT Receptor Type 1A, TRPV1, Transient Receptor Potential Vanilloid 1 Channels, business, Hypoactivity, Neuroscience, FAAH, Fatty Acid Amide Hydrolase
-
11
المؤلفون: Esraa Aly, Willias Masocha
المصدر: IBRO Neuroscience Reports, Vol 10, Iss, Pp 109-118 (2021)
IBRO Neuroscience Reportsمصطلحات موضوعية: Cannabidivarin, Cannabinoid receptor, medicine.medical_treatment, CBD, cannabidiol, CBRs, cannabinoid receptors, HIV-NP, HIV-associated neuropathic pain, Pharmacology, Neuropathic pain, chemistry.chemical_compound, RCTs, randomised clinical trials, AEA, N-arachidonoylethanolamine, TRPA, transient receptor potential ankyrin, MAGL, monoacylglycerol lipase, CINP, chemotherapy-induced neuropathic pain, CB1R, cannabinoid type 1 receptor, FAAH, fatty acid amide hydrolase, SAMRC, South African Medical Research Council, media_common, Human immunodeficiency virus, General Neuroscience, HIV-DSP, HIV-distal symmetric polyneuropathy, CBDV, cannabidivarin, Anandamide, NSAIDs, non-steroidal anti-inflammatory drugs, Endocannabinoid system, HIV, human immunodeficiency virus, delta-9-THC, delta-9-tetrahydrocannabinol, AEs, adverse effects, lipids (amino acids, peptides, and proteins), ddC, 2′-3′-dideoxycytidine, NP, neuropathic pain, NAPE, N-acyl-phosphatidylethanolamine, medicine.drug, RC321-571, Drug, L-29, palmitoylallylamide, CB2R, cannabinoid type 2 receptor, media_common.quotation_subject, Neurosciences. Biological psychiatry. Neuropsychiatry, BCP, β-caryophyllene, CNS, central nervous system, WHO, World Health Organization, IPM, indomethacin plus minocycline, 2-AG, 2-arachidonoylglycerol, medicine, gp, glycoprotein, ABHD6, α-β-hydrolase domain-containing 6, PNP, peripheral neuropathic pain, TRPV, transient receptor potential vanilloid, Cannabinoid, Articles from the Special Issue on Neuroscience in Africa, Edited by James O. Olopade, ABHD12, α-β-hydrolase domain-containing 12, DSP, distal symmetric polyneuropathy, Cannabis, Endocannabinoid, NAPE-PLD, NAPE-specific phospholipase D, DAGL, DAG lipase, business.industry, URB597, FDA, Food and Drug Administration, Antiretroviral, COX, cyclooxygenase, chemistry, MAIDS, murine acquired immunodeficiency syndrome, OTC, over the counter, GPCRs, G protein-coupled receptors, business, DDS, descriptor differential scale, DAG, diacylglycerol, PLWH, people living with HIV, ECS, endocannabinoid system
-
12DataSheet1_The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor.DOCX
المؤلفون: Beatriz Bueschbell, Prashiela Manga, Anke C. Schiedel
مصطلحات موضوعية: Biochemistry, Molecular Biology, Structural Biology, Enzymes, Protein Trafficking, Proteomics and Intermolecular Interactions (excl. Medical Proteomics), Receptors and Membrane Biology, Signal Transduction, Structural Biology (incl. Macromolecular Modelling), Synthetic Biology, orphan receptors, GPCRs (G protein-coupled receptors), GPR143, ocular albinism type 1 (OA1), melanosome, intracellular GPCR, pigment cells
-
13
المؤلفون: Yitao Wang, Jingxin Liu, Ligen Lin
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 220-236 (2019)مصطلحات موضوعية: SNS, sympathetic nervous system, C/EBPα, CCAAT/enhancer binding protein α, PDEs, phosphodiesterases, OXPHOS, oxidative phosphorylation, FGF21, fibroblast growth factor 21, Review, Type 2 diabetes, Brown adipose tissue, Bioinformatics, Energy homeostasis, CRABP-II, cellular RA binding protein type II, 0302 clinical medicine, HFD, high fat diet, Weight loss, RA, retinoic acid, RARE, RA response element, BMP8b, bone morphogenetic protein 8b, General Pharmacology, Toxicology and Pharmaceutics, media_common, 0303 health sciences, SIRT1, silent mating type information regulation 2 homolog 1, PXR, pregnane X receptor, TFAM, mitochondrial transcription factor A, WAT, white adipose tissue, Thermogenesis, PPREs, peroxisome proliferator response elements, FAS, fatty acid synthase, Thermogenin, cAMP, cyclic adenosine monophosphate, PTP1B, protein-tyrosine phosphatase 1B, medicine.anatomical_structure, BA, bile acids, 030220 oncology & carcinogenesis, VDR, vitamin D receptor, CRE, cAMP response element, medicine.symptom, PET-CT, positron emission tomography combined with computed tomography, PRDM16, PR domain containing 16, ATP, adenosine triphosphate, RXR, retinoid X receptor, media_common.quotation_subject, VDRE, VDR response elements, AKT, protein kinase B, 03 medical and health sciences, TMEM26, transmembrane protein 26, CLA, cis-12 conjugated linoleic acid, ERE, estrogen response element, UCP1, uncoupling protein 1, medicine, PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1-α, Obesity, β3-AR, β3-adrenergic receptor, 030304 developmental biology, ERs, estrogen receptors, LXR, liver X receptors, PPARs, peroxisome proliferator-activated receptors, business.industry, lcsh:RM1-950, Cidea, cell death-inducing DNA fragmentation factor α-like effector A, Uncoupling protein 1, Appetite, RMR, resting metabolic rate, medicine.disease, Dio2, iodothyronine deiodinase type 2, Beige cells, ALDH9, aldehyde dehydrogenase 9, BAT, brown adipose tissue, AMPK, AMP-activated protein kinase, lcsh:Therapeutics. Pharmacology, RAR, RA receptor, cGMP, cyclic guanosine monophosphate, PKA, protein kinase A, GPCRs, G protein-coupled receptors, TRPs, transient receptor potential cation channels, business, MAPK, mitogen-activated protein kinase
-
14
المؤلفون: Vera Maria Morsch, Karine Paula Reichert, Milagros Fanny Vera Castro, Naiara Stefanello, Vanessa Valéria Miron, Andréia Machado Cardoso, Maria Rosa Chitolina Schetinger, Charles Elias Assmann, Nathieli B. Bottari
المصدر: Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111273-(2021)
Biomedicine & Pharmacotherapyمصطلحات موضوعية: BP, blood pressure, HIF-1α, hypoxia-inducible factor-1α, Adenosine, Up4A, uridine adenosine tetraphosphate, Cell Communication, Review, APCs, antigen presenting cells, BFR, blood flow restriction, 0302 clinical medicine, PNP, purine nucleoside phosphorylase, Diabetic cardiomyopathy, Purinergic P2 Receptor Antagonists, HIAE, high intensity aerobic, Medicine, NOS, nitric oxide synthase, 5'-Nucleotidase, 5′-NT, CD73, ecto-5′-nucleotidase, Ectonucleotidases, GLP-1, glucagon-like peptide-1, General Medicine, PAP, prostatic acid phosphatase, GLUT, glucose transporter, NTPDase1/CD39, E-NTPDase family, 030220 oncology & carcinogenesis, TReg, regulatory T cells, ATP, adenosine 5′-triphosphate, P1, purinergic receptors family 1, DBP, diastolic blood pressure, RM1-950, ADP, adenosine 5′-diphosphate, STZ, streptozotocin, LIAE, low intensity aerobic exercise, HIIT, high-intensity intermittent training, 03 medical and health sciences, Antigens, CD, Diabetes Mellitus, Humans, Exercise, Ado, Adenosine, PBMCs, peripheral blood mononuclear cells, Pharmacology, NO, nitric oxide, Receptors, Purinergic P2, UTP, uridine-5′-triphosphate, Receptors, Purinergic P1, T2DM, type 2 diabetes mellitus, medicine.disease, IL, interleukin, CGA, chlorogenic acid, 030104 developmental biology, Glucose, ER, endoplasmatic reticulum, GABA, gamma-aminobutyric acid, Ino, inosine, PKA, protein kinase A, SHR, spontaneously hypertensive rat, 0301 basic medicine, Adenosine Deaminase, STAT3, signal transducer and activator of transcription 3, SIT, sprint interval training, UDP, uridine diphosphate, Bioinformatics, Adenosine deaminase, VO2máx, maximal oxygen uptake, DM, diabetes mellitus, E-NPP, ecto-nucleotide pyrophosphatase/phosphodiesterase, Receptor, ADA, adenosine deaminase, NOD-mice, Non-obese diabetic mice, NF-κB, nuclear factor kappa B, TNF-α, tumor necrosis factor α, biology, AMP, adenosine 5′-monophosphate, Apyrase, T1DM, type 1 diabetes mellitus, Purinergic receptor, E-NTPDase, ecto-nucleoside triphosphate diphosphohydrolase, eNOS, endothelial nitric oxide synthase, MICT, moderate intensity continuous training, Purinergic signalling, IRS-1, insulin receptor substrate 1, VEGF, vascular endothelial growth factor, mRNA, messenger RNA, MSNA, muscle sympathetic nerve activity, Hypertension, Ap3A, diadenosine triphosphate, Blood pressure, Diet, Healthy, DCs, dendritic cells, Purinergic receptors, Signal Transduction, medicine.drug, P2Y, purinergic metabotropic receptor family 2, TNAP, tissue-nonspecific alkaline phosphatase, HbA1c, glycosylated hemoglobin, P2 receptor, CNS, central nervous system, APs, alkaline phosphatases, SIRT1, Sirtuin 1, GPCRs, G-protein-coupled receptors, L-NAME, L-NG-nitroarginine methyl ester, P2X, purinergic ionotropic receptor family 2, Diabetes mellitus, Animals, TXA2, thromboxane A2, ComputingMethodologies_COMPUTERGRAPHICS, NLRP3, NLR family pyrin domain containing 3, cAMP, cyclic adenosine 5′-monophosphate, business.industry, SBP, systolic blood pressure, AngII, angiotensin-II, ATP, AMPK, AMP-activated protein kinase, NFAT, nuclear factor of activated T-cells, Purinergic P1 Receptor Antagonists, DAMP, molecular pattern associated with damage, Purines, TGF-β1, transforming growth factor-beta 1, biology.protein, Therapeutics. Pharmacology, business, DAG, diacylglycerol
-
15
المؤلفون: Pamula, Filip
المساهمون: Schertler, Gebhard, Dutzler, Raimund, Pilhofer, Martin, Tsai, Ching-Ju
مصطلحات موضوعية: ddc:570, GPCRs, G-protein coupled receptors, Structural biology, Life sciences
وصف الملف: application/application/pdf
-
16
المؤلفون: Graeme Milligan, Valerica Raicu, Richard J. Ward, Michael R. Stoneman, John D. Pediani, Sara Marsango, Richard Jolly, Tracy M. Handel, Gabriel Biener
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, mEGFP, monomeric enhanced green fluorescent protein, Benzylamines, Protein Conformation, Receptor expression, medicine.disease_cause, confocal microscopy, Cyclams, Ligands, Biochemistry, Oligomer, chemistry.chemical_compound, Chemokine receptor, FIF, fluorescence intensity fluctuation, IT1t, isothiourea-1t, Heterocyclic Compounds, Receptor, Cells, Cultured, Mutation, CXCR4 antagonist, dimerization, Chemistry, Thiourea, Cell biology, RoIs, regions of interest, GPCRs, G protein–coupled receptors, tertiary structure, PSF, point spread function, Research Article, Protein Binding, Signal Transduction, MEU, monomeric equivalent unit, Receptors, CXCR4, microscopic imaging, QB, quantal brightness, Anti-HIV Agents, Recombinant Fusion Proteins, Green Fluorescent Proteins, oligomerization, Small Molecule Libraries, 03 medical and health sciences, medicine, Humans, BRET, bioluminescence resonance energy transfer, Molecular Biology, G protein-coupled receptor, 030102 biochemistry & molecular biology, chemokine, Antagonist, G protein–coupled receptor (GPCR), Cell Biology, 030104 developmental biology, SpIDA, spatial intensity distribution analysis, Protein Multimerization, SD, standard deviation
وصف الملف: application/pdf
-
17
المؤلفون: Liqun He, Ashwini Hariharan, Nick Weir, Thomas A Longden, Christer Betsholtz, Colin Robertson
المصدر: Frontiers in Cellular Neuroscience, Vol 14 (2020)
Frontiers in Cellular Neuroscienceمصطلحات موضوعية: 0301 basic medicine, K-ATP channels, Context (language use), Review, Energy requirement, pericytes, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Katp channels, medicine, KATP channels, Receptor, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Ion channel, G protein-coupled receptor, Membrane potential, Chemistry, Neurosciences, ion channels, neurovascular coupling (NVC), 030104 developmental biology, medicine.anatomical_structure, brain metabolism, Cellular Neuroscience, cerebral blood flow (CBF), GPCRs (G protein coupled receptors), Pericyte, Neuroscience, 030217 neurology & neurosurgery, Neurovetenskaper
وصف الملف: application/pdf
-
18
المؤلفون: Lu Tie, Xu Yan, Jing-Yu Lin, Chan Yang, Jin-Peng Sun, Wei Pan, Jin Wang, Zhao Yang, Fan Yang, Jie Cheng, Jia Wang, Ji-Xiang Du, Xiao Yu, Shi-Jie Zhang, Xin Chen
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: structure–function, Zipper, G protein, receptor, HEK293, human embryonic kidney 293, OSNs, olfactory sensory neurons, Receptors, Odorant, Biochemistry, PR, pheromone receptor, Protein Domains, Arrestin, Animals, Humans, Receptor, Molecular Biology, G protein-coupled receptor, arrestin, Effector, Chemistry, HEK 293 cells, Bombyx mori, ICLs, intracellular loops, trans-7TM, transverse seven transmembrane, Cell Biology, Bombyx, Cell biology, ORs, olfactory receptors, Transmembrane domain, β2AR, β2 adrenoreceptor, HEK293 Cells, S7, segment 7, PTX, pertussis toxin, Insect Proteins, calcium channel, GPCRs, G protein-coupled receptors, Hydrophobic and Hydrophilic Interactions, BmOR3, Research Article, BmOrco, FlAsH-BRET, fluorescein arsenical helix–bioluminescence resonance energy transfer
-
19
المؤلفون: Spillmann, Martin
المساهمون: Schertler, Gebhard F.X., Berger, Philipp, Waldhoer, Maria, Werner, Sabine
مصطلحات موضوعية: Arrestin, ddc:570, cell signaling, GPCRs, G-protein coupled receptors, Life sciences
وصف الملف: application/application/pdf
-
20
المؤلفون: Niranjan Varma, Eshita Mutt, Jonas Mühle, Valérie Panneels, Akihisa Terakita, Xavier Deupi, Przemyslaw Nogly, Gebhard F. X. Schertler, Elena Lesca
المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116 (29)مصطلحات موضوعية: 0301 basic medicine, Rhodopsin, genetic structures, Light, bistability, RHODOPSIN STRUCTURE, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, retinal, Arthropod Proteins, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, G protein-coupled receptors, Animals, Humans, Protein Isoforms, GPCRs, G-protein coupled receptors, X-ray crystallography, Crystallography, Multidisciplinary, Spiders, Stereoisomerism, Biological Sciences, Recombinant Proteins, Molecular dynamics simulation, 030104 developmental biology, HEK293 Cells, PNAS Plus, sense organs, Applied Biological Sciences, 030217 neurology & neurosurgery, Signal Transduction
وصف الملف: application/application/pdf
Full Text Finder