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المؤلفون: David A. Frank, Isidora Tošić
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)مصطلحات موضوعية: Cancer Research, p53, tumor protein 53, MEF2D, Myocyte Enhancer Factor 2D, FASN, fatty acid synthase, OXPHOS, oxidative phosphorylation, ERH, enhancer of rudimentary homolog, PDGF, platelet-derived growth factor, PFK, phosphofructokinase, CREB, cyclic AMP response element-binding protein, HDL-C, high-density lipoprotein cholesterol, chemistry.chemical_compound, PC, phosphatidylcholine, GRIM-19, gene associated with retinoid-IFN-induced mortality, Neoplasms, Transcriptional regulation, TGFβ, transforming growth factor beta, AML, acute myeloid leukemia, RC254-282, CDK, cyclin-dependent kinase, FABP6, fatty acid binding protein 6, BCL, B-cell lymphoma, CLL, chronic lymphocytic leukemia, Chemistry, LIF, leukemia inhibitory factor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, VEGF, vascular endothelial growth factor, FBP1, fructose-bisphosphatase 1, GPI, glucose-6-phosphate isomerase, Cell biology, MMP, matrix metalloproteinase, STAT, signal transducer and activator of transcription, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, GP130, glycoprotein 130, Phosphorylation, NHL, non-Hodgkin's lymphoma, JAK, Janus kinase, Adenosine triphosphate, CNTF, ciliary neurotrophic factor, STAT3 Transcription Factor, ATP, adenosine triphosphate, TAG, triacylglycerol, Protein processing, Post-translational, PPARγ, peroxisome proliferator-activated receptor gamma, ETC, electron transport chain, TNFα, tumor necrosis factor alpha, RIME, rapid immunoprecipitation mass spectrometry of endogenous proteins, GLUT1, glucose transporter 1, PGK1, phosphoglycerate kinase, MPTP, mitochondrial permeability transition pore, Mediator, Review article, CML, chronic myeloid leukemia, HIF1α, hypoxia inducible factor 1α, PIAS, protein inhibitors of activated STATs, SOCS, suppressors of cytokine signaling, Animals, Humans, IFN, interferon, LDHA, lactate dehydrogenase A, Transcription factor, PKCδ, protein kinase C δ, TF, transcription factors, EGF, epidermal growth factor, SM, sphingomyelin, SREBP1, sterol regulatory element-binding protein 1, IAP, inhibitor of apoptosis, PTP, protein tyrosine phosphatases, Tyrosine phosphorylation, Lipid metabolism, BCSC, breast cancer stem cells, IL, interleukin, Metabolism, OSM, oncostatin M, Anaerobic glycolysis, NFκB, nuclear factor kappa B, TBK1, TANK-binding kinase 1, MCL, myeloid cell leukemia, LDL-C, low-density lipoprotein cholesterol, PBP, PPARγ binding protein, CPT1B, carnitine palmitoyltransferase 1B, FAO, fatty acid oxidation
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المؤلفون: Zeinab Amini-Farsani, Mahtab Yadollahi-Farsani, Samira Asgharzade, Fatemeh Forouzanfar, Mitra Yadollahi, Samaneh Arab
المصدر: International Immunopharmacology
مصطلحات موضوعية: Disease, TRAF5, Tumor necrosis factor receptor associated factor-5, TLRs, Toll-like receptors, NF-kB, Nuclear factor kappa B, MAPK, Mitogen‑activated protein kinase, NK, Natural killer, eMDSCs, early-stage myeloid-derived suppressor cells, MIP1-α, Macrophage inflammatory protein 1-α, TNF-α, Tumor necrosis factor alpha, NF-kB, TRAF2, Tumor necrosis factor receptor associated factor-2, CNS, Central nervous system, NF-kappa B, ERK, Extracellular signal-regulated kinase, EGF, Epidermal growth factor, CRP, C-reactive protein, CD8, Cluster of differentiation 8, DEGs, Differentially expressed genes, JAK, Janus kinase, IP-10, interferon gamma-induced protein 10, SOCS3, Suppressor of cytokine signaling 3, Immunology, MCP-1/CCL2, Monocyte chemotactic protein, IP-10, Interferon IFN-γ inducible protein-10, IGF1R/PI3K, Insulin growth factor I receptor/phosphatidylinositol-3-kinase, Article, IgAN, Immunoglobulin a nephropathy, CCR2, Chemokine receptor type 2, microRNA, Humans, GP130, Glycoprotein 130, EDAR, Ectodysplasin A receptor, TNF‐β, Tumor necrosis factor-beta, Janus Kinases, Pharmacology, SLE, Lupus erythematosus, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, PTEN, Phosphatase and tensin homolog, FABP4, cells Fatty acid binding protein 4, PKC, protein kinase, IFNs, Interferons, IFNGR1, Interferon gamma receptor 1, TLR‐3, Toll-like receptor 3, IRFs, Interferon-regulatory factors, MCPIP1, Monocyte chemotactic protein-1-induced protein-1, PBMCs, Peripheral blood mononuclear cells, Bioinformatics, NFKBIA, NFKB inhibitor alpha, MCP-1, Monocyte chemoattractant protein-1, Immunology and Allergy, PIAS3, protein inhibitor of activated STAT 3, CD4, Cluster of differentiation 4, RhoB, Ras homolog family member B, RAS, Renin–angiotensin–system, COVID-19, Coronavirus disease 2019, JAK-STAT signaling pathway, ICAM1, Intercellular adhesion molecule 1, KD, Kawasaki disease, RIPK1, Receptor-interacting protein kinase 1, PCT, Procalcitonin, STAT Transcription Factors, TRIM25, Tripartite motif containing 25, IL‐21, Interleukin-21, MIP-1A, Macrophage inflammatory protein-1α, Signal transduction, medicine.symptom, ISGs, Interferon stimulated genes, IL‐6, Interleukin-6, TRADD, TNFR1 associated death domain protein, Signal Transduction, IκB-α, alpha, IL‐8, Interleukin-8, Coronavirus disease 2019 (COVID-19), Inflammation, Biology, MIP1B, Macrophage inflammatory protein-1 beta, Ang I, Angiotensin I, medicine, BALF, Bronchoalveolar lavage fluid, Ang II, Angiotensin II, CXCR2, Chemokine receptor 2, AT1R, Angiotensin II type I receptor, VLDLR, Very low-density lipoprotein receptors, Gene, miRNA, NLRP3, NLR family pyrin domain containing 3, SARS-CoV-2, PCBP2, Poly (rC)-binding protein 2, B-cells inhibitor, Nuclear factor of kappa light polypeptide gene enhancer in, IL‐1, Interleukin-1, COVID-19, ACE, Angiotensin-converting enzyme, STAT, Signal transducers and activators of transcription, TGF-β1, Transforming growth factor beta 1, NLR, Neutrophil to lymphocyte ratio, JAK/STAT, Review article, MicroRNAs, SOCS1, Suppressor of cytokine signaling 1, GCS-F, Granulocyte colony-stimulating factor, MCP‐1, Monocyte chemoattractant protein-1, DPP4R, Dipeptidyl peptidase-4 receptor, ESR, Erythrocyte sedimentation rate, IFITM3, Interferon-induced transmembrane protein 3
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المصدر: International Immunopharmacology
مصطلحات موضوعية: RhoB, Ras homolog gene family member B, M-CSF, Macrophage CSF, PPP2CA, Protein phosphatase 2 catalytic subunit alpha, RNA pol, RNA polymerase, medicine.medical_treatment, IRF, IFN regulatory factor, v-miRNA, Viral miRNA, DCs, Dendritic cells, MyD88, Myeloid differentiation factor 88, ISGs, IFN-stimulated genes, TLRs, Toll-like receptors, AT1R, Ang II receptor type 1, KCNQ1OT1, KCNQ1 overlapping transcript 1, CYLD, Cylindromatosis, IFNs-I, Type I IFNs, TNF-α, Tumor necrosis factor alpha, cPLA2, Cytoplasmic phospholipase A2, LPS, Lipopolysaccharide, Th cells, T helper cells, LPLs, Lysophospholipids, NLRP3, NOD-, LRR- and pyrin domain-containing protein 3, siRNAs, Small interfering RNAs, CNS, Central nervous system, pri-miRNAs, Primary miRNAs, MDA5, Melanoma differentiation-associated protein 5, ERK, Extracellular signal-regulated kinase, MERS-CoV, Middle East respiratory syndrome coronavirus, BBB, Blood-brain barrier, OxPLs, Oxidized phospholipids, MODS, Multiple organ dysfunction syndrome, mPGES-1, Microsomal prostaglandin E synthase-1, RNAi, RNA interference, ADAM17, A disintegrin and metalloproteinase 17, AGO, Argonaute, CRISPR, Cas13 family of clustered regularly interspaced short palindromic repeats, DAMPs, Damage-associated molecular patterns, circRNAs, Circular RNAs, CD, Cluster of differentiation, JAK, Janus kinase, TNFR, TNF receptor, Cytokine Release Syndrome, TRIM27, Tripartite motif-containing protein 27, gp130, Glycoprotein 130, MMP, Matrix metalloproteinase, 2019-nCoV, 2019 novel coronavirus, CCL, C-C motif chemokine ligand, SOCS3, Suppressor of cytokine signaling 3, Immunology, COX, Cyclooxygenase, Sry, Sex-determining region Y, Article, S protein, Spike protein, microRNA, Humans, K, Lysine, CSF, Colony-stimulating factor, RGMB-AS1, RGMB antisense RNA 1, TIMP-I, Tissue inhibitors of matrix metalloproteinases-I, S100A9, S100 calcium-binding protein A9, Pharmacology, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, NOXs, Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, CHD, Coronary heart disease, STAT, Signal transducer and activator of transcription, Virus Internalization, medicine.disease, Viral replication, NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells, miRNAs-based therapy, TBK1, TANK-binding kinase 1, ORF, Open reading frame, SOFA, Sequential organ failure assessment score, lncRNAs, Long non-coding RNAs, CatB/L, Cathepsin B/L, sIL-6R, Soluble IL-6R, ROS, Reactive oxygen species, EAE, Experimental autoimmune encephalomyelitis, RBCs, Red blood cells, MAPK, Mitogen-activated protein kinase, PBMCs, Peripheral blood mononuclear cells, N protein, Nucleocapsid protein, Ig, Immunoglobulin, Cytokine storm, Bioinformatics, Virus Replication, 3'-UTR, 3'-untranslated region, H3, Histone 3, AGEs, Advanced glycation end products, Renin-Angiotensin System, XPO5, Exportin-5, G-CSF, Granulocyte CSF, CXCL, C-X-C motif chemokine ligand, DIC, Disseminated intravascular coagulation, Immunology and Allergy, IL, Interleukin, PG, Prostaglandin, RAS, Renin-Angiotensin system, Amp, Amplifier, MCs, Mast cells, COVID-19, Coronavirus disease 2019, HSP, Heat shock protein, AA, Arachidonic acid, ASOs, Antisense oligonucleotides, IFN, Interferon, mRNA, Messenger RNA, ICU, Intensive care unit, Cytokine, RAGE, Receptor for advanced glycation end products, mIL-6R, Membrane IL-6 receptor, FOXO3, Forkhead box O3, miRNAs, LTs, Leukotrienes, miRISC, MicroRNA-induced silencing complex, IκB-ζ, Inhibitor of nuclear factor kappa B zeta, Signal transduction, me3, Trimethylation, M protein, Membrane protein, APJ, Apelin receptor, AP-1, Activator protein 1, TMPRSS2, Transmembrane serine protease 2, PRR, Pattern recognition receptor, GM-CSF, Granulocyte-macrophage CSF, RIG-I, Retinoic acid-inducible gene I, E protein, Envelope protein, Biology, hsa, Homo sapiens, TXs, Thromboxanes, LOXs, Lipoxygenases, Virus, ER, Endoplasmic reticulum, ARDS, Acute respiratory distress syndrome, Gene regulators, medicine, me2, Dimethylation, Animals, PKCα, Protein kinase C alpha, pre-miRNAs, Precursor miRNAs, DMVs, Double membrane vesicles, ceRNAs, Competing endogenous RNAs, nsp, Non-structural protein, Competing endogenous RNA, SARS-CoV-2, ALI, Acute lung injury, PaO2/FiO2, Pressure of arterial oxygen to fractional inspired oxygen concentration, COVID-19, ACE, Angiotensin-converting enzyme, ANRIL, Antisense noncoding RNA in the INK4 locus, miRNAs, MicroRNAs, MEG3, Maternally expressed gene 3, Review article, MicroRNAs, DMD, Dense matted deposits, TAB, Transforming growth factor β-activated kinase-1 (TAK1)-binding protein, HMGB1, High mobility group box protein 1, Ang, Angiotensin
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المؤلفون: Daniel Konrad, Matthias Blüher, Stephan Wueest, Timothy S. Odermatt, Pim P. van Krieken, Marcela Borsigova
المساهمون: University of Zurich
المصدر: Mol. Metab. 54:101341 (2021)
Molecular Metabolism
Molecular Metabolism, Vol 54, Iss, Pp 101341-(2021)مصطلحات موضوعية: Male, HFD, high-fat diet, medicine.medical_treatment, Adipocytes, White, Adipose tissue, epi, epididymal, White adipose tissue, OSMRΔadipo, adipocyte-specific oncostatin M receptor knockout, chemistry.chemical_compound, Mice, ERK, extracellular signal-regulated kinase, Adipocyte, Cytokine Receptor gp130, SVF, stromal vascular fraction, Internal medicine, gp130Δadipo, adipocyte-specific glycoprotein 130 knockout, gp130, glycoprotein 130, Cells, Cultured, ing, inguinal, biology, Chemistry, Oncostatin M, WAT, white adipose tissue, Thermogenin, STAT, signal transducer and activator of transcription, Browning, Ucp1, High Fat Diet, Obesity, White Adipose Tissue, Cytokine, High-fat diet, Original Article, hormones, hormone substitutes, and hormone antagonists, STAT3 Transcription Factor, medicine.medical_specialty, UCP1, 610 Medicine & health, JAK, janus kinase, CM, complete medium, 3T3-L1 Cells, UCP1, uncoupling protein 1, medicine, Animals, Humans, Molecular Biology, SOCS3, suppressor of cytokine signaling 3, Cell Biology, Glycoprotein 130, RC31-1245, BAT, brown adipose tissue, TBS-T, tris-buffered saline with 0.1% Tween, Endocrinology, OSM, oncostatin M, 10036 Medical Clinic, biology.protein, Thermogenesis
وصف الملف: application/pdf; 1_s2.0_S2212877821001885_main.pdf - application/pdf; 1-s2.0-S2212877821001885-main.pdf - application/pdf
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المؤلفون: Juliane Lokau, Johannes Haybaeck, Tina Daunke, Yvonne Garbers, Stefan Rose-John, Birte Kespohl, Samadhi Aparicio-Siegmund, Christoph Garbers, Charlotte M. Flynn, Stefan Düsterhöft
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Receptor complex, THP-1 Cells, media_common.quotation_subject, Gene Expression, recycling, DMSO, dimethyl sulfoxide, Biochemistry, Clathrin, Proinflammatory cytokine, gp130, sIL-6R, soluble IL-6 receptor, 03 medical and health sciences, PBS, phosphate buffered saline, Cytokine Receptor gp130, Jak, Janus kinase, Humans, IL-6R, interleukin 6-receptor, Receptor, Internalization, Molecular Biology, gp130, glycoprotein 130, ADAM, a disintegrin and metalloprotease, Dynamin, media_common, DMEM, Dulbecco's modified Eagle's medium, 030102 biochemistry & molecular biology, biology, Interleukin-6, Chemistry, Receptors, Interleukin, Cell Biology, Glycoprotein 130, Receptors, Interleukin-6, IL, interleukin, Cell biology, internalization, STAT, signal transducer and activator of transcription, HEK293 Cells, 030104 developmental biology, Gene Expression Regulation, interleukin-6 receptor, Interleukin-6 receptor, biology.protein, Cytokines, FCS, fetal calf serum, HeLa Cells, Signal Transduction, Research Article
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المؤلفون: Ivan Hong Wee Ng, David A. Jans, Dominic C.H. Ng, Marie A. Bogoyevitch
المصدر: Biochemical Journal
مصطلحات موضوعية: STAT3, signal transducer and activator of transcription 3, Gene Expression, Biochemistry, Gene Knockout Techniques, Mice, 0302 clinical medicine, transcriptome analysis, ERt, substrate-binding portion of the oestrogen receptor, nucleocytoplasmic trafficking, Gene expression, Transcriptional regulation, cytokine, signal transducer and activator of transcription 3 (STAT3), Phosphorylation, 10. No inequality, STAT3, transcription factor, gp130, glycoprotein 130, Cells, Cultured, iSTAT3, inducible specific STAT3 spliceform, 0303 health sciences, DMEM, Dulbecco's modified Eagle's medium, Hsp90, heat-shock protein of 90 kDa, Fc, cytoplasmic fluorescence, 030220 oncology & carcinogenesis, CLSM, confocal laser-scanning microscopy, Cytokines, JAK, Janus kinase, SH2, Src homology 2, Proto-oncogene tyrosine-protein kinase Src, Research Article, STAT3 Transcription Factor, Biology, interleukin-6 (IL-6), MEF, murine embryonic fibroblast, VP16, viral protein 16, src Homology Domains, 03 medical and health sciences, HEK, human embryonic kidney, FBS, fetal bovine serum, 4-HT, 4-hydroxytamoxifen, Animals, Humans, Molecular Biology, Gene knockout, 030304 developmental biology, GO, gene ontology, DNA Primers, Cell Nucleus, Base Sequence, Fn, nuclear fluorescence, Cell Biology, Molecular biology, WT, wild-type, IL, interleukin, Alternative Splicing, Kinetics, HEK293 Cells, OSM, oncostatin M, Amino Acid Substitution, Fn/Fc, ratio of nuclear to cytoplasmic fluorescence, SHP, SH2 domain-containing protein tyrosine phosphatase, STAT protein, biology.protein, Mutagenesis, Site-Directed, Tyrosine, Nuclear transport, MAPK, mitogen-activated protein kinase, DAPI, 4′,6-diamidino-2-phenylindole
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المؤلفون: Parisinos, Constantinos A., Serghiou, Stylianos, Katsoulis, Michail, George, Marc Jonathan, Patel, Riyaz S., Hemingway, Harry, Hingorani, Aroon D.
المصدر: Gastroenterology
مصطلحات موضوعية: IBD, inflammatory bowel disease, IL6, interleukin 6, MR, Mendelian randomization, SNP, SNP, single nucleotide polymorphism, Article, CI, confidence interval, OR, odds ratio, UC, ulcerative colitis, IL6R, IL6 receptor, Mendelian Randomization, Genetics, CD, Crohn’s disease, RCT, randomized controlled trial, Drug Target Validation, s-IL6R, soluble IL6R, gp130, glycoprotein 130