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المؤلفون: Istvan Kaldor, Ronald George Sherrill, Furfine Eric Steven, David J. Reynolds, John F. Miller, Richard J. Hazen, Michael Stephen Brieger, Andrew Spaltenstein
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3496-3500
مصطلحات موضوعية: Anti-HIV Agents, viruses, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Virus Replication, Biochemistry, Virus, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Drug Resistance, Multiple, Viral, Drug Discovery, medicine, Animals, HIV Protease Inhibitor, Protease inhibitor (pharmacology), Molecular Biology, chemistry.chemical_classification, Protease, biology, Chemistry, Organic Chemistry, HIV, HIV Protease Inhibitors, biology.organism_classification, Virology, In vitro, Rats, Enzyme, Enzyme inhibitor, Mutation, Lentivirus, biology.protein, Molecular Medicine
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المؤلفون: Mary H. Hanlon, David J.T. Porter, Furfine Eric Steven
المصدر: Biochemistry. 41:1302-1307
مصطلحات موضوعية: Aqueous solution, Chemistry, Hydrolysis, Kinetics, Analytical chemistry, Substrate (chemistry), Photochemistry, Biochemistry, Fluorescence, Catalysis, Substrate Specificity, Absorbance, Spectrometry, Fluorescence, HIV Protease, Reagent, Kinetic isotope effect, Bond cleavage
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المؤلفون: Lois L. Wright, William J. Bock, Richard J. Hazen, Francesco G. Salituro, Furfine Eric Steven, Merrick R. Almond, Andrew Spaltenstein, Roger D. Tung, Wieslaw M. Kazmierski, Darryl Cleary
المصدر: Bioorganic & Medicinal Chemistry Letters. 10:1159-1162
مصطلحات موضوعية: chemistry.chemical_classification, Protease, biology, medicine.medical_treatment, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biological activity, Biochemistry, Chemical synthesis, In vitro, chemistry.chemical_compound, Enzyme, chemistry, Enzyme inhibitor, Drug Discovery, medicine, Lactam, biology.protein, Molecular Medicine, HIV Protease Inhibitor, Molecular Biology
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المؤلفون: Edward P. Garvey, R. J. Kiff, Helen A.R. White, Karl W. Franzmann, Stephen J. Lee, Furfine Eric Steven, Daniella C.J. Sanders, Barry G. Shearer
المصدر: Bioorganic & Medicinal Chemistry Letters. 7:1763-1768
مصطلحات موضوعية: chemistry.chemical_classification, biology, Arginine, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Ornithine, Biochemistry, Chemical synthesis, In vitro, Amidine, Nitric oxide synthase, chemistry.chemical_compound, Enzyme, Enzyme inhibitor, Drug Discovery, biology.protein, Molecular Medicine, Molecular Biology
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المؤلفون: Barry G. Shearer, Edward P. Garvey, Jeffrey Alan Oplinger, Lloyd Frick, Furfine Eric Steven, Shuliang Lee
المصدر: Journal of Medicinal Chemistry. 40:1901-1905
مصطلحات موضوعية: Gene isoform, Stereochemistry, Arginine, Binding, Competitive, Isozyme, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Neurons, chemistry.chemical_classification, Trifluoromethyl, Molecular Structure, biology, Thiourea, Brain, Rats, Isoenzymes, Nitric oxide synthase, Enzyme, Biochemistry, chemistry, Enzyme inhibitor, biology.protein, Citrulline, Molecular Medicine, Nitric Oxide Synthase, Selectivity
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المؤلفون: Patrick J. Casey, William R. Tschantz, Furfine Eric Steven
المصدر: Journal of Biological Chemistry. 272:9989-9993
مصطلحات موضوعية: Models, Molecular, Lipoproteins, Farnesyltransferase, Kinetics, Protein Prenylation, Peptide, Biochemistry, Catalysis, Structure-Activity Relationship, Polyisoprenyl Phosphates, Transferases, Structure–activity relationship, Molecular Biology, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Alkyl and Aryl Transferases, biology, Cellular Regulation, Cell Biology, Dithiothreitol, Enzyme, chemistry, ras Proteins, biology.protein, Protein prenylation, Sesquiterpenes
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المؤلفون: Richard M. Myers, Barbara Maschera, Furfine Eric Steven, Margaret Tisdale, Graham Darby, Edward D. Blair, Lois L. Wright, Giorgio Palù
المصدر: Journal of Biological Chemistry. 271:33231-33235
مصطلحات موضوعية: chemistry.chemical_classification, Proteases, Protease, viruses, medicine.medical_treatment, Mutant, virus diseases, Peptide, Cell Biology, biochemical phenomena, metabolism, and nutrition, Biology, Biochemistry, Molecular biology, Enzyme, chemistry, medicine, HIV Protease Inhibitor, Enzyme kinetics, Molecular Biology, Saquinavir, medicine.drug
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المؤلفون: Yolanda Gray-Nunez, Wieslaw M. Kazmierski, Lois L. Wright, Andrew Spaltenstein, Furfine Eric Steven
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:5685-5687
مصطلحات موضوعية: Stereochemistry, Peptidomimetic, medicine.medical_treatment, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Imidazolidines, Biochemistry, Chemical synthesis, Structure-Activity Relationship, HIV Protease, HIV-1 protease, Heterocyclic Compounds, Drug Discovery, medicine, Urea, Protease inhibitor (pharmacology), Molecular Biology, chemistry.chemical_classification, Protease, biology, Chemistry, Organic Chemistry, Biological activity, HIV Protease Inhibitors, Enzyme, Cyclization, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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المؤلفون: Furfine Eric Steven, E D Blair, B Maschera
المصدر: Journal of Virology. 69:5431-5436
مصطلحات موضوعية: medicine.medical_treatment, Genetic Vectors, Molecular Sequence Data, Immunology, Mutagenesis (molecular biology technique), Biology, Polymerase Chain Reaction, Microbiology, Virus, Restriction fragment, Interferon-gamma, HIV Protease, Proviruses, Virology, Escherichia coli, medicine, Point Mutation, HIV Protease Inhibitor, Protease inhibitor (pharmacology), Amino Acid Sequence, Cloning, Molecular, DNA Primers, Protease, Base Sequence, Genetic Variation, Drug Resistance, Microbial, HIV Protease Inhibitors, Molecular biology, Recombinant Proteins, NS2-3 protease, Kinetics, Restriction enzyme, Insect Science, Mutagenesis, Site-Directed, biology.protein, Research Article