المؤلفون: Norie Murayama, Hiroshi Yamazaki

المصدر: The Journal of Toxicological Sciences. 46:371-378

مصطلحات موضوعية: Furafylline, Oxidative phosphorylation, Toxicology, Risk Assessment, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Coumarins, Humans, heterocyclic compounds, Biotransformation, Cells, Cultured, chemistry.chemical_classification, biology, Chemistry, Pneumothorax, Cytochrome P450, Coumarin, Isoenzymes, Cytosol, Enzyme, Biochemistry, Toxicity, Hepatocytes, Microsomes, Liver, biology.protein, Microsome, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78033e199d109c07774d8142181afe3f
https://doi.org/10.2131/jts.46.371

المؤلفون: Vladimir Zlabek, Galia Zamaratskaia

المصدر: Sensors, Vol 9, Iss 3, Pp 2134-2147 (2009)

مصطلحات موضوعية: Entire male pigs, castrated male pigs, porcine hepatic microsomes, EROD, MROD, HPLC, α-naphthoflavone, ellipticine, furafylline, Chemical technology, TP1-1185

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1424-8220/9/3/2134/; https://doaj.org/toc/1424-8220

URL الوصول: https://doaj.org/article/608e7e1e58d84e93ab78e158d4b7effc

المؤلفون: Norie Murayama, Shotaro Uehara, Makiko Shimizu, Tomonori Miura, Hiroshi Suemizu, Hiroshi Yamazaki

المصدر: The Journal of toxicological sciences. 46(11)

مصطلحات موضوعية: Furafylline, Chemistry, Pharmacology, Toxicology, Coumarin, chemistry.chemical_compound, Mice, Biotransformation, Pharmacokinetics, Theophylline, Oral administration, In vivo, Coumarins, Cytochrome P-450 CYP1A2, Food products, Hepatocytes, Microsomes, Liver, Animals, Humans, heterocyclic compounds, Human cytochrome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac2e930792ef2329fa4ed665295f24b
https://pubmed.ncbi.nlm.nih.gov/34719555

المؤلفون: Kouichi Yoshinari, Yasushi Yamazoe

المصدر: Drug Metabolism and Pharmacokinetics. 34:217-232

مصطلحات موضوعية: Furafylline, Rodent, Stereochemistry, Pharmaceutical Science, Ring (chemistry), 030226 pharmacology & pharmacy, Substrate Specificity, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 CYP1A2, biology.animal, Animals, Humans, Molecule, Pharmacology (medical), 030304 developmental biology, Pharmacology, 0303 health sciences, Molecular Structure, biology, Chemistry, Decision Trees, CYP1A2, Regioselectivity, Stereoisomerism, Rats, Order (biology), Substrate specificity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9feb3f5c542e1bd18e140863377e27
https://doi.org/10.1016/j.dmpk.2019.02.001

المؤلفون: Sheri Smith, Donald J. Tweedie, Karsten Menzel, Bennett Ma, Michael J. Lyman

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 49(11)

مصطلحات موضوعية: CYP2D6, Furafylline, CYP3A, Pharmaceutical Science, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, medicine, Cytochrome P-450 Enzyme Inhibitors, Humans, Drug Interactions, CYP2C9, Cells, Cultured, Pharmacology, biology, Chemistry, CYP1A2, Cytochrome P450, Coculture Techniques, Isoenzymes, Phenotype, Drug development, Biochemistry, Pharmaceutical Preparations, Tienilic acid, biology.protein, Hepatocytes, Microsomes, Liver, Algorithms, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0947ba45d4662d8ceb71fc0fcc46cfd
https://pubmed.ncbi.nlm.nih.gov/34407991

المؤلفون: Mikko Niemi, Mikko Neuvonen, Janne T. Backman, Terhi Launiainen, Anne M. Filppula, Jani Katajamäki, Helinä Kahma, Aleksi Tornio, Laura Aurinsalo, Jenni Viinamäki, Marie-Noëlle Paludetto

المساهمون: INDIVIDRUG - Individualized Drug Therapy, HUSLAB, Medicum, Department of Clinical Pharmacology, University of Helsinki, Faculty of Medicine, Research Programs Unit, Department of Diagnostics and Therapeutics, Janne Backman / Principal Investigator, Clinicum

المصدر: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 162

مصطلحات موضوعية: Time-dependent inhibition, Furafylline, CYP3A4, CYP2B6, Metabolite, Pharmaceutical Science, VIVO EXTRAPOLATION, Cytochrome P450, 02 engineering and technology, HUMAN LIVER-MICROSOMES, Pharmacology, METABOLISM, 030226 pharmacology & pharmacy, Cytochrome P-450 CYP2C8, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Tandem Mass Spectrometry, medicine, Gemfibrozil, Cytochrome P-450 Enzyme Inhibitors, Humans, ASSAY, Drug Interactions, DRUG-DRUG INTERACTIONS, Metabolic interactions, Substrate cocktail, MECHANISM-BASED INHIBITION, Cytochrome P-450 CYP2C9, Drug metabolism, GEMFIBROZIL, Chemistry, CYP1A2, 021001 nanoscience & nanotechnology, Cytochrome P-450 CYP2C8 Inhibitors, Tienilic acid, 317 Pharmacy, UNSATURATED FATTY-ACIDS, Microsomes, Liver, Ritonavir, INACTIVATION, 3111 Biomedicine, 0210 nano-technology, 1-O-beta-glucuronide, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cae6ebf48a5c802fc4670cefc2ee5b2
https://pubmed.ncbi.nlm.nih.gov/33753217

المؤلفون: Jiarong Xie, Ze Ping Yap, Linghua Harris Zhang, Aik Jiang Lau, Shiyan Chen, Siew Ying Wong, Nur Fazilah Saburulla

المصدر: Drug Metabolism and Disposition. 47:26-37

مصطلحات موضوعية: Pharmacology, Furafylline, biology, CYP3A4, Chemistry, CYP1A2, Pharmaceutical Science, Cytochrome P450, 030226 pharmacology & pharmacy, 03 medical and health sciences, Cytosol, chemistry.chemical_compound, 0302 clinical medicine, S9 fraction, Biochemistry, 030220 oncology & carcinogenesis, Microsome, biology.protein, Aldehyde oxidase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6b35a6ee4cea9232e808f0a1cffad393
https://doi.org/10.1124/dmd.118.082099

المؤلفون: Jelle Reinen, Martijn Smit, Mira Wenker

المصدر: European Journal of Drug Metabolism and Pharmacokinetics. 43:737-750

مصطلحات موضوعية: Furafylline, Cytochrome P-450 CYP1A2 Inhibitors, Pharmacology, urologic and male genital diseases, digestive system, 030226 pharmacology & pharmacy, Troleandomycin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Theophylline, Cytochrome P-450 CYP2D6 Inhibitors, medicine, Humans, Drug Interactions, heterocyclic compounds, Pharmacology (medical), Dose-Response Relationship, Drug, CYP3A4, biology, Chemistry, CYP1A2, Cytochrome P450, Glutathione, respiratory system, Dihydralazine, Mifepristone, Paroxetine, enzymes and coenzymes (carbohydrates), Verapamil, 030220 oncology & carcinogenesis, Microsomes, Liver, Microsome, biology.protein, Cytochrome P-450 CYP3A Inhibitors, Drug metabolism, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63dc44e48aed22a8ed4a2a408f6c03b
https://doi.org/10.1007/s13318-018-0485-7

المؤلفون: Guilherme Toledo-Silva, Jacó Joaquim Mattos, Guilherme Razzera, Marília N. Siebert, Afonso Celso Dias Bainy

المصدر: Aquatic Toxicology. 189:142-149

مصطلحات موضوعية: Gills, 0301 basic medicine, Gill, Furafylline, Transcription, Genetic, Health, Toxicology and Mutagenesis, 010501 environmental sciences, Aquatic Science, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Cytosol, Cytochrome P-450 CYP1A2, Microsomes, Cytochrome P-450 CYP1A1, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Gene family, Crassostrea, Cytochrome P450 Family 1, 0105 earth and related environmental sciences, chemistry.chemical_classification, Sequence Homology, Amino Acid, biology, Cytochrome P450, biology.organism_classification, Enzyme assay, Molecular Docking Simulation, Kinetics, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Cytochrome P-450 CYP1B1, biology.protein, Xenobiotic, Water Pollutants, Chemical

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f93b771b45d08d7870beec6bacc1e4
https://doi.org/10.1016/j.aquatox.2017.06.004

المؤلفون: Andrés Cruz, Hansen W. Murcia, Miguel Ángel González-Curbelo, Jeffrey León

المصدر: Journal of pharmaceutical and biomedical analysis. 164

مصطلحات موضوعية: animal structures, Furafylline, Nifedipine, CYP3A, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, High-performance liquid chromatography, Poultry, Troleandomycin, Analytical Chemistry, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Theophylline, biology.animal, Drug Discovery, Oxazines, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Spectroscopy, Biotransformation, Chromatography, High Pressure Liquid, chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, 010401 analytical chemistry, Cytochrome P450, Quail, 0104 chemical sciences, Enzyme, Biochemistry, biology.protein, Microsomes, Liver, Demethylase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a845e0ebd8425e0f9ceafb48f033176e
https://pubmed.ncbi.nlm.nih.gov/30390556

المؤلفون: Akiko Goto, Maho Okubo, Momoko Narita, Hiroshi Yamazaki, Youichi Akimoto, Norie Murayama

المصدر: Human Psychopharmacology: Clinical and Experimental. 31:83-92

مصطلحات موضوعية: Olanzapine, medicine.medical_specialty, CYP2D6, Furafylline, Metabolite, medicine.medical_treatment, Pharmacology, digestive system, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Medicine, Pharmacology (medical), Antipsychotic, business.industry, CYP1A2, Monooxygenase, Psychiatry and Mental health, Endocrinology, Neurology, chemistry, 030220 oncology & carcinogenesis, Neurology (clinical), Cytochrome P-450 CYP2D6, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c21cbee902271c9d465df2d87ff4481a
https://doi.org/10.1002/hup.2515

المؤلفون: Atsushi Kawase, Masahiro Iwaki, Hiroshi Komura, Yukiko Nakamura, Toshiro Niwa

المصدر: The Journal of toxicological sciences. 43(1)

مصطلحات موضوعية: Gene isoform, Male, Furafylline, Insecta, CYP3A, Carbazoles, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, Catalysis, law.invention, Propanolamines, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Theophylline, law, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Cells, Cultured, biology, Quinine, CYP1A2, Cytochrome P450, Stereoisomerism, Metabolism, Rats, Isoenzymes, chemistry, biology.protein, Recombinant DNA, Microsomes, Liver, Ketoconazole, Carvedilol, Aryl Hydrocarbon Hydroxylases, human activities, Oxidation-Reduction, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11122096c7013f6943357a1a44d3f99a
https://pubmed.ncbi.nlm.nih.gov/29415952

المؤلفون: Luzineide W. Tinoco, Lídia Moreira Lima, Claudia M. Rezende, Helvecio Martins-Junior, Eliezer J. Barreiro, Isabelle Karine da Costa Nunes

المصدر: ResearcherID

مصطلحات موضوعية: Male, Furafylline, Pharmacology, Sulfaphenazole, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Drug Discovery, medicine, Animals, Anti-Asthmatic Agents, Benzodioxoles, Rats, Wistar, Biotransformation, Sulfonamides, Molecular Structure, biology, CYP3A4, Chemistry, CYP1A2, Cytochrome P450, General Medicine, CYP2E1, Rats, Biochemistry, Microsomes, Liver, biology.protein, Microsome, Drug metabolism, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1e26bccd7e3407c6586a4ada0b9f7c
https://doi.org/10.2174/1568026614666140506123718

المؤلفون: Weijie Xie, Jia-Da Yang, Jie Hou, Guang-Bo Ge, Guibo Sun, Ling Yang, Zi-Ru Dai, Ping Zhou, Xiaobo Sun

المصدر: Molecules, Vol 24, Iss 15, p 2765 (2019)
Molecules
Volume 24
Issue 15

مصطلحات موضوعية: Gene isoform, species differences, Furafylline, Kinetics, Pharmaceutical Science, 010402 general chemistry, 01 natural sciences, Beagle, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Organic chemistry, In vivo, Drug Discovery, Physical and Theoretical Chemistry, Liver microsomes, Demethylation, chemistry.chemical_classification, Cytochrome P450 1A (CYP1A), Organic Chemistry, NCMN-O-demethylation, 0104 chemical sciences, Enzyme, chemistry, Biochemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Molecular Medicine, liver microsomes

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3464a95f06dc1bcfe3a72766363b78
https://doi.org/10.3390/molecules24152765

المؤلفون: Murcia, Hansen, Cruz, Andrés, León, Jeffrey, González-Curbelo, Miguel Ángel

المصدر: U.M. Zanger, M. Schwab, Cytochrome P450 enzymes in drug metabolism:regulation of gene expression, enzyme activities, and impact of geneticvariation, Pharmacol. Therap. 138 (2013) 103–141. ; D. Spaggiari, L. Geiser, Y. Daali, S. Rudaz, A cocktail approach for assessing thein vitro activity of human cytochrome P450s: an overview of currentmethodologies, J. Pharm. Biomed. Anal. 101 (2014) 221–237. ; M.C. Jerdi, Y. Daali, M.K. Oestreicher, S. Cherkaoui, P. Dayer, A simplifiedanalytical method for phenotyping cocktail of mayor CYP450biotransformation routes, J. Pharm. Biomed. Anal. 35 (2004) 1203–1212. ; O. Pelkonen, J. Mäenpää, P. Taavitsainen, A. Rautio, H. Raunio, Inhibition andinduction of human ....

مصطلحات موضوعية: Furafylline, Troleandomycin, 7-methoxyresorufin-O-demethylase activity, Nifedipine oxidase activity, Avian orthologsa

وصف الملف: application/pdf

Relation: Murcia, H., Cruz, A., León, J., & González-Curbelo, M. Á. (2018). Study on the inhibitory effect of furafylline and troleandomycin in the7-methoxyresorufin-O-demethylase and nifedipine oxidase activitiesin hepatic microsomes from four poultry species usinghigh-performance liquid chromatography coupled with fluorescenceand ultraviolet detection. Bogotá: doi:/10.1016/j.jpba.2018.10.031; http://hdl.handle.net/11634/17172; /10.1016/j.jpba.2018.10.031

الاتاحة: http://hdl.handle.net/11634/17172

المؤلفون: Murcia, Hansen, Cruz, Andrés, León, Jeffrey, González-Curbelo, Miguel Ángel

المصدر: U.M. Zanger, M. Schwab, Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation, Pharmacol. Therap. 138 (2013) 103–141. ; D. Spaggiari, L. Geiser, Y. Daali, S. Rudaz, A cocktail approach for assessing the in vitro activity of human cytochrome P450s: an overview of current methodologies, J. Pharm. Biomed. Anal. 101 (2014) 221–237. ; M.C. Jerdi, Y. Daali, M.K. Oestreicher, S. Cherkaoui, P. Dayer, A simplified analytical method for phenotyping cocktail of mayor CYP450 biotransformation routes, J. Pharm. Biomed. Anal. 35 (2004) 1203–1212. ; O. Pelkonen, J. Mäenpää, P. Taavitsainen, A. Rautio, ....

مصطلحات موضوعية: Furafylline, Troleandomycin, 7-methoxyresorufin-O-demethylase activity, Nifedipine oxidase activity, Avian orthologsa

وصف الملف: application/pdf

Relation: González-Curbelo, M. Á, León, J., Cruz, A., & Murcia, H. (2018). Study on the inhibitory effect of furafylline and troleandomycin in the 7 - methoxyresorufin - O - demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescence and ultraviolet detection. Bogotá: doi:10.1016/j.jpba.2018.10.031; http://hdl.handle.net/11634/16902

الاتاحة: http://hdl.handle.net/11634/16902
https://doi.org/10.1016/j.jpba.2018.10.031

المؤلفون: Hui Zhou, Yueming Ma, Dazheng Wu, Xinhong Wang, Bing-Liang Ma, Changhong Wang, Rong Shi, Nengneng Cheng

المصدر: Biopharmaceutics & Drug Disposition. 34:176-185

مصطلحات موضوعية: Pharmacology, Jatrorrhizine, Furafylline, CYP1A2, Glucuronidation, Pharmaceutical Science, Cytochrome P450, General Medicine, Biology, chemistry.chemical_compound, chemistry, Biochemistry, Microsome, biology.protein, Pharmacology (medical), Glucuronide, Demethylation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a79c8fe7db74099ff50cddb568e554ee
https://doi.org/10.1002/bdd.1835

المؤلفون: Atsushi Kawase, Saya Bandoh, Hitomi Hirose, Toshiro Niwa, Masahiro Iwaki, Hiroshi Komura, Megumi Itoh

المصدر: Drug metabolism and pharmacokinetics. 31(6)

مصطلحات موضوعية: CYP2D6, Furafylline, Adrenergic beta-Antagonists, Carbazoles, Pharmaceutical Science, Pharmacology, digestive system, 030226 pharmacology & pharmacy, Propanolamines, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Cytochrome P-450 Enzyme Inhibitors, Humans, Pharmacology (medical), CYP2C9, CYP3A4, biology, CYP1A2, Cytochrome P450, Antibodies, Monoclonal, Stereoisomerism, Metabolism, Isoenzymes, Kinetics, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Microsome, biology.protein, Microsomes, Liver, Carvedilol, human activities

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9997752e59193371175a77057bea310
https://pubmed.ncbi.nlm.nih.gov/27836712

المؤلفون: Sang Kyum Kim, Kye Sook Lee

المصدر: Journal of Applied Toxicology. 33:100-108

مصطلحات موضوعية: Furafylline, CYP3A4, CYP1A2, Pharmacology, Toxicology, chemistry.chemical_compound, chemistry, Biochemistry, Tienilic acid, Chlorzoxazone, medicine, CYP2A6, Drug metabolism, Cytochrome P-450 Enzyme Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f565aa0206fa33f563d32b9b01b3d940
https://doi.org/10.1002/jat.1720

المؤلفون: Van T. Ly, Barry Brock

المصدر: Chemico-Biological Interactions. 193:109-118

مصطلحات موضوعية: Male, Furafylline, Metabolite, Pharmacology, Hydroxylation, Toxicology, Sulfaphenazole, Mass Spectrometry, Rats, Sprague-Dawley, Necrosis, chemistry.chemical_compound, Adenosine Triphosphate, Glucuronides, Cytochrome P-450 Enzyme System, In vivo, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Benzopyrans, Drug Interactions, Aspartate Aminotransferases, Enzyme Inhibitors, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, L-Lactate Dehydrogenase, Molecular Structure, biology, Cytochrome P450, General Medicine, Metabolism, Glutathione, Triazoles, Rats, Ketoconazole, Liver, chemistry, Biochemistry, Toxicity, biology.protein, Tranylcypromine, Ditiocarb, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d1d1c849e289a4c32c393710d58c5d
https://doi.org/10.1016/j.cbi.2011.05.011