المؤلفون: Motoi Yamashita, Chihiro Ogawa, Baihao Zhang, Tetsuro Kobayashi, Aneela Nomura, Clive Barker, Chengcheng Zou, Satoshi Yamanaka, Ken-ichiro Hayashi, Yoichi Shinkai, Kazuyo Moro, Sidonia Fargarasan, Koshi Imami, Jun Seita, Fumiyuki Shirai, Tatsuya Sawasaki, Masato T. Kanemaki, Ichiro Taniuchi

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/25c223a99b6c459b9d22b8d5fd64d60c

المؤلفون: Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, Takashi Umehara, Mikako Shirouzu, Yosuke Nishigaya, Tatsunobu Sumiya, Noriaki Hashimoto, Ryosuke Namie, Masaya Usui, Tomokazu Ohishi, Shun-ichi Ohba, Manabu Kawada, Yoshihiro Hayashi, Hironori Harada, Tokio Yamaguchi, Yoichi Shinkai, Yukio Nakamura, Minoru Yoshida, Akihiro Ito

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/854cca959e544001b639a7418e25c89f

المؤلفون: Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Ko Kikuzato, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Takeshi Sonoda, Noriaki Hashimoto, Ryosuke Namie, Teruki Honma, Takashi Umehara, Mikako Shirouzu, Hiroo Koyama, Minoru Yoshida, Akihiro Ito, Fumiyuki Shirai

المصدر: Journal of Medicinal Chemistry. 66:4059-4085

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b9a221523e9478c8605cd7012c963963
https://doi.org/10.1021/acs.jmedchem.2c02059

المؤلفون: Fumiyuki Shirai, Akiyoshi Kakita, Kunikazu Tanji, Takehiro Fukami, Jun Utsumi, Koichi Wakabayashi, Fumiaki Mori, Hiroyuki Seimiya

المصدر: Biochemical and biophysical research communications. 537

مصطلحات موضوعية: 0301 basic medicine, Poly Adenosine Diphosphate Ribose, Sodium arsenite, Cytoplasmic inclusion, Arsenites, Poly ADP ribose polymerase, Biophysics, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Protein Aggregates, 0302 clinical medicine, Cell Line, Tumor, mental disorders, medicine, Humans, Amyotrophic lateral sclerosis, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, Polymerase, Cell Nucleus, Tankyrases, biology, nutritional and metabolic diseases, Cell Biology, Frontotemporal lobar degeneration, medicine.disease, nervous system diseases, Cell biology, DNA-Binding Proteins, 030104 developmental biology, HEK293 Cells, chemistry, 030220 oncology & carcinogenesis, TDP-43 Proteinopathies, biology.protein, Immunohistochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69372226c569338b510bd021b13ca2a8
https://pubmed.ncbi.nlm.nih.gov/33387887

المؤلفون: Takehiro Fukami, Yui Mazaki, Kenichi Washizuka, Hideaki Niwa, Takeshi Tsumura, Hiroo Koyama, Yuko Kano, Yasuko Koda, Fumiyuki Shirai, Kouichi Kitamura, Yoko Yashiroda, Anna Mizutani, Hitomi Yuki, Eiki Shitara, Hiroyuki Seimiya, Teruki Honma, Shin Sato, Tsubasa Chikada, Minoru Yoshida, Masayuki Okue, Takashi Watanabe, Takashi Umehara, Yukiko Muramatsu, Akiko Nagamori, Myung-Kyu Jang, Haruka Yoshida, Mikako Shirouzu

المصدر: Journal of medicinal chemistry. 63(8)

مصطلحات موضوعية: Colorectal cancer, Administration, Oral, Mice, SCID, 01 natural sciences, 03 medical and health sciences, Mice, Mice, Inbred NOD, Tankyrases, Cell Line, Tumor, Drug Discovery, AXIN2, medicine, Animals, Humans, Enzyme Inhibitors, Polymerase, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Chemistry, Cell growth, Wnt signaling pathway, medicine.disease, Highly selective, Xenograft Model Antitumor Assays, 0104 chemical sciences, Protein Structure, Tertiary, Rats, 010404 medicinal & biomolecular chemistry, Enzyme, Treatment Outcome, Drug Design, Colonic Neoplasms, Cancer research, biology.protein, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30c01958ef416b8aff1cab18d74f999
https://pubmed.ncbi.nlm.nih.gov/32202790

المؤلفون: Tsubasa Chikada, Minoru Yoshida, Yukiko Muramatsu, Yoko Yashiroda, Takehiro Fukami, Fumiyuki Shirai, Masayuki Okue, Anna Mizutani, Haruka Yoshida, Hiroyuki Seimiya, Takeshi Tsumura

المصدر: Cancer Science

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Adenomatous polyposis coli, Colorectal cancer, Cell Survival, Adenomatous Polyposis Coli Protein, Administration, Oral, colorectal cancer, Antineoplastic Agents, medicine.disease_cause, law.invention, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, tankyrase inhibitor, law, Cell Line, Tumor, medicine, AXIN2, Animals, Humans, Enzyme Inhibitors, mouse xenograft model, Cell Proliferation, Tankyrases, biology, Cell growth, Chemistry, Wnt signaling pathway, General Medicine, Original Articles, medicine.disease, HCT116 Cells, Xenograft Model Antitumor Assays, Wnt/β‐catenin signaling, 030104 developmental biology, Drug Discovery and Delivery, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, biology.protein, Suppressor, Original Article, poly(ADP‐ribose) polymerase, Carcinogenesis, Colorectal Neoplasms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108b4f5f96dc0c462e0db92f54d35b64
http://europepmc.org/articles/PMC6272098

المؤلفون: Yasuko Koda, Fumiyuki Shirai, Junko Mikuni, Hiroo Koyama, Ko Kikuzato, Mikako Shirouzu, Hitomi Yuki, Yuri Tomabechi, Akiko Tanaka, Mutsuko Kukimoto-Niino, Teruki Honma

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:4994-4998

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Apoptosis, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, hemic and lymphatic diseases, Drug Discovery, Humans, Structure–activity relationship, Pyrroles, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, Organic Chemistry, Myeloid leukemia, Protein Structure, Tertiary, Amino acid, Molecular Docking Simulation, Leukemia, Myeloid, Acute, Pyrimidines, 030104 developmental biology, fms-Like Tyrosine Kinase 3, chemistry, Cell culture, 030220 oncology & carcinogenesis, Proto-Oncogene Proteins c-hck, Thermodynamics, Molecular Medicine, Flt3 itd

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c465825580e961f19a0a973c9f23908
https://doi.org/10.1016/j.bmcl.2017.10.012

المؤلفون: Sibo Feng, Tarun M Kapoor, Fumiyuki Shirai, Andrew P Combs, Stuart L Schreiber

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.broadinstitute.org/chembio/lab_schreiber/pubs/pdffiles/227.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.587.9130; http://www.broadinstitute.org/chembio/lab_schreiber/pubs/pdffiles/227.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.587.9130
http://www.broadinstitute.org/chembio/lab_schreiber/pubs/pdffiles/227.pdf

المؤلفون: Shigeki Kunikawa, Akira Tanaka, Fumiyuki Shirai, Koichiro Mukoyoshi, Hiroaki Tominaga, Mamoru Tasaki, Shinya Nagashima, Noboru Chida

المصدر: Bioorganic & Medicinal Chemistry. 23:3269-3277

مصطلحات موضوعية: Drug, Halogenation, T-Lymphocytes, T cell, media_common.quotation_subject, Clinical Biochemistry, Protein Kinase C-theta, Gene Expression, Pharmaceutical Science, Pharmacology, Inhibitory postsynaptic potential, Biochemistry, Dependent drug, Structure-Activity Relationship, Drug Discovery, medicine, Cytochrome P-450 CYP3A, Humans, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, Protein Kinase Inhibitors, Molecular Biology, Protein Kinase C, media_common, CYP3A4, Chemistry, Organic Chemistry, medicine.disease, Transplant rejection, Isoenzymes, Pyrimidines, medicine.anatomical_structure, Drug Resistance, Neoplasm, Rheumatoid arthritis, Microsomes, Liver, Molecular Medicine, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c37f4c6647b65cee9cedf5d86f4a70e
https://doi.org/10.1016/j.bmc.2015.04.050

المؤلفون: Fumiyuki Shirai, Akihiro Kunisawa, Zenzaburo Tozuka, Yoshinori Ishii

المصدر: Trends in Research. 1

مصطلحات موضوعية: Biochemistry, Chemistry, Drug discovery, Lc ms ms, DNA-binding protein, Pyridoxal kinase, Quinone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::67c5ab80af39c74ef1564ddcd05c500f
https://doi.org/10.15761/tr.1000113

المؤلفون: Junko Mikuni, Hitomi Yuki, Hiroo Koyama, Yuri Tomabechi, Mikako Shirouzu, Fumiyuki Shirai, Teruki Honma, Ko Kikuzato, Yasuko Koda, Mutsuko Kukimoto-Niino, Akiko Tanaka

المصدر: Bioorganicmedicinal chemistry. 25(16)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Pyrimidine, Stereochemistry, Clinical Biochemistry, Ab initio, Pharmaceutical Science, chemistry.chemical_element, Ionic bonding, Crystal structure, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, Humans, Pyrroles, Molecular Biology, Protein Kinase Inhibitors, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Nitrogen, Amino acid, 030104 developmental biology, Binding conformation, Pyrimidines, chemistry, 030220 oncology & carcinogenesis, Proto-Oncogene Proteins c-hck, Molecular Medicine, Amine gas treating

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773e7b1480a8efc69aa39e4ed1e2b93d
https://pubmed.ncbi.nlm.nih.gov/28662963

المؤلفون: Shintaro Nishimura, Masahiko Morita, Kazuhiko Osoda, Fumiyuki Shirai, Nobuya Matsuoka, Hiroyuki Arakawa, Mayako Yamazaki

المصدر: Brain Research. 1295:186-191

مصطلحات موضوعية: Naproxen, medicine.medical_specialty, Diclofenac, Amyloid, Transgene, Indomethacin, Fluorescent Antibody Technique, Enzyme-Linked Immunosorbent Assay, Ibuprofen, law.invention, Animals, Genetically Modified, chemistry.chemical_compound, Immune system, Confocal microscopy, law, Internal medicine, medicine, Animals, Benzothiazoles, Caenorhabditis elegans, Molecular Biology, Analysis of Variance, Amyloid beta-Peptides, Microscopy, Confocal, Dose-Response Relationship, Drug, General Neuroscience, Anti-Inflammatory Agents, Non-Steroidal, medicine.disease, Thiazoles, Endocrinology, chemistry, Thioflavin, Neurology (clinical), Alzheimer's disease, Developmental Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130c821c78d7b14f266a71288d4ab539
https://doi.org/10.1016/j.brainres.2009.08.002

المؤلفون: Fumiyuki Shirai, Toshiaki Kamimura, Masayoshi Murata, Satoru Kuroda, Kenichi Washizuka, Hidenori Azami, Keiji Matsuda, Toshiyuki Chiba, Hideo Tsutsumi, Minoru Sakurai, David A. Barrett

المصدر: Bioorganic & Medicinal Chemistry. 7:1665-1682

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Substituent, Cationic polymerization, Pharmaceutical Science, Biochemistry, Medicinal chemistry, chemistry.chemical_compound, chemistry, Morpholine, Drug Discovery, Molecular Medicine, Moiety, Imidazole, Methylene, Antibacterial activity, Molecular Biology, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f2c35d3bf7555f05888d2c89cd64ca0c
https://doi.org/10.1016/s0968-0896(99)00085-1

المؤلفون: James P. Morken, Tarun M. Kapoor, Stuart L. Schreiber, Sibo Feng, Fumiyuki Shirai

المصدر: Journal of the American Chemical Society. 120:30-36

مصطلحات موضوعية: Ligand, Stereochemistry, Chemistry, Binding protein, Cooperative binding, Proline binding, General Chemistry, Biochemistry, Combinatorial chemistry, Small molecule, Catalysis, SH3 domain, Colloid and Surface Chemistry, Binding domain, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b25c2d3e7c232a427eb8001927a2eb15
https://doi.org/10.1021/ja972729m

المؤلفون: David A. Barrett, Toshiyuki Chiba, Hidenori Azami, Kazuo Sakane, Fumiyuki Shirai, Akihiko Fujikawa

المصدر: Chemical and Pharmaceutical Bulletin. 45:209-213

مصطلحات موضوعية: Reaction mechanism, Bicyclic molecule, Chemistry, Stereochemistry, Diastereomer, Cationic polymerization, General Chemistry, General Medicine, Pyrrolidine, chemistry.chemical_compound, Drug Discovery, Hydrogen–deuterium exchange, Epimer, Isomerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c9420371e7f0c5453b200c18d1fd437
https://doi.org/10.1248/cpb.45.209

المؤلفون: Sibo Feng, Tarun M. Kapoor, Stuart L. Schreiber, Andrew P. Combs, Fumiyuki Shirai

المصدر: Chemistry & Biology. 3(8):661-670

مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Protein Conformation, Stereochemistry, ligand binding, Clinical Biochemistry, Ligands, Biochemistry, SH3 domain, src Homology Domains, Molecular recognition, Protein structure, Drug Discovery, Escherichia coli, Amino Acid Sequence, Binding site, protein structure, Molecular Biology, combinatorial synthesis, Pharmacology, Binding Sites, Molecular Structure, Chemistry, General Medicine, Nuclear magnetic resonance spectroscopy, Basis (universal algebra), Affinities, Combinatorial chemistry, Drug Design, N MR, Mutation, Molecular Medicine, Src SH3, Protein Binding, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f92bb07a6765fc4eddae8af9fd7125b

المؤلفون: Fumiyuki Shirai, Takeshi Nakai, J.‐H. Gu

المصدر: ChemInform. 23

مصطلحات موضوعية: Silylation, Stereochemistry, organic chemicals, Acetal, Ketene, 3-Hydroxybutanoate, General Medicine, Condensation reaction, Dilithium, chemistry.chemical_compound, chemistry, Aldol reaction, health occupations, Titanium tetrachloride, heterocyclic compounds

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::611560061f0678d43b38eae41c886b09
https://doi.org/10.1002/chin.199212049

المؤلفون: Kazuo Sakane, Toshiyuki Chiba, Akihiko Fujikawa, Fumiyuki Shirai, David A. Barrett, Hidenori Azami

المصدر: ChemInform. 28

مصطلحات موضوعية: chemistry.chemical_compound, Aqueous solution, chemistry, Pyridine, Diastereomer, Cationic polymerization, Epimer, Hydrogen–deuterium exchange, General Medicine, Medicinal chemistry, Isomerization, Pyrrolidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8d13d6b42e80ec49c1d990d1b0024aa9
https://doi.org/10.1002/chin.199731208

المؤلفون: Fumiyuki Shirai, Takeshi Nakai, J.‐H. Gu

المصدر: Chemistry Letters. 19:1931-1934

مصطلحات موضوعية: Silylation, organic chemicals, Acetal, Ketene, General Chemistry, Reaction intermediate, Medicinal chemistry, Acid catalysis, chemistry.chemical_compound, chemistry, Aldol reaction, health occupations, Titanium tetrachloride, heterocyclic compounds, Aldol condensation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dcff9a6e24766c1996e16ae1e1162320
https://doi.org/10.1246/cl.1990.1931

المؤلفون: Shuichi Tawara, Fumiyuki Shirai, Hidenori Azami, Hiroshi Sasaki, Minoru Sakurai, Keiji Matsuda, David A. Barrett, Yoshimi Matsumoto, Takeshi Terasawa, Toshiyuki Chiba, Akira Tanaka

المصدر: Bioorganicmedicinal chemistry. 9(4)

مصطلحات موضوعية: Staphylococcus aureus, Magnetic Resonance Spectroscopy, Pyrrolidines, Spectrophotometry, Infrared, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Microbial Sensitivity Tests, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Moiety, Animals, Humans, Pseudomonas Infections, Molecular Biology, Alkyl, Antibacterial agent, chemistry.chemical_classification, Mice, Inbred ICR, Bacteria, Organic Chemistry, Cationic polymerization, Haplorhini, Staphylococcal Infections, Anti-Bacterial Agents, Rats, chemistry, Carbapenems, Area Under Curve, Pseudomonas aeruginosa, Lactam, Molecular Medicine, Indicators and Reagents, Antibacterial activity, Bacterial Outer Membrane Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dc49fdda65b8bc7f69c269ba3b7d85
https://pubmed.ncbi.nlm.nih.gov/11354680