المؤلفون: Phillip, Moshe, Achenbach, Peter, Addala, Ananta, Albanese-O'Neill, Anastasia, Battelino, Tadej, Bell, Kirstine J, Besser, Rachel E J, Bonifacio, Ezio, Colhoun, Helen M, Couper, Jennifer J, Craig, Maria E, Danne, Thomas, de Beaufort, Carine, Dovc, Klemen, Driscoll, Kimberly A, Dutta, Sanjoy, Ebekozien, Osagie, Larsson, Helena Elding, Feiten, Daniel J, Frohnert, Brigitte I, Gabbay, Robert A, Gallagher, Mary P, Greenbaum, Carla J, Griffin, Kurt J, Hagopian, William, Haller, Michael J, Hendrieckx, Christel, Hendriks, Emile, Holt, Richard I G, Hughes, Lucille, Ismail, Heba M, Jacobsen, Laura M, Johnson, Suzanne B, Kolb, Leslie E, Kordonouri, Olga, Lange, Karin, Lash, Robert W, Lernmark, Åke, Libman, Ingrid, Lundgren, Markus, Maahs, David M, Marcovecchio, M Loredana, Mathieu, Chantal, Miller, Kellee M, O'Donnell, Holly K, Oron, Tal, Patil, Shivajirao P, Pop-Busui, Rodica, Rewers, Marian J, Rich, Stephen S, Schatz, Desmond A, Schulman-Rosenbaum, Rifka, Simmons, Kimber M, Sims, Emily K, Skyler, Jay S, Smith, Laura B, Speake, Cate, Steck, Andrea K, Thomas, Nicholas P B, Tonyushkina, Ksenia N, Veijola, Riitta, Wentworth, John M, Wherrett, Diane K, Wood, Jamie R, Ziegler, Anette-Gabriele, DiMeglio, Linda A

المصدر: Diabetologia EXODIAB: Excellence of Diabetes Research in Sweden. 67(9):1731-1759

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

URL الوصول: https://lup.lub.lu.se/record/27583c70-0377-4959-87d2-99a92e69bfd0
http://dx.doi.org/10.1007/s00125-024-06205-5

المؤلفون: Frohnert, Brigitte I., Ghalwash, Mohamed, Li, Ying, Ng, Kenney, Dunne, Jessica L., Lundgren, Markus, Hagopian, William, Lou, Olivia, Winkler, Christiane, Toppari, Jorma, Veijola, Riitta, Anand, Vibha

المصدر: Diabetes Care EXODIAB: Excellence of Diabetes Research in Sweden. 46(10):1753-1761

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

URL الوصول: https://lup.lub.lu.se/record/85a3970c-8fe0-4d31-8b5d-2ee6b2130ceb
http://dx.doi.org/10.2337/dc22-1960

المؤلفون: Ng, Kenney, Anand, Vibha, Stavropoulos, Harry, Veijola, Riitta, Toppari, Jorma, Maziarz, Marlena, Lundgren, Markus, Waugh, Kathy, Frohnert, Brigitte I., Martin, Frank, Lou, Olivia, Hagopian, William, Achenbach, Peter

المصدر: Diabetologia EXODIAB: Excellence of Diabetes Research in Sweden. 66(1):93-104

مصطلحات موضوعية: Islet autoantibody levels, Machine learning, Risk prediction models, Type 1 diabetes, Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

URL الوصول: https://lup.lub.lu.se/record/47964497-d34a-49c3-bc1e-c756153379ce
http://dx.doi.org/10.1007/s00125-022-05799-y

المؤلفون: Buckner, Teresa, Johnson, Randi K, Vanderlinden, Lauren A, Carry, Patrick M, Romero, Alex, Onengut-Gumuscu, Suna, Chen, Wei-Min, Kim, Soojeong, Fiehn, Oliver, Frohnert, Brigitte I, Crume, Tessa, Perng, Wei, Kechris, Katerina, Rewers, Marian, Norris, Jill M

مصطلحات موضوعية: Biomedical and Clinical Sciences, Nutrition and Dietetics, Genetics, Human Genome, Prevention, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Good Health and Well Being, oxylipin, inflammation, pediatric, genome-wide association study, polyunsaturated fatty acids, lipid mediators, Agricultural Biotechnology, Nutrition and dietetics

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2j4094vm
https://escholarship.org/content/qt2j4094vm/qt2j4094vm.pdf

المؤلفون: Buckner, Teresa, Johnson, Randi K, Vanderlinden, Lauren A, Carry, Patrick M, Romero, Alex, Onengut-Gumuscu, Suna, Chen, Wei-Min, Fiehn, Oliver, Frohnert, Brigitte I, Crume, Tessa, Perng, Wei, Kechris, Katerina, Rewers, Marian, Norris, Jill M

المصدر: Nutrients. 15(4)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Nutrition and Dietetics, Pediatric, Nutrition, Prevention, Autoimmune Disease, Clinical Research, Diabetes, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Child, Adolescent, Humans, Diabetes Mellitus, Type 1, Oxylipins, Autoimmunity, Islets of Langerhans, Risk Factors, Case-Control Studies, Nutrients, oxylipin, nutrient pattern, type 1 diabetes, reduced rank regression, Food Sciences, Clinical sciences, Nutrition and dietetics, Public health

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/98v5v5nk
https://escholarship.org/content/qt98v5v5nk/qt98v5v5nk.pdf

المؤلفون: Kwon, Bum Chul, Anand, Vibha, Achenbach, Peter, Dunne, Jessica L, Hagopian, William, Hu, Jianying, Koski, Eileen, Lernmark, Åke, Lundgren, Markus, Ng, Kenney, Toppari, Jorma, Veijola, Riitta, Frohnert, Brigitte I

المصدر: Nature Communications EXODIAB: Excellence of Diabetes Research in Sweden. 13:1-9

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

URL الوصول: https://lup.lub.lu.se/record/b144512f-e3e6-4a65-9102-2dc4423d068c
http://dx.doi.org/10.1038/s41467-022-28909-1

المؤلفون: Kwon, Bum Chul, Achenbach, Peter, Dunne, Jessica L., Hagopian, William, Lundgren, Markus, Ng, Kenney, Veijola, Riitta, Frohnert, Brigitte I., Anand, Vibha, Group, the T1DI Study

مصطلحات موضوعية: Computer Science - Machine Learning

URL الوصول: http://arxiv.org/abs/2012.05324

المؤلفون: Buckner, Teresa, Vanderlinden, Lauren A, DeFelice, Brian C, Carry, Patrick M, Kechris, Katerina, Dong, Fran, Fiehn, Oliver, Frohnert, Brigitte I, Clare-Salzler, Michael, Rewers, Marian, Norris, Jill M

المصدر: Diabetologia. 64(8)

مصطلحات موضوعية: Nutrition, Prevention, Autoimmune Disease, Clinical Research, Diabetes, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Adolescent, Arachidonic Acid, Autoantibodies, Autoimmunity, Case-Control Studies, Child, Child, Preschool, Chromatography, High Pressure Liquid, Diabetes Mellitus, Type 1, Docosahexaenoic Acids, Female, Follow-Up Studies, Glutamate Decarboxylase, HLA-DR3 Antigen, HLA-DR4 Antigen, Humans, Insulin, Linoleic Acid, Male, Oxylipins, Prospective Studies, Receptor-Like Protein Tyrosine Phosphatases, Class 8, Tandem Mass Spectrometry, Inflammation, Lipid mediators, Paediatric, Proinflammatory, Pro-resolving, Type 1 diabetes, Clinical Sciences, Paediatrics and Reproductive Medicine, Public Health and Health Services, Endocrinology & Metabolism

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3cj4407v

المؤلفون: Phillip, Moshe, Achenbach, Peter, Addala, Ananta, Albanese‑O’Neill, Anastasia, Battelino, Tadej, Bell, Kirstine J., Besser, Rachel E. J., Bonifacio, Ezio, Colhoun, Helen M., Couper, Jennifer J., Craig, Maria E., Danne, Thomas, de Beaufort, Carine, Dovc, Klemen, Driscoll, Kimberly A., Dutta, Sanjoy, Ebekozien, Osagie, Larsson, Helena Elding, Feiten, Daniel J., Frohnert, Brigitte I., Gabbay, Robert A., Gallagher, Mary P., Greenbaum, Carla J., Griffin, Kurt J., Hagopian, William, Haller, Michael J., Hendrieckx, Christel, Hendriks, Emile, Holt, Richard I. G., Hughes, Lucille, Ismail, Heba M., Jacobsen, Laura M., Johnson, Suzanne B., Kolb, Leslie E., Kordonouri, Olga, Lange, Karin, Lash, Robert W., Lernmark, Åke, Libman, Ingrid, Lundgren, Markus, Maahs, David M., Marcovecchio, M. Loredana, Mathieu, Chantal, Miller, Kellee M., O’Donnell, Holly K., Oron, Tal, Patil, Shivajirao P., Pop‑Busui, Rodica, Rewers, Marian J., Rich, Stephen S.

المصدر: Diabetologia ; volume 67, issue 9, page 2012-2014 ; ISSN 0012-186X 1432-0428

الاتاحة: https://doi.org/10.1007/s00125-024-06266-6
https://link.springer.com/content/pdf/10.1007/s00125-024-06266-6.pdf
https://link.springer.com/article/10.1007/s00125-024-06266-6/fulltext.html

المؤلفون: Kwon, Bum Chul, Anand, Vibha, Severson, Kristen A, Ghosh, Soumya, Sun, Zhaonan, Frohnert, Brigitte I, Lundgren, Markus, Ng, Kenney

مصطلحات موضوعية: Computer Science - Machine Learning, Computer Science - Human-Computer Interaction, Statistics - Machine Learning

URL الوصول: http://arxiv.org/abs/1904.11652

المؤلفون: Li, Qian, Parikh, Hemang, Butterworth, Martha D, Lernmark, Åke, Hagopian, William, Rewers, Marian, She, Jin-Xiong, Toppari, Jorma, Ziegler, Anette-G, Akolkar, Beena, Fiehn, Oliver, Fan, Sili, Krischer, Jeffrey P, Barbour, Aaron, Bautista, Kimberly, Baxter, Judith, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I, Stahl, Marisa, Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Peacock, Stesha, Shorrosh, Hanan, Steck, Andrea, Stern, Megan, Villegas, Erica, Waugh, Kathleen, Simell, Olli G, Adamsson, Annika, Ahonen, Suvi, Åkerlund, Mari, Hakola, Leena, Hekkala, Anne, Holappa, Henna, Hyöty, Heikki, Ikonen, Anni, Ilonen, Jorma, Jäminki, Sinikka, Jokipuu, Sanna, Karlsson, Leena, Kero, Jukka, Kähönen, Miia, Knip, Mikael, Koivikko, Minna-Liisa, Koskinen, Merja, Koreasalo, Mirva, Kurppa, Kalle, Kytölä, Jarita, Latva-aho, Tiina, Lindfors, Katri, Lönnrot, Maria, Mäntymäki, Elina, Mattila, Markus, Miettinen, Maija, Multasuo, Katja, Mykkänen, Teija, Niininen, Tiina, Niinistö, Sari, Nyblom, Mia, Oikarinen, Sami, Ollikainen, Paula, Othmani, Zhian, Pohjola, Sirpa, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riski, Eija, Pekkola, Miia, Romo, Minna, Ruohonen, Satu, Simell, Satu, Sjöberg, Maija, Stenius, Aino, Tossavainen, Päivi, Vähä-Mäkilä, Mari, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Viinikangas, Irene, Virtanen, Suvi M, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Bryant, Jennifer, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Anderson, Stephen W, Jacobsen, Laura, Marks, John, Towe, PD

المصدر: Diabetes. 69(3)

مصطلحات موضوعية: Pediatric, Autoimmune Disease, Diabetes, Prevention, Nutrition, Metabolic and endocrine, Alanine, Amino Acids, Branched-Chain, Autoantibodies, Child, Preschool, Dehydroascorbic Acid, Diabetes Mellitus, Type 1, Fatty Acids, Female, Genetic Predisposition to Disease, Glutamate Decarboxylase, Humans, Infant, Infant, Newborn, Insulin Antibodies, Longitudinal Studies, Male, Metabolome, Methionine, Phosphatidylethanolamines, Prodromal Symptoms, Proline, Risk, Triglycerides, gamma-Aminobutyric Acid, TEDDY Study Group, Medical and Health Sciences, Endocrinology & Metabolism

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/55z361j6

المؤلفون: Nakayasu, Ernesto S, Bramer, Lisa M, Ansong, Charles, Schepmoes, Athena A, Fillmore, Thomas L, Gritsenko, Marina A, Clauss, Therese R, Gao, Yuqian, Piehowski, Paul D, Stanfill, Bryan A, Engel, Dave W, Orton, Daniel J, Moore, Ronald J, Qian, Wei-Jun, Sechi, Salvatore, Frohnert, Brigitte I, Toppari, Jorma, Ziegler, Anette-G, Lernmark, Åke, Hagopian, William, Akolkar, Beena, Smith, Richard D, Rewers, Marian J, Webb-Robertson, Bobbie-Jo M, Metz, Thomas O

المصدر: Cell Reports Medicine EXODIAB: Excellence of Diabetes Research in Sweden. 4(7)

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes, Medicinska och farmaceutiska grundvetenskaper, Cell- och molekylärbiologi, Basic Medicine, Cell and Molecular Biology

URL الوصول: https://lup.lub.lu.se/record/f7b25941-20c9-40ab-adc5-a3a9cc8161d6
http://dx.doi.org/10.1016/j.xcrm.2023.101093

المؤلفون: Ullitz Thorsen, Steffen, Liu, Xiang, Kataria, Yachana, Mandrup-poulsen, Thomas, Kaur, Simranjeet, Uusitalo, Ulla, Virtanen, Suvi M., Norris, Jill, Rewers, Marian, Hagopian, William, Yang, Jimin, She, Jin-xiong, Akolkar, Beena, Rich, Stephen S., Aronsson, Carin Andrén, Lernmark, Åke, Ziegler, Anette-gabriele, Toppari, Jorma, Krischer, Jeffrey P., Parikh, Hemang M., Ellervik, Christina, Svensson, Jannet, Barbour, Aaron, Bautista, Kimberly, Baxter, Judith, Felipe-morales, Daniel, Frohnert, Brigitte I., Stahl, Marisa, Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Munoz, Alondra, O’donnell, Holly, Peacock, Stesha, Shorrosh, Hanan, Steck, Andrea, Stern, Megan, Waugh, Kathleen, Simell, Olli G., Adamsson, Annika, Ahonen, Suvi, Åkerlund, Mari, Anttila, Sirpa, Hakola, Leena, Hekkala, Anne, Agardh, Daniel

المصدر: Ullitz Thorsen , S , Liu , X , Kataria , Y , Mandrup-poulsen , T , Kaur , S , Uusitalo , U , Virtanen , S M , Norris , J , Rewers , M , Hagopian , W , Yang , J , She , J , Akolkar , B , Rich , S S , Aronsson , C A , Lernmark , Å , Ziegler , A , Toppari , J , Krischer , J P , Parikh , H M , Ellervik , C , Svensson , J , Rewers , M , Barbour ....

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/interaction-between-dietary-iron-intake-and-genetically-determined-iron-overload(8f212276-6644-4251-8800-850659b936c9).html
https://doi.org/10.2337/dc22-1359
https://curis.ku.dk/ws/files/338435240/Interaction_Between_Dietary.pdf

المؤلفون: Frost, Holly M., Geno Rasmussen, Cristy, Shorrosh, Hanan, Pyle, Laura, Bautista, Kimberly, Frohnert, Brigitte I., Stahl, Marisa, Simmons, Kimber, Steck, Andrea K., Jia, Xiaofan, Yu, Liping, Rewers, Marian

المساهمون: Leona M. and Harry B. Helmsley Charitable Trust, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Janssen Research and Development, Courtnay C. and Lucy Patten Davis Foundation, National Institute of Diabetes and Digestive and Kidney Diseases, Juvenile Diabetes Research Foundation International

المصدر: Journal of Primary Care & Community Health ; volume 14 ; ISSN 2150-1319 2150-1327

الاتاحة: https://doi.org/10.1177/21501319231189147
https://journals.sagepub.com/doi/pdf/10.1177/21501319231189147
https://journals.sagepub.com/doi/full-xml/10.1177/21501319231189147

المؤلفون: Törn, Carina, Liu, Xiang, Onengut-Gumuscu, Suna, Counts, Kevin M., Moreno, Jose Leonardo, Remedios, Cassandra L., Chen, Wei-Min, LeFaive, Jonathon, Butterworth, Martha D., Akolkar, Beena, Krischer, Jeffrey P., Lernmark, Åke, Rewers, Marian, She, Jin-Xiong, Toppari, Jorma, Ziegler, Anette-Gabriele, Ratan, Aakrosh, Smith, Albert V., Hagopian, William A., Rich, Stephen S., Parikh, Hemang M., Barbour, Aaron, Bautista, Kimberly, Baxter, Judith, Felipe-Morales, Daniel, Frohnert, Brigitte I., Stahl, Marisa, Gesualdo, Patricia, Haley, Rachel, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Munoz, Alondra, Norris, Jill, Peacock, Stesha, Shorrosh, Hanan, Steck, Andrea, Stern, Megan, Waugh, Kathleen, Simell, Olli G., Adamsson, Annika, Aaltonen, Sanna-Mari, Ahonen, Suvi, Åkerlund, Mari, Hakola, Leena, Hekkala, Anne, Holappa, Henna, Hyöty, Heikki, Ikonen, Anni, Ilonen, Jorma

المساهمون: National Institutes of Diabetes and Digestive and Kidney Diseases, Lund University

المصدر: Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322

الاتاحة: http://dx.doi.org/10.1038/s41598-022-08058-7
https://www.nature.com/articles/s41598-022-08058-7.pdf
https://www.nature.com/articles/s41598-022-08058-7

المؤلفون: Melin, Jessica, Lynch, Kristian F., Lundgren, Markus, Aronsson, Carin Andrén, Larsson, Helena Elding, Johnson, Suzanne Bennett, Rewers, Marian, Barbour, Aaron, Bautista, Kimberly, Baxter, Judith, Felipe-Morales, Daniel, Frohnert, Brigitte I., Stahl, Marisa, Gesualdo, Patricia, Haley, Rachel, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Munoz, Alondra, Norris, Jill, Peacock, Stesha, Shorrosh, Hanan, Steck, Andrea, Stern, Megan, Waugh, Kathleen, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Aaltonen, Sanna-Mari, Ahonen, Suvi, Åkerlund, Mari, Hakola, Leena, Hekkala, Anne, Holappa, Henna, Hyöty, Heikki, Ikonen, Anni, Ilonen, Jorma, Jokipuu, Sanna, Karlsson, Leena, Kähönen, Jukka Kero Miia, Knip, Mikael, Koivikko, Minna-Liisa, Kokkonen, Katja, Koskinen, Merja, Koreasalo, Mirva, Kurppa, Kalle, Kuusela, Salla, Kytölä, Jarita, Lahtinen, Sinikka, Laiho, Jutta

المساهمون: Lund University

المصدر: BMC Endocrine Disorders ; volume 22, issue 1 ; ISSN 1472-6823

الاتاحة: http://dx.doi.org/10.1186/s12902-021-00929-w
https://link.springer.com/content/pdf/10.1186/s12902-021-00929-w.pdf
https://link.springer.com/article/10.1186/s12902-021-00929-w/fulltext.html

المؤلفون: Chahla, Saydi E, Frohnert, Brigitte I, Thomas, William, Kelly, Aaron S, Nathan, Brandon M, Polgreen, Lynda E

مصطلحات موضوعية: Prevention, Nutrition, Obesity, Cancer, Metabolic and endocrine, Cardiovascular, Oral and gastrointestinal, adolescents, obesity, osteocalcin, physical activity, Public Health and Health Services

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/05h543g3

المؤلفون: Ghalwash, Mohamed, Anand, Vibha, Ng, Kenney, Dunne, Jessica L., Lou, Olivia, Lundgren, Markus, Hagopian, William A., Rewers, Marian, Ziegler, Anette-G., Veijola, Riitta, Ziegler, Anette G., Bonifacio, Ezio, Achenbach, Peter, Winkler, Christiane, Frohnert, Brigitte I., Norris, Jill, Steck, Andrea, Waugh, Kathleen, Yu, Liping, Killian, Michael

المصدر: Diabetes Care; Aug2024, Vol. 47 Issue 8, p1424-1431, 8p

مصطلحات موضوعية: TYPE 1 diabetes, AUTOANTIBODIES, HIERARCHICAL clustering (Cluster analysis), SURVIVAL analysis (Biometry), SEROCONVERSION

المؤلفون: Kwon, Bum Chul, Achenbach, Peter, Anand, Vibha, Frohnert, Brigitte I, Hagopian, William, Hu, Jianying, Koski, Eileen, Lernmark, Åke, Lou, Olivia, Martin, Frank, Ng, Kenney, Toppari, Jorma, Veijola, Riitta

المصدر: Diabetes EXODIAB: Excellence of Diabetes Research in Sweden. 71(12):2632-2641

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

URL الوصول: https://lup.lub.lu.se/record/e6a9fab3-d1fb-48b4-a344-e088b8dae81c
http://dx.doi.org/10.2337/db22-0360

المؤلفون: Nakayasu, Ernesto S., Gritsenko, Marina, Piehowski, Paul D., Gao, Yuqian, Orton, Daniel J., Schepmoes, Athena A., Fillmore, Thomas L., Frohnert, Brigitte I., Rewers, Marian, Krischer, Jeffrey P., Ansong, Charles, Suchy-Dicey, Astrid M., Evans-Molina, Carmella, Qian, Wei-Jun, Webb-Robertson, Bobbie-Jo M., Metz, Thomas O.

المصدر: Nature Protocols ; volume 16, issue 8, page 3737-3760 ; ISSN 1754-2189 1750-2799

الاتاحة: http://dx.doi.org/10.1038/s41596-021-00566-6
https://www.nature.com/articles/s41596-021-00566-6.pdf
https://www.nature.com/articles/s41596-021-00566-6