المؤلفون: Christopher R. Wellaway (7148462), Ian R. Baldwin (1523716), Paul Bamborough (1343466), Daniel Barker (272779), Michelle A. Bartholomew (6566705), Chun-wa Chung (1343454), Birgit Dümpelfeld (2391988), John P. Evans (1312302), Neal J. Fazakerley (4714458), Paul Homes (1523515), Steven P. Keeling (11859605), Xiao Q. Lewell (1494235), Finlay W. McNab (11859608), Joanne Morley (633656), Deborah Needham (1859719), Margarete Neu (1840468), Antoon J. M. van Oosterhout (11859611), Anshu Pal (11859614), Friedrich B. M. Reinhard (8209701), Francesco Rianjongdee (9260972), Craig M. Robertson (1533145), Paul Rowland (1523731), Rishi R. Shah (8232807), Emma B. Sherriff (11859617), Lisa A. Sloan (1523527), Simon Teague (11859620), Daniel A. Thomas (1932538), Natalie Wellaway (2202247), Justyna Wojno-Picon (8551074), James M. Woolven (2119828), Diane M. Coe (1494211)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequent investigations revealed, compromised kinome selectivity, mouse lung pharmacokinetic, computational docking studies, ao binding site, inhaled jak inhibitors, aldehyde oxidase metabolism, aldehyde oxidase, tyrosine kinases, specific substituents, severe asthma, receptor signaling, quinazoline series, quinazoline 2, potential issue, parent compound, lung delivery, low exposure, low concentrations, janus kinase, janus family, jak inhibitors, identify quinazolines

Relation: https://figshare.com/articles/journal_contribution/Investigation_of_Janus_Kinase_JAK_Inhibitors_for_Lung_Delivery_and_the_Importance_of_Aldehyde_Oxidase_Metabolism/17303699

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01765.s003

المؤلفون: Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough, Daniel Barker, Michelle A. Bartholomew, Chun-wa Chung, Birgit Dümpelfeld, John P. Evans, Neal J. Fazakerley, Paul Homes, Steven P. Keeling, Xiao Q. Lewell, Finlay W. McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J. M. van Oosterhout, Anshu Pal, Friedrich B. M. Reinhard, Francesco Rianjongdee, Craig M. Robertson, Paul Rowland, Rishi R. Shah, Emma B. Sherriff, Lisa A. Sloan, Simon Teague, Daniel A. Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M. Woolven, Diane M. Coe

المصدر: Journal of Medicinal Chemistry. 65:633-664

مصطلحات موضوعية: Models, Molecular, Mice, Inbred BALB C, Binding Sites, Aldehyde Oxidase, Molecular Docking Simulation, Mice, Structure-Activity Relationship, Drug Delivery Systems, Liver, Drug Discovery, Quinazolines, Animals, Humans, Janus Kinase Inhibitors, Molecular Medicine, Administration, Intravenous, Female, Lung, Administration, Intranasal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25612a371cd9b4befcdd69bdbd64fbaa
https://doi.org/10.1021/acs.jmedchem.1c01765

المؤلفون: Giovanna Bergamini, Stefano Livia, Kenneth David Down, Marcus Bantscheff, Nick Barton, Friedrich B M Reinhard, Paola Grandi, Daniel Thomas, David N. Mallett, Paul Martin Gore, Sophie M. Bertrand, Z.A. Henley, Edith M. Hessel, James E. Rowedder, Mark Price, J. Nicole Hamblin, Birgit Dümpelfeld, Augustin Amour, Steve Keeling, Christina Rau, Máire A. Convery, Chris D. Edwards, Jonathan A. Taylor, Paul Rowland, Aoife C. Maxwell

المصدر: Journal of Medicinal Chemistry. 63:638-655

مصطلحات موضوعية: Models, Molecular, Cell Membrane Permeability, Cell membrane permeability, Class I Phosphatidylinositol 3-Kinases, Biological Availability, Class iii, Crystallography, X-Ray, Binding, Competitive, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Phosphoinositide-3 Kinase Inhibitors, Drug discovery, Chemistry, Class III Phosphatidylinositol 3-Kinases, Combinatorial chemistry, Rats, Bioavailability, Isoenzymes, Molecular Docking Simulation, Toxicity, Molecular Medicine, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee509ec4ce8051c7f53718e7e95b2637
https://doi.org/10.1021/acs.jmedchem.9b01585

المؤلفون: Friedrich B M Reinhard, Anne T. Nies, Gerard Drewes, Melissa S Unger, David Weigt, Maciej J. Zamek-Gliszczynski, Sandra Schulz, Thomas Enzlein, Carsten Hopf, Matthias Schwab, Lena Schumacher

المصدر: Analytical chemistry. 92(17)

مصطلحات موضوعية: Chemistry, Drug discovery, Cell, Substrate (chemistry), Organic Anion Transporters, Transporter, Biological Transport, Analytical Chemistry, Solute carrier family, Matrix (chemical analysis), medicine.anatomical_structure, Pharmacokinetics, Biochemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, medicine, Humans, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e648759575120a13b2ba2bb04db73f1
https://pubmed.ncbi.nlm.nih.gov/32867487

المؤلفون: Maciej J. Zamek-Gliszczynski, Melissa S Unger, Matthias Schwab, Gerard Drewes, Jennypher Mudunuru, Carsten Hopf, Friedrich B M Reinhard, Anne T. Nies

المصدر: Molecular Pharmaceutics.

مصطلحات موضوعية: Drug, Cell Survival, media_common.quotation_subject, Drug Evaluation, Preclinical, Organic Anion Transporters, Pharmaceutical Science, 02 engineering and technology, Dibromofluorescein, Pharmacology, Transfection, 030226 pharmacology & pharmacy, Incubation period, Erlotinib Hydrochloride, Inhibitory Concentration 50, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Drug Discovery, Ic50 values, Humans, Medicine, Drug Interactions, Intestinal Mucosa, IC50, media_common, Drug disposition, business.industry, Biological Transport, Transporter, Fluoresceins, 021001 nanoscience & nanotechnology, HEK293 Cells, Liver, Molecular Medicine, 0210 nano-technology, business, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4034c9f3a0d04a678186e4075523c7
https://doi.org/10.1021/acs.molpharmaceut.9b00897

المؤلفون: Thilo Werner, Christina Rau, Marcus Bantscheff, David H. Drewry, Stephanie Lehmann, H. Christian Eberl, Peiling Chen, Gerard Drewes, Marcel Muelbaier, Friedrich B M Reinhard, Douglas W. Thomson, Cunyu Zhang

المصدر: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Proteome, Dasatinib, lcsh:Medicine, Kinases, Plasma protein binding, Article, Chromatography, Affinity, Monocytes, Substrate Specificity, Sepharose, 03 medical and health sciences, Mice, 0302 clinical medicine, Dogs, Target identification, medicine, Animals, Humans, Kinome, Chemoproteomics, lcsh:Science, Protein Kinase Inhibitors, Janus Kinases, Multidisciplinary, Chemistry, Kinase, lcsh:R, Microspheres, 030104 developmental biology, HEK293 Cells, Biochemistry, 030220 oncology & carcinogenesis, lcsh:Q, Janus kinase, K562 Cells, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a9de49167af020ba0934799448773c
http://europepmc.org/articles/PMC6775116

المؤلفون: Holger Franken, Dirk Eberhard, Marcus Bantscheff, Mikhail M. Savitski, Friedrich B M Reinhard, Wolfgang Huber, Dorothee Childs, Thilo Werner, Maria Fälth Savitski, Carola Doce, Gerard Drewes

المصدر: Nature Methods. 12:1129-1131

مصطلحات موضوعية: ATP-binding cassette transporter, Cell Biology, Plasma protein binding, Biology, Proteomics, Biochemistry, Jurkat cells, Transmembrane protein, Cell biology, Membrane, Denaturation (biochemistry), Receptor, Molecular Biology, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fcb9a1dc0e49393e87bdfe376c868c9c
https://doi.org/10.1038/nmeth.3652

المؤلفون: Marcus Bantscheff, Ina Tögel, Holger Franken, Thilo Werner, Wolfgang Huber, Dorothee Childs, Gerard Drewes, Stephan Gade, Toby Mathieson, Carola Doce, Gavain Sweetman, Mikhail M. Savitski, Friedrich B M Reinhard

المصدر: Nature protocols. 10(10)

مصطلحات موضوعية: Proteome, Drug discovery, Protein Stability, Protein Array Analysis, Temperature, Computational biology, Biology, Mass spectrometry, Tandem mass tag, Molecular biology, General Biochemistry, Genetics and Molecular Biology, Melting curve analysis, Mass Spectrometry, Database normalization, chemistry.chemical_compound, Drug Delivery Systems, chemistry, Panobinostat, Humans, K562 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b66295e225640bdc595031cda30c77
https://pubmed.ncbi.nlm.nih.gov/26379230

المؤلفون: Friedrich B M Reinhard, Krzysztof Paliga, Konrad Beyreuther, Simone Eggert, Genevieve Evin, Andreas Weidemann, Markus Vogel, Colin L. Masters, Gottfried Baier

المصدر: Biochemistry. 41:2825-2835

مصطلحات موضوعية: Blotting, Western, Molecular Sequence Data, Biochemistry, Presenilin, Amyloid beta-Protein Precursor, Alzheimer Disease, mental disorders, Presenilin-1, Tumor Cells, Cultured, Amyloid precursor protein, Animals, Protease Inhibitors, Amino Acid Sequence, APH-1, DNA Primers, Base Sequence, biology, Hydrolysis, P3 peptide, Membrane Proteins, Biochemistry of Alzheimer's disease, Transmembrane domain, Alpha secretase, COS Cells, biology.protein, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224a32e82ed29ad2c931d4c9fac819c7
https://doi.org/10.1021/bi015794o

المؤلفون: Rebecca Dovega, Dirk Eberhard, Marcus Bantscheff, Maria Fälth Savitski, Bernhard Kuster, Holger Franken, Thilo Werner, Susan Klaeger, Pär Nordlund, Gerard Drewes, Mikhail M. Savitski, Rozbeh Jafari, Daniel Martinez Molina, Friedrich B M Reinhard

المصدر: Science (New York, N.Y.). 346(6205)

مصطلحات موضوعية: Proteomics, Thermal shift assay, Protein Denaturation, Hot Temperature, Proteome, Antineoplastic Agents, Plasma protein binding, Pharmacology, Ligands, Adapter molecule crk, medicine, Staurosporine, Humans, Adenosine Triphosphatases, Multidisciplinary, biology, Protein Stability, Ferrochelatase, Cell biology, CRKL, Dasatinib, biology.protein, K562 Cells, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e145dcfe517651974daaf6afc00632e8
https://pubmed.ncbi.nlm.nih.gov/25278616

المؤلفون: Andreas Weidemann, Colin L. Masters, Krzysztof Paliga, Friedrich B M Reinhard, Genevieve Evin, Oliver Schuckert, Ulrike Dürrwang

المصدر: Journal of Biological Chemistry. 274:5823-5829

مصطلحات موضوعية: Cytoplasm, Proteases, Molecular Sequence Data, Apoptosis, Cysteine Proteinase Inhibitors, Biochemistry, Presenilin, Amyloid beta-Protein Precursor, Jurkat Cells, Alzheimer Disease, mental disorders, medicine, Amyloid precursor protein, Animals, Humans, Amino Acid Sequence, Molecular Biology, Peptide sequence, Caspase, biology, Hydrolysis, Neurodegeneration, Cell Biology, medicine.disease, Molecular biology, Recombinant Proteins, Enzyme Activation, Kinetics, Alpha secretase, Caspases, COS Cells, Mutagenesis, Site-Directed, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0431993a7171bd5a5591cb545b0e28b2
https://doi.org/10.1074/jbc.274.9.5823

المؤلفون: Katie Ellard, Marcus Bantscheff, Satoko Shimamura, Kathryn Bell, Carsten Hopf, Faiza Rharbaoui, Nigel Ramsden, Mikhail M. Savitski, Gerard Drewes, Gitte Neubauer, Raffaella Mangano, Andrew Cansfield, Toby Mathieson, Ivan Plavec, Christina Rau, Friedrich B M Reinhard, Daniel Leggate, Alison O'Mahony, Thilo Werner, Carola Doce, Jessica Perrin, Katrin Müller, Giovanna Bergamini, Oliver Rausch, Emilio Hirsch

المصدر: Nature chemical biology. 8(6)

مصطلحات موضوعية: Male, Cellular differentiation, Biology, Binding, Competitive, Cell Line, Small Molecule Libraries, Mice, Structure-Activity Relationship, In vivo, Cell Movement, Drug Discovery, medicine, Structure–activity relationship, Animals, Class Ib Phosphatidylinositol 3-Kinase, Humans, Chemoproteomics, Enzyme Inhibitors, Rats, Wistar, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Molecular Structure, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, Interleukin-17, Cell Differentiation, Cell Biology, T helper cell, T-Lymphocytes, Helper-Inducer, Arthritis, Experimental, In vitro, Cell biology, Rats, Mice, Inbred C57BL, medicine.anatomical_structure, Cell culture, Mice, Inbred DBA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b747e5342fff30edde4865e7369029c5
https://pubmed.ncbi.nlm.nih.gov/22544264

المؤلفون: Andrea, Wolf, Satoko, Shimamura, Friedrich B M, Reinhard

المصدر: Methods in molecular biology (Clifton, N.J.). 803

مصطلحات موضوعية: Small Molecule Libraries, Solutions, Kinetics, Light, Solubility, Regression Analysis, Scattering, Radiation, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::833cea913eacba5db6d2620b1806009e
https://pubmed.ncbi.nlm.nih.gov/22065231

المؤلفون: Friedrich B M Reinhard, Genevieve Evin, Andreas Weidemann, Dai Zhang, Colin L. Masters, Ulrike Dürrwang, Krzysztof Paliga, Konrad Beyreuther, Rupert Sandbrink

مصطلحات موضوعية: Proteases, Amyloid, biology, medicine.diagnostic_test, Chemistry, Proteolysis, P3 peptide, Presenilin, Cell biology, Biochemistry of Alzheimer's disease, mental disorders, biology.protein, Amyloid precursor protein, medicine, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::631d0d33eb60be4b791285841cb9418f
https://doi.org/10.1385/1-59259-195-7:333

المؤلفون: Vincenzo Carbone, Janetta G. Culvenor, Friedrich B M Reinhard, M. Fleur Sernee, Robyn A. Sharples, Genevieve Evin, Andreas Weidemann, Colin L. Masters, R. M. Damian Holsinger, and Konrad Beyreuther

المصدر: Biochemistry. 40(28)

مصطلحات موضوعية: Immunoprecipitation, Detergents, Biotin, Cleavage (embryo), Biochemistry, Binding, Competitive, Presenilin, chemistry.chemical_compound, Mice, Alzheimer Disease, mental disorders, Endopeptidases, Pepstatins, Presenilin-2, Amyloid precursor protein, Presenilin-1, Tumor Cells, Cultured, Animals, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, Cells, Cultured, Sequence Deletion, Mice, Knockout, biology, Molecular mass, Hydrolysis, Membrane Proteins, Cholic Acids, Exons, Molecular biology, Precipitin Tests, nervous system diseases, Blot, Molecular Weight, nervous system, chemistry, COS Cells, biology.protein, Amyloid Precursor Protein Secretases, Pepstatin, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f869be842b5380a1da11de1d8b850a88
https://pubmed.ncbi.nlm.nih.gov/11444983

المؤلفون: Carola Doce, Friedrich B M Reinhard, Thilo Werner, Raffaella Mangano, Satoko Shimamura, Katrin Müller, Nigel Ramsden, Gerard Drewes, Daniel Leggate, Gitte Neubauer, Jessica Perrin, Toby Mathieson, Alison O'Mahony, Marcus Bantscheff, Andrew Cansfield, Faiza Rharbaoui, Kathryn Bell, Carsten Hopf, Oliver Rausch, Mikhail M. Savitski, Ivan Plavec, Christina Rau, Katie Ellard, Giovanna Bergamini, Emilio Hirsch

المصدر: Nature Chemical Biology. 8:737-737

مصطلحات موضوعية: Chemistry, Nat, Cellular differentiation, Cell Biology, Molecular Biology, Molecular biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::03c6db21d6695aadcb73d0425a7c3a4c
https://doi.org/10.1038/nchembio0812-737b

المؤلفون: Robert E. Mulvey, William Clegg, Lynne Horsburgh, Friedrich B. M. Reinhard, Kenneth W. Henderson

المصدر: Journal of the American Chemical Society. 116:10777-10778

مصطلحات موضوعية: Magnesium, Stereochemistry, Aryl, Intermetallic, chemistry.chemical_element, General Chemistry, Crystal structure, Cresol, Biochemistry, Catalysis, chemistry.chemical_compound, Trigonal bipyramidal molecular geometry, Crystallography, Colloid and Surface Chemistry, chemistry, medicine, Lithium, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::db0bc038a914a8c4e2b0ead0eeb90502
https://doi.org/10.1021/ja00102a050

المؤلفون: Andreas Weidemann, Krzysztof Paliga, Simone Eggert, Friedrich B M Reinhard, Joachim Stumm, Stefan Scheuermann

المصدر: Neurobiology of Aging. 21:263

مصطلحات موضوعية: Genetics, Aging, General Neuroscience, Amyloid precursor protein, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Biology, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4837febdd0acb801a1e5533fe7837cfe
https://doi.org/10.1016/s0197-4580(00)83136-x

المؤلفون: Friedrich B M Reinhard, Sylvia Kreger, Simone Eggert, Andreas Weidemann, Peter Soba

المصدر: Neurobiology of Aging. 21:112

مصطلحات موضوعية: Aging, Transmembrane domain, Chemistry, General Neuroscience, PRESENILIN 2, Biophysics, Charge (physics), Neurology (clinical), Geriatrics and Gerontology, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6403d38131089c95ac676b2c1d31c0d6
https://doi.org/10.1016/s0197-4580(00)82304-0