المؤلفون: Dugdale, Caitlin M, Ufio, Ogochukwu, Alba, Christopher, Permar, Sallie R, Stranix‐Chibanda, Lynda, Cunningham, Coleen K, Fouda, Genevieve G, Myer, Landon, Weinstein, Milton C, Leroy, Valériane, McFarland, Elizabeth J, Freedberg, Kenneth A, Ciaranello, Andrea L

المصدر: Journal of the International AIDS Society. 26(1)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Pediatric AIDS, Infectious Diseases, HIV/AIDS, Sexually Transmitted Infections, Cost Effectiveness Research, Pediatric, Prevention, Clinical Research, Comparative Effectiveness Research, Women's Health, Health Services, 6.1 Pharmaceuticals, 3.3 Nutrition and chemoprevention, Infection, Reproductive health and childbirth, Good Health and Well Being, Infant, Newborn, Humans, Infant, Female, Child, Pregnancy, Broadly Neutralizing Antibodies, HIV Infections, Cost-Benefit Analysis, Anti-Retroviral Agents, HIV Antibodies, Cote d'Ivoire, Infectious Disease Transmission, Vertical, HIV-1, broadly neutralizing antibodies, cost-effectiveness analysis, HIV prevention and control, infant HIV prophylaxis, vertical HIV transmission, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences, Clinical sciences, Epidemiology, Public health

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2tq5x47s
https://escholarship.org/content/qt2tq5x47s/qt2tq5x47s.pdf

المؤلفون: Kazemian, Pooyan, Ding, Delaney, Scott, Justine, Feser, Mary, Biello, Katie, Thomas, Beena, Dange, Alpana, Bedoya, C, Balu, Vinoth, Rawat, Shruta, Kumarasamy, Nagalingeswaran, OCleirigh, Conall, Weinstein, Milton, Kumar, Jacob, Kumar, Senthil, Mayer, Kenneth, Safren, Steven, Freedberg, Kenneth, Mimiaga, Matthew

المصدر: AIDS. 36(9)

مصطلحات موضوعية: Cost-Benefit Analysis, Female, HIV Infections, Homosexuality, Male, Humans, India, Male, Psychosocial Intervention, Sexual and Gender Minorities

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8zc2f009

المؤلفون: Neilan, Anne M, Landovitz, Raphael J, Le, Mylinh H, Grinsztejn, Beatriz, Freedberg, Kenneth A, McCauley, Marybeth, Wattananimitgul, Nattanicha, Cohen, Myron S, Ciaranello, Andrea L, Clement, Meredith E, Reddy, Krishna P, Hyle, Emily P, Paltiel, A David, Walensky, Rochelle P

المصدر: Annals of Internal Medicine. 175(4)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Health Disparities, Clinical Research, Behavioral and Social Science, Sexually Transmitted Infections, Comparative Effectiveness Research, Prevention, Cost Effectiveness Research, Women's Health, Infectious Diseases, Health Services, Clinical Trials and Supportive Activities, Sexual and Gender Minorities (SGM/LGBT*), HIV/AIDS, Good Health and Well Being, Anti-HIV Agents, Child, Cost-Benefit Analysis, Drugs, Generic, Emtricitabine, Female, HIV Infections, Homosexuality, Male, Humans, Male, Pre-Exposure Prophylaxis, Sexual and Gender Minorities, Tenofovir, United States, PrEP program costs, PrEP drug costs, HIV care costs, ART drug costs, Public Health and Health Services

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4r38f2jh
https://escholarship.org/content/qt4r38f2jh/qt4r38f2jh.pdf

المؤلفون: Neilan, Anne M, Bulteel, Alexander JB, Hosek, Sybil G, Foote, Julia HA, Freedberg, Kenneth A, Landovitz, Raphael J, Walensky, Rochelle P, Resch, Stephen C, Kazemian, Pooyan, Paltiel, A David, Weinstein, Milton C, Wilson, Craig M, Ciaranello, Andrea L

المصدر: Clinical Infectious Diseases. 73(7)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Comparative Effectiveness Research, Sexually Transmitted Infections, Minority Health, Behavioral and Social Science, Clinical Research, Prevention, Infectious Diseases, Pediatric, HIV/AIDS, Health Services, Adolescent Sexual Activity, Social Determinants of Health, Health Disparities, Pediatric AIDS, Sexual and Gender Minorities (SGM/LGBT*), Cost Effectiveness Research, Clinical Trials and Supportive Activities, 4.4 Population screening, Infection, Good Health and Well Being, Adolescent, Adult, CD4 Lymphocyte Count, Cost-Benefit Analysis, HIV Infections, Homosexuality, Male, Humans, Male, Quality-Adjusted Life Years, Sexual and Gender Minorities, United States, Young Adult, Young men who have sex with men, adolescents and young adults, HIV, screening, cost-effectiveness, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences

URL الوصول: https://escholarship.org/uc/item/2219k7h8

المؤلفون: D’Couto, Helen, Thielking, Acadia M, Sewpaul, Ronel, Levy, Douglas E, Rigotti, Nancy A, Chrysanthopoulou, Stavroula A, Siedner, Mark J, Freedberg, Kenneth A, Wood, Robin, Hyle, Emily P, Reddy, Krishna P

المساهمون: National Institute of Allergy and Infectious Diseases, National Heart, Lung, and Blood Institute, Massachusetts General Hospital, National Institute on Drug Abuse, Wellcome Trust, National Institute on Aging

المصدر: BMJ Global Health ; volume 9, issue 12, page e017049 ; ISSN 2059-7908

الاتاحة: https://doi.org/10.1136/bmjgh-2024-017049
https://syndication.highwire.org/content/doi/10.1136/bmjgh-2024-017049

المؤلفون: Mohareb, Amir, Kouamé, Menan Gérard, Nouaman, Marcellin, Kim, Arthur, Larmarange, Joseph, Neilan, Anne, Lacombe, Karine, Freedberg, Kenneth, Boyd, Anders, Coffie, Patrick, Hyle, Emily

المساهمون: Massachusetts General Hospital Boston, Harvard Medical School Boston (HMS), Université Félix Houphouët-Boigny Abidjan, Côte d'Ivoire (UFHB), Programme PAC-CI, ANRS France Recherche Nord & sud Sida-hiv hépatites, Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Santé, vulnérabilités et relations de genre au sud (SAGESUD - ERL Inserm U1244), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité)-Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Harvard School of Public Health, Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, National Institute for Allergy and Infectious Diseases. Grant Numbers: K01AI166126, R37AI058736Harvard University Center for AIDS Research. Grant Number: P30AI060354Eunice Kennedy Shriver National Institute of Child Health and Human Development. Grant Number: R01HD111355Massachusetts General Hospital (MGH) Department of Medicine Transformative Scholars AwardJerome and Celia Reich Endowed Scholar in HIV/AIDS Research at MGHNational Institutes of Health. Grant Numbers: K01AI166126, P30AI060354, R01HD111355, R37AI058736

المصدر: EISSN: 1758-2652 ; Journal of the International AIDS Society ; https://hal.science/hal-04491666 ; Journal of the International AIDS Society, 2024, 27 (3), pp.e26218. ⟨10.1002/jia2.26218⟩ ; https://onlinelibrary.wiley.com/doi/10.1002/jia2.26218

مصطلحات موضوعية: HIV, PrEP, cabotegravir, hepatitis, hepatitis B, long-acting PrEP, long-acting antiretroviral therapy, tenofovir, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation

Relation: info:eu-repo/semantics/altIdentifier/pmid/38444112; IRD: fdi:010089701; PUBMED: 38444112

الاتاحة: https://hal.science/hal-04491666
https://hal.science/hal-04491666v1/document
https://hal.science/hal-04491666v1/file/Journal%20of%20the%20International%20AIDS%20Society%20-%202024%20-%20Mohareb%20-%20What%20does%20the%20scale%E2%80%90up%20of%20long%E2%80%90acting%20HIV%20pre%E2%80%90exposure.pdf
https://doi.org/10.1002/jia2.26218

المؤلفون: MOHAREB, Amir M, KIM, Arthur Y, BOYD, Anders, NOUBARY, Farzad, KOUAME, Menan Gerard, ANGLARET, Xavier, COFFIE, Patrick A, EHOLIE, Serge Paul, FREEDBERG, Kenneth A, HYLE, Emily P

مصطلحات موضوعية: Hepatology, Public health, VIROLOGY, Sciences du Vivant [q-bio]/Santé publique et épidémiologie

Relation: https://oskar-bordeaux.fr/handle/20.500.12278/199664

الاتاحة: https://oskar-bordeaux.fr/handle/20.500.12278/199664
https://hdl.handle.net/20.500.12278/199664
https://doi.org/10.1136/bmjopen-2023-073498

المؤلفون: Thielking, Acadia M., Fitzmaurice, Kieran P., Sewpaul, Ronel, Chrysanthopoulou, Stavroula A., Dike, Lotanna, Levy, Douglas E., Rigotti, Nancy A., Siedner, Mark J., Wood, Robin, Paltiel, A. David, Freedberg, Kenneth A., Hyle, Emily P., Reddy, Krishna P.

المساهمون: National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, National Heart, Lung, and Blood Institute

المصدر: Journal of the International AIDS Society ; volume 27, issue 6 ; ISSN 1758-2652 1758-2652

الاتاحة: http://dx.doi.org/10.1002/jia2.26315
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jia2.26315

المؤلفون: Boyce, Ceejay L, Sils, Tatiana, Milne, Ross S, Wallner, Jackson J, Hardy, Samantha R, Ko, Daisy, Wong-On-Wing, Annie, Mackey, Malia, Higa, Nikki, Beck, Ingrid A, Styrchak, Sheila M, DeMarrais, Patricia, Tierney, Camlin, Fowler, Mary G, Frenkel, Lisa M, Flynn, Patricia M, Currier, Judith, Fiscus, Susan, Luzuriaga, Katherine, Weinberg, Adriana, McIntyre, James, Chipato, Tsungai, Fox, Lawrence, Klingman, Karin L, Browning, Renee, Mofenson, Lynne M, Siberry, George K, Watts, Heather, Purdue, Lynette, Shapiro, David, Fenton, Terrence, Cababasay, Mae P, Britto, Paula, Wang, Yan, Liu, Li, Brummel, Sean, Angelidou, Konstantia, Basar, Michael, Millar, Linda, Kaiser, Kathleen, Gaeddert, John, Marillo, Linda, Ciaranello, Andrea, Freedberg, Kenneth, Barlow-Mosha, Linda, Toye, Mary Patricia, Mirochnick, Mark, Bhattacharya, Debika, Jennings, Amy, Manzella, Adam

المساهمون: International Maternal Pediatric Adolescent AIDS Clinical Trials Network

المصدر: Open Forum Infectious Diseases ; volume 11, issue 7 ; ISSN 2328-8957

الاتاحة: http://dx.doi.org/10.1093/ofid/ofae383
https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae383/58539572/ofae383.pdf
https://academic.oup.com/ofid/article-pdf/11/7/ofae383/58650817/ofae383.pdf

المؤلفون: Borre, Ethan D, Ahonkhai, Aima A, Chi, Kyu-young Kevin, Osman, Amna, Thayer, Krista, Person, Anna K, Weddle, Andrea, Flanagan, Clare F, Pettit, April C, Closs, David, Cotton, Mia, Agwu, Allison L, Cespedes, Michelle S, Ciaranello, Andrea L, Gonsalves, Gregg, Hyle, Emily P, Paltiel, A David, Freedberg, Kenneth A, Neilan, Anne M

المساهمون: Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institute of Allergy and Infectious Diseases, National Institute on Drug Abuse, National Institute of Mental Health, National Institutes of Health

المصدر: Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

الاتاحة: http://dx.doi.org/10.1093/cid/ciae243
https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciae243/58319367/ciae243.pdf

المؤلفون: Luz, Paula M., Spaeth, Hailey, Scott, Justine A., Grinsztejn, Beatriz, Veloso, Valdilea G., Freedberg, Kenneth A., Losina, Elena

المساهمون: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico

المصدر: The Brazilian Journal of Infectious Diseases ; volume 28, issue 1, page 103722 ; ISSN 1413-8670

الاتاحة: http://dx.doi.org/10.1016/j.bjid.2024.103722
https://api.elsevier.com/content/article/PII:S1413867024000059?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1413867024000059?httpAccept=text/plain

المؤلفون: Fridman, Ilona, Ubel, Peter A, Blumenthal-Barby, Jennifer, England, Cameron V, Currier, Judith S, Eyal, Nir, Freedberg, Kenneth A, Halpern, Scott D, Kelley, Colleen F, Kuritzkes, Daniel R, Le, Catherine N, Lennox, Jeffrey L, Pollak, Kathryn I, Zikmund-Fisher, Brian J, Scherr, Karen A

المصدر: AIDS and Behavior. 24(7)

مصطلحات موضوعية: Public Health, Health Sciences, Clinical Research, Behavioral and Social Science, Clinical Trials and Supportive Activities, HIV/AIDS, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Decision Making, Drug Therapy, Female, HIV Infections, Humans, Intention, Male, Middle Aged, Patients, Research Personnel, Surveys and Questionnaires, Behavior, Cure, Decision-making, HIV, PLWHIV, Remission, Public Health and Health Services, Social Work, Public health

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/59k1c3k5

المؤلفون: Borre, Ethan D, Ahonkhai, Aima A, Chi, Kyu-young Kevin, Osman, Amna, Thayer, Krista, Person, Anna K, Weddle, Andrea, Flanagan, Clare F, Pettit, April C, Closs, David, Cotton, Mia, Agwu, Allison L, Cespedes, Michelle S, Ciaranello, Andrea L, Gonsalves, Gregg, Hyle, Emily P, Paltiel, A David, Freedberg, Kenneth A, Neilan, Anne M

المصدر: Clinical Infectious Diseases; 12/15/2024, Vol. 79 Issue 6, p1458-1467, 10p

مصطلحات موضوعية: HIV infection risk factors, DIAGNOSIS of HIV infections, HIV prevention, COMPUTER simulation, STATISTICAL models, HEALTH services accessibility, RISK assessment, RESEARCH funding, HEALTH policy, HIV infections, PREGNANT women, DESCRIPTIVE statistics, COST benefit analysis, PRE-exposure prophylaxis, MEN who have sex with men, BLACK people, AIDS serodiagnosis, CONDOMS, TRANS women, COMPARATIVE studies, HEALTH care rationing, HUMAN trafficking, MEDICAL care costs

مصطلحات جغرافية: TENNESSEE

الشركة/الكيان: CENTERS for Disease Control & Prevention (U.S.)

المؤلفون: Dugdale, Caitlin, M, Dugdale, Caitlin, Alba, Christopher, Permar, Sallie, R, Stranix-Chibanda, Lynda, Cunningham, Coleen, K, Fouda, Genevieve, G, Myer, Landon, Weinstein, Milton, C, Leroy, Valériane, Mcfarland, Elizabeth, J, Freedberg, Kenneth, A, Ciaranello, Andrea, L

المساهمون: Massachusetts General Hospital Boston, Harvard Medical School Boston (HMS), Weill Cornell Medicine Cornell University, Cornell University New York, University of Zimbabwe (UZ), University of California Irvine (UC Irvine), University of California (UC), Children's Hospital of Orange County (CHOC), Duke University Medical Center, Duke Human Vaccine Institute, University of Cape Town, Harvard T.H. Chan School of Public Health, Equipe SPHERE (CERPOP), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Colorado Anschutz Medical Campus Aurora, Children’s Hospital Colorado, Massachusetts General Hospital Boston, MA, USA

المصدر: EISSN: 1758-2652 ; Journal of the International AIDS Society ; https://hal.science/hal-04768824 ; Journal of the International AIDS Society, 2023, 26 (1), pp.e26052. ⟨10.1002/jia2.26052/full|10.1002/jia2.26052⟩

مصطلحات موضوعية: broadly neutralizing antibodies, cost-effectiveness analysis, HIV prevention and control, HIV-1, infant HIV prophylaxis, vertical HIV transmission, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

Relation: info:eu-repo/semantics/altIdentifier/pmid/36604316; PUBMED: 36604316; PUBMEDCENTRAL: PMC9816086

الاتاحة: https://hal.science/hal-04768824
https://hal.science/hal-04768824v1/document
https://hal.science/hal-04768824v1/file/Dugdale_2023.pdf
https://doi.org/10.1002/jia2.26052/full%7C10.1002/jia2.26052

المؤلفون: Alba, Christopher, Malhotra, Shelly, Horsfall, Stephanie, Barnhart, Matthew, E, Bekker, Adrie, Chapman, Katerina, Cunningham, Coleen, K, Fast, Patricia, E, Fouda, Genevieve, G, Freedberg, Kenneth, A, Goga, Ameena, Ghazaryan, Lusine, R, Leroy, Valériane, Mann, Carlyn, Mccluskey, Margaret, M, Mcfarland, Elizabeth, J, Muturi-Kioi, Vincent, Permar, Sallie, R, Shapiro, Roger, Sok, Devin, Stranix-Chibanda, Lynda, Weinstein, Milton, C, Ciaranello, Andrea, L, Dugdale, Caitlin, M

المساهمون: Harvard School of Public Health, University of Pretoria South Africa, Equipe SPHERE (CERPOP), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Immunology and Microbial Sciences, The Scripps Research Institute La Jolla, San Diego, Department of Applied Physics and Applied Mathematics New York (APAM), Columbia University New York, Massachusetts General Hospital Boston, MA, USA, Harvard Medical School Boston (HMS)

المصدر: ISSN: 2731-4553 ; BMC Primary Care ; https://hal.science/hal-04352855 ; BMC Primary Care, 2023, 23 (1), pp.1071. ⟨10.1101/2023.11.06.23298184⟩.

مصطلحات موضوعية: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

الاتاحة: https://hal.science/hal-04352855
https://hal.science/hal-04352855v1/document
https://hal.science/hal-04352855v1/file/2023.11.06.23298184.full.pdf
https://doi.org/10.1101/2023.11.06.23298184

المؤلفون: Keyvanshokooh, Esmaeil, Fattahi, Mohammad, Freedberg, Kenneth A., Kazemian, Pooyan

المساهمون: National Institutes of Health

المصدر: Naval Research Logistics (NRL) ; volume 71, issue 1, page 41-63 ; ISSN 0894-069X 1520-6750

الاتاحة: http://dx.doi.org/10.1002/nav.22117
https://onlinelibrary.wiley.com/doi/pdf/10.1002/nav.22117

المؤلفون: Luz, Paula M., Deshpande, Vijeta, Kazemian, Pooyan, Scott, Justine A., Shebl, Fatma M., Spaeth, Hailey, Pimenta, Cristina, Stern, Madeline, Pereira, Gerson, Struchiner, Claudio J., Grinsztejn, Beatriz, Veloso, Valdilea G., Freedberg, Kenneth A.

المساهمون: National Institute of Allergy and Infectious Diseases

المصدر: BMC Public Health ; volume 23, issue 1 ; ISSN 1471-2458

الاتاحة: http://dx.doi.org/10.1186/s12889-023-15994-0
https://link.springer.com/content/pdf/10.1186/s12889-023-15994-0.pdf
https://link.springer.com/article/10.1186/s12889-023-15994-0/fulltext.html

المؤلفون: Levison, Julie H., Del Cueto, Paola, Mendoza, Jaime Vladimir, Ashour, Dina, Lydston, Melis, Freedberg, Kenneth A., Shebl, Fatma M.

المساهمون: Harvard University Center for AIDS Research, US National Institute of Allergy and Infectious Disease, CFAR Adelante award, NIH-funded Centers for AIDS Research, Steve and Deborah Gorlin Research Scholars Award

المصدر: AIDS and Behavior ; volume 27, issue 12, page 4070-4083 ; ISSN 1090-7165 1573-3254

الاتاحة: http://dx.doi.org/10.1007/s10461-023-04121-0
https://link.springer.com/content/pdf/10.1007/s10461-023-04121-0.pdf
https://link.springer.com/article/10.1007/s10461-023-04121-0/fulltext.html

المؤلفون: Pei, Pamela P., Fitzmaurice, Kieran P., Le, Mylinh H., Panella, Christopher, Jones, Michelle L., Pandya, Ankur, Horsburgh, C. Robert, Freedberg, Kenneth A., Weinstein, Milton C., Paltiel, A. David, Reddy, Krishna P.

المساهمون: National Institute of Allergy and Infectious Diseases

المصدر: MDM Policy & Practice ; volume 8, issue 2 ; ISSN 2381-4683 2381-4683

الاتاحة: http://dx.doi.org/10.1177/23814683231198873
http://journals.sagepub.com/doi/pdf/10.1177/23814683231198873
http://journals.sagepub.com/doi/full-xml/10.1177/23814683231198873

المؤلفون: Shebl, Fatma M., Qian, Yiqi, Foote, Julia H. A., Wattananimitgul, Nattanicha, Reddy, Krishna P., Neilan, Anne M., Ciaranello, Andrea L., Losina, Elena, Freedberg, Kenneth A., Hyle, Emily P.

المساهمون: Pepito, Veincent Christian, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Heart, Lung, and Blood Institute, National Institutes of Health, National Institute on Aging, MGH Executive Committee on Research

المصدر: PLOS ONE ; volume 18, issue 8, page e0290113 ; ISSN 1932-6203

الاتاحة: http://dx.doi.org/10.1371/journal.pone.0290113
https://dx.plos.org/10.1371/journal.pone.0290113