المؤلفون: Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Murilo Sena Amaral, Adriana S A Pereira, Gilbert Oliveira Silveira, David da Silva Pires, Sergio Verjovski-Almeida, Frank J Dekker, Dante Rotili, Antonello Mai, Eduardo José Lopes-Torres, Dina Robaa, Wolfgang Sippl, Raymond J Pierce, M Teresa Borrello, A Ganesan, Julien Lancelot, Silvana Thiengo, Monica Ammon Fernandez, Amanda Roberta Revoredo Vicentino, Marina Moraes Mourão, Fernanda Sales Coelho, Marcelo Rosado Fantappié

المصدر: PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008332 (2020)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

URL الوصول: https://doaj.org/article/f432fe7b163b45aa9006ab8d3eb9c2cc

المؤلفون: Deng Chen, Chunlong Zhao, Jianqiu Zhang, Catharina W. J. Knol, Angelina Osipyan, Nad'a Majerníková, Tingting Chen, Zhangping Xiao, Jeaunice Adriana, Andrew J. Griffith, Abel Soto Gamez, Petra E. van derWouden, Robert P. Coppes, Amalia M. Dolga, Hidde J. Haisma, Frank J. Dekker

المصدر: Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)

مصطلحات موضوعية: DNA repair, ferroptosis, homologous recombination, inhibitor, macrophage migration inhibitory factor (MIF), Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2198-3844

URL الوصول: https://doaj.org/article/5f1b5535d1c64d3381cee0b2777a4e5b

المؤلفون: Marloes M. Oosterhof, Louis Coussement, Alienke van Pijkeren, Marcel Kwiatkowski, Martijn R. H. Zwinderman, Frank J. Dekker, Tim de Meyer, Vera A. Reitsema, Rainer Bischoff, Victor Guryev, Hjalmar R. Bouma, Rob H. Henning, Marianne G. Rots

المصدر: Epigenetics Communications, Vol 4, Iss 1, Pp 1-14 (2024)

مصطلحات موضوعية: HDAC, HAT, RNA sequencing, Epigenetics, Histone acetylation, WGBS, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2730-7034

URL الوصول: https://doaj.org/article/69c8df83b754412d957260d7a49f95cc

المؤلفون: Francesco Fiorentino, Sara Sementilli, Martina Menna, Federica Turrisi, Stefano Tomassi, Francesca Romana Pellegrini, Angela Iuzzolino, Francesca D’Acunzo, Alessandra Feoli, Hannah Wapenaar, Sophie Taraglio, Caterina Fraschetti, Donatella Del Bufalo, Gianluca Sbardella, Frank J. Dekker, Alessandro Paiardini, Daniela Trisciuoglio, Antonello Mai, Dante Rotili

المساهمون: Fiorentino, Francesco, Sementilli, Sara, Menna, Martina, Turrisi, Federica, Tomassi, Stefano, Pellegrini, FRANCESCA ROMANA, Iuzzolino, Angela, D'Acunzo, Francesca, Feoli, Alessandra, Wapenaar, Hannah, Taraglio, Sophie, Fraschetti, Caterina, Del Bufalo, Donatella, Sbardella, Gianluca, Dekker, Frank J., Paiardini, Alessandro, Trisciuoglio, Daniela, Mai, Antonello, Rotili, Dante

مصطلحات موضوعية: lysine acetyltransfera, n-phenyl-5-pyrazolone derivative, kat8

Relation: info:eu-repo/semantics/altIdentifier/pmid/37155735; info:eu-repo/semantics/altIdentifier/wos/WOS:000988858800001; volume:66; issue:10; firstpage:6591; lastpage:6616; numberofpages:26; journal:JOURNAL OF MEDICINAL CHEMISTRY; https://hdl.handle.net/11573/1681512; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85159627845

الاتاحة: https://hdl.handle.net/11573/1681512
https://doi.org/10.1021/acs.jmedchem.2c01937

المؤلفون: Zhangping Xiao (5855825), Angelina Osipyan (5666825), Shanshan Song (500562), Deng Chen (4047067), Reinder A. Schut (11966038), Ronald van Merkerk (3138039), Petra E. van der Wouden (6615692), Robbert H. Cool (2386171), Wim J. Quax (1881640), Barbro N. Melgert (7951046), Gerrit J. Poelarends (1264938), Frank J. Dekker (1514791)

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, play key roles, cellular models systems, activated protein kinase, improved antiproliferative activity, 5d , 50 , mif2 tautomerase activity, biological activity, dopachrome tautomerase, h <, targeting mif2, molecules binding, high selectivity, drug target, cell cultures, cancer treatment, >] pyrimidine, >

Time: 3

Relation: https://figshare.com/articles/journal_contribution/Thieno_2_3_i_d_i_pyrimidine-2_4_1_i_H_i_3_i_H_i_dione_Derivative_Inhibits_d_Dopachrome_Tautomerase_Activity_and_Suppresses_the_Proliferation_of_Non-Small_Cell_Lung_Cancer_Cells/18665515

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01598.s001

المؤلفون: Alienke van Pijkeren (11432272), Jörn Dietze (11432275), Alejandro Sánchez Brotons (11432278), Anna-Sophia Egger (9187145), Tim Lijster (9652445), Andrei Barcaru (1400770), Madlen Hotze (6508691), Philipp Kobler (11432281), Frank J. Dekker (1514791), Peter Horvatovich (1961725), Barbro N. Melgert (7951046), Mathias Ziegler (11432284), Kathrin Thedieck (81799), Ines Heiland (144632), Rainer Bischoff (600606), Marcel Kwiatkowski (594571)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Inorganic Chemistry, Plant Biology, Computational Biology, Chemical Sciences not elsewhere classified, using uniformly 13c, translational protein modification, resolution mass spectrometry, labeled acetic anhydride, cometchem methodology provides, specific histone acetylation, cometchem enables site, specific acetylation dynamics, specific acetylation, specific quantification, labeled glucose, lysine acetylation, stable isotope, reversible post, reveal site, reaction rates, new approach, epigenetic regulation, comprehensive description, combines metabolic, combined metabolic, chemically equivalent

Relation: https://figshare.com/articles/journal_contribution/Combined_Metabolic_and_Chemical_CoMetChem_Labeling_Using_Stable_Isotopes_a_Strategy_to_Reveal_Site-Specific_Histone_Acetylation_and_Deacetylation_Rates_by_LC_MS/16618015

الاتاحة: https://doi.org/10.1021/acs.analchem.1c01359.s005

المؤلفون: Alienke van Pijkeren (10108262), Jörn Dietze (10108264), Alejandro Sánchez Brotons (10108256), Tim Lijster (10108277), Andrei Barcaru (10108253), Anna-Sophia Egger (10108260), Madlen Hotze (10108257), Frank J. Dekker (10108250), Peter Horvatovich (10108248), Barbro Melgert (9680912), Mathias Ziegler (10108251), Kathrin Thedieck (10108245), Ines Heiland (10108243), Rainer Bischoff (10108244), Marcel Kwiatkowski (10107706)

مصطلحات موضوعية: Biochemical Analysis, Mass Spectrometry, Proteomics, Fluxomics, Histone Acetylation

Relation: https://figshare.com/articles/preprint/Combined_Metabolic_and_Chemical_CoMetChem_Labeling_Using_Stable_Isotopes_a_Strategy_to_Reveal_Site-Specific_Histone_Acetylation_and_Deacetylation_Rates_by_LC-MS/13726843

الاتاحة: https://doi.org/10.26434/chemrxiv.13726843.v2

المؤلفون: Piermichele Kobauri, Frank J. Dekker, Wiktor Szymanski, Ben L. Feringa

المصدر: Angewandte Chemie International Edition.

مصطلحات موضوعية: General Medicine, General Chemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a70022b770c44085c31e0201595f354
https://doi.org/10.1002/anie.202300681

المؤلفون: Chunlong Zhao, Deng Chen, Fengzhi Suo, Rita Setroikromo, Wim J. Quax, Frank J. Dekker

المساهمون: Chemical and Pharmaceutical Biology, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Medicinal Chemistry and Bioanalysis (MCB)

المصدر: Bioorganic Chemistry, 136:106546

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Molecular Biology, Biochemistry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc9492662efcf45a8eb34bc2e087c04
https://doi.org/10.1016/j.bioorg.2023.106546

المؤلفون: Martijn R. H. Zwinderman, Sander de Weerd, Frank J. Dekker

المصدر: Epigenomes; Volume 3; Issue 3; Pages: 19

مصطلحات موضوعية: asthma, COPD, inflammation, NF-κB, HDAC, acetylation, post translational modification (PTM), inhibitor, drug design, co-repressor complex, review

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/epigenomes3030019

الاتاحة: https://doi.org/10.3390/epigenomes3030019

المؤلفون: Grietje H. Prins, Theerut Luangmonkong, Dorenda Oosterhuis, Henricus A. M. Mutsaers, Frank J. Dekker, Peter Olinga

المصدر: Nutrients; Volume 11; Issue 3; Pages: 507

مصطلحات موضوعية: NAFLD, non-alcoholic fatty liver disease, ex vivo, pathophysiological model, metabolism, steatosis

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/nu11030507

الاتاحة: https://doi.org/10.3390/nu11030507

المؤلفون: Martijn R. H. Zwinderman, Peter M. Lansdorp, Marcel A. T. M. van Vugt, Petra E van der Wouden, Frank J. Dekker, Victor Guryev, Diana C.J. Spierings, Thamar Jessurun Lobo

المساهمون: Chemical and Pharmaceutical Biology, Stem Cell Aging Leukemia and Lymphoma (SALL), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Research Institute for Asthma and COPD (GRIAC), Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: ACS Chemical Biology
ACS chemical biology, 16(11), 2193-2201. AMER CHEMICAL SOC

مصطلحات موضوعية: DNA Replication, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Biochemistry, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Stress, Physiological, BINDING, Humans, Hydroxyurea, Sister chromatids, HELICASE, Replication protein A, Polymerase, 030304 developmental biology, DAMAGE, 0303 health sciences, biology, Chemistry, DNA replication, Articles, General Medicine, Processivity, Chromatin, Cell biology, ATR, Gene Expression Regulation, Replication Initiation, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Tumor Suppressor Protein p53, DNA

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d071ef73e3164387cd275fe1c1a53f0e
https://doi.org/10.1021/acschembio.1c00321

المؤلفون: Petra E van der Wouden, Zhangping Xiao, Frank J. Dekker, Deng Chen, Dea Gogishvili, Rita Setroikromo, Hao Guo

المساهمون: Chemical and Pharmaceutical Biology, Chemical and Pharmaceutical Biology (GRIP), Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International ed. in English), 60(40), 21875-21883. WILEY-V C H VERLAG GMBH

مصطلحات موضوعية: musculoskeletal diseases, endocrine system diseases, activity-based probes, Molecular Conformation, Context (language use), Activity‐Based Probes | Hot Paper, Catalysis, Lipoxygenase, inhibitors, bromodomains, Arachidonate 15-Lipoxygenase, Humans, Enzyme Inhibitors, Research Articles, biology, integumentary system, Chemistry, Chromatin binding, food and beverages, Lipid metabolism, General Medicine, General Chemistry, lipoxygenases, Bromodomain, Chromatin, oxidoreductases, Histone, Biochemistry, biology.protein, lipids (amino acids, peptides, and proteins), Nuclear localization sequence, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcaf1ff2001ab82da878efb2ea45452
https://doi.org/10.1002/anie.202106968

المؤلفون: Madlen Hotze, Kathrin Thedieck, Tim Lijster, Alienke van Pijkeren, Anna Sophia Egger, Peter Horvatovich, Andrei Barcaru, Jörn Dietze, Rainer Bischoff, Ines Heiland, Barbro N. Melgert, Alejandro Sánchez Brotons, Frank J. Dekker, Mathias Ziegler, Philipp Kobler, Marcel Kwiatkowski

المساهمون: Analytical Biochemistry, Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Molecular Pharmacology, Groningen Research Institute for Asthma and COPD (GRIAC), Nanomedicine & Drug Targeting

المصدر: Analytical Chemistry, 93(38), 12872-12880. AMER CHEMICAL SOC INC
Analytical Chemistry

مصطلحات موضوعية: Histone acetylation and deacetylation, Lysine, Tandem mass spectrometry, 01 natural sciences, Article, Epigenesis, Genetic, Analytical Chemistry, Histones, 03 medical and health sciences, chemistry.chemical_compound, Isotopes, Tandem Mass Spectrometry, Liquid chromatography–mass spectrometry, Epigenetics, 030304 developmental biology, 0303 health sciences, biology, Chemistry, 010401 analytical chemistry, Acetylation, 0104 chemical sciences, Acetic anhydride, Histone, Biochemistry, biology.protein, Protein Processing, Post-Translational, Chromatography, Liquid

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108a696629af4a3af1f9e4987bac26ad
https://doi.org/10.1021/acs.analchem.1c01359

المؤلفون: Fangyuan Cao, Martijn R. H. Zwinderman, Frank J. Dekker

المصدر: Molecules, Vol 23, Iss 3, p 551 (2018)

مصطلحات موضوعية: histone deacetylase 3 (HDAC3), selective, drug discovery, inhibitor, isoenzyme, Organic chemistry, QD241-441

Relation: http://www.mdpi.com/1420-3049/23/3/551; https://doaj.org/toc/1420-3049; https://doaj.org/article/5dfa6e74243d42a8ab9c5a043c921ebc

الاتاحة: https://doi.org/10.3390/molecules23030551
https://doaj.org/article/5dfa6e74243d42a8ab9c5a043c921ebc

المؤلفون: Jan G.T. Vogel, Joko P. Wibowo, Hillina Fan, Rita Setroikromo, Kan Wang, Alexander Dömling, Frank J. Dekker, Wim J. Quax

المساهمون: Chemical and Pharmaceutical Biology, Drug Design, Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Nanotechnology and Biophysics in Medicine (NANOBIOMED)

المصدر: Microbes and infection, 24:105017. ELSEVIER SCIENCE BV

مصطلحات موضوعية: Infectious Diseases, Bacterial Proteins, Iron, Pseudomonas aeruginosa, Immunology, Siderophores, Benzopyrans, Microbiology, Amidohydrolases

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa610065d8bd792b06d1cdc6d34fde6
https://research.rug.nl/en/publications/b69659aa-1277-49fc-a5fc-e0852f04f3c5

المؤلفون: Zhangping Xiao, Gerrit J. Poelarends, Wim J. Quax, Shanshan Song, Barbro N. Melgert, Frank J. Dekker, Robbert H. Cool, Deng Chen, Ronald van Merkerk, Petra E van der Wouden

المساهمون: Chemical and Pharmaceutical Biology, Molecular Pharmacology, Chemical and Pharmaceutical Biology (GRIP), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Nanotechnology and Biophysics in Medicine (NANOBIOMED), Medicinal Chemistry and Bioanalysis (MCB)

المصدر: Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International ed. in English), 60(32), 17514-17521. WILEY-V C H VERLAG GMBH

مصطلحات موضوعية: MAPK/ERK pathway, Cell cycle checkpoint, Macrophage migration inhibitory factor (MIF), 01 natural sciences, proteolysis targeting chimera (PROTACs), ACTIVATION, BINDING, A549 cells, Research Articles, Chemistry, General Medicine, respiratory system, Small molecule, Cell biology, G2 Phase Cell Cycle Checkpoints, Intramolecular Oxidoreductases, cell cycle arrest, Cancer Therapy | Hot Paper, medicine.symptom, Research Article, MAP Kinase Signaling System, PROTEINS, Ubiquitin-Protein Ligases, Inflammation, Antineoplastic Agents, Phthalimides, chemical and pharmacologic phenomena, TAUTOMERASE INHIBITORS, 010402 general chemistry, Mitogen-activated protein kinase (MAPK) pathway, Catalysis, PROBES, Spheroids, Cellular, medicine, otorhinolaryngologic diseases, Humans, CYCLE, Macrophage Migration-Inhibitory Factors, Adaptor Proteins, Signal Transducing, Cell Proliferation, A549 cell, COMPLEX, 010405 organic chemistry, POTENT, Proteolysis targeting chimera, Cancer, General Chemistry, medicine.disease, 0104 chemical sciences, Benzoxazines, DISCOVERY, Proteolysis, Macrophage migration inhibitory factor, Drug Screening Assays, Antitumor

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d51164a0c04702db2c8059a858ded3
https://doi.org/10.1002/anie.202101864

المؤلفون: Martin D. Witte, Sebastian Thallmair, Ben L. Feringa, Piermichele Kobauri, Siewert J. Marrink, Wiktor Szymanski, Frank J. Dekker, Fangyuan Cao

المساهمون: Synthetic Organic Chemistry, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Chemical and Pharmaceutical Biology, Molecular Dynamics, Chemical Biology 2, Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Chemical Communications
Chemical Communications, 57(34), 4126-4129. ROYAL SOC CHEMISTRY

مصطلحات موضوعية: Scope (project management), 010405 organic chemistry, Computer science, Metals and Alloys, Rational design, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, 3. Good health, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Materials Chemistry, Ceramics and Composites

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09b3f1b67aec4c63e54144004440255
https://doi.org/10.1039/d1cc00950h

المؤلفون: Zhangping Xiao, Frank J. Dekker, Ali Alipour Najmi, Rainer Bischoff, Hjalmar P. Permentier

المساهمون: Analytical Biochemistry, Chemical and Pharmaceutical Biology, Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Green Chemistry, 22(19), 6455-6463. ROYAL SOC CHEMISTRY

مصطلحات موضوعية: Chloroform, DEALKYLATION, Iminium, Tropane, RETICULATED VITREOUS CARBON, TERTIARY, Alkylation, METABOLISM, Pollution, ACTIVATION, chemistry.chemical_compound, EFFICIENT SYNTHESIS, chemistry, Nucleophile, CATALYZED N-DEMETHYLATION/ACYLATION, Yield (chemistry), Oxidizing agent, Environmental Chemistry, Organic chemistry, Methanol, ELECTROORGANIC CHEMISTRY, METHODOLOGY, ANODIC-OXIDATION

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b19b83f3ad57eb2311181268e002a55
https://hdl.handle.net/11370/7ab92aac-15b5-4084-a8ac-fe9a29c06a70

المؤلفون: Reinoud Gosens, Gerard H. Koppelman, Zaid W El-Husseini, Frank J. Dekker

المصدر: The Lancet Respiratory Medicine

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Genetics, Drug, business.industry, Drug discovery, media_common.quotation_subject, Drug target, Genome-wide association study, Genomics, medicine.disease, respiratory tract diseases, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, immune system diseases, Medicine, Functional significance, 030212 general & internal medicine, business, Repurposing, Asthma, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd9bb6a7695859cdde11faacb43dd5c
https://doi.org/10.1016/s2213-2600(20)30363-5