المؤلفون: John L. Vahle, Joe Dybowski, Michael Graziano, Shigeru Hisada, Jose Lebron, Thomas Nolte, Ronald Steigerwalt, Kenjiro Tsubota, Frank D. Sistare

المصدر: Frontiers in Toxicology, Vol 6 (2024)

مصطلحات موضوعية: carcinogenicity testing, rat carcinogenicity, rasH2-Tg mouse dose selection, regulatory toxicology, carcinogenicity weight-of-evidence criteria, best practice, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2024.1377990/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/053d6740fba4457d80fc51a572935162

المؤلفون: Frank D. Sistare, Hisaharu Yamada, Kenji Inoue, Kenjiro Tsubota, Shigeru Hisada, Takanori Ikeda

المصدر: Journal of Toxicologic Pathology. 2022, 35(1):53

المؤلفون: Constance A. Mitchell, Chris Corton, Pierre Bushel, Heidrun Ellinger-Ziegelbauer, Heather Estrella, Mark Gosink, Elena McDermott, Prarthana Shankar, Ruixin Hao, Alexei Podtelezhnikov, Jan Willem van der Laan, Frank D. Sistare, Keith Q. Tanis

مصطلحات موضوعية: Toxicology (incl. clinical toxicology), molecular initiating events, mutagenicity, genomic biomarkers, transcriptomics

Relation: https://figshare.com/articles/poster/Establishing_Genomic_Biomarkers_for_the_Assessment_of_Chemical_Tumorigenicity_Risk/25883944

الاتاحة: https://doi.org/10.23645/epacomptox.25883944.v1
https://figshare.com/articles/poster/Establishing_Genomic_Biomarkers_for_the_Assessment_of_Chemical_Tumorigenicity_Risk/25883944

المؤلفون: John L. Vahle, Joe Dybowski, Michael Graziano, Shigeru Hisada, Jose Lebron, Thomas Nolte, Ronald Steigerwalt, Kenjiro Tsubota, Frank D. Sistare

مصطلحات موضوعية: Pharmacology, Toxicology, Immunology, Toxicology (incl. Clinical Toxicology), Nanotoxicology, Health and Safety, carcinogenicity testing, rat carcinogenicity, rasH2-Tg mouse dose selection, regulatory toxicology, carcinogenicity weight-of-evidence criteria, best practice

Relation: https://figshare.com/articles/dataset/DataSheet1_ICH_S1_prospective_evaluation_study_and_weight_of_evidence_assessments_commentary_from_industry_representatives_PDF/25885630

الاتاحة: https://doi.org/10.3389/ftox.2024.1377990.s001
https://figshare.com/articles/dataset/DataSheet1_ICH_S1_prospective_evaluation_study_and_weight_of_evidence_assessments_commentary_from_industry_representatives_PDF/25885630

المؤلفون: Keren J. Carss, Aimee M. Deaton, Alberto Del Rio-Espinola, Dorothée Diogo, Mark Fielden, Diptee A. Kulkarni, Jonathan Moggs, Peter Newham, Matthew R. Nelson, Frank D. Sistare, Lucas D. Ward, Jing Yuan

المصدر: Nature Reviews Drug Discovery. 22:145-162

مصطلحات موضوعية: Pharmacology, Drug Discovery, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d65a4e33cccbc51f5c412d2c20da9fed
https://doi.org/10.1038/s41573-022-00561-w

المؤلفون: J Christopher Corton, Constance A Mitchell, Scott Auerbach, Pierre Bushel, Heidrun Ellinger-Ziegelbauer, Patricia A Escobar, Roland Froetschl, Alison H Harrill, Kamin Johnson, James E Klaunig, Arun R Pandiri, Alexei A Podtelezhnikov, Julia E Rager, Keith Q Tanis, Jan Willem van der Laan, Alisa Vespa, Carole L Yauk, Syril D Pettit, Frank D Sistare

المصدر: Toxicological Sciences. 188:4-16

مصطلحات موضوعية: Carcinogenesis, Carcinogenicity Tests, Neoplasms, Biomarkers, Tumor, Carcinogens, Animals, Rodentia, Genomics, Toxicology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1ea167ef959d91cb05ee2aeb0e6fc9
https://doi.org/10.1093/toxsci/kfac041

المؤلفون: Katerina, Vlasakova, Jennifer, Bourque, Wendy J, Bailey, Shetal, Patel, Elizabeth G, Besteman, Raymond J, Gonzalez, Frank D, Sistare, Warren E, Glaab

المصدر: Toxicological Sciences. 187:219-233

مصطلحات موضوعية: Inflammation, Tissue Inhibitor of Metalloproteinase-1, Orosomucoid, Acute Kidney Injury, Toxicology, Pregnancy-Associated alpha 2-Macroglobulins, Rats, Lipocalin-2, ROC Curve, Pregnancy, Albumins, Animals, Female, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b063b32a14b4046a9ff7c68d7d3fd6a5
https://doi.org/10.1093/toxsci/kfac030

المؤلفون: Stephanie Born, Yi-Zhong Gu, Larry Handt, Vasudevan Bakthavatchalu, Katerina Vlasakova, Frank D. Sistare, Guillermo Fernandez, Warren E. Glaab, Roger Smith

المصدر: Toxicologic Pathology. 50:35-46

مصطلحات موضوعية: medicine.medical_specialty, Pathology, Biopsy, Urinary system, Kidney, Toxicology, Pathology and Forensic Medicine, chemistry.chemical_compound, medicine, Animals, Osteopontin, Molecular Biology, Blood urea nitrogen, Creatinine, medicine.diagnostic_test, Clusterin, biology, urogenital system, business.industry, Gene Expression Profiling, Cell Biology, Acute Kidney Injury, Macaca mulatta, medicine.anatomical_structure, chemistry, Tobramycin, biology.protein, Histopathology, business, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7000c83ea307a501b9d6a6443782431f
https://doi.org/10.1177/01926233211049171

المؤلفون: José A. Lebrón, Kaushik Mitra, Keith Q. Tanis, Thomas G. Griffiths, Stephen Pacchione, Matthew Kuhls, Ian Knemeyer, Donald J Marsh, Wen Kang, Frank D. Sistare, Zhibin Wang, Qing Chen, Kimberly B. Bleicher, Ming Su, George M. Laws, Alexei A. Podtelezhnikov

المصدر: Toxicological Sciences. 177:121-139

مصطلحات موضوعية: Male, 0301 basic medicine, Drug, media_common.quotation_subject, Alternatives to animal testing, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Animals, Medicine, Rats, Wistar, media_common, Liver injury, business.industry, Drug discovery, medicine.disease, Rats, 030104 developmental biology, Pharmaceutical Preparations, Toxicity, Chemical and Drug Induced Liver Injury, business, Toxicogenomics, Risk assessment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7417a59766a499501f8970dc21422c
https://doi.org/10.1093/toxsci/kfaa094

المؤلفون: Sam V Machotka, Frank D. Sistare, Amy G. Aslamkhan, Alex M Tamburino, Todd Pippert, Raymond Evers, Kaushik Mitra, Keith Q. Tanis, Timothy E. Johnson, Donna Lynch, Wen Kang, Truyen Nguyen, Randy R. Miller, James J Monroe, Tamara D. Cabalu, Alexei A. Podtelezhnikov, Nancy G. B. Agrawal, Jairam Palamanda

المصدر: Toxicological Sciences

مصطلحات موضوعية: Male, 0301 basic medicine, Drug, Pharmaceutical drug, AcademicSubjects/SCI01040, drug safety, NF-E2-Related Factor 2, media_common.quotation_subject, medicine.medical_treatment, Pharmacology, lead optimization, Toxicology, 030226 pharmacology & pharmacy, NRF1, NRF2, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Drug Development, In vivo, Animals, Medicine, transcriptional biomarkers, Rats, Wistar, Regulatory Science, Risk Assessment, and Decision Making, media_common, Liver injury, bioactivation, drug candidate attrition, Kelch-Like ECH-Associated Protein 1, AcademicSubjects/MED00305, business.industry, medicine.disease, KEAP1, Rats, rat liver, 030104 developmental biology, Pharmaceutical Preparations, Drug development, Biomarker (medicine), Chemical and Drug Induced Liver Injury, business, drug-induced liver injury, chemically reactive metabolites

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2892a55e03df13402f0ef50b67f49d4b
https://doi.org/10.1093/toxsci/kfaa088

المؤلفون: Yi-Zhong Gu, Katerina Vlasakova, Glen Miller, Nicholas T. Gatto, Paul J. Ciaccio, Sabu Kuruvilla, Elizabeth G. Besteman, Roger Smith, Spencer J. Reynolds, Rupesh P. Amin, Warren E. Glaab, Gordon Wollenberg, Jose Lebron, Frank D. Sistare

المصدر: Toxicologic Pathology. :019262332311628

مصطلحات موضوعية: Cell Biology, Toxicology, Molecular Biology, Pathology and Forensic Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ca81b65118f034c663e621457909c3ff
https://doi.org/10.1177/01926233231162809

المؤلفون: Bhavana Bhatt, Frank D. Sistare, Kiran Palyada, Feifei Chen, Isabelle Bourgeois, Christopher Brynczka, Rupesh P. Amin, Katerina Vlasakova, José A. Lebrón, Roger Smith, Kenneth A. Koeplinger, Kenneth D Anderson, Kathleen Cox, Robert Houle, Warren E. Glaab, Yi-Zhong Gu, Xiaoyan Chu

المصدر: Toxicological Sciences. 172:155-166

مصطلحات موضوعية: PEG 400, Kidney, Organic cation transport proteins, biology, Organic anion transporter 1, 02 engineering and technology, Polyethylene glycol, Prodrug, Pharmacology, 021001 nanoscience & nanotechnology, Toxicology, 030226 pharmacology & pharmacy, Nephrotoxicity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.anatomical_structure, chemistry, PEG ratio, biology.protein, medicine, 0210 nano-technology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7c8a93f2d09b4d982560ba5c94462b
https://doi.org/10.1093/toxsci/kfz186

المؤلفون: Allen Kaczor, Qiuwei Xu, José A. Lebrón, Amy G Aslamkhan, John Imredy, Yan Yu, Christina Wei, Matthew Kuhls, Kaushik Mitra, Michael P. Ruth, Kara Pearson, Andy Liaw, Liping Liu, Heather Vu, Frank D. Sistare, Raymond J. Gonzalez

المصدر: Chemical Research in Toxicology. 32:1528-1544

مصطلحات موضوعية: Liver injury, 0303 health sciences, Bioenergetics, General Medicine, Metabolism, 010501 environmental sciences, Mitochondrion, Toxicology, medicine.disease, 01 natural sciences, Glutamine, Leloir pathway, 03 medical and health sciences, chemistry.chemical_compound, Mitochondrial toxicity, chemistry, Biochemistry, Galactose, medicine, 030304 developmental biology, 0105 earth and related environmental sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::17919a6e2badadf5dc61110f063a9a8b
https://doi.org/10.1021/acs.chemrestox.9b00033

المؤلفون: Todd Pippert, Amy G Aslamkhan, Keith Q. Tanis, Stephen Pacchione, Chunhua Qin, Warren E. Glaab, Alexei A. Podtelezhnikov, Frank D. Sistare, Kara Pearson, Erika Frank

المصدر: Toxicological Sciences. 171:46-55

مصطلحات موضوعية: 0301 basic medicine, Drug, biology, business.industry, media_common.quotation_subject, CYP1A2, respiratory system, Pharmacology, Toxicology, Aryl hydrocarbon receptor, respiratory tract diseases, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug development, Toxicity, Gene expression, biology.protein, Medicine, Biomarker (medicine), business, 030217 neurology & neurosurgery, Carcinogen, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09655b3ee0c00149bae8d17846d0bf5
https://doi.org/10.1093/toxsci/kfz125

المؤلفون: Sean P. Troth, Susan Todd, Frank D. Sistare, Frank J. Simutis, Gary S. Friedman

المصدر: Seminars in Nephrology. 39:120-131

مصطلحات موضوعية: 0301 basic medicine, Drug, media_common.quotation_subject, Best practice, 030232 urology & nephrology, Clinical settings, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Humans, Medicine, Renal Insufficiency, Chronic, Drug pipeline, Pharmaceutical industry, media_common, Clinical Trials as Topic, Kidney Toxicity, Scope (project management), business.industry, Acute Kidney Injury, 030104 developmental biology, Drug development, Risk analysis (engineering), Nephrology, Models, Animal, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa5bc83bda52183eeff79c052792c66
https://doi.org/10.1016/j.semnephrol.2018.12.002

المؤلفون: Thomas R. Skopek, Warren E. Glaab, Laura Michna, Carolann Beare, Wendy J. Bailey, Frank D. Sistare, Daniel J. Holder, Nagaraja Muniappa, David Gerhold, Joseph F. Sina, Yudong D He, Jeffrey W. Lawrence, Zoltan Erdos, Pamela Lane, Keith Q. Tanis

المصدر: Toxicological sciences : an official journal of the Society of Toxicology. 181(2)

مصطلحات موضوعية: Gastrointestinal tract, Pathology, medicine.medical_specialty, Kidney, Urinary bladder, Gene Expression Profiling, Skeletal muscle, Toxicology, Risk Assessment, Rats, Tissue Degeneration, Real-time polymerase chain reaction, medicine.anatomical_structure, Liver, Pharmaceutical Preparations, medicine, Biomarker (medicine), Animals, Pancreas, Transcriptome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d035f511764e56dbc4c0a33dd1ef1df
https://pubmed.ncbi.nlm.nih.gov/33837425

المؤلفون: Yi-Zhong Gu (9657860), Larry Handt (11580178), Katerina Vlasakova (9098095), Vasudevan Bakthavatchalu (827868), Roger Smith (10569), Guillermo E. Fernandez (11580181), Stephanie L. Born (11580184), Warren E. Glaab (9098098), Frank D. Sistare (8834348)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences not elsewhere classified, kidney biopsy, kidney safety biomarkers, monkey model, clusterin, osteopontin, kidney injury molecule 1, gene expression, drug-induced kidney injury

Relation: https://figshare.com/articles/journal_contribution/Supplemental_Material_sj-docx-1-tpx-10_1177_01926233211049171_-_Kidney_Injury_Monitoring_in_Tobramycin-Treated_Rhesus_Monkeys_Supplementing_Urinary_Kidney_Biomarkers_With_Kidney_Biopsy_Gene_Expression_Profiling/16832020

الاتاحة: https://doi.org/10.25384/sage.16832020.v1

المؤلفون: Frank D. Sistare, Sean P. Troth, Warren E. Glaab, Katerina Vlasakova

المصدر: Toxicologic pathology. 48(5)

مصطلحات موضوعية: Primates, Urinary system, Physiology, Lipocalin, Toxicology, Kidney, Pathology and Forensic Medicine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Lipocalin-2, medicine, Animals, Cystatin C, Molecular Biology, 030304 developmental biology, 0303 health sciences, Creatinine, Retinol binding protein 4, biology, Clusterin, business.industry, Cell Biology, Acute Kidney Injury, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, biology.protein, Biomarker (medicine), Cisplatin, Gentamicins, business, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010759ec4ac355eb7dcf4292328ba910
https://pubmed.ncbi.nlm.nih.gov/32633702

المؤلفون: Frank D. Sistare, Raja Mangipudy, Diann Blanset, Karyn Colman, Matthew S. Bogdanffy, David Garcia-Tapia, Thomas M. Monticello, Jacob Lesniak

المصدر: International journal of toxicology. 39(3)

مصطلحات موضوعية: Drug Industry, Drug-Related Side Effects and Adverse Reactions, 040301 veterinary sciences, Systematic survey, Carcinogenicity Tests, media_common.quotation_subject, Drug Evaluation, Preclinical, Positive control, Mice, Transgenic, Toxicology, 030226 pharmacology & pharmacy, 0403 veterinary science, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Global health, Animals, Quality (business), media_common, Animal use, Pharmaceutical industry, business.industry, Clinical study design, 04 agricultural and veterinary sciences, Disease Models, Animal, Genes, ras, Work (electrical), Risk analysis (engineering), Research Design, Carcinogens, Biological Assay, Business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6212451347521b319744728a1a42c1
https://pubmed.ncbi.nlm.nih.gov/32372678

المؤلفون: James J. Monroe, Ian Knemeyer, Robert Houle, Andreas Baudy, Frank D. Sistare, Michael J. Hafey, Raymond Evers, Jackie Shang, Qing Chen, Keith Q. Tanis

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 48(11)

مصطلحات موضوعية: Taurocholic Acid, Drug Evaluation, Preclinical, Pharmaceutical Science, ATP-binding cassette transporter, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, Inhibitory Concentration 50, 0302 clinical medicine, Cholestasis, In vivo, Drug Discovery, medicine, Humans, ABCB11, IC50, ATP Binding Cassette Transporter, Subfamily B, Member 11, Liver injury, Chemistry, medicine.disease, Bile Salt Export Pump, In vitro, Coculture Techniques, Multidrug Resistance-Associated Protein 2, 030220 oncology & carcinogenesis, Hepatocytes, Chemical and Drug Induced Liver Injury, Multidrug Resistance-Associated Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21253d6763d1c3e2f5fa4f7a61d5a63a
https://pubmed.ncbi.nlm.nih.gov/32943412