المؤلفون: Xinying Wang, Yukiko Miyazaki, Daniel Ken Inaoka, Endah Dwi Hartuti, Yoh-Ichi Watanabe, Tomoo Shiba, Shigeharu Harada, Hiroyuki Saimoto, Jeremy Nicholas Burrows, Francisco Javier Gamo Benito, Tomoyoshi Nozaki, Kiyoshi Kita

المصدر: Genes; Volume 10; Issue 6; Pages: 471

مصطلحات موضوعية: membrane protein, mitochondria, Plasmodium falciparum, energy metabolism, drug target, inhibitor screening

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Microbial Genetics and Genomics; https://dx.doi.org/10.3390/genes10060471

الاتاحة: https://doi.org/10.3390/genes10060471

المؤلفون: Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Reto Brun, Ralf Brunner, Stephan Buchmann, Jeremy Burrows, Koen J Dechering, Michael Delves, Sonja Ewerling, Santiago Ferrer, Christoph Fischli, Francisco Javier Gamo-Benito, Nina F Gnädig, Bibia Heidmann, María Belén Jiménez-Díaz, Didier Leroy, Maria Santos Martínez, Solange Meyer, Joerg J Moehrle, Caroline L Ng, Rintis Noviyanti, Andrea Ruecker, Laura María Sanz, Robert W Sauerwein, Christian Scheurer, Sarah Schleiferboeck, Robert Sinden, Christopher Snyder, Judith Straimer, Grennady Wirjanata, Jutta Marfurt, Ric N Price, Thomas Weller, Walter Fischli, David A Fidock, Martine Clozel, Sergio Wittlin

المصدر: PLoS Medicine, Vol 13, Iss 10, p e1002138 (2016)

مصطلحات موضوعية: Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1549-1277; https://doaj.org/toc/1549-1676

URL الوصول: https://doaj.org/article/c760742987d34859b710bc8b89e29d3c

المؤلفون: Xinying, Wang, Yukiko, Miyazaki, Daniel Ken, Inaoka, Endah Dwi, Hartuti, Yoh-Ichi, Watanabe, Tomoo, Shiba, Shigeharu, Harada, Hiroyuki, Saimoto, Jeremy Nicholas, Burrows, Francisco Javier Gamo, Benito, Tomoyoshi, Nozaki, Kiyoshi, Kita

المصدر: Genes

مصطلحات موضوعية: Plasmodium berghei, Plasmodium falciparum, Malaria, Cerebral, Malates, Quinones, inhibitor screening, Gene Expression Regulation, Enzymologic, Article, drug target, Mitochondria, Antimalarials, Mice, parasitic diseases, energy metabolism, Animals, Humans, membrane protein, Enzyme Inhibitors, Malaria, Falciparum, Oxidoreductases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f429f65813beb879861a288c4f1f716b
https://pubmed.ncbi.nlm.nih.gov/31234346

المؤلفون: Emily R. Derbyshire, Rene Raphemot, Francisco Javier Gamo-Benito, Maria J. Lafuente-Monasterio, Jon Clardy

المصدر: Antimicrobial Agents and Chemotherapy. 60:1430-1437

مصطلحات موضوعية: 0301 basic medicine, Oxidoreductases Acting on CH-CH Group Donors, Plasmodium berghei, Plasmodium falciparum, Dihydroorotate Dehydrogenase, Drug Evaluation, Preclinical, Drug resistance, Pharmacology, Plasmodium, Animals, Genetically Modified, Small Molecule Libraries, Antimalarials, 03 medical and health sciences, parasitic diseases, Anopheles, medicine, Animals, Humans, Parasite hosting, Experimental Therapeutics, Pharmacology (medical), Molecular Targeted Therapy, biology, Hep G2 Cells, biology.organism_classification, medicine.disease, Virology, Genetically modified organism, 030104 developmental biology, Infectious Diseases, Malaria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8c1ec4a0291e6932d2d12b6455360a
https://doi.org/10.1128/aac.02110-15

المؤلفون: Thomas Weller, Jeremy N. Burrows, David A. Fidock, Sergio Wittlin, Rintis Noviyanti, Robert W. Sauerwein, Grennady Wirjanata, Robert E. Sinden, María Santos Martínez, Christoph Binkert, Christopher Snyder, Nina F. Gnädig, Stephan Buchmann, Ruben de Kanter, Andrea Ruecker, Christoph Fischli, Michael J. Delves, Joerg J. Moehrle, Iñigo Angulo-Barturen, Koen J. Dechering, Christian Scheurer, Francisco Javier Gamo Benito, Solange Meyer, Laura M. Sanz, Christoph Boss, Sarah Schleiferboeck, Martine Clozel, Sonja Ewerling, Caroline L. Ng, Reto Brun, María Belén Jiménez-Díaz, Didier Leroy, Jutta Marfurt, Santiago Ferrer, Walter Fischli, Amélie Le Bihan, Judith Straimer, Bibia Heidmann, Ric N. Price, Ralf Brunner

المساهمون: Medicines for Malaria Venture

المصدر: Plos Medicine, 13, e1002138
Plos Medicine, 13, 10, pp. e1002138
PLoS Medicine
PLoS Medicine, Vol 13, Iss 10, p e1002138 (2016)

مصطلحات موضوعية: 0301 basic medicine, Plasmodium, Physiology, Plasmodium berghei, Plasmodium vivax, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Pharmacology, Gametocytes, Piperazines, Mice, Animal Cells, Mice, Inbred NOD, Medicine and Health Sciences, Artemisinin, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Protozoans, biology, Pharmaceutics, Malarial Parasites, Drugs, General Medicine, 11 Medical And Health Sciences, Animal Models, Hematology, Artemisinins, 3. Good health, Body Fluids, Blood, Medicine, Female, Cellular Types, Anatomy, Multidrug Resistance-Associated Proteins, medicine.drug, Research Article, Combination therapy, 030106 microbiology, Plasmodium falciparum, Cmax, Mouse Models, Microbial Sensitivity Tests, Research and Analysis Methods, 03 medical and health sciences, Antimalarials, Model Organisms, Dose Prediction Methods, General & Internal Medicine, Parasite Groups, parasitic diseases, medicine, Gametocyte, Parasitic Diseases, Animals, Humans, Acrylamides, Dose-Response Relationship, Drug, Organisms, Biology and Life Sciences, Cell Biology, biology.organism_classification, Tropical Diseases, Parasitic Protozoans, Malaria, Germ Cells, Pharmacodynamics, Parasitology, Apicomplexa

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81f5d3e85fe3cd56c12d27168761c39
https://edoc.unibas.ch/44422/

المؤلفون: Rosemary Rochford, Kristina S. Wickham, Xavier C. Ding, David A. Fidock, Margaret A. Phillips, Thomas Rueckle, Sandra March, Brice Campo, Anna Marie Zeeman, Andrea Ruecker, Iñigo Angulo-Barturen, Xiaoyi Deng, Sergio Wittlin, Michael J. Delves, Farah El Mazouni, Susan A. Charman, Diana R. Tomchick, Laura Maria Sanz Alonso, Jacqueline W. Njoroge, Robert E. Sinden, Jeremy N. Burrows, Ian Bathhurst, Anthony Dayan, Lalitha V. Iyer, Trevor Laird, Koen J. Dechering, Caroline L. Ng, Sandra Duffy, Janet Gahagen, Jon C. Mirsalis, M. John Rogers, Kennan C. Marsh, Yanbin Lao, Pradipsinh K. Rathod, James B. Louttit, Santiago Ferrer Bazaga, Julie Lotharius, Yi Cui, Sreekanth Kokkonda, Francisco Javier Gamo Benito, Arun Sridhar, John H. White, María Santos Martínez, Maria J. Lafuente-Monasterio, María Belén Jiménez-Díaz, John N. Haselden, Sangeeta N. Bhatia, Didier Leroy, Robert W. Sauerwein, Clemens H. M. Kocken, Vicky M. Avery, Ed Riccio, Karen L. White

المساهمون: Institute for Medical Engineering and Science, Harvard University--MIT Division of Health Sciences and Technology, Bhatia, Sangeeta N, March-Riera, Sandra

المصدر: Science Translational Medicine, 7, 296, pp. 296ra111
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
PMC
Science Translational Medicine, 7, 296ra111

مصطلحات موضوعية: Drug, Oxidoreductases Acting on CH-CH Group Donors, media_common.quotation_subject, Molecular Sequence Data, Plasmodium falciparum, Dihydroorotate Dehydrogenase, Drug Evaluation, Preclinical, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Administration, Oral, Mice, SCID, Pharmacology, Crystallography, X-Ray, Article, Substrate Specificity, Antimalarials, Inhibitory Concentration 50, Mice, 03 medical and health sciences, Dogs, Pharmacokinetics, Mice, Inbred NOD, medicine, Animals, Humans, Enzyme Inhibitors, Malaria, Falciparum, 030304 developmental biology, Dihydroorotate Dehydrogenase Inhibitor, media_common, 0303 health sciences, biology, 030306 microbiology, Biological activity, Haplorhini, General Medicine, Triazoles, Oxidoreductase inhibitor, medicine.disease, biology.organism_classification, 3. Good health, Pyrimidines, Area Under Curve, Dihydroorotate dehydrogenase, Rabbits, Caco-2 Cells, Malaria

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fcc77c46ef071db2bb33bf845ab1ab
https://doi.org/10.1126/scitranslmed.aaa6645

المؤلفون: R. Kiplin Guy, Santiago Ferrer-Bazaga, Tanya Parkinson, Iñigo Angulo-Barturen, Francisco Javier Gamo-Benito, Michele Connelly, Sandra Duffy, Julie Lotharius, Julie Clark, Balachandra Bandodkar, Nikhil Rautela, Jörg J. Möhrle, Pavithra Viswanath, Timothy N. C. Wells, Sowmya Bharath, Vicky M. Avery

المصدر: Malaria Journal

مصطلحات موضوعية: Male, Drug, Candidate drug re-profiling, medicine.drug_class, Plasmodium berghei, Medicina, media_common.quotation_subject, Plasmodium falciparum, Anti-malarial drugs, Biology, Pharmacology, Antimalarials, Mice, Parasitic Sensitivity Tests, In vitro, In vivo, medicine, Animals, Malaria, Falciparum, Biología y Biomedicina, media_common, Mice, Inbred BALB C, Research, Drug repositioning, in vitro, Protein kinase inhibitor, biology.organism_classification, Malaria, in vivo, Infectious Diseases, Humanized mouse, Parasitology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca663113f92c210767ce7fb50e7460e9
https://hdl.handle.net/10016/37901

المؤلفون: Marcus Bantscheff, Sonja Ghidelli-Disse, Leslie J. Street, Kelly Chibale, Yassir Younis, Tanya Paquet, Francisco Javier Gamo-Benito, Maria Jose Lafuente-Monasterio, Gerard Drewes, Michael J Witty, David Waterson

المساهمون: Department of Chemistry, Faculty of Science

المصدر: Malaria Journal

مصطلحات موضوعية: Veterinary medicine, Kinase, Chemistry, Drug discovery, Antiparasitic, medicine.drug_class, antimalarial drugs, Sepharose, Infectious Diseases, Biochemistry, Poster Presentation, medicine, Amine gas treating, Chemoproteomics, Parasitology, Linker, Function (biology), resistant parasites

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03feacd8438806fcfe3a6993f9d121e0