المؤلفون: Matthew D. Hill, Maria-Jesus Blanco, Francesco G. Salituro, Zhu Bai, Jacob T. Beckley, Michael A. Ackley, Jing Dai, James J. Doherty, Boyd L. Harrison, Ethan C. Hoffmann, Tatiana M. Kazdoba, David Lanzetta, Michael Lewis, Michael C. Quirk, Albert J. Robichaud

المصدر: Journal of Medicinal Chemistry. 65:9063-9075

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::55c17424c1aec1450e3aa6abf75d1774
https://doi.org/10.1021/acs.jmedchem.2c00313

المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d97954935b2f34d5dfe50e66a1f7f5
https://doi.org/10.1158/2159-8290.22531945.v1

المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd472a11c8ff29b3f26438ea494ea5d
https://doi.org/10.1158/2159-8290.22531936

المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9f6f1fb6d2a1049263137b504fc3a
https://doi.org/10.1158/2159-8290.22531939

المؤلفون: Ronald W Irwin, Christine M Solinsky, Carlos M Loya, Francesco G Salituro, Kathleen E Rodgers, Gerhard Bauer, Michael A Rogawski, Roberta Diaz Brinton

المصدر: PLoS ONE, Vol 10, Iss 6, p e0128313 (2015)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/040fc371d0ab4f1ca16b64dd413384d7

المؤلفون: James J. Doherty, Michael A. Ackley, Ethan Hoffmann, Tatiana M. Kazdoba, Zhu Bai, Boyd L. Harrison, Albert J. Robichaud, Andrew Griffin, Mike Lewis, Gabriel Martinez Botella, Francesco G. Salituro, Daniel S. La, Jing Dai, Michael Quirk

المصدر: Journal of Medicinal Chemistry. 62:7526-7542

مصطلحات موضوعية: Allosteric modulator, Neuroactive steroid, Chemistry, Drug Discovery, Allosteric regulation, Molecular Medicine, NMDA receptor, Structure–activity relationship, Biological activity, Long-term potentiation, Pharmacology, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d85c93f6e01f9e02e46c0fd48ba0202c
https://doi.org/10.1021/acs.jmedchem.9b00591

المؤلفون: Kirsten C Verhein, Francesco G Salituro, Mark W Ledeboer, Allison D Fryer, David B Jacoby

المصدر: PLoS ONE, Vol 8, Iss 9, p e75351 (2013)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3776780?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/66ce2464328b48c3bdcfa9e5346a7270

المؤلفون: Hua Yang, Muriel D. David, Jeffrey O. Saunders, Lemieux Rene M, Gui Yao, Luke Utley, Véronique Saada, Xiaobing Lv, Yue Chen, Fang Wang, Shengfang Jin, Ping Chen, Erin Artin, Stéphane de Botton, Cheng Fang, Hyeryun Kim, Giovanni Cianchetta, Stefan Gross, Lenny Dang, Zhenwei Cai, Scott A. Biller, Andrew J. Olaharski, Erica Tobin, Cui Dawei, Katharine E. Yen, Virginie Penard-Lacronique, Liping Yan, Ding Zhou, Lee Silverman, Cyril Quivoron, Zhiyong Luo, Jeremy Travins, Janeta Popovici-Muller, Shinsan M. Su, Kimberly Straley, Zhiwei Gu, Francesco G. Salituro

المصدر: ACS Medicinal Chemistry Letters

مصطلحات موضوعية: mutant IDH1, 0301 basic medicine, Letter, IDH1, ivosidenib, Cellular differentiation, Point mutation, Organic Chemistry, Mutant, 2-hydroxyglutarate, Biology, Biochemistry, AG-120, 03 medical and health sciences, differentiation therapy, 030104 developmental biology, 0302 clinical medicine, Isocitrate dehydrogenase, Differentiation therapy, 030220 oncology & carcinogenesis, Drug Discovery, Cancer cell, Cancer research, isocitrate dehydrogenase, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0eaa35709cac29ca18fde3960dca69
https://doi.org/10.1021/acsmedchemlett.7b00421

المؤلفون: Francesco G. Salituro, Caitlin A. Newman, Maria-Jesus Blanco, Boyd L. Harrison, Quinn Coughlin, Daniel La, Andrew Griffin

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:61-70

مصطلحات موضوعية: 0301 basic medicine, Neuroactive steroid, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Receptors, N-Methyl-D-Aspartate, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Central Nervous System Diseases, Drug Discovery, Animals, Humans, Receptor, Molecular Biology, Neurotransmitter Agents, Dose-Response Relationship, Drug, Chemistry, GABAA receptor, Drug discovery, Organic Chemistry, Glutamate receptor, Receptors, GABA-A, 030104 developmental biology, nervous system, Molecular Medicine, NMDA receptor, Signal transduction, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d135b8adc8e1a60374c554f57b2196
https://doi.org/10.1016/j.bmcl.2017.11.043

المؤلفون: Francesco G. Salituro, Gabriel Martinez Botella, James J. Doherty, Rebecca S. Hammond, Alison L. Althaus, Carla Maciag, Albert J. Robichaud, Michael A. Ackley

المصدر: Epilepsy Research. 134:16-25

مصطلحات موضوعية: Male, 0301 basic medicine, Allosteric modulator, Neuroactive steroid, medicine.medical_treatment, Action Potentials, Convulsants, Pregnanolone, Pharmacology, Hippocampus, Rats, Sprague-Dawley, Fragile X Mental Retardation Protein, Mice, 03 medical and health sciences, Epilepsy, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Seizures, Convulsion, Kindling, Neurologic, Potassium Channel Blockers, medicine, Animals, gamma-Aminobutyric Acid, Mice, Knockout, Electroshock, GABAA receptor, Allopregnanolone, medicine.disease, Rats, Disease Models, Animal, 030104 developmental biology, Anticonvulsant, Neurology, Mechanism of action, chemistry, Pentylenetetrazole, Anticonvulsants, Neurology (clinical), medicine.symptom, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ebdf33e1a2544115114f31f08ce039
https://doi.org/10.1016/j.eplepsyres.2017.05.001

المؤلفون: Olivia Bawa, Monika Pilichowska, Paule Opolon, Jeffrey O. Saunders, Fang Wang, Cyril Quivoron, Anil K. Padyana, Zenon D. Konteatis, Kimberly Straley, Erica Tobin, Sophie Broutin, Marion Dorsch, Hua Yang, Byron DeLaBarre, Jeremy Travins, Sung Choe, Yue Chen, Lei Jin, Wentao Wei, Virginie Penard-Lacronique, Raj Nagaraja, Wei Liu, Lenny Dang, Shengfang Jin, Cheng Fang, Lee Silverman, Fan Jiang, Katharine E. Yen, Giovanni Cianchetta, Olivier Bernard, Erin Artin, Muriel D. David, Shin-San Michael Su, Stefan Gross, Francesco G. Salituro, Véronique Saada, Stéphane de Botton, Scott A. Biller, Angelo Paci, Benoit S. Marteyn, Yingxia Xu

المساهمون: Agios Pharmaceuticals, Hématopoïèse normale et pathologique (U1170 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Institut Gustave Roussy (IGR), Plateforme d’évaluation préclinique (PFEP), Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pharmacologie, Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Laboratoire de thérapie cellulaire, Département de médecine oncologique [Gustave Roussy], Pathogénie microbienne moléculaire, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Tufts Medical Center, ShangPharma, Viva Biotech Ltd., This work was funded by Agios Pharmaceuticals, Inc., the French National Institute of Health (INSERM-AVIESAN), the National Cancer Institute (INCa-DGOS-Inserm_6043 and INCa 2012-1-RT-09), and the Fondation Association pour la Recherche sur le Cancer (ARC, SL220130607089 Programme Labellisé to V. Penard-Lacronique and S. de Botton). M.D. David is funded by a fellowship from the Institut National du Cancer (INCa-DGOS_5733).

المصدر: Cancer Discovery
Cancer Discovery, American Association for Cancer Research, 2017, 7 (5), pp.478-493. ⟨10.1158/2159-8290.CD-16-1034⟩

مصطلحات موضوعية: 0301 basic medicine, Myeloid, IDH1, Cellular differentiation, Myeloid leukemia, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Enasidenib, medicine.disease, Molecular biology, IDH2, 03 medical and health sciences, Leukemia, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Isocitrate dehydrogenase, Oncology, 030220 oncology & carcinogenesis, medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5319b71d47ef568ebb071e758566cc
https://doi.org/10.1158/2159-8290.cd-16-1034

المؤلفون: Alison L, Althaus, Michael A, Ackley, Gabriel M, Belfort, Steven M, Gee, Jing, Dai, David P, Nguyen, Tatiana M, Kazdoba, Amit, Modgil, Paul A, Davies, Stephen J, Moss, Francesco G, Salituro, Ethan, Hoffmann, Rebecca S, Hammond, Albert J, Robichaud, Michael C, Quirk, James J, Doherty

المصدر: Neuropharmacology

مصطلحات موضوعية: Male, Binding Sites, Diazepam, Neuroactive steroid, GABAA receptor, Brain, Drug Synergism, Electroencephalography, Pregnanes, Hippocampus, Antidepressive Agents, Article, Rats, Sprague-Dawley, Mice, Receptors, GABA, Seizures, Animals, Humans, Pyrazoles, Anticonvulsants, Steroids, GABA-A Receptor Agonists, Positive allosteric modulator, GABA Modulators, gamma-Aminobutyric Acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::803df3ac66651e96237254d26cf7e615
https://pubmed.ncbi.nlm.nih.gov/32976892

المؤلفون: Maria-Jesus Blanco, Bingsong Han, Francesco G. Salituro

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Allosteric modulator, 010405 organic chemistry, GABAA receptor, Drug discovery, Organic Chemistry, Allosteric regulation, 01 natural sciences, Biochemistry, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Nuclear receptor, Drug Discovery, Neuroscience, Maraviroc, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54908045e3234932e018a3ba35b01717
https://pubmed.ncbi.nlm.nih.gov/33062158

المؤلفون: Daniel S, La, Francesco G, Salituro, Gabriel, Martinez Botella, Andrew M, Griffin, Zhu, Bai, Michael A, Ackley, Jing, Dai, James J, Doherty, Boyd L, Harrison, Ethan C, Hoffmann, Tatiana M, Kazdoba, Michael C, Lewis, Michael C, Quirk, Albert J, Robichaud

المصدر: Journal of medicinal chemistry. 62(16)

مصطلحات موضوعية: Male, Molecular Structure, Long-Term Potentiation, Age Factors, Hippocampus, Methylation, Receptors, N-Methyl-D-Aspartate, Structure-Activity Relationship, Cognition, Allosteric Regulation, Animals, Humans, Rats, Wistar, Neurosteroids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::8edd1a5945ab2bc16424985f2d7c6fb6
https://pubmed.ncbi.nlm.nih.gov/31390523

المؤلفون: Paul Davies, Albert J. Robichaud, Ethan Hoffmann, James J. Doherty, Tatiana M. Kazdoba, Amit Modgil, Steven M. Gee, Stephen J. Moss, Rebecca S. Hammond, Gabriel M. Belfort, Alison L. Althaus, David P. Nguyen, Jing Dai, Michael Quirk, Francesco G. Salituro, Michael A. Ackley

المصدر: Neuropharmacology. 181:108333

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, GABAA receptor positive allosteric modulator, Benzodiazepine, Neuroactive steroid, Chemistry, medicine.drug_class, GABAA receptor, Central nervous system, 03 medical and health sciences, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, Metabotropic receptor, medicine.anatomical_structure, Slice preparation, medicine, Receptor, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::99890c8b94a6266c6c6c30159fa25bcf
https://doi.org/10.1016/j.neuropharm.2020.108333

المؤلفون: Zhu Bai, Scott J. Grossman, Jiamiao Wang, Richard Thomas Beresis, Ethan Hoffmann, Gabriel Martinez Botella, Carlos M. Loya, Kaisheng Shen, Francesco G. Salituro, Albert J. Robichaud, Boyd L. Harrison, Michael A. Ackley, Shiling Jia, Gabriel M. Belfort, James J. Doherty

المصدر: Journal of Medicinal Chemistry. 58:3500-3511

مصطلحات موضوعية: Neuroactive steroid, Stereochemistry, Allosteric regulation, Central nervous system, Pregnanolone, Pharmacology, Aminobutyric acid, Mice, Structure-Activity Relationship, Allosteric Regulation, Receptors, GABA, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Receptor, Neurotransmitter Agents, Chemistry, GABAA receptor, musculoskeletal, neural, and ocular physiology, Rats, medicine.anatomical_structure, nervous system, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526fcbe06be37d20a154344dc5f6e61e
https://doi.org/10.1021/acs.jmedchem.5b00032

المؤلفون: James J. Doherty, Y. Ueyama, Gabriel M. Belfort, Albert J. Robichaud, W.W. Muir, Jing Dai, Francesco G. Salituro, B.L. Youngblood, R.H. Hammond

المصدر: Journal of neuroscience methods. 305

مصطلحات موضوعية: Male, Neuroactive steroid, Consciousness, 040301 veterinary sciences, Sedation, Conscious Sedation, Pilot Projects, 0403 veterinary science, 03 medical and health sciences, 0302 clinical medicine, Level of consciousness, Dogs, 030202 anesthesiology, Medicine, Animals, Hypnotics and Sedatives, Propofol, Anesthetics, Dose-Response Relationship, Drug, business.industry, General Neuroscience, Cardiorespiratory fitness, 04 agricultural and veterinary sciences, Alertness, Anesthesia, Bispectral index, Anesthetic, Administration, Intravenous, Steroids, medicine.symptom, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f160f4a7bb8d81962d33da8d3579869
https://pubmed.ncbi.nlm.nih.gov/29772269

المؤلفون: Yingxia Xu, Shin-San Michael Su, Zhiwei Gu, Scott A. Biller, Charles Kung, Xiaobing Lv, Cheng Fang, Collin Hill, Yaguang Si, Zhiyong Luo, Penelope A. Kosinski, Francesco G. Salituro, Lenny Dang, Huachun Tang, Hua Yang, Lee Silverman, Kendall Johnson, Janeta Popovici-Muller, Gui Yao, Jeff Hixon, Gavin Histen, Stefan Gross, Yue Chen, Byron DeLaBarre, Giovanni Cianchetta

مصطلحات موضوعية: Hemolytic anemia, Erythrocytes, Anemia, Immunology, Allosteric regulation, Pyruvate Kinase, Enzyme Activators, Pharmacology, Biology, Pyruvate Metabolism, Inborn Errors, Biochemistry, Piperazines, 03 medical and health sciences, Mice, 0302 clinical medicine, Red Cells, Iron, and Erythropoiesis, medicine, Animals, Humans, Glycolysis, chemistry.chemical_classification, Sulfonamides, Cell Biology, Hematology, Anemia, Hemolytic, Congenital Nonspherocytic, medicine.disease, Molecular biology, Recombinant Proteins, Tissue Donors, Enzyme Activation, Kinetics, Enzyme, chemistry, 030220 oncology & carcinogenesis, Quinolines, Pyruvate kinase, Ex vivo, 030215 immunology, Pyruvate kinase deficiency

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb277a9c117d8e84c9102a59b1821f1f
https://europepmc.org/articles/PMC5609468/

المؤلفون: Ethan Hoffmann, Carlos M. Loya, Albert J. Robichaud, Boyd L. Harrison, Richard Thomas Beresis, Jing Dai, Gabriel M. Belfort, Alison L. Althaus, Michael A. Ackley, James J. Doherty, Maria-Jesus Blanco, Zhu Bai, Scott J. Grossman, Francesco G. Salituro, Gabriel Martinez Botella

المصدر: Journal of medicinal chemistry. 60(18)

مصطلحات موضوعية: 0301 basic medicine, Pregnan-20-one, medicine.medical_specialty, Allosteric modulator, Neuroactive steroid, Allosteric regulation, Pregnanolone, Pharmacology, Aminobutyric acid, Depression, Postpartum, 03 medical and health sciences, Mice, 0302 clinical medicine, Allosteric Regulation, Internal medicine, Drug Discovery, medicine, Animals, GABA-A Receptor Agonists, Receptor, Depressive Disorder, Major, Chemistry, GABAA receptor, Receptors, GABA-A, Rats, 030104 developmental biology, Endocrinology, Molecular Medicine, Pyrazoles, Female, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92adadab7380c7344ed988b15618ea47
https://pubmed.ncbi.nlm.nih.gov/28753313

المؤلفون: Shunqi Yan, Scott A. Biller, Fang Wang, David P. Schenkein, Marion Dorsch, Shinsan M. Su, Jeffrey O. Saunders, Jeremy Travins, Wentao Wei, Kimberly Straley, Wei Liu, Stefan Gross, Camelia Gliser, Lenny Dang, Elena Mylonas, Hua Yang, Sam Agresta, Erica Hansen, Véronique Saada, Stéphane de Botton, Byron DeLaBarre, Katharine E. Yen, Janeta Popovici-Muller, Stuart Murray, Erin Artin, Stefanie Schalm, Cyril Quivoron, Andrew Kernytsky, Virginie Penard-Lacronique, Yi Gao, Francesco G. Salituro

المصدر: Science. 340:622-626

مصطلحات موضوعية: Leukemia, Multidisciplinary, IDH1, Differentiation therapy, Cellular differentiation, Allosteric regulation, Cancer cell, Mutant, medicine, Biology, Enasidenib, medicine.disease, Molecular biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::29fb3aa7882e5c926f2b401241cd644f
https://doi.org/10.1126/science.1234769