المؤلفون: Jiménez-Alesanco, Ana, Eckhard, Ulrich, Asencio del Río, Marta, Vega, Sonia, Guevara, Tibisay, Velázquez-Campoy, Adrián, Gomis-Rüth, F. Xavier, Abian, Olga

المساهمون: Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), Fundació La Marató de TV3, Gobierno de Aragón, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), European Commission

مصطلحات موضوعية: Allosteric inhibitors, Bacteroides fragilis, Drug repurposing, Fragilysin, Molecular experimental screening, Zinc-dependent metalloproteases

وصف الملف: application/pdf

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107725RB-I00/ES/BIOQUIMICA DE LA PROTEOLISIS: FUNCION, REGULACION Y ESTRUCTURA DE PEPTIDASAS DE RELEVANCIA BIOMEDICA O BIOTECNOLOGICA Y DE SUS INHIBIDORES/; info:eu-repo/grantAgreement/MINECO//BFU2016-78232-P; Publisher's version; http://dx.doi.org/10.1002/pro.4427; Sí; e-issn: 1469-896X; Protein Science 31(10): e4427 (2022); http://hdl.handle.net/10261/288530; http://dx.doi.org/10.13039/501100011033; http://dx.doi.org/10.13039/501100004587; http://dx.doi.org/10.13039/501100010067; http://dx.doi.org/10.13039/100008666; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100003329

الاتاحة: http://hdl.handle.net/10261/288530
https://doi.org/10.1002/pro.4427
https://doi.org/10.13039/501100011033
https://doi.org/10.13039/501100004587
https://doi.org/10.13039/501100010067
https://doi.org/10.13039/100008666
https://doi.org/10.13039/501100000780
https://doi.org/10.13039/501100003329

المؤلفون: Walter J. Lukiw

المصدر: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

مصطلحات موضوعية: Alzheimer's disease (AD), Bacteroides fragilis and BFT (fragilysin), dysbiosis, lipopolysaccharide (LPS), microbiome and microbial genetics, neurofilament light (NF-L), Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcimb.2020.00022/full; https://doaj.org/toc/2235-2988

URL الوصول: https://doaj.org/article/d90c6177e3b44262b7bec56ab377ce0e

المؤلفون: Ana Jimenez‐Alesanco, Ulrich Eckhard, Marta Asencio del Rio, Sonia Vega, Tibisay Guevara, Adrian Velazquez‐Campoy, Francesc Xavier Gomis‐Rüth, Olga Abian

المساهمون: Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), Fundació La Marató de TV3, Gobierno de Aragón, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), European Commission

مصطلحات موضوعية: Enzyme Precursors, Virulence Factors, Molecular experimental screening, Bacterial Toxins, Drug repurposing, Metalloendopeptidases, Fragilysin, Bacterial Infections, Biochemistry, Anti-Bacterial Agents, Bacteroides fragilis, Zinc-dependent metalloproteases, Humans, Allosteric inhibitors, Molecular Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e534a972551c53b55b3cb913fa450bc8
http://hdl.handle.net/10261/288530

المؤلفون: Ezequiel Valguarnera, Juliane Bubeck Wardenburg

المصدر: Journal of Molecular Biology. 432:765-785

مصطلحات موضوعية: Proteomics, Population, Enterotoxin, Biology, Gut flora, Microbiology, Bacteroides fragilis, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Animals, Humans, Metabolomics, education, Molecular Biology, 030304 developmental biology, 0303 health sciences, education.field_of_study, Genomics, biology.organism_classification, Fragilysin, Commensalism, Microscopy, Electron, Bacteroides, Asymptomatic carrier, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190678b91f5023c414bc244a9f2b7c2c
https://doi.org/10.1016/j.jmb.2019.12.003

المؤلفون: Fatima Khodakhast, Ameerah AlAzmi, Jόzsef Sόki, Wafaa Jamal, Ghayda Al-Hashem, Vincent O. Rotimi

المصدر: BMC Microbiology, Vol 20, Iss 1, Pp 1-7 (2020)
BMC Microbiology

مصطلحات موضوعية: Microbiology (medical), Male, Imipenem, Bacterial Toxins, lcsh:QR1-502, Tigecycline, Microbial Sensitivity Tests, Biology, Enterotoxin, Amoxicillin-Potassium Clavulanate Combination, Microbiology, Meropenem, lcsh:Microbiology, Bacteroides fragilis, 03 medical and health sciences, Cefoxitin, Feces, Metronidazole, Sepsis, Drug Resistance, Bacterial, medicine, Prevalence, Humans, Prospective Studies, Respiratory Tract Infections, 030304 developmental biology, Piperacillin, 0303 health sciences, 030306 microbiology, Clindamycin, Fragilysin, biology.organism_classification, Bacteroides Infections, Carbapenem-resistance, Anti-Bacterial Agents, Kuwait, Wound Infection, Female, medicine.drug, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537b1918263e7cda8c7320250ee06116
https://doaj.org/article/ad4bacfe74f047ce97ecd957df238487

المؤلفون: KARAHASAN, AYŞEGÜL, GÜLLÜOĞLU, MAHMUT BAHADIR, ÜLGER, NURVER

المساهمون: Toprak, N. Ulger, Yagci, A., Gulluoglu, B. M., Akin, M. L., Demirkalem, P., Celenk, T., Soyletir, G.

مصطلحات موضوعية: Bacteroides fragilis, bft gene, colorectal cancer, enterotoxin, fragilysin, PCR, INTESTINAL EPITHELIAL-CELLS, INFLAMMATORY-BOWEL-DISEASE, EXPRESSION, CHILDREN, METALLOPROTEASE, SECRETION, DIARRHEA, PROTEIN, TOXIN, IL-8

وصف الملف: application/pdf

Relation: CLINICAL MICROBIOLOGY AND INFECTION; https://hdl.handle.net/11424/241725; WOS:000238654600011

الاتاحة: https://hdl.handle.net/11424/241725
https://doi.org/10.1111/j.1469-0691.2006.01494.x

المؤلفون: Aaron L. Hecht, Wei Ping Teoh, Juliane Bubeck Wardenburg, Julien Herrou, Jerrold R. Turner, Vivian M. Choi, Sean Crosson

المصدر: Nature medicine

مصطلحات موضوعية: 0301 basic medicine, Proteases, medicine.medical_treatment, Bacterial Toxins, Blotting, Western, Virulence, Fluorescent Antibody Technique, Bacteremia, Enterotoxin, Crystallography, X-Ray, General Biochemistry, Genetics and Molecular Biology, Article, Microbiology, Sepsis, Bacteroides fragilis, 03 medical and health sciences, Bacteria, Anaerobic, Mice, Bacterial Proteins, Cysteine Proteases, medicine, Animals, Protease, biology, Metalloendopeptidases, General Medicine, biology.organism_classification, Fragilysin, medicine.disease, Bacteroides Infections, Colitis, 030104 developmental biology, Bacteroides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e06be121f60f749aa86fa7f1ada510
http://europepmc.org/articles/PMC4860040

المؤلفون: Paul Metz, Martijn J. H. Tjan, Shaoguang Wu, Mehrosh Pervaiz, Susanne Hermans, Aishwarya Shettigar, Cynthia L. Sears, Tina Ritschel, Bas E. Dutilh, Annemarie Boleij

المساهمون: Sub Bioinformatics, Theoretical Biology and Bioinformatics

المصدر: Frontiers in cellular and infection microbiology, 9. Frontiers Media S.A.
Frontiers in Cellular and Infection Microbiology, 9
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)

مصطلحات موضوعية: 0301 basic medicine, Cell, lcsh:QR1-502, Molecular Conformation, Bacteriodes fragilis enterotoxin, lcsh:Microbiology, chemistry.chemical_compound, Cellular and Infection Microbiology, Chenodeoxycholic acid, Drug Discovery, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], computational drug design and discovery, Original Research, enterotoxigenic Bacteroides fragilis (ETBF), Drug discovery, Metalloendopeptidases, Fragilysin, inflammatory bowel disease (IBD), 3. Good health, Molecular Docking Simulation, Drug repositioning, Infectious Diseases, medicine.anatomical_structure, Cell Transformation, Neoplastic, chenodeoxycholic acid, Bacteroides fragilis, Bacteroides fragilis enterotoxin, Protein Binding, Microbiology (medical), In silico, 030106 microbiology, Immunology, colorectal cancer, Biology, Molecular Dynamics Simulation, Microbiology, 03 medical and health sciences, Structure-Activity Relationship, All institutes and research themes of the Radboud University Medical Center, medicine, Humans, bacterial toxin, Secretion, drug screening, Toxins, Biological, Drug Repositioning, biology.organism_classification, Gastrointestinal Microbiome, Endotoxins, 030104 developmental biology, chemistry, Cancer research, Carcinogens

وصف الملف: image/pdf; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d432db37c28727b7915a7ebae06e60c
https://dspace.library.uu.nl/handle/1874/388154

المؤلفون: Huizi Tan, Zhiming Yu, Chen Wang, Qingsong Zhang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei Chen

المصدر: Frontiers in Genetics, Vol 9 (2018)

مصطلحات موضوعية: 0301 basic medicine, antibiotic resistance, lcsh:QH426-470, 030106 microbiology, Virulence, Biology, Bacteroides ovatus, Microbiology, law.invention, 03 medical and health sciences, Probiotic, Antibiotic resistance, Plasmid, In vivo, law, Genetics, Genetics (clinical), virulence genes, safety evaluation, Fragilysin, next-generation probiotics, Acute toxicity, In vitro, lcsh:Genetics, 030104 developmental biology, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5ee94c5d0acac612edccf2a4c609d6
https://doi.org/10.3389/fgene.2018.00539

المؤلفون: Cheng-Bei Zhou, Jing-Yuan Fang

المصدر: Critical reviews in microbiology. 44(4)

مصطلحات موضوعية: 0301 basic medicine, Cytolethal distending toxin, Colorectal cancer, Microbial metabolism, Biology, Applied Microbiology and Biotechnology, Microbiology, 03 medical and health sciences, Microbial ecology, medicine, Animals, Humans, Intestinal Mucosa, chemistry.chemical_classification, Bacteria, Host (biology), General Medicine, Metabolism, Fragilysin, medicine.disease, digestive system diseases, Amino acid, Gastrointestinal Microbiome, 030104 developmental biology, chemistry, Cancer research, Colorectal Neoplasms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203376e1c65a16265f633d0a359d19ad
https://pubmed.ncbi.nlm.nih.gov/29359994

المؤلفون: Norihito Muranaka, Andrei V. Chernov, Albert G. Remacle, Corey M. Dambacher, Muskan Kukreja, Petr Čapek, Khatereh Motamedchaboki, Piotr Cieplak, Igor A. Kozlov, Vladislav S. Golubkov, Manuel Perucho, Alex Y. Strongin, Sergey A. Shiryaev

المصدر: Journal of Biological Chemistry. 288:34956-34967

مصطلحات موضوعية: Genomic Islands, Proteolysis, Virulence, Matrix metalloproteinase, Biochemistry, Substrate Specificity, Bacteroides fragilis, Neoplasms, medicine, Humans, Amino Acid Sequence, Molecular Biology, Peptide sequence, Inflammation, Metalloproteinase, biology, medicine.diagnostic_test, Microbiota, food and beverages, Metalloendopeptidases, Molecular Bases of Disease, Cell Biology, biology.organism_classification, Fragilysin, Molecular biology, Matrix Metalloproteinase 2, Proprotein Convertases, Bacteroides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635cd6d997f35e5ffa0af735146cf144
https://doi.org/10.1074/jbc.m113.516153

المؤلفون: Dmitry G. Alexeev, Ilya Altukhov, Daria Kharlampieva, Oleg V. Podgorny, Vadim M. Govorun, Sergey Kovalchuk, Valentin A. Manuvera, Vasily Lazarev, Olga Pobeguts

المصدر: Biochimie. 95:2123-2131

مصطلحات موضوعية: medicine.disease_cause, Biochemistry, law.invention, Bacteroides fragilis, HT29 Cells, law, Catalytic Domain, Escherichia coli, medicine, Humans, Cloning, Molecular, Proprotein, Metalloproteinase, Expression vector, biology, Caseins, Metalloendopeptidases, Gene Expression Regulation, Bacterial, General Medicine, Cadherins, Fragilysin, biology.organism_classification, Molecular biology, Recombinant DNA, Gelatin, Collagen, Azo Compounds

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc750baa6adf392430980be6c593a59
https://doi.org/10.1016/j.biochi.2013.08.005

المؤلفون: You, Lv, Tao, Ye, Hui-Peng, Wang, Jia-Ying, Zhao, Wen-Jie, Chen, Xin, Wang, Chen-Xia, Shen, Yi-Bin, Wu, Yuan-Kun, Cai

المصدر: World Journal of Gastroenterology

مصطلحات موضوعية: Recombinant proteins, Caspase 3, Body Weight, Dextran Sulfate, Azoxymethane, Administration, Oral, Metalloendopeptidases, Fragilysin, Basic Study, Immunohistochemistry, Colorectal neoplasms, Bacteroides fragilis, Intestines, Mice, Inbred C57BL, Mice, Ki-67 Antigen, Cell Line, Tumor, Animals, Humans, Bacteroides fragilis toxin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::b25fd2d4867632a212d715940ef88307
https://pubmed.ncbi.nlm.nih.gov/28216966

المؤلفون: Harris D. Bernstein, Jessica V. Pierce

المصدر: PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0158171 (2016)

مصطلحات موضوعية: 0301 basic medicine, Molecular biology, lcsh:Medicine, Genome, Bacteroides fragilis, Enterotoxins, DNA library construction, Mobile Genetic Elements, Gene Order, Bacteroides, lcsh:Science, Phylogeny, Genetics, Multidisciplinary, Mammalian Genomics, biology, High-Throughput Nucleotide Sequencing, Genomics, Fragilysin, Genomic Library Construction, Research Article, Transposable element, 030106 microbiology, DNA construction, Microbiology, Evolution, Molecular, 03 medical and health sciences, Genetic Elements, Genetic variation, Gene Prediction, Gene, Bacteria, lcsh:R, Gut Bacteria, Organisms, Transposable Elements, Genetic Variation, Biology and Life Sciences, Computational Biology, Bacteriology, biology.organism_classification, Genome Analysis, Pathogenicity island, Research and analysis methods, 030104 developmental biology, Molecular biology techniques, Genes, Bacterial, Genetic Loci, Animal Genomics, Biofilms, lcsh:Q, Bacterial Biofilms, Genome, Bacterial

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7bcbe3ee498c4d6ba9106bd77c4b6f
https://pubmed.ncbi.nlm.nih.gov/27348220

المؤلفون: Nurver TOPRAK ÜLGER, Arzu İLKİ, Neşe BALKAN, Nilay ÖZEL, Güner SÖYLETİR

المصدر: Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Vol 16, Iss 1, Pp 17-22 (2011)

مصطلحات موضوعية: Bacteroides fragilis, Metallo-beta-lactamase, lcsh:QR1-502, Fragilysin, lcsh:RC109-216, bft gene, lcsh:Microbiology, cfiA gene, lcsh:Infectious and parasitic diseases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doajarticles::a74afef8f594d2cfec458e48118b1847
http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2011-16-1-017-022.pdf

المؤلفون: Vassili N. Lazarev, Ilya Altukhov, Ekaterina N. Grafskaia, Olga Pobeguts, Oleg V. Podgorny, Sergey Kovalchuk, Vadim M. Govorun, Valentin A. Manuvera, Daria Kharlampieva

المصدر: Microbial pathogenesis.

مصطلحات موضوعية: Gene isoform, medicine.disease_cause, Cleavage (embryo), Microbiology, law.invention, Cell Line, Bacteroides fragilis, law, medicine, Escherichia coli, Humans, Protein Isoforms, Metalloproteinase, biology, Cadherin, Metalloendopeptidases, Epithelial Cells, biology.organism_classification, Fragilysin, Cadherins, Molecular biology, Recombinant Proteins, Infectious Diseases, Biochemistry, Proteolysis, Recombinant DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3965b4f793cd512e2488e4971a95f4ad
https://pubmed.ncbi.nlm.nih.gov/25998017

المؤلفون: Geraldo Renato de Paula, Lucy Seldin, Aderbal Sabrá, Regina Maria Cavalcanti Pilotto Domingues, Deyse C. Vallim, Maria Candida de Souza Ferreira, Eduardo N.F Antunes, Eliane de Oliveira Ferreira

المصدر: Anaerobe. 8:17-22

مصطلحات موضوعية: Genetics, Genetic diversity, Biology, Fragilysin, medicine.disease_cause, biology.organism_classification, Microbiology, law.invention, Infectious Diseases, law, medicine, Bacteroides fragilis, Allele, Escherichia coli, Gene, Polymerase chain reaction, Feces

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0375e6f73f667ca91c098521305d6515
https://doi.org/10.1006/anae.2002.0410

المؤلفون: Alex Y. Strongin, Albert G. Remacle, Sergey A. Shiryaev

المصدر: PLoS ONE, Vol 9, Iss 11, p e113896 (2014)
PLoS ONE

مصطلحات موضوعية: Proteases, Genomic Islands, lcsh:Medicine, Virulence, Biochemistry, Microbiology, Adherens junction, Bacteroides fragilis, 03 medical and health sciences, Bacterial Proteins, Catalytic Domain, Cell Line, Tumor, Humans, lcsh:Science, Gene, 030304 developmental biology, Genetics, 0303 health sciences, Multidisciplinary, biology, 030306 microbiology, Cadherin, lcsh:R, Cell Membrane, Biology and Life Sciences, Proteins, Metalloendopeptidases, biology.organism_classification, Fragilysin, Cadherins, HCT116 Cells, Pathogenicity island, Recombinant Proteins, Enzymes, Microscopy, Fluorescence, Proteolysis, Enzymology, MCF-7 Cells, Metalloproteases, lcsh:Q, HT29 Cells, Genome, Bacterial, Research Article, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91177e97b9ea14ae0d03d4a8d392f2ef
https://pubmed.ncbi.nlm.nih.gov/35666733

المؤلفون: Alex Y. Strongin, Igor A. Kozlov, Norihito Muranaka, Sergey A. Shiryaev, Piotr Cieplak, Albert G. Remacle, David A. Routenberg, Robert C. Liddington, Alexander E. Aleshin, Muskan Kukreja

المصدر: The FEBS journal. 281(11)

مصطلحات موضوعية: Genetics, Gene isoform, Proteases, biology, Genomic Islands, Virulence, Cell Biology, Fragilysin, biology.organism_classification, Biochemistry, Pathogenicity island, Isozyme, Genome, Article, Microbiology, Bacteroides fragilis, Metalloproteases, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cc380dc3fd6ae228d0d5a22e87fac9
https://pubmed.ncbi.nlm.nih.gov/24698179

المؤلفون: Richard R. Vines, Tracy D. Wilkins, Lisa Barroso, Danielle R Sentz, J. Scott Moncrief, Rhonda L. Wright, Samuel S Perdue

المصدر: Vaccine. 19:655-660

مصطلحات موضوعية: Cholera Toxin, Ovalbumin, Immunoglobulins, Enterotoxin, medicine.disease_cause, Microbiology, Mice, Adjuvants, Immunologic, Antigen, Animals, Outbred Strains, medicine, Animals, Immunity, Mucosal, Administration, Intranasal, Antigens, Bacterial, Mice, Inbred BALB C, General Veterinary, General Immunology and Microbiology, biology, Vaccination, Cholera toxin, Public Health, Environmental and Occupational Health, Metalloendopeptidases, biology.organism_classification, Fragilysin, Antibodies, Bacterial, Infectious Diseases, Humoral immunity, biology.protein, Molecular Medicine, Female, Antibody, Bacteroides fragilis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410c83be195227d9665ce6b1ad12e737
https://doi.org/10.1016/s0264-410x(00)00254-1