المؤلفون: Magalie Penaud-Budloo, Emilie Lecomte, Quentin Lecomte, Simon Pacouret, Frédéric Broucque, Aurélien Guy-Duché, Jean-Baptiste Dupont, Laurence Jeanson-Leh, Cécile Robin, Véronique Blouin, Eduard Ayuso, Oumeya Adjali

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101305- (2024)

مصطلحات موضوعية: gene therapy, AAV vectors, bioproduction, quality control, residual nucleic acids, microRNA, Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050124001219; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/042640a504cc42909af1d623d410fa67

المؤلفون: Pauline F. Schmit, Simon Pacouret, Eric Zinn, Elizabeth Telford, Fotini Nicolaou, Frédéric Broucque, Eva Andres-Mateos, Ru Xiao, Magalie Penaud-Budloo, Mohammed Bouzelha, Nicolas Jaulin, Oumeya Adjali, Eduard Ayuso, Luk H. Vandenberghe

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 107-121 (2020)

مصطلحات موضوعية: capsid mosaics, adeno-associated virus, aav, library, cross-packaging, mosaic, Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050119301391; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/01e94c81cf474557ad14df40eac9da49

المؤلفون: Achille François, Mohammed Bouzelha, Emilie Lecomte, Frédéric Broucque, Magalie Penaud-Budloo, Oumeya Adjali, Philippe Moullier, Véronique Blouin, Eduard Ayuso

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 223-236 (2018)

مصطلحات موضوعية: Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050118300676; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/e86bc233d9c34383bc042649c09abbea

المؤلفون: Emilie Lecomte, Benoît Tournaire, Benjamin Cogné, Jean-Baptiste Dupont, Pierre Lindenbaum, Mélanie Martin-Fontaine, Frédéric Broucque, Cécile Robin, Matthias Hebben, Otto-Wilhelm Merten, Véronique Blouin, Achille François, Richard Redon, Philippe Moullier, Adrien Léger

المصدر: Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)

مصطلحات موضوعية: DNA contaminants, next generation sequencing, quality control, rAAV, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253116300452; https://doaj.org/toc/2162-2531

URL الوصول: https://doaj.org/article/741f46340a074fda945084019638521d

المؤلفون: Susan D'Costa, Veronique Blouin, Frederic Broucque, Magalie Penaud-Budloo, Achille Fçranois, Irene C Perez, Christine Le Bec, Philippe Moullier, Richard O Snyder, Eduard Ayuso

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)

مصطلحات موضوعية: Genetics, QH426-470, Cytology, QH573-671

Relation: http://www.sciencedirect.com/science/article/pii/S2329050116301607; https://doaj.org/toc/2329-0501; https://doaj.org/article/abdbfb21a81743f3b6a2cf91a09b3f39

الاتاحة: https://doi.org/10.1038/mtm.2016.19
https://doaj.org/article/abdbfb21a81743f3b6a2cf91a09b3f39

المؤلفون: Cécile Robin, Laurie Brun, Frédéric Broucque, Luk H. Vandenberghe, Magalie Penaud-Budloo, Lucie Ménard, Aurélien Jacob, Oumeya Adjali, Eduard Ayuso, Achille François, Mohammed Bouzelha, Aline Roblin, Véronique Blouin, Paloma Jiménez Gil

المساهمون: Laboratoire de Thérapie Génique Translationnelle des Maladies Génétiques (Inserm UMR 1089), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Department of Ophthalmology [Boston, MA, USA] (Ocular Genomics Institute), Harvard Medical School [Boston] (HMS), Grousbeck Gene Therapy Center [Boston, MA, USA], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Harvard Stem Cell Institute [Cambridge, USA] (HSCI), Harvard University [Cambridge], JAULIN, Nicolas, Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: Biotechnology Journal
Biotechnology Journal, Wiley-VCH Verlag, 2020, 16 (1), pp.e2000014. ⟨10.1002/biot.202000014⟩

مصطلحات موضوعية: 0106 biological sciences, baculovirus expression vector, viruses, [SDV]Life Sciences [q-bio], Genetic Vectors, homologous recombination, Computational biology, Gene delivery, Biology, 01 natural sciences, Applied Microbiology and Biotechnology, Genome, Viral vector, law.invention, Transposition (music), Tn7 transposition, law, 010608 biotechnology, Vector (molecular biology), Gene, 010401 analytical chemistry, Gene Transfer Techniques, General Medicine, Dependovirus, gene therapy, 0104 chemical sciences, [SDV] Life Sciences [q-bio], manufacturing, rAAV vectors, Recombinant DNA, Molecular Medicine, Homologous recombination, Baculoviridae

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e9148c18c1e178eb17cfa8320549b4
https://www.hal.inserm.fr/inserm-03190097

المؤلفون: Frédéric Broucque, Magalie Penaud-Budloo, Katell Harrouet, Susan M. D'Costa, Mohammed Bouzelha, Martin Lock, Richard O. Snyder, Véronique Blouin, Sandy Douthe, Eduard Ayuso, Sylvie Saleun, Oumeya Adjali, Sushma Ogram

المساهمون: Laboratoire de Thérapie Génique Translationnelle des Maladies Génétiques (Inserm UMR 1089), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Brammer Bio [Alachua, FL, USA], Department of Pathology and Laboratory Medicine [Philadelphia, PA, USA] (Perelman School of Medicine), University of Pennsylvania [Philadelphia], Financial support to E.A.’s laboratory was provided by INSERM, University of Nantes, CHU of Nantes, Fondation d’Entreprises pour la Thérapie Génique en Pays de la Loire, and Région Pays de la Loire and Pre-industrial gene therapy consortium (Agence Nationale de la Recherche - Investissements d’Avenir, grant number 10-DPBS-0001)., ANR-10-DPBS-0001,PGT,Consortium préindustriel des vecteurs de thérapie génique(2010), University of Pennsylvania, JAULIN, Nicolas, Démonstrateurs - Consortium préindustriel des vecteurs de thérapie génique - - PGT2010 - ANR-10-DPBS-0001 - DPBS - VALID

المصدر: Gene Therapy
Gene Therapy, Nature Publishing Group, 2019, 26 (5), pp.211-215. ⟨10.1038/s41434-019-0072-9⟩
Gene Therapy, 2019, 26 (5), pp.211-215. ⟨10.1038/s41434-019-0072-9⟩

مصطلحات موضوعية: 0301 basic medicine, Serotype, [SDV]Life Sciences [q-bio], Genetic Vectors, Biology, medicine.disease_cause, Virus Replication, Virus, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, Humans, Dosing, Vector (molecular biology), Molecular Biology, Reference standards, Adeno-associated virus, Cryopreservation, Protein Stability, Dependovirus, Reference Standards, Virology, 3. Good health, [SDV] Life Sciences [q-bio], Titer, 030104 developmental biology, HEK293 Cells, Capsid, 030220 oncology & carcinogenesis, Practice Guidelines as Topic, Molecular Medicine, Capsid Proteins

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49e95058cd6bf8be45d9f3a3b6458b9
https://pubmed.ncbi.nlm.nih.gov/30926961

المؤلفون: Eduard Ayuso, Véronique Blouin, Philippe Moullier, Achille François, Magalie Penaud-Budloo, Oumeya Adjali, Emilie Lecomte, Mohammed Bouzelha, Frédéric Broucque

المساهمون: Laboratoire de Thérapie Génique Translationnelle des Maladies Génétiques (Inserm UMR 1089), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), This research was supported by the Fondation d’Entreprise Thérapie Génique en Pays de Loire, the Commissariat Général à l’Investissement (ANR Program, Investissements d’Avenir, Preindustrial Gene Therapy vector consortium), the Association Française contre les Myopathies (AFM), the Agence Nationale de Sécurité des Médicaments (ANSM), the Centre Hospitalier Universitaire (CHU) of Nantes, and the INSERM., JAULIN, Nicolas, Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: Molecular Therapy-Methods and Clinical Development
Molecular Therapy-Methods and Clinical Development, Nature Publishing Group, 2018, 10, pp.223-236. ⟨10.1016/j.omtm.2018.07.004⟩
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss, Pp 223-236 (2018)

مصطلحات موضوعية: 0301 basic medicine, titration, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, lcsh:QH426-470, Transgene, Genetic enhancement, viruses, Computational biology, Biology, Genome, Virus, Article, law.invention, AAV vectors, 03 medical and health sciences, law, Genetics, Vector (molecular biology), lcsh:QH573-671, quality control, Molecular Biology, Infectivity, lcsh:Cytology, infectivity, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, gene therapy, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, lcsh:Genetics, 030104 developmental biology, Recombinant DNA, Molecular Medicine, Cell fractionation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daac8905945bdb002b514d6e8040ecf9
https://www.hal.inserm.fr/inserm-01858411

المؤلفون: Eva Andres-Mateos, Frédéric Broucque, Rajani Shelke, Ru Xiao, Magalie Penaud-Budloo, Trisha Barungi, Eduard Ayuso, Anna C. Maurer, Heikki Turunen, Véronique Blouin, Mathieu Mével, Luk H. Vandenberghe, Philippe Moullier, Mohammed Bouzelha, Simon Pacouret

المساهمون: Laboratoire de Thérapie Génique Translationnelle des Maladies Génétiques (Inserm UMR 1089), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), JAULIN, Nicolas

المصدر: Molecular Therapy
Molecular Therapy, Cell Press, 2017, 25 (6), pp.1375-1386. ⟨10.1016/j.ymthe.2017.04.001⟩

مصطلحات موضوعية: 0301 basic medicine, [SDV]Life Sciences [q-bio], viruses, Genetic Vectors, Gene transfer, Computational biology, adeno-associated virus, Biology, medicine.disease_cause, identity assay, AAV vectors, 03 medical and health sciences, Consistency (database systems), Structure-Activity Relationship, Capsid, CMC, Drug Discovery, Genetics, medicine, Humans, quality control, Molecular Biology, Adeno-associated virus, identity, Pharmacology, capsid thermostability, Protein Stability, Protein level, Reproducibility of Results, Dependovirus, Virology, gene therapy, [SDV] Life Sciences [q-bio], manufacturing, 030104 developmental biology, homogeneity, Spectrometry, Fluorescence, Mutation, Molecular Medicine, Thermodynamics, Original Article, Capsid Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e2a3d128dbf47191393d947a8e96e9
https://europepmc.org/articles/PMC5475248/

المؤلفون: Philippe Moullier, Irene C. Perez, Frédéric Broucque, Christine Le Bec, Eduard Ayuso, Achille Fçranois, Richard O. Snyder, Magalie Penaud-Budloo, Véronique Blouin, Susan M. D'Costa

المساهمون: Center of Excellence for Regenerative Health Biotechnology [Florida, USA], University of Florida [Gainesville] (UF), Laboratoire de Thérapie Génique Translationnelle des Maladies Génétiques (Inserm UMR 1089), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Généthon, Department of Molecular Genetics and Microbiology [Gainesville, FL, USA] (Center for NeuroGenetics ), This work was performed under a Cooperative Agreement between CHU-Nantes, INSERM, AFM, and the University of Florida Center of Excellence for Regenerative Health Biotechnology., JAULIN, Nicolas, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)

المصدر: Molecular Therapy-Methods and Clinical Development
Molecular Therapy-Methods and Clinical Development, Nature Publishing Group, 2016, 5, pp.16019. ⟨10.1038/mtm.2016.19⟩
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy. Methods & Clinical Development

مصطلحات موضوعية: 0301 basic medicine, Focus (geometry), lcsh:QH426-470, viruses, [SDV]Life Sciences [q-bio], Computational biology, Biology, Genome, Article, law.invention, 03 medical and health sciences, Plasmid, law, Genetics, Vector (molecular biology), lcsh:QH573-671, Molecular Biology, Reference standards, lcsh:Cytology, [SDV] Life Sciences [q-bio], Titer, lcsh:Genetics, 030104 developmental biology, Real-time polymerase chain reaction, Recombinant DNA, Molecular Medicine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9633be604bd5efac050fe3d1b1d1284b
https://www.hal.inserm.fr/inserm-01799010/document

المؤلفون: Maurer Anna Claire, Simon Pacouret, Heikki Turunen, Magalie Penaud-Budloo, Mohammed Bouzelha, Mathieu Mével, Ru Xiao, Luk H. Vandenberghe, Philippe Moullier, Véronique Blouin, Frédéric Broucque, Rajani Shelke, Eduard Ayuso

المصدر: Molecular Therapy. 24:S15

مصطلحات موضوعية: Pharmacology, Thermal shift assay, viruses, Sf9, Biology, Fluorescence, Molecular biology, chemistry.chemical_compound, chemistry, Dynamic light scattering, Capsid, In vivo, Drug Discovery, Genetics, Biophysics, Molecular Medicine, Molecular Biology, Polyacrylamide gel electrophoresis, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::69fc26b55e901b5851033c15d6d0af1d
https://doi.org/10.1016/s1525-0016(16)32843-x