المؤلفون: Salisbury NHS Foundation Trust, University of Southampton, Dorset County Hospital NHS Foundation Trust, The Leeds Teaching Hospitals NHS Trust, Mid Yorkshire Teaching NHS Trust, Newcastle-upon-Tyne Hospitals NHS Trust, University Hospitals Dorset NHS Foundation Trust, Somerset NHS Foundation Trust, Swansea Bay University Health Board, Portsmouth Hospitals NHS Trust, Hampshire Hospitals NHS Foundation Trust, Royal Devon and Exeter NHS Foundation Trust, Sussex Partnership NHS Foundation Trust, London North West Healthcare NHS Trust, Manchester University NHS Foundation Trust, NHS Greater Glasgow and Clyde, The Christie NHS Foundation Trust

المصدر: REMACS - Understanding the Impact of Perineal Reconstruction After Extended MArgin Cancer Surgery on Longer-term Quality of Life, Morbidity and Health Economic Outcomes - a Prospective Longitudinal Cohort Study

المؤلفون: Imperial College Healthcare NHS Trust, Newcastle-upon-Tyne Hospitals NHS Trust, University Hospital Birmingham NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust, Norfolk and Norwich University Hospitals NHS Foundation Trust, Nottingham University Hospitals NHS Trust, University Hospital Plymouth NHS Trust, Royal Surrey County Hospital NHS Foundation Trust, University Hospitals Coventry and Warwickshire NHS Trust, Guy's and St Thomas' NHS Foundation Trust, Portsmouth Hospitals NHS Trust, Barking, Havering and Redbridge University Hospitals NHS Trust, Northern Care Alliance NHS Foundation Trust, Brighton and Sussex University Hospitals NHS Trust, University College London Hospitals, Cardiff and Vale University Health Board, NHS Lothian, NHS Tayside, York Teaching Hospitals NHS Foundation Trust, The Harley Street Clinic

المصدر: Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer

المؤلفون: The Hillingdon Hospitals NHS Foundation Trust, University of Leicester, Southern Health NHS Foundation Trust, Imperial College London, Queen Mary University of London, King's College London, Papworth Hospital NHS Foundation Trust, King's College Hospital NHS Trust

المصدر: Validation of an Artificial Intelligence Enabled Diagnostic Support Software (ArtiQ.Spiro) in Primary Care Spirometry Datasets - a Retrospective Analysis

المؤلفون: Pancreatic Cancer UK, Imperial College Healthcare NHS Trust, Royal Free Hospital NHS Foundation Trust, Liverpool University Hospitals NHS Foundation Trust, The Leeds Teaching Hospitals NHS Trust, Sheffield Teaching Hospitals NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust, Royal Surrey County Hospital NHS Foundation Trust, University Hospital Birmingham NHS Foundation Trust, Manchester University NHS Foundation Trust, Newcastle-upon-Tyne Hospitals NHS Trust, Swansea Bay University Health Board, Dorset County Hospital NHS Foundation Trust, North Tees and Hartlepool NHS Foundation Trust, University Hospital Plymouth NHS Trust, Barts & The London NHS Trust, Milton Keynes University Hospital NHS Foundation Trust, Buckinghamshire Healthcare NHS Trust, Southern Health

المصدر: Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma (VAPOR 1 / BIORESOURCE)

المؤلفون: National Institute for Health Research, United Kingdom, Chelsea and Westminster NHS Foundation Trust, Imperial College Healthcare NHS Trust, Royal Marsden NHS Foundation Trust, London North West Healthcare NHS Trust

المصدر: The COlorectal BReath Analysis (COBRA2) Study: Non-invasive Testing to Detect Colorectal Cancer

المؤلفون: Great Ormond Street Hospital for Children NHS Foundation Trust, Radboud University Medical Center, University of Leeds, Guy's and St Thomas' NHS Foundation Trust

المصدر: The Prevalence of RYR1-related Disease - an International, Collaborative Multicentre Study
Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, Treves S, Dirksen RT, Meissner G, Muntoni F, Jungbluth H. Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene. Neuromuscul Disord. 2010 Mar;20(3):166-73. doi: 10.1016/j.nmd.2009.12.005. Epub 2010 Jan 18.
Wilmshurst JM, Lillis S, Zhou H, Pillay K, Henderson H, Kress W, Muller CR, Ndondo A, Cloke V, Cullup T, Bertini E, Boennemann C, Straub V, Quinlivan R, Dowling JJ, Al-Sarraj S, Treves S, Abbs S, Manzur AY, Sewry CA, Muntoni F, Jungbluth H. RYR1 mutations are a common cause of congenital myopathies with central nuclei. Ann Neurol. 2010 Nov;68(5):717-26. doi: 10.1002/ana.22119.
Maggi L, Scoto M, Cirak S, Robb SA, Klein A, Lillis S, Cullup T, Feng L, Manzur AY, Sewry CA, Abbs S, Jungbluth H, Muntoni F. Congenital myopathies--clinical features and frequency of individual subtypes diagnosed over a 5-year period in the United Kingdom. Neuromuscul Disord. 2013 Mar;23(3):195-205. doi: 10.1016/j.nmd.2013.01.004. Epub 2013 Feb 8.
Loseth S, Voermans NC, Torbergsen T, Lillis S, Jonsrud C, Lindal S, Kamsteeg EJ, Lammens M, Broman M, Dekomien G, Maddison P, Muntoni F, Sewry C, Radunovic A, de Visser M, Straub V, van Engelen B, Jungbluth H. A novel late-onset axial myopathy associated with mutations in the skeletal muscle ryanodine receptor (RYR1) gene. J Neurol. 2013 Jun;260(6):1504-10. doi: 10.1007/s00415-012-6817-7. Epub 2013 Jan 18.
Lopez RJ, Byrne S, Vukcevic M, Sekulic-Jablanovic M, Xu L, Brink M, Alamelu J, Voermans N, Snoeck M, Clement E, Muntoni F, Zhou H, Radunovic A, Mohammed S, Wraige E, Zorzato F, Treves S, Jungbluth H. An RYR1 mutation associated with malignant hyperthermia is also associated with bleeding abnormalities. Sci Signal. 2016 Jul 5;9(435):ra68. doi: 10.1126/scisignal.aad9813.
Levano S, Vukcevic M, Singer M, Matter A, Treves S, Urwyler A, Girard T. Increasing the number of diagnostic mutations in malignant hyperthermia. Hum Mutat. 2009 Apr;30(4):590-8. doi: 10.1002/humu.20878.
Jungbluth H, Zhou H, Hartley L, Halliger-Keller B, Messina S, Longman C, Brockington M, Robb SA, Straub V, Voit T, Swash M, Ferreiro A, Bydder G, Sewry CA, Muller C, Muntoni F. Minicore myopathy with ophthalmoplegia caused by mutations in the ryanodine receptor type 1 gene. Neurology. 2005 Dec 27;65(12):1930-5. doi: 10.1212/01.wnl.0000188870.37076.f2.
Dowling JJ, Lillis S, Amburgey K, Zhou H, Al-Sarraj S, Buk SJ, Wraige E, Chow G, Abbs S, Leber S, Lachlan K, Baralle D, Taylor A, Sewry C, Muntoni F, Jungbluth H. King-Denborough syndrome with and without mutations in the skeletal muscle ryanodine receptor (RYR1) gene. Neuromuscul Disord. 2011 Jun;21(6):420-7. doi: 10.1016/j.nmd.2011.03.006. Epub 2011 Apr 22.
Dlamini N, Voermans NC, Lillis S, Stewart K, Kamsteeg EJ, Drost G, Quinlivan R, Snoeck M, Norwood F, Radunovic A, Straub V, Roberts M, Vrancken AF, van der Pol WL, de Coo RI, Manzur AY, Yau S, Abbs S, King A, Lammens M, Hopkins PM, Mohammed S, Treves S, Muntoni F, Wraige E, Davis MR, van Engelen B, Jungbluth H. Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis. Neuromuscul Disord. 2013 Jul;23(7):540-8. doi: 10.1016/j.nmd.2013.03.008. Epub 2013 Apr 28.
Amburgey K, McNamara N, Bennett LR, McCormick ME, Acsadi G, Dowling JJ. Prevalence of congenital myopathies in a representative pediatric united states population. Ann Neurol. 2011 Oct;70(4):662-5. doi: 10.1002/ana.22510.

المؤلفون: Chelsea and Westminster NHS Foundation Trust, The Hillingdon Hospitals NHS Foundation Trust, Barts & The London NHS Trust, University Hospital Birmingham NHS Foundation Trust, University Hospitals, Leicester, Manchester University NHS Foundation Trust, Royal Free Hospital NHS Foundation Trust, London North West University Health Care NHS Trust

المصدر: Xpert MTB/RIF Ultra Assay for the Detection of Mycobacterium Tuberculosis (MTB) in Bronchoalveolar Lavage (BAL) for Pulmonary TB and Endobronchial Ultrasound Guided Transbronchial Needle Aspiration (EBUS-TBNA) Samples for Mediastinal TB

المؤلفون: Minderoo Foundation, Verastem, Inc., Royal Marsden NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, Cancer Research UK, University of Cambridge

المصدر: A Phase 1/2 Trial of the Doublet Combination of Avutometinib and Defactinib and As a Triplet in Combination with Temozolomide in Patients with High Grade Malignant Brain Tumours Within the 5G Platform

المؤلفون: Cancer Research UK, Imperial College Healthcare NHS Trust, Sandwell & West Birmingham Hospitals NHS Trust, University College London Hospitals, County Durham and Darlington NHS Foundation Trust, Walsall Healthcare NHS Trust, Surrey and Sussex Healthcare NHS Trust, Airedale NHS Foundation Trust, Abertawe Bro Morgannwg University Health Board, Gateshead Health NHS Foundation Trust, Norfolk and Norwich University Hospitals NHS Foundation Trust, The Leeds Teaching Hospitals NHS Trust, NHS Lothian, East Lancashire Hospitals NHS Trust, University Hospitals Bristol and Weston NHS Foundation Trust, Royal Surrey County Hospital NHS Foundation Trust, Royal Marsden NHS Foundation Trust, Velindre NHS Trust, Cardiff and Vale University Health Board, South Tees Hospitals NHS Foundation Trust, West Hertfordshire Hospitals NHS Trust, The Christie NHS Foundation Trust, Manchester University NHS Foundation Trust, NHS Greater Glasgow and Clyde

المصدر: Cancer Loyalty Card Study: a Retrospective Observational Case-Control Study
Flanagan JM, Skrobanski H, Shi X, Hirst Y. Self-Care Behaviors of Ovarian Cancer Patients Before Their Diagnosis: Proof-of-Concept Study. JMIR Cancer. 2019 Jan 17;5(1):e10447. doi: 10.2196/10447.
Brewer HR, Chadeau-Hyam M, Johnson E, Sundar S, Flanagan J, Hirst Y. Cancer Loyalty Card Study (CLOCS): feasibility outcomes for an observational case-control study focusing on the patient interval in ovarian cancer. BMJ Open. 2023 Jun 14;13(6):e066022. doi: 10.1136/bmjopen-2022-066022.
Brewer HR, Hirst Y, Sundar S, Chadeau-Hyam M, Flanagan JM. Cancer Loyalty Card Study (CLOCS): protocol for an observational case-control study focusing on the patient interval in ovarian cancer diagnosis. BMJ Open. 2020 Sep 8;10(9):e037459. doi: 10.1136/bmjopen-2020-037459.

المؤلفون: University of Oxford, Manchester University NHS Foundation Trust, Northern Care Alliance NHS Foundation Trust

المساهمون: Yvonne Kiera Bartlett, Lecturer

المصدر: Developing Evidence-based Text Messages to Target Diet and Physical Activity Behaviour for People with Type 2 Diabetes Mellitus
Michie S, Richardson M, Johnston M, Abraham C, Francis J, Hardeman W, Eccles MP, Cane J, Wood CE. The behavior change technique taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions. Ann Behav Med. 2013 Aug;46(1):81-95. doi: 10.1007/s12160-013-9486-6.
Bartlett YK, Farmer A, Rea R, French DP. Use of Brief Messages Based on Behavior Change Techniques to Encourage Medication Adherence in People With Type 2 Diabetes: Developmental Studies. J Med Internet Res. 2020 May 13;22(5):e15989. doi: 10.2196/15989.

المؤلفون: Sheffield Teaching Hospitals NHS Foundation Trust, Royal Free Hospital NHS Foundation Trust, Golden Jubilee National Hospital, Papworth Hospital NHS Foundation Trust, University of Bath

المصدر: Developing the Probability Algorithm for Pulmonary Hypertension Echocardiography

المؤلفون: University of Bath, University College, London, Royal Victoria Infirmary, King's College Hospital NHS Trust, North Bristol NHS Trust, University of Liverpool, St. George's Hospital, London, Northern Care Alliance NHS Foundation Trust, Burton Hospitals NHS Foundation Trust, Doncaster And Bassetlaw Hospitals NHS Foundation Trust, Sandwell & West Birmingham Hospitals NHS Trust, London North West Healthcare NHS Trust, Nottingham University Hospitals NHS Trust, Sheffield Teaching Hospitals NHS Foundation Trust

المساهمون: Hector Chinoy, Professor

المصدر: MYOPROSP: a Prospective Cohort Study to Identify a Stratified Approach in the Diagnosis, Treatment and Delivery of Care in Adult Idiopathic Inflammatory Myopathy

المؤلفون: Liverpool University Hospitals NHS Foundation Trust, The Clatterbridge Cancer Centre NHS Foundation Trust, University of Liverpool, Cancer Research UK, National Institute for Health Research, United Kingdom, Cancer Vaccines Charitable Trust

المصدر: A Phase I Clinical Study to Determine the Optimal Dose for the Safe Immune Restoration and Immune Response of Allogeneic Cell Immunotherapy (ACIT-1) in Adult Cancer Patients

المؤلفون: Wellcome Trust, GW Pharmaceuticals Ltd, Myonex, Cambridge Cognition Ltd, Premier Research Group plc, Diagram B.V., Cambridgeshire and Peterborough NHS Foundation Trust, Oxford Health NHS Foundation Trust, West London NHS Trust, University of Augsburg, Charite University, Berlin, Germany, University of Cologne, Ludwig Maximilian university of Munich, The Sheba Fund for Health Services and Research, Shalvata Mental Health Center, Geha Mental Health Center, Amsterdam University Medical Center, Hospital General Universitario Gregorio Marañon, National and Kapodistrian University of Athens, Medical University of Vienna, Hospitales Universitarios Virgen del Rocío, University of Campania Luigi Vanvitelli, Swansea University, Psychiatric University Hospital, Zurich, IDEA Regulatory

المصدر: Augmentation with Cannabidiol in First Episode Psychosis: a Double-blind, Randomised Controlled Trial

المؤلفون: Helmholtz Zentrum München, University Hospital Carl Gustav Carus, Kinderkrankenhaus auf der Bult, Skane University Hospital, Universitaire Ziekenhuizen KU Leuven, Newcastle-upon-Tyne Hospitals NHS Trust, Cambridge University Hospitals NHS Foundation Trust, Birmingham Women's and Children's NHS Foundation Trust

المصدر: Anti-viral Action Against Type 1 Diabetes Autoimmunity

المؤلفون: Medical University of Vienna, Hospital Barmherzige Brüder St. Veit, Klinikum Klagenfurt am Wörthersee, Johannes Kepler University of Linz, Krankenhaus Barmherzige Schwestern Linz, Barmherzige Brüder Vienna, Erasme University Hospital, The Queen Elizabeth Hospital, Goethe University, Kages, KABEG Management, Centre Hospitalier Régional de la Citadelle, Centre Hospitalier Universitaire de Charleroi, Centre Hospitalier Universitaire Mons, Wuerzburg University Hospital, Royal Bolton Hospital NHS Foundation Trust, Heartlands Hospital, Royal Oldham Hospital, East Lancashire Hospitals NHS Trust, University of Plymouth, The Royal Victoria Hospital, Belfast, Great Western Hospital, Mid Yorkshire Teaching NHS Trust, Musgrove Park Hospital, Scunthorpe General Hospital, Guy's and St Thomas' NHS Foundation Trust, Nottingham University Hospitals, Hospital Barmherzige Brüder Graz, University Hospital Kiel, University Hospital, Bonn, Johannes Gutenberg University Mainz, University Hospital, Essen, Klinikum rechts der Isar der TUM, Landeskrankenhaus Villach

المصدر: The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients With Severe Vitamin D Deficiency: a Multicenter, Placebo-controlled Double-blind Phase III Randomized Controlled Trial (RCT)
Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, Urbanic Purkart T, Waltensdorfer A, Munch A, Warnkross H, Stojakovic T, Bisping E, Toller W, Smolle KH, Berghold A, Pieber TR, Dobnig H. Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA. 2014 Oct 15;312(15):1520-30. doi: 10.1001/jama.2014.13204. Erratum In: JAMA. 2014 Nov 12;312(18):1932.
Amrein K, Christopher KB, McNally JD. Understanding vitamin D deficiency in intensive care patients. Intensive Care Med. 2015 Nov;41(11):1961-4. doi: 10.1007/s00134-015-3937-4. Epub 2015 Jul 4. No abstract available.
Amrein K. Vitamin D status in critical care: Contributor or marker of poor health? Lung India. 2014 Jul;31(3):299-300. No abstract available.
Amrein K, Papinutti A, Mathew E, Vila G, Parekh D. Vitamin D and critical illness: what endocrinology can learn from intensive care and vice versa. Endocr Connect. 2018 Dec 1;7(12):R304-R315. doi: 10.1530/EC-18-0184.
National Heart, Lung, and Blood Institute PETAL Clinical Trials Network; Ginde AA, Brower RG, Caterino JM, Finck L, Banner-Goodspeed VM, Grissom CK, Hayden D, Hough CL, Hyzy RC, Khan A, Levitt JE, Park PK, Ringwood N, Rivers EP, Self WH, Shapiro NI, Thompson BT, Yealy DM, Talmor D. Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients. N Engl J Med. 2019 Dec 26;381(26):2529-2540. doi: 10.1056/NEJMoa1911124. Epub 2019 Dec 11.
Kobayashi H, Amrein K, Mahmoud SH, Lasky-Su JA, Christopher KB. Metabolic phenotypes and vitamin D response in the critically ill: A metabolomic cohort study. Clin Nutr. 2024 Nov;43(11):10-19. doi: 10.1016/j.clnu.2024.09.030. Epub 2024 Sep 18.
Geiger C, McNally JD, Christopher KB, Amrein K. Vitamin D in the critically ill - update 2024. Curr Opin Clin Nutr Metab Care. 2024 Nov 1;27(6):515-522. doi: 10.1097/MCO.0000000000001068. Epub 2024 Aug 26.
Shakoor H, Feehan J, Al Dhaheri AS, Cheikh Ismail L, Ali HI, Alhebshi SH, Apostolopoulos V, Stojanovska L. Role of vitamin D supplementation in aging patients with COVID-19. Maturitas. 2021 Oct;152:63-65. doi: 10.1016/j.maturitas.2021.03.006. Epub 2021 Mar 16. No abstract available.
Amrein K, Parekh D, Westphal S, Preiser JC, Berghold A, Riedl R, Eller P, Schellongowski P, Thickett D, Meybohm P; VITDALIZE Collaboration Group. Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study). BMJ Open. 2019 Nov 12;9(11):e031083. doi: 10.1136/bmjopen-2019-031083.

المؤلفون: South London and Maudsley NHS Foundation Trust, Sussex Partnership NHS Foundation Trust, Cumbria, Northumberland Tyne and Wear NHS Foundation Trust

المصدر: SloMo2: a Process Evaluation, Effectiveness, and Cost-effectiveness Study of a Digitally Supported Therapy for Psychosis in Routine Care

المؤلفون: South London and Maudsley NHS Foundation Trust, Barnet, Enfield and Haringey Mental Health NHS Trust, Hospital Universitari Vall d'Hebron Research Institute, Empatica, Inc., Örebro University, Sweden, Concentris research management gmbh, Attention Deficit Disorder Information and Support Service, The European Association for the Study of Obesity, Cumbria, Northumberland Tyne and Wear NHS Foundation Trust, Tees, Esk and Wear Valleys NHS Foundation Trust, South West London and St George's Mental Health NHS Trust, East London NHS Foundation Trust, Avon and Wiltshire Mental Health Partnership NHS Trust

المصدر: ADHD Remote Technology Study of Cardiometabolic Risk Factors and Medication Adherence ('ART-CARMA')

المؤلفون: National Rehabilitation Hospital, Ireland, Belfast Health and Social Care Trust, Western Health and Social Care Trust, Southern Health and Social Care Trust, Northern Health and Social Care Trust, Barnsley Hospital NHS Foundation Trust, NHS Lothian, Walton Centre NHS Foundation Trust, Hull University Teaching Hospitals NHS Trust, Imperial College Healthcare NHS Trust, Royal Hospital for Neuro-disability, South Warwickshire NHS Foundation Trust, Sheffield Teaching Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Trust, Castel Froma Neuro Care, Inspire Neurocare, The Huntercombe Group, Active Care Group

المصدر: EEG Based Awareness Detection and Communication in Prolonged Disorders of Consciousness and Physical Disability

المؤلفون: University Hospitals, Leicester, University Hospital Southampton NHS Foundation Trust, Azienda Ospedaliera Universitaria Integrata Verona, Centre Hospitalier Universitaire de Besancon, Assistance Publique - Hôpitaux de Paris, Ziekenhuis Oost-Limburg, University Hospital Muenster, University of Hamburg-Eppendorf, Institute for Clinical and Experimental Medicine, Northern General Hospital, Herries Road, Sheffield, Liverpool Heart and Chest Hospital NHS Foundation Trust, University Hospital, Udine, Italy, Heart Center Leipzig - University Hospital, Cliniques universitaires Saint-Luc- Université Catholique de Louvain, AZ Sint-Jan AV, University Hospital, Antwerp, Universitaire Ziekenhuizen KU Leuven, University of Turin, Italy, University of Barcelona

المساهمون: Fausto Biancari, Professor

المصدر: European Registry of Type A Aortic Dissection
Biancari F, Mariscalco G, Yusuff H, Tsang G, Luthra S, Onorati F, Francica A, Rossetti C, Perrotti A, Chocron S, Fiore A, Folliguet T, Pettinari M, Dell'Aquila AM, Demal T, Conradi L, Detter C, Pol M, Ivak P, Schlosser F, Forlani S, Chetty G, Harky A, Kuduvalli M, Field M, Vendramin I, Livi U, Rinaldi M, Ferrante L, Etz C, Noack T, Mastrobuoni S, De Kerchove L, Jormalainen M, Laga S, Meuris B, Schepens M, El Dean Z, Vento A, Raivio P, Borger M, Juvonen T. European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria. J Cardiothorac Surg. 2021 Jun 10;16(1):171. doi: 10.1186/s13019-021-01536-5. Erratum In: J Cardiothorac Surg. 2021 Aug 9;16(1):225. doi: 10.1186/s13019-021-01606-8.