المؤلفون: Francisco J. Medrano, Sergio de la Hoz-Rodríguez, Sergio Martí, Kemel Arafet, Tanja Schirmeister, Stefan J. Hammerschmidt, Christin Müller, Águeda González-Martínez, Elena Santillana, John Ziebuhr, Antonio Romero, Collin Zimmer, Annabelle Weldert, Robert Zimmermann, Alessio Lodola, Katarzyna Świderek, Vicent Moliner, Florenci V. González

المصدر: Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2399-3669

URL الوصول: https://doaj.org/article/3ea31cb9aaef4184b8998a4dd4345a66

المؤلفون: Lledó Bou-Iserte, Antonio Latorre, Santiago Rodríguez, Florenci V. González

المصدر: ACS Omega, Vol 4, Iss 1, Pp 2261-2267 (2019)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/c8ca4c42d2484dd7890253fd9d8470c4

المؤلفون: Laura Agost-Beltrán, Sergio de la Hoz-Rodríguez, Lledó Bou-Iserte, Santiago Rodríguez, Adrián Fernández-de-la-Pradilla, Florenci V. González

المصدر: Molecules, Vol 27, Iss 8, p 2523 (2022)

مصطلحات موضوعية: COVID-19, main protease, Mpro, inhibitors, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/8/2523; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/358398801d674c0db1d692fc0986d422

المؤلفون: Michael Gütschow, Jean Jacques Vanden Eynde, Josef Jampilek, CongBao Kang, Arduino A. Mangoni, Paola Fossa, Rafik Karaman, Andrea Trabocchi, Peter J. H. Scott, Jóhannes Reynisson, Simona Rapposelli, Stefania Galdiero, Jean-Yves Winum, Chiara Brullo, Katalin Prokai-Tatrai, Arun K. Sharma, Matthieu Schapira, Yasu-Taka Azuma, Laura Cerchia, Mariana Spetea, Giangiacomo Torri, Simona Collina, Athina Geronikaki, Alfonso T. García-Sosa, M. Helena Vasconcelos, Maria Emília Sousa, Ivan Kosalec, Tiziano Tuccinardi, Iola F. Duarte, Jorge A. R. Salvador, Massimo Bertinaria, Maurizio Pellecchia, Jussara Amato, Giulio Rastelli, Paula A. C. Gomes, Rita C. Guedes, Jean-Marc Sabatier, Ana Estévez-Braun, Bruno Pagano, Stefano Mangani, Rino Ragno, George Kokotos, Margherita Brindisi, Florenci V. González, Fernanda Borges, Mariarosaria Miloso, Jarkko Rautio, Diego Muñoz-Torrero

المصدر: Molecules, Vol 25, Iss 13, p 2968 (2020)

مصطلحات موضوعية: n/a, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/13/2968; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/d1b45d5624194ce7bc35f0b2a26b0ee6

المؤلفون: Víctor E. Macías-Villamizar, Luís Cuca-Suárez, Santiago Rodríguez, Florenci V. González

المصدر: Molecules, Vol 25, Iss 3, p 692 (2020)

مصطلحات موضوعية: lignans, epoxides, cycloaddition, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/3/692; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/b38058d3695a45139bb880b00be6dffe

المؤلفون: Patrick Müller, Mergim Meta, Jan Laurenz Meidner, Marvin Schwickert, Jessica Meyr, Kevin Schwickert, Christian Kersten, Collin Zimmer, Stefan Josef Hammerschmidt, Ariane Frey, Albin Lahu, Sergio de la Hoz-Rodríguez, Laura Agost-Beltrán, Santiago Rodríguez, Kira Diemer, Wilhelm Neumann, Florenci V. Gonzàlez, Bernd Engels, Tanja Schirmeister

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7226

مصطلحات موضوعية: covalent inhibitors, in vitro study, protease inhibitors, peptidomimetic sequence, warhead, reactivity and selectivity study

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pharmacology; https://dx.doi.org/10.3390/ijms24087226

الاتاحة: https://doi.org/10.3390/ijms24087226

المؤلفون: Kemel Arafet, Santiago Royo, Tanja Schirmeister, Fabian Barthels, Florenci V. González, Vicent Moliner

المصدر: ACS Catalysis. 13:6289-6300

مصطلحات موضوعية: General Chemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::36c9b9c286df81e34318693fa85a6949
https://doi.org/10.1021/acscatal.3c01035

المؤلفون: Florenci V. Gonzalez

المصدر: Proceedings; Volume 22; Issue 1; Pages: 86

مصطلحات موضوعية: proteases, inhibitors, malaria, trypanosomiasis, leishmaniasis

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/proceedings2019022086

الاتاحة: https://doi.org/10.3390/proceedings2019022086

المؤلفون: Florenci V. Gonzalez

المصدر: Proceedings, Vol 1, Iss 6, p 672 (2017)

مصطلحات موضوعية: n/a, General Works

Relation: https://www.mdpi.com/2504-3900/1/6/672; https://doaj.org/toc/2504-3900; https://doaj.org/article/8013142b576b4273a7df448e330a768a

الاتاحة: https://doi.org/10.3390/proceedings1060672
https://doaj.org/article/8013142b576b4273a7df448e330a768a

المؤلفون: Lledó Bou-Iserte, Ana María Sánchez-Pérez, Christian Kersten, Sandra Sánchez-Sarasúa, Borja Miguel-López, Verónica Espinosa-Fernández, Florenci V. González, Sergio de la Hoz-Rodríguez

المصدر: ChemistrySelect. 5:8015-8019

مصطلحات موضوعية: organic chemicals, fungi, food and beverages, General Chemistry, fluorescent analogues, Fluorescence, abscisic acid, chemistry.chemical_compound, chemical probes, Design synthesis, chemistry, Biochemistry, inflammation, neurodegenerative disorders, lipids (amino acids, peptides, and proteins), Abscisic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03597adec7ab8c38570cba46e4c44f9
https://doi.org/10.1002/slct.202002294

المؤلفون: Florenci V. González Adelantado

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cfb5c69311739a6bb139588cf28644bb
https://doi.org/10.1515/9783110590050-005

المؤلفون: Vicent Moliner, Florenci V. González, Kemel Arafet

المصدر: Repositori Universitat Jaume I
Universitat Jaume I

مصطلحات موضوعية: Proteases, 2019-20 coronavirus outbreak, Stereochemistry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Cysteine Proteinase Inhibitors, Molecular Dynamics Simulation, 010402 general chemistry, 01 natural sciences, QM/MM, Catalysis, Cysteine Proteases, Exergonic reaction, rhodesain, 010405 organic chemistry, Chemistry, Organic Chemistry, Dual mode, General Chemistry, Cysteine protease, molecular dynamics, 0104 chemical sciences, Cysteine Endopeptidases, dipeptidyl enoates, inhibition mechanism, Cysteine, free energy surfaces

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2708aeb97818ea829d7397b3a2f53b57
https://doi.org/10.1002/chem.202100892

المؤلفون: Florenci V. González, Santiago Rodríguez, Lledó Bou-Iserte, Antonio Latorre

المصدر: ACS Omega, Vol 4, Iss 1, Pp 2261-2267 (2019)
Repositori Universitat Jaume I
Universitat Jaume I
ACS Omega

مصطلحات موضوعية: Chemistry, Reducing agent, General Chemical Engineering, General Chemistry, Reductive amination, reductive amination, Article, reaction (inorg.), lcsh:Chemistry, chemistry.chemical_compound, lcsh:QD1-999, Diamine, carbonyl compounds (organic), Darzens reaction, Organic chemistry, Amine gas treating, Vicinal

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1418c39fb1054b8978bcb73fcbbe8c79
https://doaj.org/article/c8ca4c42d2484dd7890253fd9d8470c4

المؤلفون: Santiago Rodríguez, Marcel Kaiser, Florenci V. González, Santiago Royo, Tanja Schirmeister, Sascha Jung, José M. Bautista

المساهمون: We also thank Serveis Centrals d’Instrumentació Científica from Universitat Jaume I for technical support. The authors thank Sabine Maehrlein, Nicole Denk and Ulrike Nowe for performing the enzyme assays, Susana Pérez-Benavente for technical assistance in cytotoxicity and antimalarial assays, Dr. Jochen Kesselring for performing the dialysis and dilution assays, and Patrick Johé for expression and purification of enzymes. S.R. thanks the Generalitat Valenciana for a postdoctoral research grant under theVALi + d Program and the UJI for a postdoctoral researcher position.

المصدر: Bioorganic & Medicinal Chemistry. 26:4624-4634

مصطلحات موضوعية: 0301 basic medicine, sleeping sickness, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Cathepsin B, inhibitors, Drug Discovery, chemistry.chemical_classification, biology, Chemistry, Dipeptides, Hep G2 Cells, Molecular Docking Simulation, Cysteine Endopeptidases, Antiprotozoal, Molecular Medicine, Chagas disease, Proteases, Cell Survival, medicine.drug_class, Plasmodium falciparum, Trypanosoma brucei brucei, malaria, Antiprotozoal Agents, Cysteine Proteinase Inhibitors, Trypanosoma brucei, cysteine proteases, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, parasitic diseases, medicine, Humans, Trypanosoma cruzi, Molecular Biology, chagas disease, Binding Sites, 010405 organic chemistry, Organic Chemistry, biology.organism_classification, medicine.disease, Protein Structure, Tertiary, 0104 chemical sciences, 030104 developmental biology, Enzyme, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8eed4d01a5b603892381ef8655d2b46
https://doi.org/10.1016/j.bmc.2018.07.015

المؤلفون: Kemel Arafet, Silvia Ferrer, Vicent Moliner, Florenci V. González

المصدر: Physical Chemistry Chemical Physics. 19:12740-12748

مصطلحات موضوعية: Proteases, Stereochemistry, Trypanosoma cruzi, Protozoan Proteins, General Physics and Astronomy, Protonation, Cysteine Proteinase Inhibitors, Molecular Dynamics Simulation, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Molecular mechanics, Molecular dynamics, Cysteine Proteases, 0103 physical sciences, Physical and Theoretical Chemistry, chemistry.chemical_classification, 010304 chemical physics, Ketones, Cysteine protease, 0104 chemical sciences, Cysteine Endopeptidases, Enzyme, chemistry, Epoxy Compounds, Quantum Theory, Thermodynamics, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b426f62595e5d3c7d26f109f4e4b08
https://doi.org/10.1039/c7cp01726j

المؤلفون: Florenci V. González, Jochen Kesselring, Santiago Royo, Santiago Rodríguez, Marcel Kaiser, Tanja Schirmeister

المصدر: ChemMedChem. 10:1484-1487

مصطلحات موضوعية: trypanosomiasis, Stereochemistry, sleeping sickness, Cathepsin L, Drug Evaluation, Preclinical, Chemistry Techniques, Synthetic, Inhibition kinetics, Cysteine Proteinase Inhibitors, Biochemistry, Cathepsin B, Inhibitory Concentration 50, Structure-Activity Relationship, inhibitors, Drug Discovery, Humans, Moiety, Molecular Targeted Therapy, General Pharmacology, Toxicology and Pharmaceutics, IC50, Volume concentration, rhodesain, Pharmacology, Chemistry, Organic Chemistry, Dual mode, Dipeptides, Trypanocidal Agents, Combinatorial chemistry, Molecular Docking Simulation, Cysteine Endopeptidases, Kinetics, dipeptidyl enoates, Trypanosomiasis, African, Docking (molecular), Molecular Medicine, Cysteine thiolate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c3d6a8bca0959ced3afdf9b6e0a2c7
https://doi.org/10.1002/cmdc.201500204

المؤلفون: Azim Ziyaei Halimehjani, Florenci V. González, Yazdanbakhsh Lotfi Nosood

المصدر: The Journal of organic chemistry. 83(3)

مصطلحات موضوعية: beta position, 010405 organic chemistry, regio-selective, Organic Chemistry, Epoxide, Regioselectivity, steel beams and girders, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, imidazopyridines, chemistry.chemical_compound, chemistry, Nucleophile, Diamine, benzodiazepines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6d31d7a586d13f8e5bccda828451d6
https://pubmed.ncbi.nlm.nih.gov/29313339

المؤلفون: Rubén Gil-Redondo, Pedro Marset Campos, Juan Agut, Federico Mayor, Cristina Murga, Florenci V. González, Antonio Morreale, Annemieke Kavelaars, Elisa Lucas, Paula Ramos, Hanneke L.D.M. Willemen, Cobi J. Heijnen

المصدر: Biochemical Journal. 459:427-439

مصطلحات موضوعية: Male, MAPK/ERK pathway, Lipopolysaccharide, Drug Evaluation, Preclinical, Mice, Transgenic, Molecular Dynamics Simulation, Pharmacology, Biology, p38 Mitogen-Activated Protein Kinases, Biochemistry, Monocytes, Article, Cell Line, Mice, Random Allocation, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, medicine, Animals, Humans, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Cells, Cultured, Analgesics, Oxadiazoles, Kinase, Macrophages, Anti-Inflammatory Agents, Non-Steroidal, Cell Biology, Mice, Inbred C57BL, Molecular Docking Simulation, chemistry, Hyperalgesia, Female, Tumor necrosis factor alpha, Signal transduction, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2dec17bbdf7e50ba7704d6747dc2f6a
https://doi.org/10.1042/bj20130172

المؤلفون: Andreu Vidal-Albalat, Santiago Rodriguez, Florenci V. González

المصدر: Organic Letters. 16:1752-1755

مصطلحات موضوعية: Molecular Structure, Reducing agent, Chemistry, Organic Chemistry, Stereoisomerism, Diamines, Nitro Compounds, Biochemistry, Combinatorial chemistry, Catalysis, Piperazines, Ammonia, chemistry.chemical_compound, Pyrazines, Quinoxalines, Epoxy Compounds, Organic chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a009b80aa83dfc075f48b6de3510121e
https://doi.org/10.1021/ol500444z

المؤلفون: Vicent Moliner, Florenci V. González, Kemel Arafet

المصدر: Chemistry – A European Journal. 26:1891-1891

مصطلحات موضوعية: Proteases, Chemistry, Stereochemistry, Organic Chemistry, General Chemistry, Molecular mechanics, Catalysis, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::edcf41899d294f57c9a1e1f17b39fe5a
https://doi.org/10.1002/chem.201905164