المؤلفون: Christopher R. Wellaway (7148462), Ian R. Baldwin (1523716), Paul Bamborough (1343466), Daniel Barker (272779), Michelle A. Bartholomew (6566705), Chun-wa Chung (1343454), Birgit Dümpelfeld (2391988), John P. Evans (1312302), Neal J. Fazakerley (4714458), Paul Homes (1523515), Steven P. Keeling (11859605), Xiao Q. Lewell (1494235), Finlay W. McNab (11859608), Joanne Morley (633656), Deborah Needham (1859719), Margarete Neu (1840468), Antoon J. M. van Oosterhout (11859611), Anshu Pal (11859614), Friedrich B. M. Reinhard (8209701), Francesco Rianjongdee (9260972), Craig M. Robertson (1533145), Paul Rowland (1523731), Rishi R. Shah (8232807), Emma B. Sherriff (11859617), Lisa A. Sloan (1523527), Simon Teague (11859620), Daniel A. Thomas (1932538), Natalie Wellaway (2202247), Justyna Wojno-Picon (8551074), James M. Woolven (2119828), Diane M. Coe (1494211)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequent investigations revealed, compromised kinome selectivity, mouse lung pharmacokinetic, computational docking studies, ao binding site, inhaled jak inhibitors, aldehyde oxidase metabolism, aldehyde oxidase, tyrosine kinases, specific substituents, severe asthma, receptor signaling, quinazoline series, quinazoline 2, potential issue, parent compound, lung delivery, low exposure, low concentrations, janus kinase, janus family, jak inhibitors, identify quinazolines

Relation: https://figshare.com/articles/journal_contribution/Investigation_of_Janus_Kinase_JAK_Inhibitors_for_Lung_Delivery_and_the_Importance_of_Aldehyde_Oxidase_Metabolism/17303699

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01765.s003

المؤلفون: Christopher R. Wellaway (7148462), Ian R. Baldwin (1523716), Paul Bamborough (1343466), Daniel Barker (272779), Michelle A. Bartholomew (6566705), Chun-wa Chung (1343454), Birgit Dümpelfeld (2391988), John P. Evans (1312302), Neal J. Fazakerley (4714458), Paul Homes (1523515), Steven P. Keeling (11859605), Xiao Q. Lewell (1494235), Finlay W. McNab (11859608), Joanne Morley (633656), Deborah Needham (1859719), Margarete Neu (1840468), Antoon J. M. van Oosterhout (11859611), Anshu Pal (11859614), Friedrich B. M. Reinhard (8209701), Francesco Rianjongdee (9260972), Craig M. Robertson (1533145), Paul Rowland (1523731), Rishi R. Shah (8232807), Emma B. Sherriff (11859617), Lisa A. Sloan (1523527), Simon Teague (11859620), Daniel A. Thomas (1932538), Natalie Wellaway (2202247), Justyna Wojno-Picon (8551074), James M. Woolven (2119828), Diane M. Coe (1494211)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, subsequent investigations revealed, compromised kinome selectivity, mouse lung pharmacokinetic, computational docking studies, ao binding site, inhaled jak inhibitors, aldehyde oxidase metabolism, aldehyde oxidase, tyrosine kinases, specific substituents, severe asthma, receptor signaling, quinazoline series, quinazoline 2, potential issue, parent compound, lung delivery, low exposure, low concentrations, janus kinase, janus family, jak inhibitors, identify quinazolines

Relation: https://figshare.com/articles/dataset/Investigation_of_Janus_Kinase_JAK_Inhibitors_for_Lung_Delivery_and_the_Importance_of_Aldehyde_Oxidase_Metabolism/17303696

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01765.s002