المصدر: Determination of the Effect of Age and Gender on the Pharmacokinetics and Tolerability of a Single Dose of Finafloxacin-HCL in Healthy Volunteers

المؤلفون: Sarah V. Harding, Kay B. Barnes, Stephen Hawser, Christine E. Bentley, Andreas Vente

المصدر: Antibiotics; Volume 12; Issue 7; Pages: 1096

مصطلحات موضوعية: finafloxacin, in vitro activity, acidic pH, cystic fibrosis

وصف الملف: application/pdf

Relation: Novel Antimicrobial Agents; https://dx.doi.org/10.3390/antibiotics12071096

الاتاحة: https://doi.org/10.3390/antibiotics12071096

المؤلفون: Kay B. Barnes, Marc Bayliss, Carwyn Davies, Mark I. Richards, Thomas R. Laws, Andreas Vente, Sarah V. Harding

المصدر: Frontiers in Microbiology, Vol 13 (2022)

مصطلحات موضوعية: glanders, finafloxacin, co-trimoxazole, Burkholderia mallei, mouse models, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2022.1057202/full; https://doaj.org/toc/1664-302X

URL الوصول: https://doaj.org/article/65b439ec2bce445b839620f425b81232

المؤلفون: Yingying Kong, Chao Li, Gangfeng Li, Ting Yang, Mohamed S. Draz, Xinyou Xie, Jun Zhang, Zhi Ruan

المصدر: Microbiology Spectrum, Vol 10, Iss 3 (2022)

مصطلحات موضوعية: Mycoplasma hominis, Ureaplasma spp., delafloxacin, finafloxacin, fluoroquinolone-resistant, in vitro activity, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2165-0497

URL الوصول: https://doaj.org/article/103964ae53c34685b0b7b046d522e3cf

المصدر: A Multi-Dose, Double-Blind, Double-Dummy, Active- Control, Randomized Clinical (Phase II) Study of Two Dosing Regimens of Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis Requiring Hospitalisation.
Wagenlehner F, Nowicki M, Bentley C, Luckermann M, Wohlert S, Fischer C, Vente A, Naber K, Dalhoff A. Explorative Randomized Phase II Clinical Study of the Efficacy and Safety of Finafloxacin versus Ciprofloxacin for Treatment of Complicated Urinary Tract Infections. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02317-17. doi: 10.1128/AAC.02317-17. Print 2018 Apr.
Taubert M, Luckermann M, Vente A, Dalhoff A, Fuhr U. Population Pharmacokinetics of Finafloxacin in Healthy Volunteers and Patients with Complicated Urinary Tract Infections. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02328-17. doi: 10.1128/AAC.02328-17. Print 2018 Apr.
Vente A, Bentley C, Luckermann M, Tambyah P, Dalhoff A. Early Clinical Assessment of the Antimicrobial Activity of Finafloxacin Compared to Ciprofloxacin in Subsets of Microbiologically Characterized Isolates. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02325-17. doi: 10.1128/AAC.02325-17. Print 2018 Apr.

المؤلفون: Thomas R. Laws, Kay B. Barnes, Dominic C. Jenner, Alejandro Núñez, Mark I. Richards, Joanne E. Thwaite, Andreas Vente, David Rushton, Michelle Nelson, Sarah V. Harding

المصدر: Antibiotics; Volume 11; Issue 10; Pages: 1442

مصطلحات موضوعية: Burkholderia pseudomallei, antibiotic, finafloxacin, co-trimoxazole, relapse, eosin

وصف الملف: application/pdf

Relation: Antibiotics in Animal Health; https://dx.doi.org/10.3390/antibiotics11101442

الاتاحة: https://doi.org/10.3390/antibiotics11101442

المصدر: An Open-Label Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile in Plasma and Epithelial Lining Fluid of Finafloxacin After Single and Multiple Doses Administered Orally in Healthy Volunteers

المصدر: Finafloxacin - A Double-blind, Placebo-controlled, Randomised, Dose-escalating, Crossover Study to Determine the Safety and Tolerability of Single and Multiple Intravenous Doses of Finafloxacin in Healthy Subjects
Taubert M, Chiesa J, Luckermann M, Fischer C, Dalhoff A, Fuhr U. Pharmacokinetics of Intravenous Finafloxacin in Healthy Volunteers. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e01122-17. doi: 10.1128/AAC.01122-17. Print 2017 Oct.

المؤلفون: Chalhoub, Houssein, Harding, Sarah V, Tulkens, Paul M., Van Bambeke, Françoise

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Clinical Microbiology and Infection, Vol. 26, no.9, p. 1254.e1-1254.e8 (2020)

مصطلحات موضوعية: Burkholderia thailandensis, Finafloxacin, Fluoroquinolones, Francisella philomiragia, Imipenem, Intracellular infection, Yersinia pseudotuberculosis

Relation: boreal:240788; http://hdl.handle.net/2078.1/240788; info:pmid/31404671; urn:ISSN:1198-743X; urn:EISSN:1469-0691

الاتاحة: http://hdl.handle.net/2078.1/240788
https://doi.org/10.1016/j.cmi.2019.07.028

المؤلفون: Kay B. Barnes, Karleigh A. Hamblin, Mark I. Richards, Thomas R. Laws, Andreas Vente, Helen S. Atkins, Sarah V. Harding

المصدر: Frontiers in Microbiology, Vol 10 (2019)

مصطلحات موضوعية: finafloxacin, Francisella tularensis, therapeutic, in vivo efficacy, biothreat, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2019.00904/full; https://doaj.org/toc/1664-302X

URL الوصول: https://doaj.org/article/009529c55e954f5595493ff386d79cf6

المساهمون: Prof. Dr. P. Malfertheiner, Director

المصدر: An Open-Label, Randomized, Multicenter, Two-Arms Efficacy and Safety Study of 14 Days Treatment With Finafloxacin 400 mg b.i.d. Plus Amoxicillin 1000 mg b.i.d.Versus Finafloxacin 400 mg b.i.d. Plus Esomeprazole 40 mg b.i.d. in Patients With Helicobacter Pylori Infection

المساهمون: Jasper Hein, MD, Prinzipal Investigator

المصدر: A Double-Blind, Double-Dummy, Prospective, Randomized Multiple-Site Study of Oral Finafloxacin 300 mg b.i.d. Versus Oral Ciprofloxacin 250 mg b.i.d. in Patients With Lower Uncomplicated UTI (uUTI) With a Treatment Duration of 3 Days
Vente A, Bentley C, Luckermann M, Tambyah P, Dalhoff A. Early Clinical Assessment of the Antimicrobial Activity of Finafloxacin Compared to Ciprofloxacin in Subsets of Microbiologically Characterized Isolates. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02325-17. doi: 10.1128/AAC.02325-17. Print 2018 Apr.

المساهمون: Michael Seiberling, MD, Prinzipal Study Investigator

المصدر: A Double-Blind, Placebo-Controlled, Randomized, Dose-Escalating Study of Single and Multiple Oral Doses of Finafloxacin Hydrochloride in Healthy Subjects and a Study of H. Pylori Treatment in Healthy Carriers

المؤلفون: Nimmy Robin, Etedad Nour Alla Eadl Elbasier Suliman, Asim Ahmed Elnour, Mark Maas, Dixon Thomas

المصدر: Drugs & Therapy Perspectives. 37:470-479

مصطلحات موضوعية: medicine.medical_specialty, medicine.drug_class, business.industry, Antibiotics, biochemical phenomena, metabolism, and nutrition, Fosfomycin, Plazomicin, Ciprofloxacin, chemistry.chemical_compound, Finafloxacin, chemistry, Levofloxacin, Internal medicine, polycyclic compounds, medicine, Ceftriaxone, Pharmacology (medical), business, Ertapenem, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1e435798c94dd721c9ee370a0a991c9a
https://doi.org/10.1007/s40267-021-00858-7

المؤلفون: Thomas R. Laws, Christine Bentley, Joanne E. Thwaite, Sarah V. Harding, Alejandro Núñez, Mark I. Richards, Kay B. Barnes

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: Bubonic plague, Microbiology, Tularemia, 03 medical and health sciences, chemistry.chemical_compound, Mice, In vivo, Medicine, Animals, Pharmacology (medical), Experimental Therapeutics, finafloxacin, Francisella tularensis, Aerosolization, 030304 developmental biology, Pharmacology, 0303 health sciences, Mice, Inbred BALB C, Plague, biology, 030306 microbiology, business.industry, biology.organism_classification, medicine.disease, Ciprofloxacin, Finafloxacin, Infectious Diseases, Yersinia pestis, chemistry, business, medicine.drug, Fluoroquinolones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711b7b323010d610e0375a371d99257b
http://europepmc.org/articles/PMC8315961

المؤلفون: Tanel Tenson, Ivana Kerkez, Françoise Van Bambeke, Paul M. Tulkens, Marta Putrinš

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Antimicrobial Agents and Chemotherapy, Vol. 65, p. e0146821 (2021)

مصطلحات موضوعية: Pharmacology, Multidrug tolerance, Chemistry, medicine.drug_class, Sulfamethoxazole, Intracellular parasite, Antibiotics, bacterial infections and mycoses, Microbiology, Ciprofloxacin, Finafloxacin, chemistry.chemical_compound, Infectious Diseases, Ampicillin, medicine, Pharmacology (medical), Gentamicin, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f47c031f6103cbcfcf46618afd7e63
https://doi.org/10.1128/aac.01468-21

المؤلفون: Daniela Leto, Annie Brooks, Mazen S. Bader, Mark Loeb

المصدر: Postgraduate Medicine. 132:234-250

مصطلحات موضوعية: medicine.medical_specialty, 030209 endocrinology & metabolism, Tigecycline, 030204 cardiovascular system & hematology, Fosfomycin, Plazomicin, Meropenem, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Drug Resistance, Bacterial, polycyclic compounds, medicine, Humans, Pyelonephritis, business.industry, Fosfomycin Tromethamine, General Medicine, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Anti-Bacterial Agents, Drug Combinations, Finafloxacin, Pivmecillinam, chemistry, Nitrofurantoin, Urinary Tract Infections, bacteria, Drug Therapy, Combination, Gram-Negative Bacterial Infections, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d451f92793eb83f03e1fe6598278f95c
https://doi.org/10.1080/00325481.2019.1680052

المؤلفون: Aya A.M. Mohammed, Ghadeer A. R. Y. Suaifan

المصدر: Bioorganic & Medicinal Chemistry. 27:3005-3060

مصطلحات موضوعية: Antifungal, medicine.drug_class, Clinical Biochemistry, Antibiotics, Pharmaceutical Science, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Antibiotic resistance, Moxifloxacin, Drug Discovery, medicine, Humans, Molecular Biology, Traditional medicine, 010405 organic chemistry, Organic Chemistry, Quinolone, Antimicrobial, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Finafloxacin, chemistry, Molecular Medicine, Delafloxacin, Fluoroquinolones, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f2869ef2b82f61bb1946899d5532d6
https://doi.org/10.1016/j.bmc.2019.05.038

المؤلفون: Ioana-Andreea Lungu, Aura Rusu, Octavia-Laura Moldovan, Gabriel Hancu, Corneliu Tanase

المصدر: Pharmaceutics
Pharmaceutics, Vol 13, Iss 1289, p 1289 (2021)

مصطلحات موضوعية: Traditional medicine, structure-activity relationship, Pharmaceutical Science, DNA gyrase, Review, Biology, Fifth generation, Zabofloxacin, RS1-441, chemistry.chemical_compound, Finafloxacin, Pharmacy and materia medica, Antibiotic resistance, chemistry, antibacterial activity, topoisomerase IV, Fluoro quinolones, Nadifloxacin, quinolones, fluoroquinolones, Antibacterial activity, Nemonoxacin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676a7b49cf327b7b242541e249a3e585
https://pubmed.ncbi.nlm.nih.gov/34452252

المؤلفون: Adam O. Whelan, Isobel H. Norville, Frédéric Peyrusson, Françoise Van Bambeke, Margaret G. Hartley, Sarah V. Harding

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Antimicrobial Agents and Chemotherapy, Vol. 65, p. e0106121 (2021)
Antimicrob Agents Chemother

مصطلحات موضوعية: medicine.drug_class, THP-1 Cells, Antibiotics, Azithromycin, Microbiology, chemistry.chemical_compound, Levofloxacin, Ciprofloxacin, medicine, Humans, Experimental Therapeutics, Pharmacology (medical), Doxycycline, Pharmacology, biology, Chemistry, Coxiella burnetii, biology.organism_classification, bacterial infections and mycoses, Anti-Bacterial Agents, Finafloxacin, Infectious Diseases, bacteria, Q Fever, Intracellular, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4998c7d2f5e7890a100864ef2e9cc7
https://hdl.handle.net/2078.1/253073