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1Academic Journal
المؤلفون: Marina Pajic, Vishal Kothari, Diego Chacon Fajardo, Chad L Moore, Sean Porazinski, Benjamin McLean, Eve Borbilas, Tim Machajewski, Fernando Rock, Scott M Turner
المصدر: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2051-1426
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2Academic Journal
المؤلفون: Manuel Muñoz, Vishal Kothari, Tim Machajewski, Fernando Rock, Scott M Turner, Selorm Tamakloe, Colin Magowan, Gail Lee, Darren Finkelstein, Tim Hom, Dennis Monteleone, Subramanian Karu, Erine Budi, Prerna Kotak, Shamra Martin, Katherine Jenkins, Martin Decaris
المصدر: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2051-1426
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3Academic JournalDual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
المؤلفون: Martin L. Decaris, Johanna R. Schaub, Chun Chen, Jacob Cha, Gail G. Lee, Megi Rexhepaj, Steve S. Ho, Vikram Rao, Megan M. Marlow, Prerna Kotak, Erine H. Budi, Lisa Hooi, Jianfeng Wu, Marina Fridlib, Shamra P. Martin, Shaoyi Huang, Ming Chen, Manuel Muñoz, Timothy F. Hom, Paul J. Wolters, Tushar J. Desai, Fernando Rock, Katerina Leftheris, David J. Morgans, Eve-Irene Lepist, Patrick Andre, Eric A. Lefebvre, Scott M. Turner
المصدر: Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
مصطلحات موضوعية: Transforming growth factor-β, Precision-cut lung slice, Antifibrotic, αv integrin, PLN-74809, Diseases of the respiratory system, RC705-779
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1465-993X
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4Academic Journal
المؤلفون: Thavy Long, Liliana Rojo-Arreola, Da Shi, Nelly El-Sakkary, Kurt Jarnagin, Fernando Rock, Maliwan Meewan, Alberto A Rascón, Lin Lin, Katherine A Cunningham, George A Lemieux, Larissa Podust, Ruben Abagyan, Kaveh Ashrafi, James H McKerrow, Conor R Caffrey
المصدر: PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005680 (2017)
مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
وصف الملف: electronic resource
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5Academic Journal
المؤلفون: Martin L. Decaris (11583707), Johanna R. Schaub (11583710), Chun Chen (38350), Jacob Cha (11583713), Gail G. Lee (11583716), Megi Rexhepaj (7111103), Steve S. Ho (11583719), Vikram Rao (11583722), Megan M. Marlow (11583725), Prerna Kotak (11583728), Erine H. Budi (11583731), Lisa Hooi (11583734), Jianfeng Wu (360829), Marina Fridlib (11583737), Shamra P. Martin (11583740), Shaoyi Huang (11583743), Ming Chen (115604), Manuel Muñoz (2322163), Timothy F. Hom (1498903), Paul J. Wolters (11583746), Tushar J. Desai (11583749), Fernando Rock (4245667), Katerina Leftheris (2459563), David J. Morgans (324326), Eve-Irene Lepist (517179), Patrick Andre (11583752), Eric A. Lefebvre (11583755), Scott M. Turner (11583758)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Transforming growth factor-β, Precision-cut lung slice, Antifibrotic, αv integrin, PLN-74809
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6
المؤلفون: Vishal Kothari, Colin Magowan, Darren Finkelstein, Gail Lee, Chun Chen, Tim Hom, Manuel Muñoz, Dennis Monteleone, Subramanian Karur, Marta Bogaczynska, Erin Budi, Prerna Kotak, Shamra Martin, Katherine Jenkins, Simon Wong, Timothy Machajewski, Fernando Rock, Scott Turner
المصدر: Regular and Young Investigator Award Abstracts.
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7Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
المؤلفون: Patrick Andre, Martin Decaris, Chun Chen, Munoz Manuel, Hom Timothy, Scott M. Turner, Ming Chen, Tushar J. Desai, Megan M. Marlow, Cha Jacob, Eric Lefebvre, Steve S. Ho, Paul J. Wolters, Shaoyi Huang, Eve-Irene Lepist, Katerina Leftheris, David J Morgans, Lisa Hooi, Johanna R. Schaub, Vikram R. Rao, Jianfeng Wu, Marina Fridlib, Fernando Rock, Megi Rexhepaj, Erine H. Budi, Prerna Kotak, Gail Lee, Shamra Martin
المصدر: Respiratory research, vol 22, iss 1
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)مصطلحات موضوعية: Precision-cut lung slice, Respiratory System, αv integrin, alpha(v) integrin, Cardiorespiratory Medicine and Haematology, Inbred C57BL, Mice, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Receptors, Pulmonary fibrosis, Phosphorylation, alpha 1 Chain, Lung, biology, Transforming growth factor-β, Pirfenidone, Transforming growth factor-beta, medicine.anatomical_structure, 5.1 Pharmaceuticals, Respiratory, Nintedanib, Antifibrotic Agents, Development of treatments and therapeutic interventions, Cell activation, Type I collagen, Signal Transduction, medicine.drug, Integrin, Clinical Sciences, Collagen Type I, Cell Line, Diseases of the respiratory system, Bleomycin, Rare Diseases, medicine, Animals, Humans, Vitronectin, Smad3 Protein, PLN-74809, RC705-779, Integrin alpha6beta1, Animal, Epithelial Cells, Fibroblasts, medicine.disease, Coculture Techniques, Idiopathic Pulmonary Fibrosis, chemistry, Disease Models, Cancer research, biology.protein, Antifibrotic
وصف الملف: application/pdf
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8
المؤلفون: Robert T. Jacobs, Rianna Stefanakis, Nancy Tricoche, Eric E. Easom, Yvonne Freund, Kee Chong Lim, James H. McKerrow, David S. Carter, Christina A. Bulman, Brian M. Suzuki, Christopher S. Lunde, Pamela Berry, Judy A. Sakanari, Jacob J. Plattner, Chelsea Fischer, Sara Lustigman, Tsutomu Akama, Fernando Rock
المصدر: ACS Infectious Diseases
مصطلحات موضوعية: Boron Compounds, Male, 0301 basic medicine, Benzimidazole, Letter, Ketone, 030106 microbiology, Administration, Oral, Flubendazole, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Onchocerciasis, Ocular, parasitic diseases, medicine, Animals, lymphatic filariasis, chemistry.chemical_classification, flubendazole, organoboron, Blindness, biology, Chemistry, onchocerciasis, Ketones, medicine.disease, biology.organism_classification, Onchocerca volvulus, Disease Models, Animal, Filaricides, 030104 developmental biology, Infectious Diseases, Nematode, tubulin, Benzimidazoles, Female, Gerbillinae, Onchocerciasis
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9
المؤلفون: Tsutomu Akama, Yvonne R. Freund, Pamela W. Berry, David S. Carter, Eric E. Easom, Kurt Jarnagin, Christopher S. Lunde, Jacob J. Plattner, Fernando Rock, Rianna Stefanakis, Chelsea Fischer, Christina A. Bulman, Kee Chong Lim, Brian M. Suzuki, Nancy Tricoche, Abdelmoneim Mansour, Utami DiCosty, Scott McCall, Ben Carson, John W. McCall, James McKerrow, Marc P. Hübner, Sabine Specht, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari, Robert T. Jacobs
المصدر: ACS Infectious Diseases
مصطلحات موضوعية: Boron Compounds, Male, flubendazole, Letter, organoboron, onchocerciasis, Amides, Onchocerca volvulus, Infectious Diseases, Filaricides, tubulin, parasitic diseases, Brugia, Animals, Benzimidazoles, Female, Gerbillinae, lymphatic filariasis
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10
المؤلفون: Eduard Gorina, Johanna R. Schaub, Chun Chen, Fernando Rock, Martin Decaris, Scott Turner, Eric Lefebvre, Eve Irene Lepist
المصدر: Idiopathic interstitial pneumonias.
مصطلحات موضوعية: Lung, biology, business.industry, Integrin, SMAD, respiratory system, Pharmacology, medicine.disease, Idiopathic pulmonary fibrosis, medicine.anatomical_structure, Fibrosis, In vivo, biology.protein, Medicine, Phosphorylation, business, IC50
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11
المؤلفون: Vincent Hernandez, Liang Liu, M. R. K. Alley, Iñigo Angulo-Barturen, Manisha Mohan, Baojie Wan, Andrés Palencia, Wai Choi, Zhenkun Ma, Lisa Feng, Scott G. Franzblau, Charles Z. Ding, Maliwan Meewan, David Barros, James C. Sacchettini, Joaquín Rullas, Paul Houston, Fernando Rock, Wei Bu, Anne J. Lenaerts, Tanya Parish, Alfonso Mendoza, Xianfeng Li, Lisa K. Woolhiser, Yasheen Zhou, M. Gerard Waters, Christopher B. Cooper, Jacob J. Plattner, Suoming Zhang, Eric E. Easom, Stephen Cusack, Veronica Gruppo, Theresa O’Malley, Holly Sexton, Esther Pérez-Herrán, Thomas R. Ioerger, Yuehong Wang
المصدر: Antimicrobial Agents and Chemotherapy
'Antimicrobial Agents and Chemotherapy ', vol: 60, pages: 6271-6280 (2016)مصطلحات موضوعية: 0301 basic medicine, Drug, Tuberculosis, media_common.quotation_subject, 030106 microbiology, Mycobacterium smegmatis, Antitubercular Agents, Drug Evaluation, Preclinical, Administration, Oral, Mice, Inbred Strains, Microbial Sensitivity Tests, Pharmacology, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, medicine, Animals, Humans, Pharmacology (medical), Experimental Therapeutics, Vero Cells, media_common, Protein Synthesis Inhibitors, Mice, Inbred BALB C, Protein synthesis inhibitor, biology, Leucyl-tRNA synthetase, Isoniazid, biology.organism_classification, medicine.disease, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Infectious Diseases, chemistry, Streptomycin, Linezolid, Female, Leucine-tRNA Ligase, medicine.drug
وصف الملف: application/pdf
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12
المؤلفون: Mahmoud A. Ghannoum, Tate Winter, Anthony Rycerz, Bryan C. Markinson, Aditya K. Gupta, Fernando Rock
المصدر: Journal of the American Podiatric Medical Association. 108(1)
مصطلحات موضوعية: 0301 basic medicine, Boron Compounds, medicine.medical_specialty, 030106 microbiology, Trichophyton rubrum, Microbial Sensitivity Tests, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Onychomycosis, medicine, Humans, Trichophyton, skin and connective tissue diseases, Efinaconazole, Fungal protein, Tavaborole, biology, Ciclopirox, business.industry, General Medicine, Nail plate, biology.organism_classification, Bridged Bicyclo Compounds, Heterocyclic, Dermatology, medicine.anatomical_structure, Treatment Outcome, Nails, Nail (anatomy), business, medicine.drug
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13
المؤلفون: Joaquín Rullas, Manisha Mohan, Wai Choi, David Barros, M. R. K. Alley, Vincent Hernandez, Wuxin Zou, Sabrinia D. Crouch, Weimin Mao, Jacob J. Plattner, Ilaria Giordano, Yasheen Zhou, Iñigo Angulo-Barturen, Fátima Ortega, Carlos Alemparte, Alfonso Mendoza-Losana, Eric E. Easom, Esther Pérez-Herrán, Xianfeng Li, Fernando Rock, Yvonne Mak
المصدر: Journal of medicinal chemistry. 60(19)
مصطلحات موضوعية: 0301 basic medicine, Boron Compounds, 030106 microbiology, Antitubercular Agents, Heterocyclic Compounds, 2-Ring, Substrate Specificity, Mycobacterium tuberculosis, 03 medical and health sciences, Mice, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Mode of action, IC50, chemistry.chemical_classification, biology, Chemistry, Drug discovery, Leucyl-tRNA synthetase, respiratory system, bacterial infections and mycoses, biology.organism_classification, In vitro, Mice, Inbred C57BL, 030104 developmental biology, Enzyme, Biochemistry, Molecular Medicine, Female, Leucine-tRNA Ligase
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14
المؤلفون: Maliwan Meewan, Lin Lin, Fernando Rock, Kurt Jarnagin, Thavy Long, Katherine A. Cunningham, Da Shi, James H. McKerrow, George A. Lemieux, Alberto A. Rascón, Liliana Rojo-Arreola, Larissa M. Podust, Nelly El-Sakkary, Ruben Abagyan, Kaveh Ashrafi, Conor R. Caffrey
المساهمون: Geary, Timothy G
المصدر: PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases, vol 11, iss 7
Long, T; Rojo-Arreola, L; Shi, D; El-Sakkary, N; Jarnagin, K; Rock, F; et al.(2017). Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Neglected Tropical Diseases, 11(7). doi: 10.1371/journal.pntd.0005680. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/37t2q5gm
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005680 (2017)مصطلحات موضوعية: 0301 basic medicine, Schistosoma Mansoni, Nematoda, Mutant, Medical and Health Sciences, Biochemistry, Animals, Genetically Modified, Database and Informatics Methods, 0302 clinical medicine, Catalytic Domain, 2.1 Biological and endogenous factors, Aetiology, Enzyme Inhibitors, Cloning, Molecular, Schistosoma Japonicum, Caenorhabditis elegans, Genetics, Anthelmintics, biology, Drug discovery, lcsh:Public aspects of medicine, Schistosoma japonicum, Schistosoma mansoni, Animal Models, Biological Sciences, 3. Good health, Infectious Diseases, Experimental Organism Systems, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Schistosoma, Development of treatments and therapeutic interventions, Type 4, Sequence Analysis, Locomotion, Biotechnology, Research Article, Cyclic Nucleotide Phosphodiesterases, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Bioinformatics, Transgene, Phenotypic screening, Genetically Modified, Research and Analysis Methods, 03 medical and health sciences, Rare Diseases, Model Organisms, Sequence Motif Analysis, Tropical Medicine, Helminths, Animals, Public Health, Environmental and Occupational Health, Wild type, Organisms, Molecular, Biology and Life Sciences, lcsh:RA1-1270, biology.organism_classification, Molecular biology, Invertebrates, Schistosoma Haematobium, Cyclic Nucleotide Phosphodiesterases, Type 4, Vector-Borne Diseases, 030104 developmental biology, Orphan Drug, Good Health and Well Being, Caenorhabditis, Enzymology, Phosphodiesterase 4 Inhibitors, Sequence Alignment, Cloning
وصف الملف: application/pdf
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15
المؤلفون: Liang Liu, Yasheen Zhou, Kurt Jarnagin, Charlotte Virtucio, Xiaoqing Fan, Yong-Kang Zhang, Fernando Rock, Wei Bu, Tsutomu Akama, David C. Sullivan, Yvonne Freund, Chen Dong, Anne Wu
المصدر: Journal of Pharmacology and Experimental Therapeutics. 347:615-625
مصطلحات موضوعية: Boron Compounds, Models, Molecular, Muscle Relaxation, Myocytes, Smooth Muscle, Aorta, Thoracic, Blood Pressure, Biology, Muscle, Smooth, Vascular, Rats, Sprague-Dawley, Jurkat Cells, Structure-Activity Relationship, Protein Phosphatase 1, Rats, Inbred SHR, Animals, Humans, Structure–activity relationship, Kinome, Phosphorylation, Protein kinase A, Protein Kinase Inhibitors, Rho-associated protein kinase, Pharmacology, rho-Associated Kinases, Kinase, Muscle, Smooth, Smooth muscle contraction, Rats, Trachea, Biochemistry, Cytokines, Molecular Medicine, Cytokine secretion, Muscle Contraction
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16
المؤلفون: Michael Richard Kevin Alley, Jacob J. Plattner, Robert T. Jacobs, Dawei Li, Yaxue Zhao, Huchen Zhou, Qing Wang, Guo-Qiang Chen, Dazhong Ding, Fernando Rock, Qingqing Meng, Guangwei Gao, Bakela Nare
المصدر: Journal of Medicinal Chemistry. 54:1276-1287
مصطلحات موضوعية: Models, Molecular, Antiparasitic, medicine.drug_class, Stereochemistry, Trypanosoma brucei brucei, Trypanosoma brucei, Cell Line, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Structure–activity relationship, African trypanosomiasis, chemistry.chemical_classification, biology, Leucyl-tRNA synthetase, Stereoisomerism, medicine.disease, biology.organism_classification, Boronic Acids, Trypanocidal Agents, Enzyme, chemistry, Biochemistry, Docking (molecular), Drug Design, Molecular Medicine, Leucine-tRNA Ligase, Growth inhibition
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17
المؤلفون: Francis Johnson, M. R. K. Alley, Teruo Kirikae, Jun-ichiro Sekiguchi, Iwao Ojima, Todd J. Sullivan, Hua Xu, Fernando Rock, Stephen G. Walker, Christopher F. Stratton, Peter J. Tonge, Weimin Mao
المصدر: Biochemistry. 47:4228-4236
مصطلحات موضوعية: Models, Molecular, Staphylococcus aureus, Stereochemistry, Molecular Sequence Data, Population, Biology, Reductase, medicine.disease_cause, Biochemistry, Catalysis, Article, Substrate Specificity, chemistry.chemical_compound, Enzyme activator, medicine, Amino Acid Sequence, Enzyme Inhibitors, education, Conserved Sequence, chemistry.chemical_classification, education.field_of_study, Molecular Structure, Phenyl Ethers, Diphenyl ether, Enoyl-(Acyl-Carrier-Protein) Reductase (NADH), Enzyme Activation, Kinetics, Acyl carrier protein, Enzyme, chemistry, Product inhibition, Mutation, biology.protein, Sequence Alignment
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18
المؤلفون: Yasheen Zhou, Charlotte Virtucio, Yvonne Mak, Diogo Baia, Maliwan Meewan, Shamra Martin, Shannon Jones-Iatauro, Holly Sexton, Joshua Dee, Chen Dong, Kurt Jarnagin, Grober Baltazar, Tsutomu Akama, Olga Zemska, Fernando Rock
المصدر: The Journal of pharmacology and experimental therapeutics. 358(3)
مصطلحات موضوعية: 0301 basic medicine, Boron Compounds, Models, Molecular, medicine.medical_specialty, Thymic stromal lymphopoietin, medicine.medical_treatment, Administration, Topical, Pharmacology, Biology, Dermatitis, Atopic, 03 medical and health sciences, Mice, Thymic Stromal Lymphopoietin, Internal medicine, Psoriasis, Catalytic Domain, medicine, Leukocytes, Animals, Phosphorylation, Cyclic AMP Response Element-Binding Protein, Skin, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Kinase, Phosphodiesterase, Crisaborole, Atopic dermatitis, medicine.disease, Bridged Bicyclo Compounds, Heterocyclic, Cyclic Nucleotide Phosphodiesterases, Type 4, 030104 developmental biology, Cytokine, Endocrinology, Gene Expression Regulation, Molecular Medicine, Cytokines, Tumor necrosis factor alpha, Female, Phosphodiesterase 4 Inhibitors
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19
المؤلفون: Yong-Kang Zhang, Maliwan Meewan, Vincent Hernandez, Stephen Cusack, Keramane El Mehdi, Jacob J. Plattner, David M. Livermore, Liang Liu, Marina Warner, Nerissa L. Simon, Peter L. De Marsh, Mahipal Reddy Anugula, Manisha Mohan, Shazad Mushtaq, M. R. K. Alley, Rashmi Sharma, Anita Sheoran, Rajeshwar Singh, Tsutomu Akama, Ann O'Leary, Yvonne Freund, Yanchen Zhang, Wei Bu, Holly Sexton, Thibaut Crépin, Yasheen Zhou, D. Shekhar Reddy, Lisa Feng, Weimin Mao, Andrés Palencia, Kingsley Savariraj, Stephen J. Baker, Rajendra Subedi, James A. Nieman, Fernando Rock
المصدر: Antimicrobial agents and chemotherapy. 57(3)
مصطلحات موضوعية: Boron Compounds, Gram-negative bacteria, medicine.drug_class, Antibiotics, Microbial Sensitivity Tests, medicine.disease_cause, Crystallography, X-Ray, beta-Lactamases, Microbiology, Amino Acyl-tRNA Synthetases, Mice, Structure-Activity Relationship, Bacterial Proteins, Leucine, Intensive care, Drug Resistance, Multiple, Bacterial, Drug Discovery, medicine, Escherichia coli, Animals, Humans, Pharmacology (medical), Experimental Therapeutics, Pharmacology, biology, Pseudomonas aeruginosa, biology.organism_classification, Enterobacteriaceae, Anti-Bacterial Agents, Molecular Docking Simulation, Infectious Diseases, Biochemistry, Thigh, Female, Efflux, Gram-Negative Bacterial Infections, beta-Lactamase Inhibitors, Bacteria
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20
المؤلفون: Stephen J. Baker, Yasheen Zhou, Manisha Mohan, M. R. K. Alley, Kathy Cao, Jacob J. Plattner, Charles Z. Ding, Guofeng Jia, Maureen Kully, Maliwan Meewan, Fernando Rock, Sarah Lux, Yi Xia
المصدر: Bioorganicmedicinal chemistry letters. 21(8)
مصطلحات موضوعية: Boron Compounds, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Biochemistry, Chemical synthesis, beta-Lactamases, Structure-Activity Relationship, Drug Discovery, Enterobacter cloacae, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Beta-Lactamase Inhibitors, Antibacterial agent, Benzoxazoles, biology, Chemistry, Organic Chemistry, bacterial infections and mycoses, biology.organism_classification, Anti-Bacterial Agents, Enzyme inhibitor, Pyrazines, biology.protein, Molecular Medicine, Antibacterial activity, beta-Lactamase Inhibitors, Linker
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