المؤلفون: Ferdinando Maria Milazzo, Loredana Vesci, Anna Maria Anastasi, Caterina Chiapparino, Antonio Rosi, Giuseppe Giannini, Maurizio Taddei, Elena Cini, Valentina Faltoni, Elena Petricci, Gianfranco Battistuzzi, Laura Salvini, Valeria Carollo, Rita De Santis

المصدر: Frontiers in Oncology, Vol 9 (2020)

مصطلحات موضوعية: ADC (antibody drug conjugate), HDACi (Histone deacetylase inhibitor), trastuzumab, ErbB2, solid tumors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.01534/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/9cacfddaa65c4f5289baf37bf07c9122

المؤلفون: Olga Minenkova, Daniela Santapaola, Ferdinando Maria Milazzo, Anna Maria Anastasi, Gianfranco Battistuzzi, Caterina Chiapparino, Antonio Rosi, Giuseppe Gritti, Gianmaria Borleri, Alessandro Rambaldi, Cl('(e))lia Dental, C('(e))cile Viollet, Bruno Pagano, Laura Salvini, Emanuele Marra, Laura Luberto, Antonio Rossi, Anna Riccio, Emilio Merlo Pich, Maria Gabriella Santoro, Rita De Santis

المساهمون: O. Minenkova, D. Santapaola, F. Maria Milazzo, A. Maria Anastasi, G. Battistuzzi, C. Chiapparino, A. Rosi, G. Gritti, G. Borleri, A. Rambaldi, C. Dental, C. Viollet, B. Pagano, L. Salvini, E. Marra, L. Luberto, A. Rossi, A. Riccio, E. Merlo Pich, M. Gabriella Santoro, R. De Santis

مصطلحات موضوعية: Settore MED/10 - Malattie dell'Apparato Respiratorio

Relation: numberofpages:22; http://hdl.handle.net/2434/903753; https://www.biorxiv.org/content/10.1101/2021.06.04.447066v2.full.pdf+html

الاتاحة: http://hdl.handle.net/2434/903753
https://doi.org/10.1101/2021.06.04.447066
https://www.biorxiv.org/content/10.1101/2021.06.04.447066v2.full.pdf+html

المؤلفون: Claudio Cianferotti, Rita De Santis, Gianfranco Battistuzzi, Caterina Chiapparino, Elena Petricci, Maurizio Taddei, Valentina Faltoni, Laura Salvini, Giuseppe Giannini, Francesca Migliorini, Elena Cini, Anna Maria Anastasi, Ferdinando Maria Milazzo, Elena Ermini

مصطلحات موضوعية: Materials Chemistry, Metals and Alloys, Surfaces, Coatings and Films, General Chemistry, Ceramics and Composites, Electronic, Optical and Magnetic Materials, Catalysis

Relation: url:https://www.openaccessrepository.it/communities/itmirror; https://www.openaccessrepository.it/record/92365

الاتاحة: https://www.openaccessrepository.it/record/92365
https://doi.org/10.1039/d0cc06131j

المؤلفون: Franco Zunino, Claudio Cavazza, Paolo Carminati, Daniela Passeri, Augusto Orlandi, Valentina Zuco, Paola Perego, Monica Tortoreto, Giovanna Petrangolini, Massimo Zucchetti, Maurizio D'Incalci, Marcella Barbarino, Rosanna Foderà, Mario Berardino Guglielmi, Ferdinando Maria Milazzo, Loredana Vesci, Claudio Pisano

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcfa0370cc6132cda6f4246b52792b6
https://doi.org/10.1158/1078-0432.22442519

المؤلفون: Franco Zunino, Claudio Cavazza, Paolo Carminati, Daniela Passeri, Augusto Orlandi, Valentina Zuco, Paola Perego, Monica Tortoreto, Giovanna Petrangolini, Massimo Zucchetti, Maurizio D'Incalci, Marcella Barbarino, Rosanna Foderà, Mario Berardino Guglielmi, Ferdinando Maria Milazzo, Loredana Vesci, Claudio Pisano

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491ac695a485ceb3b81abb9e02d9f54d
https://doi.org/10.1158/1078-0432.c.6519233.v1

المؤلفون: Ferdinando Maria Milazzo, Fiorella Petronzelli, Antonio Rosi, Rita De Santis, Gianfranco Battistuzzi, Anna Maria Anastasi, Giuseppe Giannini, Loredana Leone, Claudio Albertoni, Laura Salvini, Lorenzo Tei

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Biology, Molecular Medicine, Biochemistry

Relation: url:https://www.openaccessrepository.it/communities/itmirror; https://www.openaccessrepository.it/record/83235

الاتاحة: https://www.openaccessrepository.it/record/83235
https://doi.org/10.1016/j.bmc.2019.05.047

المؤلفون: Ferdinando Maria Milazzo, Federico Pepi, Francesco Saccoliti, Daniela De Vita, Giuliana Cassinelli, Gianfranco Battistuzzi, Alessandro De Leo, Luigi Scipione, Laura Scalvini, Giuseppe Giannini, Martina Bortolami, Fabiana Fosca Ferrara, Valeria Tudino, Marco Mor, Luca Pescatori, Antonella Messore, Valentina Noemi Madia, Silvia Rivara, Roberto Di Santo, Roberta Costi, Emiliano Pavoni, Giuseppe Roscilli

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

Relation: url:https://www.openaccessrepository.it/communities/itmirror; https://www.openaccessrepository.it/record/91581

الاتاحة: https://www.openaccessrepository.it/record/91581
https://doi.org/10.1021/acs.jmedchem.8b01497

المؤلفون: Giuseppe Gritti, Maria Gabriella Santoro, Daniela Santapaola, Olga Minenkova, Bruno Pagano, Alessandro Rambaldi, Gianfranco Battistuzzi, Rita De Santis, Gianmaria Borleri, Caterina Chiapparino, Laura Salvini, Emilio Merlo Pich, Cécile Viollet, Antonio Rosi, Anna Maria Anastasi, Clélia Dental, Antonio Rossi, Laura Luberto, Ferdinando Maria Milazzo, Anna Riccio, Emanuele Marra

المساهمون: Minenkova, Olga, Santapaola, Daniela, Milazzo, Ferdinando Maria, Anastasi, Anna Maria, Battistuzzi, Gianfranco, Chiapparino, Caterina, Rosi, Antonio, Gritti, Giuseppe, Borleri, Gianmaria, Rambaldi, Alessandro, Dental, Clélia, Viollet, Cécile, Pagano, Bruno, Salvini, Laura, Marra, Emanuele, Luberto, Laura, Rossi, Antonio, Riccio, Anna, Pich, Emilio Merlo, Santoro, Maria Gabriella, De Santis, Rita

المصدر: Molecular therapy
(2022). doi:10.1016/j.ymthe.2022.02.013
info:cnr-pdr/source/autori:Minenkova O.; Santapaola D.; Milazzo F.M.; Anastasi A.M.; Battistuzzi G.; Chiapparino C.; Rosi A.; Gritti G.; Borleri G.; Rambaldi A.; Dental C.; Viollet C.; Pagano B.; Salvini L.; Marra E.; Luberto L.; Rossi A.; Riccio A.; Merlo Pich E.; Santoro M.G.; De Santis R./titolo:Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy/doi:10.1016%2Fj.ymthe.2022.02.013/rivista:Molecular therapy (Print)/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume

مصطلحات موضوعية: Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Antibodies, Viral, Epitope, Antibody fragments, Drug Discovery, Genetics, COVID-19 pandemic, COVID-19 therapy, SARS-CoV-2 variant neutralization, aerosol therapy, anti-COVID-19 antibody, human single-chain antibody, inhalation, intranasal administration, phage display, Single-chain variable fragment, Medicine, Animals, Humans, Immunoglobulin Fragments, Molecular Biology, Pharmacology, Immune status, biology, business.industry, SARS-CoV-2, COVID-19, Virology, Antibodies, Neutralizing, aerosol therapy, anti-COVID-19 antibody, COVID-19 pandemic, COVID-19 therapy, human single-chain antibody, inhalation, intranasal administration, phage display, SARS-CoV-2 variant neutralization, Spike Glycoprotein, Coronavirus, biology.protein, Molecular Medicine, Nasal administration, Antibody, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e679834cc702fe42637f514ee848dae1
http://hdl.handle.net/11588/873896

المؤلفون: Giuseppe Giannini, Ferdinando Maria Milazzo, Silvia Rivara

مصطلحات موضوعية: Drug Discovery, Pharmacology, Molecular Medicine

Relation: url:https://www.openaccessrepository.it/communities/itmirror; https://www.openaccessrepository.it/record/128607

الاتاحة: https://www.openaccessrepository.it/record/128607
https://doi.org/10.4155/fmc-2016-0012

المؤلفون: Gian Marco Elisi, Alessio Lodola, Silvia Rivara, Laura Scalvini, Giuseppe Giannini, Gilberto Spadoni, Gianfranco Battistuzzi, Daniele Pala, Giuseppe Roscilli, Emiliano Pavoni, Ferdinando Maria Milazzo, Marco Mor, Fabiana Fosca Ferrara

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1685-1696 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

مصطلحات موضوعية: Models, Molecular, Drug Evaluation, Preclinical, Cancer therapy, RM1-950, macromolecular substances, Ligands, 01 natural sciences, Article, heparanase, Structure-Activity Relationship, Heparanase, heparan sulphate, virtual screening, Drug Discovery, Humans, Enzyme Inhibitors, Glucuronidase, Pharmacology, Virtual screening, Dose-Response Relationship, Drug, Molecular Structure, Heparan sulphate, 010405 organic chemistry, Chemistry, General Medicine, Ligand (biochemistry), Amides, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cancer research, Therapeutics. Pharmacology, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e333e97e5652d79d3757bd13a5bdd51f

المؤلفون: Ferdinando Maria Milazzo, Loredana Vesci, Anna Maria Anastasi, Caterina Chiapparino, Antonio Rosi, Giuseppe Giannini, Maurizio Taddei, Elena Cini, Valentina Faltoni, Elena Petricci, Gianfranco Battistuzzi, Laura Salvini, Valeria Carollo, Rita De Santis

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, ADC (antibody drug conjugate), HDACi (Histone deacetylase inhibitor), trastuzumab, ErbB2, solid tumors

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_ErbB2_Targeted_Epigenetic_Modulation_Anti-tumor_Efficacy_of_the_ADC_Trastuzumab-HDACi_ST8176AA1_PDF/11692230

الاتاحة: https://doi.org/10.3389/fonc.2019.01534.s001
https://figshare.com/articles/dataset/Data_Sheet_1_ErbB2_Targeted_Epigenetic_Modulation_Anti-tumor_Efficacy_of_the_ADC_Trastuzumab-HDACi_ST8176AA1_PDF/11692230

المؤلفون: Barbara Leoni, Rita De Santis, Loredana Vesci, Caterina Chiapparino, Antonio Rosi, Anna Maria Anastasi, Fiorella Petronzelli, Ferdinando Maria Milazzo

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, Receptor, ErbB-2, medicine.drug_class, Apoptosis, Breast Neoplasms, Pharmacology, Antibodies, Monoclonal, Humanized, Monoclonal antibody, 03 medical and health sciences, 0302 clinical medicine, ErbB2, pertuzumab, Trastuzumab, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Tumor Cells, Cultured, cancer, Humans, Medicine, Panitumumab, Biotinylation, Epidermal growth factor receptor, Cell Proliferation, Cetuximab, biology, business.industry, avidinOX, Avidin, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Monoclonal, biology.protein, Female, Pertuzumab, business, Research Paper, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2099011e43b94efb62ddd33137caed
https://doi.org/10.18632/oncotarget.15145

المؤلفون: Marco Mor, Emiliano Pavoni, Daniele Pala, Silvia Rivara, Giuseppe Giannini, Ferdinando Maria Milazzo, Giuseppe Roscilli

المصدر: Glycobiology

مصطلحات موضوعية: Protein Conformation, alpha-Helical, 0301 basic medicine, SST0001, Molecular model, homology modeling, Amino Acid Motifs, Plasma protein binding, Molecular Dynamics Simulation, Biochemistry, Molecular Docking Simulation, heparanase, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Polysaccharides, Humans, Protein Interaction Domains and Motifs, Heparanase, Homology modeling, Enzyme Inhibitors, Glucuronidase, Binding Sites, kinetic inhibition analysis, Heparin, Computational Biology, Heparan sulfate, Recombinant Proteins, Acidobacteria, Enzyme binding, Kinetics, 030104 developmental biology, Carbohydrate Sequence, Fondaparinux, chemistry, Structural Homology, Protein, Docking (molecular), 030220 oncology & carcinogenesis, Biophysics, roneparstat, Thermodynamics, Protein Conformation, beta-Strand, ORIGINAL ARTICLES, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf21583957a39be8cce04528c2923fe
https://doi.org/10.1093/glycob/cww003

المؤلفون: Alessandro De Leo, Emiliano Pavoni, Giuliana Cassinelli, Silvia Rivara, Luca Pescatori, Giuseppe Giannini, Antonella Messore, Valentina Noemi Madia, Valeria Tudino, Fabiana Fosca Ferrara, Luigi Scipione, Marco Mor, Gianfranco Battistuzzi, Giuseppe Roscilli, Martina Bortolami, Ferdinando Maria Milazzo, Roberta Costi, Francesco Saccoliti, Roberto Di Santo, Laura Scalvini

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Indoles, Angiogenesis, Protein Conformation, pharmaceutical science, Fibroblast growth factor, Glycosaminoglycan, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, Humans, Heparanase, Enzyme Inhibitors, Glucuronidase, molecular medicine, chemistry.chemical_classification, Chemistry, Heparan sulfate, Amino acid, drug discovery 3003, 030104 developmental biology, Enzyme, Biochemistry, Cell culture, 030220 oncology & carcinogenesis, Drug Design

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410fbad8d4e372bc8d7ddad793352e95
http://hdl.handle.net/11573/1176836

المؤلفون: Gianfranco Battistuzzi, Anna Maria Anastasi, Valentina Faltoni, Elena Petricci, Laura Salvini, Elena Cini, Giuseppe Giannini, Rita De Santis, Maurizio Taddei, Loredana Vesci, Ferdinando Maria Milazzo

المصدر: Chemical Science

مصطلحات موضوعية: 0301 basic medicine, Drug, Cetuximab, biology, Chemistry, media_common.quotation_subject, Chemistry (all), General Chemistry, body regions, 03 medical and health sciences, 030104 developmental biology, Histone, In vivo, Acetylation, Cancer research, medicine, biology.protein, Cytotoxic T cell, Internalization, IC50, medicine.drug, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4ed18e6daa7388c61593656cd9b913
http://hdl.handle.net/11365/1057738

المؤلفون: Carlo Tallarico, Elena Cini, Silvia Pace, Giuseppe Giannini, Francesco Manera, Rita De Santis, Loredana Vesci, Maria Antonietta Stasi, Ferdinando Maria Milazzo, Elena Petricci, Fabrizio Manetti

مصطلحات موضوعية: 0301 basic medicine, Colorectal cancer, Cell Survival, Hedgehog inhibitor, In vivo pharmacokinetics, Gram-scale synthesis, ADME-Tox, LS180 xenograft, Acylguanidine, Mice, Nude, Antineoplastic Agents, Cell Line, 03 medical and health sciences, Mice, Structure-Activity Relationship, In vivo, Oral administration, Hedgehog inhibitor, Drug Discovery, Hh signalling pathway, medicine, Gram-scale synthesis, Animals, Humans, Hedgehog Proteins, Guanidine, ADME, Cell Proliferation, Pharmacology, Antitumor activity, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, In vivo pharmacokinetics, Organic Chemistry, Thiourea, Acylguanidine, General Medicine, Neoplasms, Experimental, medicine.disease, In vitro, Hedgehog signaling pathway, LS180 xenograft, 030104 developmental biology, Colonic Neoplasms, Cancer research, NIH 3T3 Cells, ADME-Tox, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9df7475996f039d0a7b4021640421d0
http://hdl.handle.net/11365/1064674

المؤلفون: Ferdinando Maria Milazzo, Annamaria Naggi, Giuseppe Roscilli, Giuseppe Giannini, Uri Barash, Emiliano Esposito, Israel Vlodavsky

المصدر: European Journal of Medicinal Chemistry. 186:111831

مصطلحات موضوعية: medicine.medical_treatment, Melanoma, Experimental, Biotin, Antineoplastic Agents, Pharmacology, 01 natural sciences, Glycols, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Potency, Glycoside Hydrolase Inhibitors, Heparanase, Antidote, Cell Proliferation, Glucuronidase, 030304 developmental biology, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, Heparin, 010405 organic chemistry, Chemistry, Melanoma, Optical Imaging, Organic Chemistry, General Medicine, medicine.disease, 0104 chemical sciences, Mice, Inbred C57BL, Toxicity, Female, Drug Screening Assays, Antitumor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3590953a18c37fadb56f97bc1c25af
https://doi.org/10.1016/j.ejmech.2019.111831

المؤلفون: Valeria Carollo, Giuseppe Giannini, Silvia Pace, Loredana Vesci, Ferdinando Maria Milazzo

المصدر: International Journal of Oncology

مصطلحات موضوعية: Cancer Research, Mice, Nude, Antineoplastic Agents, Protein degradation, Mice, client proteins, In vivo, Heat shock protein, Cell Line, Tumor, Animals, Humans, HSP90 Heat-Shock Proteins, heat shock protein 90, antitumor, Cell Proliferation, biology, Oncogene, Cell growth, Articles, Isoxazoles, Neoplasms, Experimental, Resorcinols, Cell cycle, Molecular biology, Hsp90, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Oncology, Chaperone (protein), biology.protein, Cancer research, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49746b31f7f8462cfd18f085201e74c9
http://europepmc.org/articles/PMC4151799

المؤلفون: Loredana, Vesci, Rita De Santis, Ferdinando Maria Milazzo, Giannini, Giuseppe, Taddei, Maurizio, Faltoni, Valentina, Petricci, Elena

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1820::85b967e251ff29806bfab32282460092
http://hdl.handle.net/11365/1038889

المؤلفون: Rita De Santis, Antonio Rosi, Anna Maria Anastasi, Caterina Chiapparino, Claudio Albertoni, Barbara Leoni, Angela Pelliccia, Daniela Santapaola, Valeria Carollo, Emanuele Marra, Luigi Aurisicchio, Brunilde Arseni, Maria Lucrezia Pacello, Fiorella Petronzelli, Ferdinando Maria Milazzo, PALMIERI, Gabriella, BATTELLA, SIMONE

المساهمون: Rita De, Santi, Antonio, Rosi, Anna Maria, Anastasi, Caterina, Chiapparino, Claudio, Albertoni, Barbara, Leoni, Angela, Pelliccia, Daniela, Santapaola, Valeria, Carollo, Emanuele, Marra, Luigi, Aurisicchio, Brunilde, Arseni, Maria Lucrezia, Pacello, Palmieri, Gabriella, Battella, Simone, Fiorella, Petronzelli, Ferdinando Maria, Milazzo

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/25238453; info:eu-repo/semantics/altIdentifier/wos/WOS:000348033800032; volume:5; firstpage:9239; lastpage:9255; numberofpages:17; journal:ONCOTARGET; http://hdl.handle.net/11573/594183; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84910049818

الاتاحة: http://hdl.handle.net/11573/594183