يعرض 1 - 18 نتائج من 18 نتيجة بحث عن '"Fennell, Brian J"', وقت الاستعلام: 0.44s تنقيح النتائج
  1. 1
    Academic Journal
    Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation

    المؤلفون: Bone, Ruth, Fennell, Brian J, Tam, Amy, Sheldon, Richard, Nocka, Karl, Varghese, Sreeja, Chang, Chew Shun, Hawerkamp, Heike C, Yeow, Aoife, Saunders, Sean P, Hams, Emily, Walsh, Patrick T, Cunningham, Orla, Fallon, Padraic G

    المساهمون: Science Foundation Ireland

    المصدر: Antibody Therapeutics ; volume 5, issue 4, page 258-267 ; ISSN 2516-4236

    الاتاحة: https://doi.org/10.1093/abt/tbac022
    https://academic.oup.com/abt/advance-article-pdf/doi/10.1093/abt/tbac022/46580289/tbac022.pdf
    https://academic.oup.com/abt/article-pdf/5/4/258/46607190/tbac022.pdf

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  2. 2
    Academic Journal
    Impacts of fast production of afucosylated antibodies and Fc mutants in ExpiCHO-S™ for enhancing FcγRIIIa binding and NK cell activation

    المؤلفون: Zhong, Xiaotian, Schenk, Jennifer, Sakorafas, Paul, Chamberland, John, Tam, Amy, Thomas, L. Michael, Yan, Grace, D’ Antona, Aaron M., Lin, Laura, Nocula-Lugowska, Malgorzata, Zhang, Yan, Sousa, Eric, Cohen, Justin, Gu, Ling, Abel, Molica, Donahue, Jacob, Lim, Sean, Meade, Caryl, Zhou, Jing, Riegel, Logan, Birch, Alex, Fennell, Brian J., Franklin, Edward, Gomes, Jose M., Tzvetkova, Boriana, Scarcelli, John J.

    المصدر: Journal of Biotechnology ; volume 360, page 79-91 ; ISSN 0168-1656

    الاتاحة: http://dx.doi.org/10.1016/j.jbiotec.2022.10.016
    https://api.elsevier.com/content/article/PII:S0168165622002607?httpAccept=text/xml
    https://api.elsevier.com/content/article/PII:S0168165622002607?httpAccept=text/plain

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  3. 3
    Academic Journal
    Augmented Binary Substitution : Single-pass CDR germ-lining and stabilization of therapeutic antibodies

    المؤلفون: Townsend, Sue, Fennell, Brian J., Apgar, James R., Lambert, Matthew, McDonnell, Barry, Grant, Joanne, Wade, Jason, Franklin, Edward, Foy, Niall, Shúilleabháin, Deirdre Ní, Fields, Conor, Darmanin-Sheehan, Alfredo, King, Amy, Paulsen, Janet E., Hickling, Timothy P., Tchistiakova, Lioudmila, Cunningham, Orla, Finlay, William J. J.

    المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2015 Dec . 112(50), 15354-15359.

    URL الوصول: https://www.jstor.org/stable/26466600

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  4. 4
    Academic Journal
    Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

    المؤلفون: Avery, Lindsay B., Wade, Jason, Wang, Mengmeng, Tam, Amy, King, Amy, Piche-Nicholas, Nicole, Kavosi, Mania S., Penn, Steve, Cirelli, David, Kurz, Jeffrey C., Zhang, Minlei, Cunningham, Orla, Jones, Rhys, Fennell, Brian J., McDonnell, Barry, Sakorafas, Paul, Apgar, James, Finlay, William J., Lin, Laura, Bloom, Laird, O'Hara, Denise M.

    المصدر: mAbs ; volume 10, issue 2, page 244-255 ; ISSN 1942-0862 1942-0870

    الاتاحة: http://dx.doi.org/10.1080/19420862.2017.1417718
    https://www.tandfonline.com/doi/pdf/10.1080/19420862.2017.1417718

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  5. 5
    Academic Journal
    A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

    المؤلفون: Tu, Chao, Terraube, Virginie, Tam, Amy Sze Pui, Stochaj, Wayne, Fennell, Brian J., Lin, Laura, Stahl, Mark, LaVallie, Edward R., Somers, Will, Finlay, William J.J., Mosyak, Lydia, Bard, Joel, Cunningham, Orla

    المصدر: Journal of Biological Chemistry ; volume 291, issue 3, page 1267-1276 ; ISSN 0021-9258

    الاتاحة: http://dx.doi.org/10.1074/jbc.m115.688010
    https://api.elsevier.com/content/article/PII:S0021925820361627?httpAccept=text/xml
    https://api.elsevier.com/content/article/PII:S0021925820361627?httpAccept=text/plain
    https://syndication.highwire.org/content/doi/10.1074/jbc.M115.688010

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  6. 6
    Academic Journal
    CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

    المؤلفون: Fennell, Brian J, McDonnell, Barry, Tam, Amy Sze Pui, Chang, Lijun, Steven, John, Broadbent, Ian D, Gao, Huilan, Kieras, Elizabeth, Alley, Jennifer, Luxenberg, Deborah, Edmonds, Jason, Fitz, Lori J, Miao, Wenyan, Whitters, Matthew J, Medley, Quintus G, Guo, Yongjing J, Darmanin-Sheehan, Alfredo, Autin, Bénédicte, Shúilleabháin, Deirdre Ní, Cummins, Emma, King, Amy, Krebs, Mark RH, Grace, Christopher, Hickling, Timothy P, Boisvert, Angela, Zhong, Xiaotian, McKenna, Matthew, Francis, Christopher, Olland, Stephane, Bloom, Laird, Paulsen, Janet, Somers, Will, Jensen, Allan, Lin, Laura, Finlay, William JJ, Cunningham, Orla

    المصدر: mAbs ; volume 5, issue 6, page 882-895 ; ISSN 1942-0862 1942-0870

    الاتاحة: http://dx.doi.org/10.4161/mabs.26201
    http://www.tandfonline.com/doi/pdf/10.4161/mabs.26201

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  7. 7
    Academic Journal
    An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

    المؤلفون: Shih, Heather H., Tu, Chao, Cao, Wei, Klein, Anne, Ramsey, Renee, Fennell, Brian J., Lambert, Matthew, Ní Shúilleabháin, Deirdre, Autin, Bénédicte, Kouranova, Eugenia, Laxmanan, Sri, Braithwaite, Steven, Wu, Leeying, Ait-Zahra, Mostafa, Milici, Anthony J., Dumin, Jo Ann, LaVallie, Edward R., Arai, Maya, Corcoran, Christopher, Paulsen, Janet E., Gill, Davinder, Cunningham, Orla, Bard, Joel, Mosyak, Lydia, Finlay, William J.J.

    المصدر: Journal of Biological Chemistry ; volume 287, issue 53, page 44425-44434 ; ISSN 0021-9258

    الاتاحة: http://dx.doi.org/10.1074/jbc.m112.415935
    https://api.elsevier.com/content/article/PII:S0021925820416783?httpAccept=text/xml
    https://api.elsevier.com/content/article/PII:S0021925820416783?httpAccept=text/plain
    https://syndication.highwire.org/content/doi/10.1074/jbc.M112.415935

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  8. 8
    Academic Journal
    Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials

    المؤلفون: del Casino, Alessio, Lukinovic, Valentina, Bhatt, Rakesh, Randle, Laura E, Dascombe, Michael J, Fennell, Brian J, Drew, Michael GB, Bell, Angus, Fielding, Alistair J, Ismail, Fyaz MD

    Relation: del Casino, Alessio, Lukinovic, Valentina, Bhatt, Rakesh, Randle, Laura E orcid:0000-0002-7881-2979 , Dascombe, Michael J, Fennell, Brian J, Drew, Michael GB, Bell, Angus, Fielding, Alistair J and Ismail, Fyaz MD (2018) Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials. CHEMISTRYSELECT, 3 (26). pp. 7572-7580.

    الاتاحة: http://livrepository.liverpool.ac.uk/3064584/
    https://doi.org/10.1002/slct.201801723

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  9. 9
    Academic Journal
    Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential

    المؤلفون: Mahon, Ciara M., Lambert, Matthew A., Glanville, Jacob, Wade, Jason M., Fennell, Brian J., Krebs, Mark R., Armellino, Douglas, Yang, Sharon, Liu, Xuemei, O'Sullivan, Cliona M., Autin, Benedicte, Oficjalska, Katarzyna, Bloom, Laird, Paulsen, Janet, Gill, Davinder, Damelin, Marc, Cunningham, Orla, Finlay, William J.J.

    المصدر: Journal of Molecular Biology ; volume 425, issue 10, page 1712-1730 ; ISSN 0022-2836

    الاتاحة: http://dx.doi.org/10.1016/j.jmb.2013.02.015
    https://api.elsevier.com/content/article/PII:S0022283613001010?httpAccept=text/xml
    https://api.elsevier.com/content/article/PII:S0022283613001010?httpAccept=text/plain

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  10. 10
    Academic Journal
    Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites

    المؤلفون: Dempsey, Enda, Prudêncio, Miguel, Fennell, Brian J., Gomes-Santos, Carina S., Barlow, James W., Bell, Angus

    المساهمون: Enterprise Ireland Commercialisation Fund, Irish Research Council for Science, Engineering and Technology, Science Foundation Ireland, Fundação para a Ciência e Tecnologia, Portugal

    المصدر: Molecular and Biochemical Parasitology ; volume 188, issue 2, page 116-127 ; ISSN 0166-6851

    الاتاحة: http://dx.doi.org/10.1016/j.molbiopara.2013.03.001
    https://api.elsevier.com/content/article/PII:S0166685113000340?httpAccept=text/xml
    https://api.elsevier.com/content/article/PII:S0166685113000340?httpAccept=text/plain

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  11. 11
    A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

    المؤلفون: Tu, Chao, Terraube, Virginie, Tam, Amy Sze Pui, Stochaj, Wayne, Fennell, Brian J., Lin, Laura, Stahl, Mark, LaVallie, Edward R., Somers, Will, Finlay, William J. J., Mosyak, Lydia, Bard, Joel, Cunningham, Orla

    مصطلحات موضوعية: 59 BASIC BIOLOGICAL SCIENCES

    وصف الملف: application/pdf

    Relation: http://www.osti.gov/servlets/purl/1236257; https://www.osti.gov/biblio/1236257; https://doi.org/10.1074/jbc.M115.688010

    الاتاحة: http://www.osti.gov/servlets/purl/1236257
    https://www.osti.gov/biblio/1236257
    https://doi.org/10.1074/jbc.M115.688010

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  12. 12
    Academic Journal
    Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions

    المؤلفون: Finlay, William J., Cunningham, Orla, Lambert, Matthew A., Darmanin-Sheehan, Alfredo, Liu, Xuemei, Fennell, Brian J., Mahon, Ciara M., Cummins, Emma, Wade, Jason M., O'Sullivan, Cliona M., Tan, Xiang Yang, Piche, Nicole, Pittman, Debra D., Paulsen, Janet, Tchistiakova, Lioudmila, Kodangattil, Sreekumar, Gill, Davinder, Hufton, Simon E.

    المصدر: Journal of Molecular Biology ; volume 388, issue 3, page 541-558 ; ISSN 0022-2836

    الاتاحة: http://dx.doi.org/10.1016/j.jmb.2009.03.019
    https://api.elsevier.com/content/article/PII:S0022283609002940?httpAccept=text/xml
    https://api.elsevier.com/content/article/PII:S0022283609002940?httpAccept=text/plain

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  13. 13
    Academic Journal
    A simple high-throughput purification method for hit identification in protein screening

    المؤلفون: Cummins, Emma, Luxenberg, Deborah P., McAleese, Fionnuala, Widom, Angela, Fennell, Brian J., Darmanin-Sheehan, Alfredo, Whitters, Matthew J., Bloom, Laird, Gill, Davinder, Cunningham, Orla

    المصدر: Journal of Immunological Methods ; volume 339, issue 1, page 38-46 ; ISSN 0022-1759

    الاتاحة: http://dx.doi.org/10.1016/j.jim.2008.07.016
    https://api.elsevier.com/content/article/PII:S002217590800238X?httpAccept=text/xml
    https://api.elsevier.com/content/article/PII:S002217590800238X?httpAccept=text/plain

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  14. 14
    Academic Journal
    Cellular and molecular actions of dinitroaniline and phosphorothioamidate herbicides on Plasmodium falciparum: Tubulin as a specific antimalarial target

    المؤلفون: Fennell, Brian J., Naughton, Julie Ann, Dempsey, Enda, Bell, Angus

    المصدر: Molecular and Biochemical Parasitology ; volume 145, issue 2, page 226-238 ; ISSN 0166-6851

    الاتاحة: http://dx.doi.org/10.1016/j.molbiopara.2005.08.020
    https://api.elsevier.com/content/article/PII:S0166685105003579?httpAccept=text/xml
    https://api.elsevier.com/content/article/PII:S0166685105003579?httpAccept=text/plain

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  15. 15
    Periodical
    Establishing in vitro in vivocorrelations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

    المؤلفون: Avery, Lindsay B., Wade, Jason, Wang, Mengmeng, Tam, Amy, King, Amy, Piche-Nicholas, Nicole, Kavosi, Mania S., Penn, Steve, Cirelli, David, Kurz, Jeffrey C., Zhang, Minlei, Cunningham, Orla, Jones, Rhys, Fennell, Brian J., McDonnell, Barry, Sakorafas, Paul, Apgar, James, Finlay, William J., Lin, Laura, Bloom, Laird, O'Hara, Denise M.

    المصدر: mAbs; February 2018, Vol. 10 Issue: 2 p244-255, 12p

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  16. 16
    Academic Journal
    Augmented Binary Substitution: Single-pass CDR germlining and stabilization of therapeutic antibodies.

    المؤلفون: Townsend, Sue1, Fennell, Brian J.1, Apgar, James R.2, Lambert, Matthew1, McDonnell, Barry1, Grant, Joanne1, Wade, Jason1, Franklin, Edward1, Foy, Niall1, Shúilleabháin, Deirdre Ní1, Fields, Conor1, Darmanin-Sheehan, Alfredo1, King, Amy2, Paulsen, Janet E.2, Hickling, Timothy P.3, Tchistiakova, Lioudmila2, Cunningham, Orla1, Finlay, William J. J.1 william.finlay@pfizer.com

    المصدر: Proceedings of the National Academy of Sciences of the United States of America. 12/15/2015, Vol. 112 Issue 50, p15354-15359. 6p.

    مصطلحات موضوعية: *IMMUNOGLOBULINS, *ANTIBODY diversity, *GERM cells, *CLONING, *LABORATORY rodents

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  17. 17
    Dissertation/ Thesis
    Autism spectrum disorders (ASD) and challenging behaviours (CB) : training level and content knowledge of teachers in the Republic of Ireland

    المؤلفون: Fennell, Brian James

    Thesis Advisors: Dillenburger, Karola

    مصطلحات موضوعية: 371.94

    الاتاحة: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.673852

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  18. 18
    Academic Journal
    Fundamental Characteristics of the Immunoglobulin VH Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids.

    المؤلفون: Leeying Wu1, Oficjalska, Katarzyna2, Lambert, Matthew1, Fennell, Brian J.2, Darmanin!Sheehan, Aifredo2, Ní Shúilleabháin, Deirdre2, Autin, Bénédicte2, Cummins, Emma2, Tchistiakova, Lioudmila1, Bloom, Laird1, Paulsen, Janet1, Gill, Davinder1, Cunningham, Orla2, Finlay, William J. J.1 william.finlay@pfizer.com

    المصدر: Journal of Immunology. 1/1/2012, Vol. 188 Issue 1, p322-333. 12p.

    مصطلحات موضوعية: *IMMUNOGLOBULINS, *GERM cells, *CHICKENS as laboratory animals, *CYSTEINE, *AMINO acids, *GENETIC mutation


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