المؤلفون: J. Howard Jones (2684047), Zhili Xin (1909210), Martin Himmelbauer (1297380), Michael Dechantsreiter (8774891), Istvan Enyedy (2276035), Joseph Hedde (11571227), Terry Fang (10922918), Janaky Coomaraswamy (195660), Kristopher W. King (8681439), Paramasivam Murugan (8042474), Joseph C. Santoro (8042477), Thomas Hesson (8042480), Dirk M. Walther (11571230), Ru Wei (230834), Fengmei Zheng (2706133), Douglas J. Marcotte (8042471), Kerri Spilker (8042483), P. Rajesh Kumar (10744823), Ying Liu (18461), Rab Gilfillan (8042486), Felix Gonzalez-Lopez de Turiso (1692955)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Biotechnology, Immunology, Cancer, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, transgenic animals treated, thus confirming inhibition, previously reported inhibitor, inflammatory markers (<, human tau transgenic, central nervous system, cellular stress response, uu , u , 50 , regulating kinase 1, 32 , penetrant apoptosis signal, modulate brain inflammation, selective ask1 inhibitor, vivo <

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Potent_Selective_and_Brain-Penetrant_Apoptosis_Signal-Regulating_Kinase_1_ASK1_Inhibitors_that_Modulate_Brain_Inflammation_i_In_Vivo_i_/16821287

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01458.s001

المؤلفون: Tamara Halkina (2379208), Jaclyn L. Henderson (2102971), Edward Y. Lin (10744817), Martin K. Himmelbauer (8463675), J. Howard Jones (2684047), Marta Nevalainen (1342470), Jun Feng (116162), Kristopher King (8042468), Michael Rooney (1601641), Joshua L. Johnson (1914394), Douglas J. Marcotte (8042471), Jayanth V. Chodaparambil (10744820), P. Rajesh Kumar (10744823), Thomas A. Patterson (10744826), Paramasivam Murugan (8042474), Eli Schuman (1960426), LaiYee Wong (10744829), Thomas Hesson (8042480), Sarah Lamore (10744832), Channa Bao (8681433), Michael Calhoun (6966182), Hannah Certo (10744835), Brenda Amaral (7521905), Gregory M. Dillon (8681430), Rab Gilfillan (8042486), Felix Gonzalez-Lopez de Turiso (8042489)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, vivo proof, TTBK inhibitor, disease-relevant Ser 422 epitope, kinase domain, pharmacology studies, 315 nM, azaindazole TTBK 1 inhibitors, mouse hypothermia, tau phosphorylation, Vivo Structural analysis, CNS penetration, TTBK 1, cell IC 50, Brain-Penetrant Tau Tubulin Kinase 1, NIK inhibitor 3, 571 nM, Systematic optimization, novel class

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Potent_and_Brain-Penetrant_Tau_Tubulin_Kinase_1_TTBK1_Inhibitors_that_Lower_Tau_Phosphorylation_In_Vivo/14535557

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00382.s001

المؤلفون: Felix Gonzalez Lopez de Turiso, Kevin Guckian

المصدر: Expert Opinion on Therapeutic Patents. 32:365-379

مصطلحات موضوعية: Patents as Topic, TYK2 Kinase, Pharmacology, Drug Discovery, Humans, Psoriasis, General Medicine, Protein Kinase Inhibitors, Autoimmune Diseases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9bba064ea05054097663e27663bb59
https://doi.org/10.1080/13543776.2022.2026927

المؤلفون: Terry Fang, Rab Gilfillan, Janaky Coomaraswamy, Dirk M. Walther, Martin K Himmelbauer, Zhili Xin, Kerri Spilker, Douglas Marcotte, Joseph C Santoro, Thomas Hesson, Istvan J. Enyedy, Ru Wei, Felix Gonzalez-Lopez de Turiso, J Howard Jones, Michael Dechantsreiter, Zheng Fengmei, Kristopher W King, Ying Liu, Paramasivam Murugan, P Rajesh Kumar, Joseph Hedde

المصدر: Journal of medicinal chemistry. 64(20)

مصطلحات موضوعية: Transgene, Cell, Central nervous system, Inflammation, Mice, Transgenic, Pharmacology, MAP Kinase Kinase Kinase 5, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, ASK1, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Chemistry, Brain, Rats, medicine.anatomical_structure, Apoptosis, Molecular Medicine, Pyrazoles, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bdc613fadb1b6767798fc40d289b98
https://pubmed.ncbi.nlm.nih.gov/34653340

المؤلفون: Kristopher W King, Brenda Amaral, Eli Schuman, LaiYee Wong, Michael Rooney, Marta Nevalainen, Jun Feng, Paramasivam Murugan, Jayanth V. Chodaparambil, Thomas A. Patterson, Hannah Certo, Martin K Himmelbauer, Rab Gilfillan, Tamara Halkina, Sarah Lamore, J Howard Jones, Douglas Marcotte, Gregory M Dillon, Jaclyn L. Henderson, Thomas Hesson, P Rajesh Kumar, Edward Yin-Shiang Lin, Channa Bao, Felix Gonzalez-Lopez de Turiso, Joshua L Johnson, Michael Calhoun

المصدر: Journal of medicinal chemistry. 64(9)

مصطلحات موضوعية: Indazoles, Cell, tau Proteins, Protein Serine-Threonine Kinases, 01 natural sciences, Epitope, 03 medical and health sciences, chemistry.chemical_compound, Mice, In vivo, Drug Discovery, medicine, Animals, Humans, Molecular Targeted Therapy, Phosphorylation, IC50, Protein Kinase Inhibitors, 030304 developmental biology, Tau-tubulin kinase, 0303 health sciences, Brain, 0104 chemical sciences, Cell biology, Rats, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, chemistry, Protein kinase domain, Tau phosphorylation, Drug Design, Molecular Medicine, Penetrant (biochemical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24de7147f81434a735de9781d30290ec
https://pubmed.ncbi.nlm.nih.gov/33944571

المؤلفون: Zhili Xin, Douglas Marcotte, Joseph C Santoro, Rab Gilfillan, J Howard Jones, Thomas Hesson, Istvan J. Enyedy, Martin K Himmelbauer, Paramasivam Murugan, Felix Gonzalez-Lopez de Turiso, Kristopher W King

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: 010405 organic chemistry, Kinase, Organic Chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Cns penetration, Cell biology, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Mediator, chemistry, Apoptosis, Cellular stress response, Drug Discovery, ASK1, Penetrant (biochemical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca9a306448f636bdc3b87bc3cb5c746
https://europepmc.org/articles/PMC7153032/

المؤلفون: Thomas Hesson, Istvan J. Enyedy, Kristopher W King, Martin K Himmelbauer, Joseph C. Santoro, Paramasivam Murugan, J. Howard Jones, Joshua L Johnson, Felix Gonzalez-Lopez de Turiso, Kerri Spilker, Douglas Marcotte, Rab Gilfillan, Zhili Xin, Michael Joseph Luzzio

المصدر: Journal of medicinal chemistry. 62(23)

مصطلحات موضوعية: Macrocyclic Compounds, Cell, MAP Kinase Kinase Kinase 5, 01 natural sciences, 03 medical and health sciences, In vivo, Drug Discovery, medicine, Animals, Humans, ASK1, 030304 developmental biology, 0303 health sciences, Molecular Structure, Kinase, Chemistry, Rational design, Brain, 0104 chemical sciences, Cell biology, Rats, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Protein kinase domain, Apoptosis, Drug Design, Microsomes, Liver, Molecular Medicine, Efflux

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150776d7925313644d75434a3c742926
https://pubmed.ncbi.nlm.nih.gov/31710475

المؤلفون: Iain D. G. Campuzano, Xiaolin Hao, Brian Lucas, Tisha San Miguel, Deanna Mohn, Kirk Henne, Benjamin Fisher, Minna Bui, Mario G. Cardozo, Robert S. Foti, Ron C. Kelly, Christine Vissinga, Thuy B. Tran, John D. McCarter, Leeanne Zalameda, Daniela Metz, Douglas A. Whittington, Sharon Wannberg, Yi-Ling Hu, John Whoriskey, Julio C. Medina, Felix Gonzalez-Lopez de Turiso, Timothy D. Cushing, Xuxia Zhang, Lawrence R. McGee, Michael G. Johnson, Xiao He, Gang Yu, Michelle C. Dunn, Jason Duquette, Youngsook Shin

المصدر: Journal of Medicinal Chemistry. 59:7252-7267

مصطلحات موضوعية: 0301 basic medicine, biology, Stereochemistry, Chemistry, Quinoline, In vitro, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, biology.protein, Molecular Medicine, Potency, Keyhole limpet hemocyanin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5b68313a948b3dc2d85bb6149f781869
https://doi.org/10.1021/acs.jmedchem.6b00827

المؤلفون: Andrew Tasker, Andreas Reichelt, Yi-Ling Hu, Deanna Mohn, John McCarter, Ben Fisher, Robert M. Rzasa, Yi Chen, Julio C. Medina, Gang Yu, Sharon Wannberg, Brian Lucas, Ron C. Kelly, Jennifer Seganish, Felix Gonzalez-Lopez de Turiso, Xiaolin Hao, Kristin L. Andrews, Douglas A. Whittington, Matthew Frank Brown, Dawei Zhang, Youngsook Shin, Mario G. Cardozo, Jason Duquette, Robert C. Wahl, Leeanne Zalameda, Daniela Metz, Vatee Pattaropong, Michael G. Johnson, Tisha San Miguel, Randall W. Hungate, John Whoriskey, Lawrence R. McGee, Timothy D. Cushing, Kirk Henne, Liping H. Pettus, Xiao He

المصدر: Journal of Medicinal Chemistry. 58:480-511

مصطلحات موضوعية: Models, Molecular, Adenosine, Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Mice, Transgenic, Pharmacology, Crystallography, X-Ray, Autoimmune Diseases, Structure-Activity Relationship, In vivo, Drug Discovery, Sf9 Cells, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, IC50, Cells, Cultured, Whole blood, Inflammation, Autoimmune disease, Mice, Inbred BALB C, Molecular Structure, Drug discovery, Kinase, Chemistry, medicine.disease, Protein Structure, Tertiary, Disease Models, Animal, Models, Chemical, Rats, Inbred Lew, Quinolines, Molecular Medicine, Female, Amine gas treating, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f464b8458b3d559ce036ed30580e01
https://doi.org/10.1021/jm501624r

المؤلفون: Felix, Gonzalez-Lopez de Turiso, Xiaolin, Hao, Youngsook, Shin, Minna, Bui, Iain D G, Campuzano, Mario, Cardozo, Michelle C, Dunn, Jason, Duquette, Benjamin, Fisher, Robert S, Foti, Kirk, Henne, Xiao, He, Yi-Ling, Hu, Ron C, Kelly, Michael G, Johnson, Brian S, Lucas, John, McCarter, Lawrence R, McGee, Julio C, Medina, Daniela, Metz, Tisha, San Miguel, Deanna, Mohn, Thuy, Tran, Christine, Vissinga, Sharon, Wannberg, Douglas A, Whittington, John, Whoriskey, Gang, Yu, Leeanne, Zalameda, Xuxia, Zhang, Timothy D, Cushing

المصدر: Journal of medicinal chemistry. 59(15)

مصطلحات موضوعية: Models, Molecular, B-Lymphocytes, Dose-Response Relationship, Drug, Molecular Structure, Pyridines, Class Ia Phosphatidylinositol 3-Kinase, Mice, Structure-Activity Relationship, Drug Discovery, Quinolines, Animals, Humans, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a242cbf7d7efba8c63b94dcec247686e
https://pubmed.ncbi.nlm.nih.gov/27411843

المؤلفون: Julia Winslow Lohman, David Fong, Michael G. Johnson, Xiaolin Hao, Gang Yu, Douglas A. Whittington, Helen J. McBride, Yi-Ling Hu, Vatee Pattaropong, Lawrence R. McGee, Sharon Wannberg, Kirk Henne, Jillian L. Simard, Xiao He, Deanna Mohn, Julio C. Medina, Kent Miner, Todd J. Kohn, Yi Chen, Felix Gonzalez-Lopez de Turiso, Jennifer Seganish, Mario G. Cardozo, Matthew Frank Brown, Daniela Metz, Youngsook Shin, Timothy D. Cushing

المصدر: Journal of Medicinal Chemistry. 55:7667-7685

مصطلحات موضوعية: Models, Molecular, biology, Chemistry, Drug Evaluation, Preclinical, Rational design, Arthritis, Inflammation, Pharmacology, medicine.disease, In vivo, Rheumatoid arthritis, Drug Discovery, medicine, biology.protein, Molecular Medicine, Animal studies, medicine.symptom, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Keyhole limpet hemocyanin, Phosphoinositide-3 Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d2206b5014d0cdfd1a496b0d1339bc
https://doi.org/10.1021/jm300679u

المؤلفون: Zice Fu, Yongli Su, Xuemei Wang, Hua Lucy Tang, Timothy J. Sullivan, Lisa Seitz, Felix Gonzalez-Lopez de Turiso, Julio C. Medina, Mark P. Grillo, Shanna Lawlis, Ying Sun, Wang Shen, M.J. Schmitt, Qiuping Ye, Sarah E. Lively, Matthew L. Brown, An-Rong Li, Yingcai Wang, Bettina Van Lengerich, Jill Wait, Sujen Lai, Jiwen Liu, Michael G. Johnson, Jay Danao, Tassie L. Collins, Qingge Xu

المصدر: ACS Medicinal Chemistry Letters. 2:326-330

مصطلحات موضوعية: business.industry, Organic Chemistry, Antagonist, Prostanoid, Chemotaxis, Pharmacology, Phenylacetic acid, medicine.disease, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Medicine, Prostaglandin D2, business, Receptor, G protein-coupled receptor, Asthma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1412c5f0cb7a55fd9ce712791e8a8c0f
https://doi.org/10.1021/ml1002234

المؤلفون: Hua Tu, Lisa Julian, Nigel Walker, Maren Gulsrud Willcockson, Yosup Rew, Michael DeGraffenreid, Zhulun Wang, Juan C. Jaen, Daqing Sun, Ron C. Kelly, Athena Sudom, Seb Caille, Jacob Kaizerman, Jay P. Powers, Xuelei Yan, Qiuping Ye, Stefania Ursu, Ben Jiang, Felix Gonzalez-Lopez de Turiso, Randall W. Hungate, Dustin McMinn

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:405-410

مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, 11β hsd1 inhibitors, Structure-Activity Relationship, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Organic Chemistry, Highly selective, Combinatorial chemistry, Rats, Macaca fascicularis, Enzyme, Enzyme inhibitor, Benzamides, Microsomes, Liver, biology.protein, Molecular Medicine, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d541a6a690483f033c76a34f9400098
https://doi.org/10.1016/j.bmcl.2010.10.129

المؤلفون: Felix Gonzalez-Lopez de Turiso, Daqing Sun, Yosup Rew, Sarah Bennett, Michael DeGraffenreid, Lisa Julian, Randall W. Hungate, Xuelei Yan, Sebastien Caille, Jay P. Powers, Jacob Kaizerman, Dustin McMinn

المصدر: The Journal of Organic Chemistry. 72:7455-7458

مصطلحات موضوعية: Cyclohexane, Nitrile, Cyclohexanones, Organic Chemistry, Esters, Condensation reaction, Chemical synthesis, Dieckmann condensation, chemistry.chemical_compound, chemistry, Cascade reaction, Michael reaction, Organic chemistry, Methyl acrylate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e46df816992780e17801d24874b04b
https://doi.org/10.1021/jo071202h

المؤلفون: Michael Skae, Anna Bertram, Katrina A. Jolliffe, Gerald Pattenden, Felix Gonzalez‐Lopez de Turiso, Jeffrey S. Hannam, Alexander J. Blake

المصدر: Tetrahedron. 59:6979-6990

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, General Medicine, Ring (chemistry), HEXA, Biochemistry, Cyclic peptide, Amino acid, chemistry.chemical_compound, Monomer, chemistry, Drug Discovery, Thiazole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b41fee7b3fd78c114dae08a5404529f
https://doi.org/10.1016/s0040-4020(03)00821-4

المؤلفون: Gerald Pattenden, Felix Gonzalez‐Lopez de Turiso, M. Cases

المصدر: Synlett. 2001:1869-1872

مصطلحات موضوعية: Chemistry, Organic Chemistry, Bis-deoxylophotoxin, Total synthesis, Medicinal chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ca0c0e1d1744b9047aca7eb3ffd28815
https://doi.org/10.1055/s-2001-18741

المؤلفون: Jeffery S. Hannam, Katrina A. Jolliffe, Anna Bertram, Gerald Pattenden, Felix Gonzalez‐Lopez de Turiso

المصدر: Synlett. 1999:1723-1726

مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Chemistry, Organic Chemistry, Thiazole, Combinatorial chemistry, Cyclic peptide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::36f1a023957e70fc7cfb53cf830ba2c2
https://doi.org/10.1055/s-1999-2942

المؤلفون: Christopher J. Whipp, Felix Gonzalez-Lopez de Turiso

المصدر: Tetrahedron Letters. 49:5508-5510

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Intramolecular force, Organic Chemistry, Drug Discovery, Indoline, chemistry.chemical_element, Biochemistry, Medicinal chemistry, Carbon

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1f7daf313919ab86770c1938e64eaad9
https://doi.org/10.1016/j.tetlet.2008.07.043

المؤلفون: Yosup Rew, Steve Schneider, Peter Yakowec, Lisa Julian, Jude Canon, Alexander M. Long, Xuelei Yan, Julio C. Medina, Xin Huang, Jonathan D. Oliner, Hilary Plake Beck, Felix Gonzalez-Lopez de Turiso, Dongyin Yu, Shou-Hua Xiao, Ada Chen, Mei-Chu Lo, Xiaoning Zhao, Anne Y. Saiki, David Chow, Michael D. Bartberger, Jing Zhou, Qiuping Ye, Tiffany L. Correll, Daqing Sun, Frank Kayser, Steven H. Olson, Jay P. Powers, Tao Osgood, Dustin McMinn, Paul L. Shaffer

المصدر: Journal of medicinal chemistry. 56(10)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Morpholines, Mice, Nude, Antineoplastic Agents, Crystallography, X-Ray, Cocrystal, Mice, Structure-Activity Relationship, Piperidines, In vivo, Drug Discovery, Animals, Humans, IC50, Messenger RNA, Crystallography, biology, Chemistry, Circular Dichroism, Rational design, Proto-Oncogene Proteins c-mdm2, Stereoisomerism, Small molecule, Xenograft Model Antitumor Assays, Pharmacodynamics, Drug Design, biology.protein, Molecular Medicine, Mdm2, Female, Indicators and Reagents, Tumor Suppressor Protein p53

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b2b421ad8ad7c0f32d30da3d1a9de9
https://pubmed.ncbi.nlm.nih.gov/23597064

المؤلفون: Felix Gonzalez-Lopez de Turiso, Ada Chen, Steven H. Olson, Xin Huang, Jude Canon, Anne Y. Saiki, Michael D. Bartberger, Hilary Plake Beck, Jonathan D. Oliner, David J. Kopecky, Xuelei Yan, Jing Zhou, Maria M. Toteva, Min Jiang, Mei-Chu Lo, Alexander M. Long, Darin J. Gustin, Klaus Michelsen, Tao Osgood, Steve Schneider, Qiuping Ye, Jeffrey Deignan, Yosup Rew, Peter Yakowec, Daqing Sun, Xianyun Jiao, Lixia Jin, Dongyin Yu, David Chow, Julio C. Medina, Frank Kayser, Mark L. Ragains, Yihong Li, Xiaoning Zhao, Brian M. Fox

المصدر: Journal of medicinal chemistry. 55(11)

مصطلحات موضوعية: Models, Molecular, rho GTP-Binding Proteins, Stereochemistry, Transplantation, Heterologous, Substituent, Molecular Conformation, Mice, Nude, Stereoisomerism, Antineoplastic Agents, Plasma protein binding, Acetates, Ring (chemistry), Crystallography, X-Ray, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Humans, neoplasms, Piperidones, Cell Proliferation, Rational design, Proto-Oncogene Proteins c-mdm2, Rats, Transplantation, Macaca fascicularis, chemistry, Hepatocytes, Molecular Medicine, Drug Screening Assays, Antitumor, Tumor Suppressor Protein p53, Neoplasm Transplantation, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e801db16462f352d2d21a52ca43e600
https://pubmed.ncbi.nlm.nih.gov/22624960