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1Academic JournalLonger telomere length in COPD patients with α1-antitrypsin deficiency independent of lung function.
المؤلفون: Aabida Saferali, Jee Lee, Don D Sin, Farshid N Rouhani, Mark L Brantly, Andrew J Sandford
المصدر: PLoS ONE, Vol 9, Iss 4, p e95600 (2014)
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Yonggang Wang, Yong He, Bindu Abraham, Farshid N Rouhani, Mark L Brantly, Dorothy E Scott, Jennifer L Reed
المصدر: PLoS ONE, Vol 7, Iss 11, p e51078 (2012)
وصف الملف: electronic resource
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المؤلفون: Terence R. Flotte, Alisha M. Gruntman, Florie Borel, Noel G. McElvaney, Emer P. Reeves, Gwladys Gernoux, Christian Mueller, Martha Campbell-Thompson, Margaret Humphries, Farshid N. Rouhani, Bruce C. Trapnell, Roberto Calcedo, Louis M. Messina, Jeffrey D. Chulay, James M. Wilson, Anthony T. Yachnis
المصدر: Molecular Therapy
مصطلحات موضوعية: 0301 basic medicine, Time Factors, Neutrophils, Biopsy, Genetic enhancement, Epitopes, T-Lymphocyte, Gene Expression, T-Lymphocytes, Regulatory, T-Lymphocyte Subsets, PD-1, Drug Discovery, Cytotoxic T cell, Transgenes, Alpha 1-antitrypsin deficiency, biology, Muscles, Degranulation, AAV, clinical trial, Dependovirus, Immunohistochemistry, gene therapy, AAT, 3. Good health, Neutrophil elastase, Molecular Medicine, Original Article, alpha-1 antitrypsin, Antibody, A1AT, Genetic Vectors, Tregs, rAAV, Virus, Immunophenotyping, 03 medical and health sciences, Capsid, Immune system, alpha 1-Antitrypsin Deficiency, Genetics, medicine, Humans, Molecular Biology, Pharmacology, exhausted T cells, Genetic Therapy, medicine.disease, 030104 developmental biology, alpha 1-Antitrypsin, Immunology, biology.protein, Biomarkers
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المؤلفون: Brad E. Hoffman, Farshid N. Rouhani, Mark L. Brantly, George Marek, Nazli Khodayari, Karina Krotova, George Aslanidi, Rejean L. Wang
مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, Adult, Male, Proteases, congenital, hereditary, and neonatal diseases and abnormalities, Clinical Biochemistry, Alpha (ethology), Endoplasmic Reticulum, Monocytes, Extracellular matrix, 03 medical and health sciences, Young Adult, 0302 clinical medicine, alpha 1-Antitrypsin Deficiency, Macrophages, Alveolar, medicine, Matrix Metalloproteinase 14, Humans, Matriptase, Molecular Biology, Cells, Cultured, Original Research, Aged, Extracellular Matrix Proteins, Alpha 1-antitrypsin deficiency, biology, Macrophages, Serine Endopeptidases, Cell Biology, Middle Aged, medicine.disease, Cell biology, Up-Regulation, Enzyme Activation, 030104 developmental biology, Pulmonary Emphysema, 030220 oncology & carcinogenesis, Neutrophil elastase, Enzyme Induction, alpha 1-Antitrypsin, Immunology, Mutation, biology.protein, Female, Extracellular Matrix Degradation, Intracellular
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المؤلفون: Farshid N. Rouhani, Edwin K. Silverman, John Ziniti, James D. Crapo, Dawn L. DeMeo, Mark L. Brantly, Terri H. Beaty, Douglas Curran-Everett, Craig P. Hersh, John E. Hokanson, Robert A. Sandhaus, Carla Wilson, Marilyn G. Foreman, Michael H. Cho, Gerard J. Criner
المصدر: Annals of the American Thoracic Society. 14(8)
مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Pathology, Vital Capacity, Logistic regression, Risk Assessment, White People, Cohort Studies, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Internal medicine, Forced Expiratory Volume, alpha 1-Antitrypsin Deficiency, Genotype, medicine, Humans, Allele, Aged, Original Research, COPD, Alpha 1-antitrypsin deficiency, business.industry, Middle Aged, medicine.disease, United States, respiratory tract diseases, Black or African American, 030104 developmental biology, Cross-Sectional Studies, Logistic Models, Phenotype, 030228 respiratory system, Genetic epidemiology, alpha 1-Antitrypsin, Cohort, Multivariate Analysis, Observational study, Female, business
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6SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78
المؤلفون: Mariana E. Kirst, Chen Liu, George Marek, Karina Krotova, Farshid N. Rouhani, Nazli Khodayari, Mark L. Brantly, Rejean liqun Wang
المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0172983 (2017)مصطلحات موضوعية: 0301 basic medicine, lcsh:Medicine, medicine.disease_cause, Endoplasmic Reticulum, Biochemistry, Animal Cells, Medicine and Health Sciences, Small interfering RNAs, lcsh:Science, chemistry.chemical_classification, Mutation, Multidisciplinary, Secretory Pathway, biology, Endoplasmic Reticulum Stress, Cell biology, Ubiquitin ligase, Transport protein, Amino acid, Precipitation Techniques, Nucleic acids, Protein Transport, Liver, Cell Processes, Hyperexpression Techniques, Cellular Structures and Organelles, Cellular Types, Anatomy, Research Article, Context (language use), Endoplasmic-reticulum-associated protein degradation, DNA construction, Transfection, Research and Analysis Methods, Real-Time Polymerase Chain Reaction, Cell Line, 03 medical and health sciences, medicine, Gene Expression and Vector Techniques, Genetics, Immunoprecipitation, Humans, Molecular Biology Techniques, Non-coding RNA, Molecular Biology, Molecular Biology Assays and Analysis Techniques, Endoplasmic reticulum, lcsh:R, Biology and Life Sciences, Membrane Proteins, Cell Biology, Phosphate-Binding Proteins, Gene regulation, Receptors, Autocrine Motility Factor, 030104 developmental biology, chemistry, Membrane protein, alpha 1-Antitrypsin, Plasmid Construction, Vacuoles, biology.protein, Hepatocytes, RNA, lcsh:Q, Gene expression, Carrier Proteins
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المؤلفون: James D. Crapo, Adam Wanner, Matthew J. Budoff, Mark L. Brantly, Rhea E. Powell, Eric A. Hoffman, J. Jeffrey Carr, Harry J.M. Groen, Michael H. Cho, Heather Baumhauer, Dirkje S. Postma, Pieter Zanen, Wei Gao, John E. Hokanson, H. Marike Boezen, Leslie J. Raffel, Terri H. Beaty, Edwin K. Silverman, George R. Washko, George T. O'Connor, Joel D. Kaufman, Tess D. Pottinger, Joanna Smolonska, Cisca Wijmenga, Charles A. Powell, John H. M. Austin, Josée Dupuis, Daniel Rabinowitz, Ani Manichaikul, R. Graham Barr, Karen Hinckley Stukovsky, Benjamin M. Smith, Stephen S. Rich, Farshid N. Rouhani
المساهمون: Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Research Institute for Asthma and COPD (GRIAC), Life Course Epidemiology (LCE)
المصدر: American Journal of Respiratory and Critical Care Medicine, 189(4), 408-418. AMER THORACIC SOC
American journal of respiratory and critical care medicine, vol 189, iss 4مصطلحات موضوعية: Male, Pathology, Genotyping Techniques, genetic association, Respiratory System, Genome-wide association study, VARIANTS, Cardiovascular, Critical Care and Intensive Care Medicine, Medical and Health Sciences, AIR-FLOW OBSTRUCTION, 80 and over, HOMOZYGOUS DELETIONS, 2.1 Biological and endogenous factors, Aetiology, Tomography, Lung, Aged, 80 and over, education.field_of_study, COPD, Single Nucleotide, Middle Aged, respiratory system, X-Ray Computed, ALPHA1-ANTITRYPSIN DEFICIENCY, medicine.anatomical_structure, emphysema, Pulmonary Emphysema, Cohort, multiethnic, Female, SMOKING, RNA Helicases, Cohort study, Genetic Markers, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Chronic Obstructive Pulmonary Disease, Population, Nerve Tissue Proteins, N-Acetylglucosaminyltransferases, Polymorphism, Single Nucleotide, OBSTRUCTIVE PULMONARY-DISEASE, BREAST, snRNP Core Proteins, alpha-Mannosidase, Clinical Research, Internal medicine, Mannosidases, Genetics, medicine, cohort study, Humans, MESA, Polymorphism, education, Aged, Genetic association, Emphysema, SnRNP Core Proteins, business.industry, Human Genome, computed tomography, Atherosclerosis, medicine.disease, United States, respiratory tract diseases, Thiolester Hydrolases, Tomography, X-Ray Computed, business, CARDIAC CT, Follow-Up Studies, Genome-Wide Association Study
وصف الملف: application/pdf
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المؤلفون: Dawn McGee, Mark L. Brantly, Charlie Strange, Lauren Peterka, Farshid N. Rouhani, Rebecca McClure, Laura Schwarz
المصدر: Pulmonary Medicine, Vol 2010 (2010)
Pulmonary Medicineمصطلحات موضوعية: lcsh:RC705-779, Pulmonary and Respiratory Medicine, education.field_of_study, medicine.medical_specialty, Pathology, Alpha 1-antitrypsin deficiency, Article Subject, Medication history, business.industry, Incidence (epidemiology), Population, lcsh:Diseases of the respiratory system, General Medicine, Disease, medicine.disease, Obstructive lung disease, Liver disease, Internal medicine, Medicine, Population study, business, education, Research Article
وصف الملف: text/xhtml
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المؤلفون: Mark L. Brantly, Pam Schreck, Ning Li, Adriano R. Tonelli, Farshid N. Rouhani
المصدر: International Journal of Chronic Obstructive Pulmonary Disease
Scopus-Elsevierمصطلحات موضوعية: Spirometry, forced expiratory volume in one second, Male, medicine.medical_specialty, Time Factors, Genotype, medicine.medical_treatment, Alpha (ethology), Tissue Banks, International Journal of Chronic Obstructive Pulmonary Disease, Gastroenterology, Internal medicine, Forced Expiratory Volume, alpha 1-Antitrypsin Deficiency, medicine, Humans, Enzyme Replacement Therapy, augmentation therapy, Lung, Original Research, alpha-1 antitrypsin deficiency, COPD, Alpha 1-antitrypsin deficiency, medicine.diagnostic_test, business.industry, General Medicine, Enzyme replacement therapy, Recovery of Function, Middle Aged, medicine.disease, Surgery, respiratory tract diseases, medicine.anatomical_structure, Phenotype, Treatment Outcome, Tissue bank, alpha 1-Antitrypsin, Injections, Intravenous, Smoking cessation, Female, Smoking Cessation, business
وصف الملف: text/html
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المؤلفون: Stewart J. Levine, Farshid N. Rouhani, Aminul Islam, Feras Hawari, Barbara Adamik, Jing Zhang
المصدر: Biochemical and Biophysical Research Communications. 371:505-509
مصطلحات موضوعية: Heterogeneous nuclear ribonucleoprotein, Interleukin-1beta, Biophysics, Respiratory Mucosa, Biology, Cleavage (embryo), Aminopeptidases, Biochemistry, Aminopeptidase, Article, Heterogeneous-Nuclear Ribonucleoproteins, Minor Histocompatibility Antigens, RNA interference, Extracellular, Humans, Immunoprecipitation, Molecular Biology, Gene, Vesicle, Cell Biology, respiratory system, Cell biology, Receptors, Tumor Necrosis Factor, Type I, ARTS-1, RNA Interference, Endothelium, Vascular
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المؤلفون: Mark L. Brantly, Farshid N. Rouhani, Adriano R. Tonelli
المصدر: Alpha-1 Antitrypsin ISBN: 9783319234489
مصطلحات موضوعية: medicine.medical_specialty, COPD, Alpha 1-antitrypsin deficiency, business.industry, Genetic counseling, medicine.disease, Chronic liver disease, Dried blood spot, Internal medicine, Genotype, medicine, Targeted detection, business, Genotyping
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المؤلفون: Jesus Rivera-Nieves, L. Terry Spencer, Farshid N. Rouhani, Mark L. Brantly, Peter M. Krein, Gregorino Paone
المصدر: American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L514-L520
مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, alpha-Defensins, Neutrophils, Physiology, Neutrophile, Dose-Response Relationship, Immunologic, Inflammation, Granulocyte, Leukotriene B4, alpha 1-Antitrypsin Deficiency, Physiology (medical), Macrophages, Alveolar, medicine, Humans, Macrophage, Respiratory system, Cells, Cultured, Lung, business.industry, Interleukin-8, Respiratory disease, Pneumonia, Cell Biology, Middle Aged, Cytotoxicity Tests, Immunologic, medicine.disease, medicine.anatomical_structure, alpha 1-Antitrypsin, Immunology, Female, medicine.symptom, Leukocyte Elastase, business, Bronchoalveolar Lavage Fluid, Respiratory tract
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المؤلفون: Feras Hawari, Caitriona A. Buckley, Xinle Cui, Maryann Kaler, Zu Xi Yu, Stewart J. Levine, Farshid N. Rouhani
المصدر: Proceedings of the National Academy of Sciences. 101:1297-1302
مصطلحات موضوعية: medicine.medical_treatment, Biology, Exosome, Catalysis, Epithelium, Receptors, Tumor Necrosis Factor, Membrane Microdomains, Antigens, CD, medicine, Humans, Centrifugation, Receptor, Lung, Multidisciplinary, Tumor Necrosis Factor-alpha, Vesicle, Endothelial Cells, Biological Sciences, respiratory system, Sheddase, Cell biology, Cytokine, Biochemistry, Ectodomain, Receptors, Tumor Necrosis Factor, Type I, Metalloproteases, Tumor necrosis factor alpha
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المؤلفون: Noel G. McElvaney, Christian Mueller, Alisha M. Gruntman, Martha Campbell-Thompson, James M. Wilson, Margaret Humphries, Terence R. Flotte, Gwladys Gernoux, Farshid N. Rouhani, Emer P. Reeves, Jeffrey D. Chulay
المصدر: Molecular Therapy. 24:S11-S12
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, congenital, hereditary, and neonatal diseases and abnormalities, Alpha 1-antitrypsin deficiency, Regulatory T cell, Genetic enhancement, Biology, medicine.disease, medicine.disease_cause, Epitope, Virus, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Immune system, Drug Discovery, Immunology, Genetics, medicine, Molecular Medicine, Molecular Biology, Adeno-associated virus, CD8
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المؤلفون: Stewart J. Levine, Xinle Cui, Feras Hawari, Farshid N. Rouhani
المصدر: The Journal of Immunology. 171:6814-6819
مصطلحات موضوعية: Lipoproteins, Immunology, Regulator, Biology, GPI-Linked Proteins, Aminopeptidases, Aminopeptidase, Receptors, Tumor Necrosis Factor, Minor Histocompatibility Antigens, Antigens, CD, Multienzyme Complexes, Catalytic Domain, Cell Line, Tumor, Receptors, Tumor Necrosis Factor, Member 10c, Humans, Protein Isoforms, Immunology and Allergy, Receptor, Innate immune system, Cell Membrane, Interleukin-8, Membrane Proteins, Metalloendopeptidases, Receptors, Interleukin-1, Precipitin Tests, Molecular biology, Cell biology, Mutagenesis, Insertional, Tumor Necrosis Factor Decoy Receptors, Ectodomain, Receptors, Tumor Necrosis Factor, Type I, Metalloproteases, Calcium, Tumor necrosis factor alpha, Carrier Proteins, Cytokine receptor, Interleukin-1
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المؤلفون: Farshid N. Rouhani, Xinle Cui, Stewart J. Levine, Feras Hawari
المصدر: Journal of Biological Chemistry. 278:28677-28685
مصطلحات موضوعية: Lung Neoplasms, Immunoblotting, Gene Expression, Biology, Transfection, Aminopeptidases, Biochemistry, Aminopeptidase, Receptors, Tumor Necrosis Factor, Cell Line, Substrate Specificity, Minor Histocompatibility Antigens, Antigens, CD, Tumor Cells, Cultured, Humans, Receptor, Molecular Biology, Immunosorbent Techniques, Reverse Transcriptase Polymerase Chain Reaction, Cell Membrane, Cell Biology, Type I cytokine receptor, Oligonucleotides, Antisense, Receptors, Interleukin-6, Molecular biology, Recombinant Proteins, Ectodomain, Receptors, Tumor Necrosis Factor, Type I, Interleukin-21 receptor, ARTS-1, Interleukin-6 receptor, Carcinoma, Mucoepidermoid, Carrier Proteins, Cytokine receptor, Gene Deletion
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المؤلفون: Jeffrey Hammel, James K. Stoller, Edward Eden, A. Sonia Buist, Mark L. Brantly, Farshid N. Rouhani, Gerard M. Turino, Alan F. Barker, Ronald G. Crystal, Robert J. Fallat
المصدر: Chest. 123:765-771
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Allergy, Alpha 1-antitrypsin deficiency, medicine.drug_class, business.industry, Critical Care and Intensive Care Medicine, medicine.disease, respiratory tract diseases, Surgery, VEMS, Internal medicine, Bronchodilator, Cohort, medicine, Cardiology and Cardiovascular Medicine, Prospective cohort study, business, Asthma, Cohort study
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المصدر: COPD. 11(1)
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Adult, Male, Proteinase inhibitor, Alpha (ethology), Pharmacology, law.invention, Randomized controlled trial, Double-Blind Method, law, alpha 1-Antitrypsin Deficiency, Medicine, Humans, Aged, Cross-Over Studies, business.industry, Alpha1-proteinase inhibitor human, Middle Aged, Crossover study, Clinical trial, Safety profile, Treatment Outcome, Pulmonary Emphysema, alpha 1-Antitrypsin, Immunology, Ready to use, Female, business
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المؤلفون: Yong Y. Lin, Mark L. Brantly, Shuren Ma, Farshid N. Rouhani, Gerard M. Turino, Jiangtao He
المصدر: COPD. 10(4)
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Male, congenital, hereditary, and neonatal diseases and abnormalities, Alpha (ethology), macromolecular substances, Urine, chemistry.chemical_compound, alpha 1-Antitrypsin Deficiency, Medicine, Humans, Isodesmosine, Aged, COPD, medicine.diagnostic_test, biology, business.industry, Homozygote, Middle Aged, medicine.disease, respiratory tract diseases, Desmosine, Elastin, Bronchoalveolar lavage, Phenotype, chemistry, Neutrophil elastase, alpha 1-Antitrypsin, Immunology, biology.protein, Female, business, Leukocyte Elastase, Trypsin Inhibitors, Bronchoalveolar Lavage Fluid, Biomarkers
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المؤلفون: Roberto Calcedo, James M. Wilson, Maigan A. Hulme, Lee P. Richman, Brenna Carey, Noel G. McElvaney, Guo-jie Ye, Ann Dongtao Fu, Mark L. Brantly, Todd M. Brusko, Margaret Humphries, Jeffrey D. Chulay, Qiushi Tang, Anthony T. Yachnis, Terence R. Flotte, Christian Mueller, Martha Campbell-Thompson, Farshid N. Rouhani, Bruce C. Trapnell, Suryanarayan Somanathan, Louis M. Messina, David R. Knop, Robert A. Sandhaus, Robert H. Vonderheide
المصدر: The Journal of clinical investigation. 123(12)
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, T cell, Genetic enhancement, viruses, Biopsy, Receptors, Antigen, T-Cell, alpha-beta, Recombinant Fusion Proteins, Population, Genetic Vectors, Biology, medicine.disease_cause, Lymphocyte Activation, Injections, Intramuscular, T-Lymphocytes, Regulatory, Immune system, Capsid, Antigen, alpha 1-Antitrypsin Deficiency, medicine, Humans, Vector (molecular biology), Transgenes, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, education, Muscle, Skeletal, Adeno-associated virus, education.field_of_study, General Medicine, Gene rearrangement, Genetic Therapy, Dependovirus, Clone Cells, medicine.anatomical_structure, Gene Expression Regulation, alpha 1-Antitrypsin, Immunology, Research Article