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المؤلفون: Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)مصطلحات موضوعية: MCOLN1, mucolipin 1, Review, OPTN, optineurin, UPR, unfolded protein response, LIMP1, lysosomal integral membrane protein-1, General Pharmacology, Toxicology and Pharmaceutics, BNIP3L, BCL2 interacting protein 3 like, STBD1, starch-binding domain-containing protein 1, PLIN3, perilipin 3, LIR, LC3 interacting region, PPARα, peroxisomal proliferator-activated receptor-alpha, mTORC1, mammalian target of rapamycin complex 1, Translation (biology), WIPI1, WD repeat domain phosphoinositide-interacting protein 1, TBK1, serine/threonine-protein kinase, Cell biology, GIM, GABARAP-interacting motif, CREB, cAMP response element binding protein, PP2A, protein phosphatase 2a, Liver metabolism, CLN3, lysosomal/endosomal transmembrane protein, LALP70, lysosomal apyrase-like protein of 70 kDa, LD, lipid droplet, RETREG1, reticulophagy regulator 1, PINK1, phosphatase and tensin homolog (PTEN)-induced kinase 1, RM1-950, ATL3, Atlastin GTPase 3, RTNL3, a long isoform of RTN3, LAMP2, lysosomal-associated membrane protein-2, FXR, farnesoid X receptor, Farnesoid X receptor, Cryptochrome 1, FFA, free fatty acid, TFEB/TFE3, transcription factor EB, ULK1, Unc-51 like autophagy activating kinase 1, TRAC-1, thyroid-hormone-and retinoic acid-receptor associated co-repressor 1, RTN3, reticulon 3, S6K, P70-S6 kinase, SEC62, SEC62 homolog, preprotein translocation factor, GABARAPL1, GABA type A receptor associated protein like 1, TEX264, testis expressed 264, ER-phagy receptor, DFCP1, double FYVE-containing protein 1, LXRa, liver X receptor a, SLC36A1, solute carrier family 36 member 1, V-ATPase, vacuolar-ATPase, Regeneration (biology), Quality control, AIM, Atf8 interacting motif, VLDL, very-low-density lipoprotein, CYP7A1, cholesterol 7α-hydroxylase, NBR1, BRCA1 gene 1 protein, BCL2L13, BCL2 like 13, TGR5, takeda G protein receptor 5, NCoR1, nuclear receptor co-repressor 1, PKA, protein kinase A, Function (biology), CRY1, cryptochrome 1, LAMP1, lysosomal-associated membrane protein-1, Anabolism, S6RP, S6 ribosomal protein, LIMP3, lysosomal integral membrane protein-3, FAM134B, family with sequence similarity 134, member B, Nutrient regeneration, SPIN, spindling, FOXO1, Forkhead box O1, SCARB2, scavenger receptor class B member 2, PQLC2, PQ-loop protein, SQSTM1, sequestosome 1, CMA, chaperonin mediated autophagy, PLIN2, perilipin 2, PXR, pregnane X receptor, NPC-1, Niemann-Pick disease, type C1, SLC38A9, sodium-coupled neutral amino acid transporter 9, Lysosome, TRPML1, transient receptor potential mucolipin 1, BNIP3, BCL2 interacting protein 3, BA, bile acid, ATM, ATM serine/threonine kinase, CAR, constitutive androstane receptor, MFSD1, major facilitator superfamily domain containing 1, NAFLD, non-alcoholic fatty liver disease, PKB, protein kinase B, VDR, vitamin D3 receptor, SIRT1, sirtuin 1, LYAAT-1, lysosomal amino acid transporter 1, SNAT7, sodium-coupled neutral amino acid transporter 7, Biology, S1PR2, sphingosine-1-phosphate receptor 2, ROS, reactive oxygen species, CYP27A1, sterol 27-hydroxylase, Autophagy, NDP52, calcium-binding and coiled-coil domain-containing protein 2, ATGL, adipose triglyceride lipase, Signaling proteins, Catabolism, FUNDC1, FUN14 domain containing 1, CCPG1, cell cycle progression 1, LAAT-1, lysosomal amino acid transporter 1 homologue, PEX5, peroxisomal biogenesis factor 5, PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase, SLC38A7, solute carrier family 38 member 7, Therapeutics. Pharmacology, Homeostasis, Drug metabolism
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2Academic Journal
المؤلفون: Vinay kumar Gupta, Jai Singh
المصدر: International Journal of Trend in Scientific Research and Development, 2(2), 1341-1347, (2018-02-03)
مصطلحات موضوعية: Biotechnology, Jatropha, SVO, FFA (Free fatty acid)
Relation: https://doi.org/10.31142/ijtsrd10733; oai:zenodo.org:3574137
الاتاحة: https://doi.org/10.31142/ijtsrd10733
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المؤلفون: Duangporn Werawatganon, Namthip Witayavanitkul, Prasong Siriviriyakul, Naruemon Klaikeaw, Maneerat Chayanupatkul
المصدر: Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine, Vol 11, Iss 6, Pp 503-512 (2021)مصطلحات موضوعية: medicine.medical_specialty, FFA, Free fatty acid, 0211 other engineering and technologies, Genistein, IL-13, Interleukin-13, 02 engineering and technology, Matrix metalloproteinase, DAB, Diaminobenzidine, 01 natural sciences, digestive system, Ovariectomized, chemistry.chemical_compound, NAFLD, Nonalcoholic fatty liver disease, Fibrosis, TBA, Thiobarbituric acid-reactive substances, Internal medicine, 021105 building & construction, medicine, Nonalcoholic steatohepatitis, Exercise, OVX, ovariectomized, business.industry, Therapeutic effect, Estrogen deficiency, HDAC3, histone deacetylase 3, DMSO, Dimethyl sulfoxide, medicine.disease, HDAC3, digestive system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Endocrinology, ELISA, Enzyme-linked immunosorbent assay, Complementary and alternative medicine, chemistry, Interleukin 13, Ovariectomized rat, Medicine, Original Article, MMP-12, matrix metalloelastase 12, Steatohepatitis, HFHF, High-fat high-fructose, business, NASH, Nonalcoholic steatohepatitis
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المؤلفون: Nadia Alatrakchi, Tuo Shao, Myung-Ho Kim, Wenyu Lin, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Andre J Jeyarajan, Kathleen E. Corey, Stuti Shroff, Andrew Kassa, Zhu Zhuo, Sanjoy K. Khan, Mozhdeh Sojoodi, Jacinta A Holmes, Esperance A. Schaefer
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1297-1310 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Liver Cirrhosis, Male, RC799-869, p38 Mitogen-Activated Protein Kinases, PHH, primary human hepatocyte, Mice, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, Liver Function Tests, Fibrosis, Non-alcoholic Fatty Liver Disease, Gene expression, Nonalcoholic fatty liver disease, Medicine, L-amino acid defined, high fat diet, Original Research, GFP, green fluorescent protein, YAP1, Fatty Acids, Gastroenterology, Diseases of the digestive system. Gastroenterology, Immunohistochemistry, mRNA, messenger RNA, ECM, extracellular matrix, NT, nontargeting, medicine.anatomical_structure, Hippo signaling, Hepatocyte, JNK, c-Jun N-terminal kinase, shRNA, short hairpin RNA, Disease Progression, 030211 gastroenterology & hepatology, RNAseq, RNA sequencing, Female, CDAHFD, choline-deficient, Disease Susceptibility, YAP, NASH, nonalcoholic steatohepatitis, LD, lipid droplet, Nonalcoholic Fatty Liver Disease, p38 MAPK, Models, Biological, digestive system, α-SMA, α-smooth muscle actin, 03 medical and health sciences, FFA, free fatty acid, Gene silencing, Animals, Humans, KO, knockout, Hepatology, MGH, Massachusetts General Hospital, business.industry, Gene Expression Profiling, pHSC, primary human hepatic stellate cell, Computational Biology, YAP-Signaling Proteins, medicine.disease, WT, wild-type, SS, simple steatosis, digestive system diseases, IL, interleukin, Disease Models, Animal, 030104 developmental biology, Gene Expression Regulation, siRNA, small interfering RNA, Hepatic stellate cell, Cancer research, Hepatocytes, NAFLD, nonalcoholic fatty liver disease, business, HCC, hepatocellular carcinoma, MAPK, mitogen-activated protein kinase, Biomarkers
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المؤلفون: Chang Hwa Jung, Hyunjung Lee, Hyo-Deok Seo, Jiyun Ahn, Young In Kim, Tae-Youl Ha, Seung Yeon Ha
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1201-1213 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Male, HFD, high-fat diet, Catechols, Gene Expression, ACC, acetyl-CoA carboxylase, RC799-869, Pathogenesis, Mice, 0302 clinical medicine, Genes, Reporter, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, miRNA, microRNA, Original Research, chemistry.chemical_classification, Chemistry, Fatty liver, Gastroenterology, MicroRNA, 1-Acylglycerol-3-Phosphate O-Acyltransferase, Diseases of the digestive system. Gastroenterology, mRNA, messenger RNA, ChIP, chromatin immunoprecipitation, Hepatocyte nuclear factors, HF, high-fat diet–fed group, UTR, untranslated region, Hepatocyte Nuclear Factor 4, 030211 gastroenterology & hepatology, RNA Interference, Fatty Alcohols, Intracellular, medicine.medical_specialty, TAG, triacylglycerol, DNL, de novo lipogenesis, HNF4α, hepatocyte nuclear factor 4α, 6-G, 6-gingerol, GPAT1, 03 medical and health sciences, Structure-Activity Relationship, cDNA, complementary DNA, GPAT, glycerol-3-phosphate acyltransferase, Internal medicine, NAFLD, microRNA, FFA, free fatty acid, medicine, Animals, Humans, HNF4α, Hepatology, DARTS, drug-affinity–responsive target stability, TLDA, TaqMan low-density arrays, Fatty acid, medicine.disease, Lipid Metabolism, Disease Models, Animal, MicroRNAs, 030104 developmental biology, Endocrinology, Gene Expression Regulation, LysoPA, lysophosphatidic acid, NAFLD, nonalcoholic fatty liver disease, Steatosis, 6-gingerol
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المؤلفون: Aldons J. Lusis, Raquel Floyd, Simon Sabir, Miklós Péterfy, Paola León-Mimila, Anthony E. Jones, Linsey Stiles, Dulshan W. Jayasekera, Samuel Canizales-Quinteros, Adriana Huertas-Vazquez, Varun Shravah, Angel A. Cortez, Karthickeyan Chella Krishnan, Ajit S. Divakaruni
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 2مصطلحات موضوعية: 0301 basic medicine, HMDP, Hybrid Mouse Diversity Panel, Male, OXPHOS, oxidative phosphorylation, Mitochondrion, HF/HS diet, diet rich in fat and sucrose, CDAHFD, choline-deficient, L-amino acid-defined, high-fat diet with 0.1% methionine, Oral and gastrointestinal, Hepatitis, LPK, liver pyruvate kinase, Mice, 0302 clinical medicine, GGT, gamma-glutamyl transpeptidase, Fibrosis, Loss of Function Mutation, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, 2.1 Biological and endogenous factors, Aetiology, scrRNA, scrambled RNA, Original Research, CE, cholesteryl ester, TG, triglyceride, Liver Disease, NAS, NAFLD Activity Score, Gastroenterology, Middle Aged, Up-Regulation, Liver, Gain of Function Mutation, Lipogenesis, Mitochondrial Dysfunction, shRNA, short hairpin RNA, Liver Fibrosis, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, Female, NASH, nonalcoholic steatohepatitis, ITT, insulin tolerance tests, L/PTT, lactate/pyruvate tolerance tests, Adult, medicine.medical_specialty, DEGs, differentially expressed genes, Chronic Liver Disease and Cirrhosis, ETC, electron transport chain, HDL, high-density lipoprotein, Pyruvate Kinase, DNL, de novo lipogenesis, SEM, standard error of the mean, 03 medical and health sciences, Insulin resistance, ROS, reactive oxygen species, Sex Factors, Liver Pyruvate Kinase, Internal medicine, NAFLD, AAV8, adeno-associated virus serotype 8, FFA, free fatty acid, Genetics, medicine, Animals, Humans, Genetic Predisposition to Disease, Obesity, Gene Silencing, Sex Differences, Metabolic and endocrine, TBG, thyroxine binding globulin, Nutrition, Hepatology, Animal, business.industry, Gene Expression Profiling, medicine.disease, TC, total cholesterol, Disease Models, Animal, 030104 developmental biology, Endocrinology, siRNA, small interfering RNA, Disease Models, NAFLD, nonalcoholic fatty liver disease, Steatosis, Digestive Diseases, business, Dyslipidemia, Pyruvate kinase, GTT, glucose tolerance tests
وصف الملف: application/pdf
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المؤلفون: Yanhang Liao, Yichun Yang, Zhuolin Guo, Ling-juan Zhang, Yulin Shi
المصدر: JID Innovations, Vol 2, Iss 1, Pp 100064-(2022)
JID Innovationsمصطلحات موضوعية: HFD, high-fat diet, BMI, body mass index, Adipokine, Adipose tissue, Inflammation, White adipose tissue, Review, Dermatology, PA, palmitic acid, Immune system, DC, dendritic cell, SCORAD, SCORing Atopic Dermatitis, TEWL, transepidermal water loss, Psoriasis, AT, adipose tissue, FFA, free fatty acid, Medicine, AMP, antimicrobial peptide, PSO, psoriasis, TLR, toll-like receptor, Th, T helper, Adiponectin, TG, triglyceride, integumentary system, business.industry, dFB, dermal fibroblast, OA, oleic acid, sWAT, subcutaneous white adipose tissue, KC, keratinocyte, WAT, white adipose tissue, Atopic dermatitis, DIO, diet-induced obesity, AD, atopic dermatitis, medicine.disease, BAT, brown adipose tissue, CI, confidence interval, TC, total cholesterol, RL1-803, Immunology, medicine.symptom, dWAT, dermal white adipose tissue, business
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المؤلفون: Adeline Bertola, Yeni Ait-Ahmed, Jing Ma, Bin Gao, Yukun Guan, Dechun Feng, Tamara Vanhaecke, Robim Marcelino Rodrigues, Bryan Mackowiak, Yaojie Fu, Xiaolin Wang, Wonhyo Seo, Seonghwan Hwang, Seol Hee Park, Yong He
المساهمون: Pharmaceutical and Pharmacological Sciences, Experimental in vitro toxicology and dermato-cosmetology
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 151-171 (2022)مصطلحات موضوعية: HFD, high-fat diet, Neutrophils, AdCxcl1, adenovirus-Cxcl1, Adipose tissue, MPO, myeloperoxidase, RC799-869, AST, aspartate aminotransferase, PAQ, Paquinimod, Mice, Rbp4, retinol binding protein 4, SELE, E-selectin, Non-alcoholic Fatty Liver Disease, RT-qPCR, reverse-transcription quantitative polymerase chain reaction, Original Research, Steatohepatitis, biology, Gastroenterology, IGFBP1, insulin-like growth factor-binding protein 1, ELISA, enzyme-linked immunosorbent assay, Diseases of the digestive system. Gastroenterology, CXCL1, mRNA, messenger RNA, MRP, myeloid-related protein, Adipose Tissue, GTT, glucose tolerance test, medicine.symptom, E-Selectin, NASH, nonalcoholic steatohepatitis, SELP, P-selectin, medicine.medical_specialty, TSEC, immortalized liver sinusoidal endothelial cell line, Lipolysis, Adipokine, Inflammation, digestive system, Proinflammatory cytokine, ANGPTL3, angiopoietin-like protein 3, Internal medicine, ALT, alanine aminotransferase, E-selectin, FFA, free fatty acid, medicine, Animals, Humans, ITT, insulin tolerance test, KO, knockout, Hepatology, business.industry, nutritional and metabolic diseases, CXCL1, C-X-C motif chemokine ligand 1, medicine.disease, Nonalcoholic Fatty Liver Disease (NAFLD), SELL, L-selectin, WT, wild-type, digestive system diseases, IL, interleukin, Mice, Inbred C57BL, Endocrinology, biology.protein, NAFLD, nonalcoholic fatty liver disease, Steatosis, Paquinimod, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b081b10329fc04385b5e0d0855f694
https://biblio.vub.ac.be/vubir/eselectindependent-inflammation-and-lipolysis-in-adipose-tissue-exacerbate-steatosistonash-progression-via-s100a89(8daeb805-6a0b-4ba8-b9f4-f7e041564b4f).html -
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المؤلفون: N. Castex Rizzi, Thérèse Nocera, Jean-Hilaire Saurat, L. Garidou, J. Le Digabel, C. Lauze, Gwendal Josse, Fabienne Fontao, Olivier Sorg
المصدر: JID Innovations, Vol 1, Iss 4, Pp 100057-(2021)
JID Innovationsمصطلحات موضوعية: chemistry.chemical_classification, medicine.medical_specialty, LD, lipid droplet, TG, triglyceride, Chemistry, Fatty acid, Dermatology, medicine.disease, Pathogenesis, Lipid Droplet Proteins, Blot, Endocrinology, Lipotoxicity, Lipid droplet, Internal medicine, RL1-803, FFA, free fatty acid, medicine, SMFE, Silybum marianum fruit extract, Immunohistochemistry, Original Article, Acne
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المؤلفون: Aidan J. McGlinchey, Olivier Govaere, Dawei Geng, Vlad Ratziu, Michael Allison, Jerome Bousier, Salvatore Petta, Claudia de Oliviera, Elisabetta Bugianesi, Jörn M. Schattenberg, Ann K. Daly, Tuulia Hyötyläinen, Quentin M. Anstee, Matej Orešič
المساهمون: McGlinchey, Aidan J, Govaere, Olivier, Geng, Dawei, Ratziu, Vlad, Allison, Michael, Bousier, Jerome, Petta, Salvatore, de Oliviera, Claudia, Bugianesi, Elisabetta, Schattenberg, Jörn M, Daly, Ann K, Hyötyläinen, Tuulia, Anstee, Quentin M, Orešič, Matej, Govaere, Olivier [0000-0002-4426-6930], Allison, Michael [0000-0003-3677-3294], Bugianesi, Elisabetta [0000-0002-0502-4381], Schattenberg, Jörn M [0000-0002-4224-4703], Apollo - University of Cambridge Repository
المصدر: JHEP Reports
مصطلحات موضوعية: ALT, type 2 diabetes mellitus, ROC, receiving operator characteristic, aspartate aminotransferase, HSD, LDL, low-density lipoprotein, UHPLC, ultrahigh-performance liquid chromatography, ROC, HCC, Non-alcoholic steatohepatitis, GC, PCA, NASH, Gastroenterology, 2-HB, 2-hydroxybutanoic acid, 3-HB, 3-hydroxybutanoic acid, ALT, alanine aminotransferase, AST, aspartate aminotransferase, CE, cholesterol ester, Cer, ceramide, FFA, free fatty acid, FLIP, Fatty Liver Inhibition of Progression, Fibrosis, GC, gas chromatography, HCC, hepatocellular carcinoma, HSD, honest significant difference, LC, lipid cluster, LM, lipid and metabolite, LMC, lipid, metabolite, and clinical variable, LPC, lysophosphatidylcholine, Lipidomics, Mass spectrometry, Metabolomics, NAFL, non-alcoholic fatty liver, NAFLD, non-alcoholic fatty liver disease, NAS, NASH activity score, NASH, non-alcoholic steatohepatitis, NIDDK NASH-CRN, National Institute of Digestive Diseases and Kidney NASH Clinical Research Network, NRR, non-rejection rate, PC(O), ether PC, PC, phosphatidylcholine, PCA, principal component analysis, PE, phosphatidylethanolamine, QTOFMS, quadrupole-time-of-flight mass spectrometry, SAF, steatosis, activity, and fibrosis, SM, sphingomyelin, T2DM, type 2 diabetes mellitus, TG, triacylglycerol, SAF, honest significant difference, non-rejection rate, cholesterol ester, PC, PE, free fatty acid, FLIP, BIOMARKERS, T2DM, LDL, lipid, NAFLD, 2-HB, LMC, phosphatidylcholine, Science & Technology, Gastroenterology & Hepatology, activity, nutritional and metabolic diseases, ACIDS, receiving operator characteristic, digestive system diseases, quadrupole-time-of-flight mass spectrometry, low-density lipoprotein, NAS, QTOFMS, ether PC, NRR, SCORING SYSTEM, principal component analysis, gas chromatography, LC, 2-hydroxybutanoic acid, PROGRESSION, LM, PC(O), MARKERS, UHPLC, steatosis, TOOL, Immunology and Allergy, INSULIN-RESISTANCE, Cer, SM, Fatty Liver Inhibition of Progression, hepatocellular carcinoma, 2-HB, 2-hydroxybutanoic acid, NIDDK NASH-CRN, National Institute of Digestive Diseases and Kidney NASH Clinical Research Network, NRR, non-rejection rate, Non-alcoholic steatohepatitis, PC(O), ether PC, PC, phosphatidylcholine, PCA, principal component analysis, PE, phosphatidylethanolamine, QTOFMS, quadrupole-time-of-flight mass spectrometry, ROC, receiving operator characteristic, SAF, steatosis, activity, and fibrosis, SM, T2DM, type 2 diabetes mellitus, TG, triacylglycerol, UHPLC, ultrahigh-performance liquid chromatography, ultrahigh-performance liquid chromatography, CE, LPC, 3-HB, NAFL, non-alcoholic fatty liver, TG, triacylglycerol, Life Sciences & Biomedicine, alanine aminotransferase, metabolite, sphingomyelin, lysophosphatidylcholine, and fibrosis, Internal Medicine, ceramide, National Institute of Digestive Diseases and Kidney NASH Clinical Research Network, AST, Hepatology, non-alcoholic fatty liver disease, and clinical variable, 3-hydroxybutanoic acid, NASH activity score, NIDDK NASH-CRN, lipid cluster, lipid and metabolite, phosphatidylethanolamine, FFA
وصف الملف: application/pdf; Electronic-eCollection
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المؤلفون: Robert Gruber, Sandrine Dubrac, Barbara Del Frari, Geraldine Leman, Thomas O. Eichmann, Martin Hermann, Franz P.W. Radner, Petra Pavel, Christian Ploner, Deborah Minzaghi
المصدر: JID Innovations, Vol 1, Iss 3, Pp 100033-(2021)
JID Innovationsمصطلحات موضوعية: CoA, coenzyme A, Ceramide, ATP, adenosine triphosphate, PPAR, peroxisome proliferator–activated receptor, Cer, ceramide, Dermatology, Lamellar granule, ULCFA, ultra long-chain fatty acid, chemistry.chemical_compound, TEWL, transepidermal water loss, FFA, free fatty acid, Stratum corneum, medicine, LB, lamellar body, SC, stratum corneum, ADL, lesional atopic dermatitis, KO, knockout, Epidermis (botany), FA, fatty acid, KC, keratinocyte, Peroxisome, AD, atopic dermatitis, IMQ, imiquimod, VLCFA, very-long-chain fatty acid, Molecular biology, medicine.anatomical_structure, chemistry, Anaerobic glycolysis, RL1-803, ACOX1, Original Article, HEE, human epidermal equivalent, Keratinocyte
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المؤلفون: Tirthadipa Pradhan-Sundd
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1199-1201 (2021)مصطلحات موضوعية: Male, Arteriosclerosis, SREBP, sterol regulatory element-binding protein, CREB3L3, FGF21, fibroblast growth factor 21, Bioinformatics, CREB3L3, cAMP responsive element-binding protein 3 like 3, Mice, Enterohepatic Circulation, Cyclic AMP Response Element-Binding Protein, Insig, insulin-induced gene, Original Research, GFP, green fluorescent protein, Mice, Knockout, Sterol Regulatory Element Binding Proteins, TBA, total bile acid, WD, Western diet, TG, triglyceride, Chemistry, Gastroenterology, Editorial, Hyperlipidemia, LPL, lipoprotein lipase, Female, lipids (amino acids, peptides, and proteins), Sterol Regulatory Element Binding Protein 1, HDL, high-density lipoprotein, Hyperlipidemias, SREBP, ER, endoplasmic reticulum, Competition (economics), Tg, transgenic, FFA, free fatty acid, medicine, Animals, Humans, lcsh:RC799-869, KO, knockout, PPARα, peroxisome proliferator-activated receptor alpha, Hepatology, PLA, proximity ligation assay, S1P, site-1 protease, Lipogenesis, SREBF, sterol regulatory element-binding factor, VLDL, very-low-density lipoprotein, Atherosclerosis, Lipid Metabolism, medicine.disease, Sterol regulatory element-binding protein, Mice, Inbred C57BL, TC, total cholesterol, Gene Expression Regulation, Receptors, LDL, Apo, apolipoprotein, HPLC, high-performance liquid chromatography, HSV, herpes simplex virus, lcsh:Diseases of the digestive system. Gastroenterology, LXR, liver X receptor
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المؤلفون: N. Thao N. Galvan, Mercedes Barzi, John A. Goss, William R. Lagor, David D. Moore, Adam Dean, Neil J. McKenna, Pavel Sumazin, Barry Zorman, Diane Yang, Beatrice Bissig-Choisat, Karl-Dimiter Bissig, Xavier Legras, David E. Cohen, Robert Brian York, Malgorzata Borowiak, Michele Alves-Bezerra, Scott A. Ochsner
المصدر: JHEP reports : innovation in hepatology, vol 3, iss 3
JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100281-(2021)مصطلحات موضوعية: phosphatidylinositol, Cirrhosis, Steatosis, ALT, hexosylceramide, Humanised mice, SREBP, sterol regulatory element-binding protein, PI, RC799-869, CMHs, chimeric mouse hepatocytes, 0302 clinical medicine, GGT, gamma-glutamyl transpeptidase, aspartate aminotransferase, HCC, gamma-glutamyl transpeptidase, chemistry.chemical_classification, 0303 health sciences, education.field_of_study, Western-type diet, Gastroenterology, NASH, CHHs, Diseases of the digestive system. Gastroenterology, 3. Good health, confidence transcript, HCT, cholesteryl ester, human albumin, DCER, dihydroceramide, 030211 gastroenterology & hepatology, PC, non-alcoholic steatohepatitis, PE, transgene-free Il2rg-/-/Rag2-/-/Fah, free fatty acid, LPE, lysophosphatidylethanolamine, DCER, NASH, non-alcoholic steatohepatitis, HCER, hexosylceramide, NC, normal chow, TIRF, PE, phosphatidylethanolamine, nitisinone, lysophosphatidylethanolamine, 03 medical and health sciences, dihydroceramide, Human disease modelling, NAFLD, FFA, free fatty acid, LCER, DEG, MUFA, education, phosphatidylcholine, chimeric mouse hepatocytes, FAH, SM, sphingomyelin, ALP, alkaline phosphatase, FA, fatty acid, NTBC, Fatty acid, medicine.disease, differentially expressed gene, lactosylceramide, PNPLA3, patatin-like-phospholipase domain-containing protein 3, Lipid metabolism, chemistry, fatty acid, PUFA, hALB, human albumin, TIRF, transgene-free Il2rg-/-/Rag2-/-/Fah, AST, aspartate aminotransferase, CT, confidence transcript, PC, phosphatidylcholine, monounsaturated fatty acid, DEG, differentially expressed gene, MUFA, monounsaturated fatty acid, Immunology and Allergy, MAG, monoacylglycerol, PUFA, polyunsaturated free FA, CE, cholesteryl ester, CER, diacylglycerol, FAH, fumarylacetoacetate hydrolase, Fatty liver, SM, chimeric human hepatocytes, hepatocellular carcinoma, CBPEGs, cholesterol biosynthesis pathway enzyme genes, CE, MAG, LPC, patatin-like-phospholipase domain-containing protein 3, triacylglycerol, LPE, alkaline phosphatase, sterol regulatory element-binding protein, Polyunsaturated fatty acid, Research Article, CT, NAFLD, non-alcoholic fatty liver disease, FA, HCER, TAG, triacylglycerol, fumarylacetoacetate hydrolase, monoacylglycerol, alanine aminotransferase, Population, cholesterol biosynthesis pathway enzyme genes, Biology, SREBP, PI, phosphatidylinositol, sphingomyelin, lysophosphatidylcholine, WD, ALT, alanine aminotransferase, high confidence transcriptional target, Internal Medicine, medicine, CBPEGs, ceramide, hALB, LCER, lactosylceramide, normal chow, AST, polyunsaturated free FA, WD, Western-type diet, PNPLA3, 030304 developmental biology, Hepatitis, LPC, lysophosphatidylcholine, Hepatology, DAG, non-alcoholic fatty liver disease, NTBC, nitisinone, CMHs, GGT, HCT, high confidence transcriptional target, phosphatidylethanolamine, TAG, Cancer research, CHHs, chimeric human hepatocytes, ALP, Liver function, NC, CER, ceramide, HCC, hepatocellular carcinoma, FFA, DAG, diacylglycerol, Non-alcoholic fatty liver disease
وصف الملف: application/pdf
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المؤلفون: Zhanxiang Zhou, Wei Zhong, Liuyi Hao, Haibo Dong, Tianjiao Li, Ruichao Yue, Wei Guo, Xinguo Sun
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1599-1615 (2021)مصطلحات موضوعية: ATF4, activating transcription factor 4, DGAT1, acyl-CoA:diacylglycerol acyltransferase 1, MPO, myeloperoxidase, SAH, severe alcoholic hepatitis, RC799-869, AST, aspartate aminotransferase, PF, pair-fed, Mice, Liver Function Tests, Lipid droplet, ALD, alcohol-related liver disease, Original Research, DGAT1, Liver injury, Mice, Knockout, Free Fatty Acid, LAMP2, LDH, lactate dehydrogenase, TG, triglyceride, Chemistry, Fatty Acids, Gastroenterology, Diseases of the digestive system. Gastroenterology, Endoplasmic Reticulum Stress, Cell biology, medicine.anatomical_structure, Lipotoxicity, Hepatocyte, Disease Susceptibility, Signal Transduction, Programmed cell death, LAMP2, lysosome-associated membrane protein 2, CHOP, C/EBP homologous protein, Models, Biological, ER, endoplasmic reticulum, PA, palmitic acid, Alcohol-Induced Liver Injury, Lysosomal-Associated Membrane Protein 2, ALT, alanine aminotransferase, FFA, free fatty acid, medicine, Autophagy, Animals, Humans, LC3II, microtubule-associated protein 1A/1B-light chain 3 II, Diacylglycerol O-Acyltransferase, Liver Diseases, Alcoholic, AF, alcohol-fed, PPARα, peroxisome proliferator-activated receptor α, Hepatology, OA, oleic acid, VLDL, very-low-density lipoprotein, medicine.disease, Lipid Metabolism, Disease Models, Animal, Unfolded protein response, Hepatocytes, Biomarkers
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المؤلفون: Lucia Parlati, Catherine Postic, Marion Régnier, Hervé Guillou
المساهمون: LESUR, Hélène, Impact du métabolisme des acides gras des tissus adipeux et du foie sur l'insulinorésistance - - HepAdialogue2017 - ANR-17-CE14-0015 - AAPG2017 - VALID, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Catholique de Louvain = Catholic University of Louvain (UCL), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Lucia Parlati and Catherine Postic received funding from the French association for the study of the liver (AFEF). Catherine Postic and Herve Guillou received funding from the Agence Nationale de la Recherche (ANR-17-CE14-0015Hepadialogue)., ANR-17-CE14-0015,HepAdialogue,Impact du métabolisme des acides gras des tissus adipeux et du foie sur l'insulinorésistance(2017), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
المصدر: JHEP Reports
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩مصطلحات موضوعية: HFD, high-fat diet, SREBP-1c, [SDV]Life Sciences [q-bio], Disease, Review, ACC, acetyl-CoA carboxylase, ASK1, apoptosis signal-regulating kinase 1, Chronic liver disease, Bioinformatics, ChREBP, carbohydrate responsive element–binding protein, PPARα, NEFA, TNF-α, tumour necrosis factor-α, 0302 clinical medicine, Fibrosis, Immunology and Allergy, Medicine, IL-, interleukin, VLDL, very low-density lipoprotein, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, NEFA, non-esterified fatty acid, Fatty liver, Gastroenterology, NASH, lipotoxicity, FAS, fatty acid synthase, animal models, 3. Good health, [SDV] Life Sciences [q-bio], PY, persons/years, Lipotoxicity, FXR, Saturated fatty acid, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, LXR, CAP, controlled attenuation parameter, HSL, hormone-sensitive lipase, HSC, hepatic stellate cells, GGT, gamma glutamyltransferase, NAFLD, non-alcoholic fatty liver disease, ChREBP, NASH, non-alcoholic steatohepatitis, SFA, saturated fatty acid, TCA, tricarboxylic acid, Phf2, histone demethylase plant homeodomain finger 2, digestive system, 03 medical and health sciences, glucotoxicity, FXR, farnesoid X receptor, NAFLD, FFA, free fatty acid, Internal Medicine, RCT, randomised controlled trial, Liver X receptor, PPARa, 030304 developmental biology, FGF21, fibroblast growth factor-21, MCD, methionine- and choline-deficient, HVPG, hepatic venous pressure gradient, Hepatology, business.industry, PUFAs, polyunsaturated fatty acids, nutritional and metabolic diseases, TLR4, Toll-like receptor 4, SCD1, stearoyl-CoA desaturase-1, medicine.disease, digestive system diseases, PPARα, peroxisome proliferator-activated receptor-α, SREBP-1c, sterol regulatory element–binding protein-1c, Steatosis, LXR, liver X receptor, business, HCC, hepatocellular carcinoma, MUFA, monounsaturated fatty acids, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
وصف الملف: application/pdf
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16
المؤلفون: Jordi Duran, Joan J. Guinovart, Iliana López-Soldado
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Male, endocrine system diseases, medicine.medical_treatment, Biochemistry, PGC1α, proliferator-activated receptor gamma coactivator 1-α, chemistry.chemical_compound, Mice, Glycolysis, glucose, protein targeting to glycogen (PTG), Glycogen, biology, diabetes, Intracellular Signaling Peptides and Proteins, glycolysis, FAS, fatty acid synthase, Phenotype, glycogen, Female, HSL, hormone-sensitive lipase, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Research Article, GK, glucokinase, medicine.medical_specialty, endocrine system, insulin, PTG, protein targeting to glycogen, liver, Diet, High-Fat, STZ, streptozotocin, TAG, triacylglyceride, Diabetes Mellitus, Experimental, 03 medical and health sciences, Insulin resistance, GS, glycogen synthase, Internal medicine, Diabetes mellitus, FFA, free fatty acid, medicine, Akita, Animals, Glycogen synthase, Molecular Biology, ATGL, adipose triglyceride lipase, 030102 biochemistry & molecular biology, Glucokinase, business.industry, Insulin, Gluconeogenesis, PP1, Protein phosphatase 1, SCD1, stearoyl-CoA desaturase-1, Cell Biology, medicine.disease, Streptozotocin, HFD, high-fat-diet, Liver Glycogen, ATP, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, Diabetes Mellitus, Type 2, PK, pyruvate kinase, biology.protein, PEPCK, phosphoenolpyruvate carboxykinase, business
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17
المؤلفون: Shaoping Guan, Xinping Liu, Richard W. Gross, Harold F. Sims, Beverly Gibson Dilthey, Sung Ho Moon
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100052-(2021)مصطلحات موضوعية: 0301 basic medicine, obesity, Bioenergetics, AA, arachidonic acid, 030204 cardiovascular system & hematology, Mitochondrion, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, hydroxyeicosatetraenoic acids, 0302 clinical medicine, Endocrinology, mitochondrial respiration, EET, epoxyeicosatrienoic acid, HEPiPLA2γKO, hepatocyte-specific iPLA2γ-knockout, NDGA, nordihydroguaiaretic acid, ANT, adenine nucleotide translocase, LOX, lipoxygenase, LDH, lactate dehydrogenase, MPTP, phospholipases A2, mitochondria, cell death, NC, normal-chow, diet and dietary lipids, Research Article, medicine.medical_specialty, Programmed cell death, TAG, triacylglycerol, mPTP, mitochondrial permeability transition pore, QD415-436, Diet, High-Fat, eicosanoids, 03 medical and health sciences, Insulin resistance, HF, high-fat, Internal medicine, HETE, hydroxyeicosatetraenoic acid, FFA, free fatty acid, medicine, hepatocyte, FCCP, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile, iPLA2γ, calcium-independent phospholipase A2γ, mitochondrial permeability transition pore, Cell Biology, medicine.disease, AMPP, N-(4-aminomethylphenyl) pyridinium, 030104 developmental biology, chemistry, Mitochondrial permeability transition pore, Hepatic stellate cell, Oxidative stress
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18
المؤلفون: Amelie Isabelle Sylvie Sobczak, Alan J. Stewart, Terry K. Smith, Ramzi A. Ajjan, Samantha J. Pitt
المساهمون: British Heart Foundation, University of St Andrews. School of Medicine, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Institute of Behavioural and Neural Sciences, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. Cellular Medicine Division
المصدر: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, QH301 Biology, Gene Expression, Fatty Acids, Nonesterified, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, LDL, low-density lipoprotein, GC–MS, Chemistry, HbA1c, glycated haemoglobin A1c, Fasting, Lipogenesis, RC Internal medicine, lipids (amino acids, peptides, and proteins), Female, GC-MS, T1DM, type-1 diabetes mellitus, Stearoyl-CoA Desaturase, Adult, medicine.medical_specialty, HbA1c, Adolescent, HDL, high-density lipoprotein, NDAS, 030209 endocrinology & metabolism, Serum Albumin, Human, Article, QH301, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, Diabetes mellitus, Lipidomics, FFA, free fatty acid, medicine, Humans, Non-esterified fatty acid, SCD1, stearoyl-CoA desaturase 1, Molecular Biology, Triglycerides, Glycated Hemoglobin, Type 1 diabetes, Fatty acid metabolism, D5D, delta-(5)-desaturase, Cholesterol, FAME, fatty acid methyl ester, FA, fatty acid, Cholesterol, HDL, Lipid metabolism, Cell Biology, Cholesterol, LDL, medicine.disease, Lipid Metabolism, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 1, Case-Control Studies, Gas chromatography–mass spectrometry, GC–MS, gas chromatography–mass spectrometry, HSA, human serum albumin, RC
وصف الملف: application/pdf
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19
المؤلفون: Andrew C. McCourt, Muheeb Beg, Wei Zhang, Sven Enerbäck
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Glucose uptake, Biochemistry, chemistry.chemical_compound, Mice, Thioredoxins, AMP-activated protein kinase, DOG, 2-deoxy-d-glucose, Adipocytes, Cyclic AMP, PKA, Glucose Transporter Type 1, biology, Chemistry, HA, human influenza hemagglutinin, TXNIP, thioredoxin-interacting protein, Cell biology, GLUT, glucose transporter, hormone-sensitive lipase (HSL), triacylglycerol, HSL, hormone-sensitive lipase, TXNIP, adipose triglyceride lipase (ATGL), Research Article, Thioredoxin-Interacting Protein, TAG, triacylglycerol, Lipolysis, adipocyte, AKT, protein kinase B, 03 medical and health sciences, cAMP, 3T3-L1 Cells, FFA, free fatty acid, GSK3, glycogen synthase kinase 3, Animals, Humans, Lactic Acid, Molecular Biology, thioredoxin-interacting protein (TXNIP), ATGL, adipose triglyceride lipase, 030102 biochemistry & molecular biology, Glucose transporter, glucose transport, 8-Br-cAMP, 8-bromine-cAMP, Cell Biology, Lipase, Sterol Esterase, MGL, monoacylglycerol lipase, AMPK, AMP-activated protein kinase, 030104 developmental biology, Glucose, Proteolysis, biology.protein, GLUT1, 2-Deoxy-D-glucose, Carrier Proteins, OE, overexpression
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20
المؤلفون: Tim Daniel Rose, Veera Raghavan Thangapandi, Andrej Shevchenko, Witigo von Schoenfels, Ünal Coskun, Thomas Züllig, Oskar Knittelfelder, Stephan Buch, Mario Brosch, Josch Konstantin Pauling, Clemens Schafmayer, Kai Schuhmann, Justus Gross, Yuting Wang, Judith Andrea Heidrun Wodke, Olga Vvedenskaya, Christoph Röcken, Edda Klipp, Harald Köfeler, Jürgen Hartler, Canan Has, Jacobo Miranda Ackerman, Alessandra Palladini, Jochen Hampe
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100104-(2021)مصطلحات موضوعية: Male, PR, precision recall, PG, phosphatidylglycerol, Biochemistry, chemistry.chemical_compound, AUC, area under the curve, PC, phosphatidylcholine, Endocrinology, ROC, receiver operator characteristic, AST, aspartate transaminase, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, steatosis, DG, diacylglycerol, GGT, gamma-glutamyl transferase, lipid biomarkers, biclustering analysis, PA, phosphatidic acid, NC, normal control, LPI, lyso-phosphatidylinositol, chemistry.chemical_classification, Aged, 80 and over, CE, cholesteryl ester, Chol, cholesterol, LPA, lyso-phosphatidic acid, Fatty liver, NASH, Lipidome, Middle Aged, PS, phosphatidylserine, HO, healthy obese, TG, triacylglycerol, ddc, sphingomyelins, AP, alkaline phosphatase, Liver, LPC, lyso-phosphatidylcholine, Cholesteryl ester, lipids (amino acids, peptides, and proteins), Female, NASH, nonalcoholic steatohepatitis, liver lipidome, Research Article, LPE, lysophosphatidylethanolamine, Adult, medicine.medical_specialty, Adolescent, Cer, ceramide, QD415-436, PE, phosphatidylethanolamine, digestive system, PI, phosphatidylinositol, Young Adult, GPL, glycerophospholipid, Internal medicine, NAFLD, ALT, alanine aminotransferase, Lipidomics, FFA, free fatty acid, medicine, Humans, shotgun lipidomics, PE O-, ether phosphatidylethanolamine, Aged, SM, sphingomyelin, liver biopsies, Fatty acid, nutritional and metabolic diseases, Cell Biology, Shotgun lipidomics, PC O-, ether phosphatidylcholine, medicine.disease, Lipid Metabolism, digestive system diseases, NAFL, chemistry, NAFLD, nonalcoholic fatty liver disease, Steatosis
وصف الملف: application/pdf