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المصدر: Journal of Lipid Research, Vol 62, Iss, Pp 100093-(2021)
Journal of Lipid Researchمصطلحات موضوعية: 0301 basic medicine, Very low-density lipoprotein, Hormone-sensitive lipase, 030204 cardiovascular system & hematology, Biochemistry, Carboxylesterase, Mice, SHP, small heterodimer partner, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, RCT, reverse cholesterol transport, cardiovascular disease, cholesteryl ester hydrolase, LKO, liver-specific Ces1d KO, Cells, Cultured, AADAC, arylacetamide deacetylase, Mice, Knockout, Western-type diet, Hydrolysis, Reverse cholesterol transport, WAT, white adipose tissue, lipase activity, WTD, Western-type diet, Cholesteryl ester, lipids (amino acids, peptides, and proteins), Cholesterol Esters, HSL, hormone-sensitive lipase, VLDL, Research Article, FC, free cholesterol, LD, lipid droplet, HDL, Mice, Transgenic, QD415-436, Cholesterol 7 alpha-hydroxylase, liver, SR-BI, scavenger receptor class B type I, 03 medical and health sciences, Hydrolase, Animals, Cholesterol, Cell Biology, CYP7A1, cholesterol 7α-hydroxylase, reverse cholesterol transport, TC, total cholesterol, Lox, Ces1dflox/flox, 030104 developmental biology, chemistry, 4-MU, 4-methylumbelliferone, cholesterol metabolism, Ces1d, carboxylesterase 1d
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المؤلفون: Chiara Parravicini, Luca Palazzolo, Uliano Guerrini, Elisabetta Gianazza, Ivano Eberini, Laura Calabresi, T. Laurenzi
المصدر: Journal of Lipid Research, Vol 62, Iss, Pp 100006-(2021)
Journal of Lipid Researchمصطلحات موضوعية: FC, free cholesterol, 0301 basic medicine, Apolipoprotein B, Protein Data Bank (RCSB PDB), Molecular modeling, QD415-436, 030204 cardiovascular system & hematology, CV, collective variable, Biochemistry, apoA-I, apolipoprotein A-I, Phosphatidylcholine-Sterol O-Acyltransferase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, FLD, familial LCAT deficiency, HDL/Structure, PDB, Protein Data Bank, LCAT deficiency, Transferase, Cholesterol metabolism, RMSD, root-mean-square deviation, LCAT, lecithin:cholesterol-acyl transferase, RMSF, root-mean-square fluctuation, chemistry.chemical_classification, Diseases/Dyslipidemias, CE, cholesteryl ester, biology, Cholesterol, Active site, Lecithin:cholesterol-acyl transferase (LCAT), Cell Biology, Physical biochemistry, MD, molecular dynamics, rHDL, reconstituted HDL, 030104 developmental biology, Enzyme, chemistry, Structural bioinformatics, biology.protein, Cholesteryl ester, Biophysics, lipids (amino acids, peptides, and proteins), wtMTD, well-tempered metadynamics, Research Article, Lipoprotein
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المؤلفون: Xiaoxia Liu, Qian Wang, Daici Chen, Yichen Li, Shaoyong Peng, Huaiming Wang, Wanjun Liu, Qianxin Luo, Si Chen
المصدر: Translational Oncology
Translational Oncology, Vol 14, Iss 10, Pp 101171-(2021)مصطلحات موضوعية: FC, free cholesterol, Cancer Research, RTCA, real-time cell analyzer, qRT-PCR, quantitative real time PCR, Colorectal cancer, Cell, Context (language use), SPTLC1, palmitoyl transferase long chain base subunit 1, Biology, Metastasis, OS, overall survival, ER, endoplasmic reticulum, DEG, differentially expressed gene, medicine, IF, immunofluorescence, GEF, guanine nucleotide exchange factors, GWAS, genome-wide association study, RC254-282, Original Research, TCGA, the cancer genome atlas, Gene knockdown, Cell growth, ORMDL1, HE, hematoxylin and eosin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell migration, MSI, microsatellite instability, Prognosis, medicine.disease, digestive system diseases, medicine.anatomical_structure, Oncology, ccRCC, clear cell renal cell carcinoma, CRC, colorectal cancer, Cancer research, Biomarker (medicine), GAP, gtpase-activating proteins, IHC, immunohistochemistry, EMT, epithelial-to-mesenchymal transition
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المؤلفون: Nele Ferekidis, Inna Khozin-Goldberg, Irina A. Guschina, Alaa Ismail, Daryn Robert Michael, Valerie B. O'Donnell, Dipak Purshottam Ramji, John L. Harwood, Yee-Hung Chan, Sammy Boussiba, Jessica O. Williams, Hayley Gallagher, Victoria J. Tyrrell
المصدر: Biochimica et Biophysica Acta. Molecular Basis of Disease
مصطلحات موضوعية: Lipopolysaccharides, 0301 basic medicine, medicine.medical_treatment, CD36, Interleukin-1beta, NEFA, non esterified fatty acids, Cell, ICAM-1, intercellular adhesion molecule-1, 030204 cardiovascular system & hematology, LY, lucifer yellow, TNF-α, tumour necrosis factor-α, VCAM-1, vascular cell adhesion molecule-1, Monocytes, PDGF, platelet-derived growth factor, Mice, chemistry.chemical_compound, 8,11,14-Eicosatrienoic Acid, 0302 clinical medicine, SR, scavenger receptor, Cell Movement, HASMC, human aortic smooth muscle cells, IFN-γ, interferon-γ, Foam cells, Cells, Cultured, Chemokine CCL2, FCCP, carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone, Foam cell, Mice, Knockout, HMDM, human monocyte-derived macrophages, AcLDL, acetylated LDL, biology, Chemistry, Intercellular Adhesion Molecule-1, MCP-1, monocyte chemotactic protein-1, Mitochondria, ECM, extracellular matrix, Cell biology, Endothelial stem cell, VSMC, vascular smooth muscle cells, medicine.anatomical_structure, PBMC, peripheral blood mononuclear cells, Smooth muscle cells, Cytokines, LPS, lipopolysaccharide, Molecular Medicine, medicine.symptom, FC, free cholesterol, STAT-1, signal transducer and activator of transcription-1, HUVEC, human umbilical cord endothelial cells, Inflammation, CVD, cardiovascular disease, Article, 03 medical and health sciences, TBHP, tert-butyl hydroperoxide, PUFA, polyunsaturated fatty acid, medicine, Animals, Humans, DGLA, dihomo-γ-linolenic acid, oxLDL, oxidized LDL, Scavenger receptor, Molecular Biology, Cell Proliferation, LA, linoleic acid, ABC, ATP-binding cassette transporter, LXR, liver X receptors, Dihomo-γ-linolenic acid, GLA, gamma-linolenic acid, Macrophages, Growth factor, Atherosclerosis, CE, cholesteryl esters, IL, interleukin, 030104 developmental biology, Gene Expression Regulation, Apo, apolipoprotein, RT-qPCR, real-time quantitative polymerase chain reaction, biology.protein, Gene expression, PGE1, prostaglandin E1
وصف الملف: application/pdf
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المصدر: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 13, Iss, Pp 1-6 (2018)مصطلحات موضوعية: 0301 basic medicine, FC, free cholesterol, Biophysics, Ether, Thin layer chromatography, Biochemistry, Soy oil emulsion, lcsh:Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Hydrolysis, Cholesteryl oleoyl ether, In vivo, hrs, hours, polycyclic compounds, lcsh:QD415-436, lcsh:QH301-705.5, J774 A2 macrophages, chemistry.chemical_classification, [3H]CEt-ARC, [3H] cholesteryl oleoyl ether-American Radiolabeled Chemicals, Chromatography, TLC, thin layer chromatography, 030102 biochemistry & molecular biology, CE, cholesteryl ester, [3H]CEt-PE, [3H] cholesteryl hexadecyl ether-PerkinElmer, TG, triglycerides, Thin-layer chromatography, In vitro, 3. Good health, 030104 developmental biology, Enzyme, chemistry, lcsh:Biology (General), Emulsion, lipids (amino acids, peptides, and proteins), triDHA emulsion, Cholesteryl ether, Research Article
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المؤلفون: Marion Gröger, Barbara Lengauer, Manfred Fobker, Heidemarie Rossiter, Christine Hartmann, Caterina Barresi, Johannes Pammer, Ulrich Koenig, Guenter P. Resch, Marlene Brandstetter, Gabriele Plenz
المصدر: Autophagy
مصطلحات موضوعية: RFU, relative fluorecent units, MG132, Harderian gland, SQSTM1/p62, Atg7, autophagy related 7, DMSO, dimethyl sulfoxide, Mice, MAP1LC3A/B (LC3), microtubule-associated protein 1 light chain 3 α/β, PCR, polymerase chain reaction, Lipid droplet, BCA, bicinchoninic acid assay, BODIPY, boron-dipyrromethene fluorescent dye, GFP, green fluorescent protein, PLIN2, perilipin 2, education.field_of_study, Atg12, autophagy related 12, SQSTM1, sequestosome 1/p62, ELISA, enzyme-linked immunosorbent assay, lipotoxicity, KLICK, keratosis lineariz with ichthyosis congenita and sclerosing keratoderma, Aggresome, medicine.anatomical_structure, LD, Lipid drops, lysosome, Proteasome Inhibitors, perilipin 2/adipophilin, multilamellar bodies, PARP, poly (ADP-ribose) polymerase, keratinocytes, FC, free cholesterol, autophagy, TBS-T, Tris buffered saline with Tween 20, MG312, synthetic peptide Z-Leu-Leu-Leu-al, Perilipin 2, Basic Science Research Papers, degenerative diseases, Biology, Sequestosome 1, aggresome, Lysosome, medicine, Animals, f, floxed, Secretion, education, Molecular Biology, Cell Nucleus, LSM, laser scanning microscope, TLC, thin layer chromatography, KRT14, Keratin 14, proteasome inhibitor, Endoplasmic reticulum, cholesterol, ER, edoplasmic reticulum, Epithelial Cells, Cell Biology, Molecular biology, UV, ultraviolet, Vacuoles, aggregates, biology.protein, HaGl, Harderian gland, ORO, oil red O, palmitate, BSA, bovine serum albumin, Lysosomes, Cre, Cre recombinase
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المؤلفون: Partha Krishnamurthy, Hemantkumar Chavan, Hong-Min Ni, Jibiao Li, John Y.L. Chiang, Yifeng Ding, Tiangang Li, Yifeng Wang, Wen-Xing Ding, David J. Matye
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 245-260 (2017)مصطلحات موضوعية: 0301 basic medicine, FC, free cholesterol, SREBP, sterol response element binding protein, medicine.medical_specialty, mTOR, the nutrient sensing mechanistic target of rapamycin, medicine.drug_class, Autolysosome, Sterol O-acyltransferase, CQ, chloroquine, LMP, lysosome membrane permeabilization, Biology, Cholesterol 7 alpha-hydroxylase, CE, cholesterol ester, PI, phosphatidylinositol, ACAT, acyl-CoA:cholesterol acyltransferase, ER, endoplasmic reticulum, 03 medical and health sciences, S6, tibosomal protein S6, GSK3β, glycogen synthase kinase 3β, Internal medicine, medicine, LC3, microtubule-associated protein 1A/1B-light chain 3, lcsh:RC799-869, HMGCR, HMG-CoA reductase, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, Cholestyramine, Original Research, Hepatology, Bile acid, Autophagy, Gastroenterology, DIO, diet-induced obesity, 4EBP-1, eukaryotic translation initiation factor 4E-binding protein 1, CYP7A1, cholesterol 7α-hydroxylase, LDLR, low-density lipoprotein receptor, mRNA, messenger RNA, Cell biology, Fatty Liver, 030104 developmental biology, Endocrinology, Cholesterol, HMG-CoA reductase, PM, plasma membrane, biology.protein, ChTM, cholestyramine, lipids (amino acids, peptides, and proteins), lcsh:Diseases of the digestive system. Gastroenterology, Nuclear Receptor
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المؤلفون: Lalit S. Doshi, Branislav Radovic, Dagmar Kratky, Prakash G. Chandak, Gerald Hoefler, Adelheid Kratzer, Elma Aflaki, Silvia Povoden, Sascha Obrowsky, Sanja Levak-Frank, Prakash Doddapattar, Helmut Ahammer
المصدر: Biochimica et Biophysica Acta
مصطلحات موضوعية: Apolipoprotein E, Apolipoprotein B, 030204 cardiovascular system & hematology, Intestinal absorption, chemistry.chemical_compound, Mice, 0302 clinical medicine, Cell Movement, FFA, free fatty acids, Cholesterol absorption, Cholesterol efflux, Intestinal Mucosa, Aorta, Cells, Cultured, ApoE, apolipoprotein E, 2. Zero hunger, Mice, Knockout, 0303 health sciences, biology, DGAT, acyl-CoA:diacylglycerol acyltransferase, Immunohistochemistry, Plaque, Atherosclerotic, TG, triacylglycerol, Acyl-CoA:diacylglycerol acyltransferase 1, Cholesterol, Intestinal cholesterol absorption, lipids (amino acids, peptides, and proteins), Female, medicine.symptom, FC, free cholesterol, medicine.medical_specialty, Inflammation, Article, Lesion, 03 medical and health sciences, Acyl-CoA, Apolipoproteins E, Internal medicine, medicine, Animals, Humans, Diacylglycerol O-Acyltransferase, Molecular Biology, Crosses, Genetic, Triglycerides, 030304 developmental biology, Macrophages, Cell Biology, Atherosclerosis, Lipid Metabolism, TC, total cholesterol, Apolipoprotein E knockout mice, Disease Models, Animal, Endocrinology, chemistry, WTD, western-type diet, Intestinal Absorption, FA, fatty acids, biology.protein, Acyl Coenzyme A