المؤلفون: C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, A. Schulze

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/11b1a821ae93404d9aff913722f3970e

المؤلفون: Ute F. Röhrig, Somi Reddy Majjigapu, Pierre Vogel, Aline Reynaud, Florence Pojer, Nahzli Dilek, Patrick Reichenbach, Kelly Ascenção, Melita Irving, George Coukos, Olivier Michielin, Vincent Zoete

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1773-1811 (2022)

مصطلحات موضوعية: Cancer immunotherapy, structure-based drug design, tryptophan metabolism, X-ray crystallography, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/cf28d46a56e84bc6b249d5272612f6f4

المؤلفون: Ute F. Röhrig, Olivier Michielin, Vincent Zoete

المصدر: Journal of medicinal chemistry, vol. 64, no. 24, pp. 17690-17705

مصطلحات موضوعية: Structure-Activity Relationship, Drug Discovery, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Molecular Medicine, Enzyme Inhibitors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130a935d84363adbfa69160f76414e97
https://doi.org/10.1021/acs.jmedchem.1c01665

المؤلفون: Johannes Linxweiler, Mathias T. Rosenfeldt, Martin Eckstein, Burkhard Kneitz, Sven Wach, Kerstin Junker, Markus Krebs, F. Röhrig, M. Puhr, Martin Eilers, T. Frank, Hubert Kübler, H. Marouf, Matthias Saar, Charis Kalogirou, Anna Katharina Seitz, Werner Schmitz, P. Schmucker, Martin Spahn, E. Hartmann, Gabriele Büchel, Marteinn Thor Snaebjornsson, Andreas Müller, Almut Schulze

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications

مصطلحات موضوعية: Male, Squalene monooxygenase, Antifungal drug, General Physics and Astronomy, Mice, SCID, urologic and male genital diseases, Cohort Studies, Mice, Prostate cancer, chemistry.chemical_compound, Transactivation, Neoplasm Metastasis, Cancer, Aged, 80 and over, Multidisciplinary, Middle Aged, Lipids, Gene Expression Regulation, Neoplastic, Prostatic Neoplasms, Castration-Resistant, Cholesterol, Receptors, Androgen, lipids (amino acids, peptides, and proteins), Transcriptional Activation, Cell death, Cell Survival, Science, Down-Regulation, Urological cancer, General Biochemistry, Genetics and Molecular Biology, Article, Downregulation and upregulation, Cell Line, Tumor, medicine, Animals, Humans, Enzalutamide, Metabolomics, Computer Simulation, Neoplasm Invasiveness, Terbinafine, Aged, Cell Proliferation, Neoplasm Staging, Base Sequence, business.industry, Prostatic Neoplasms, General Chemistry, Prostate-Specific Antigen, medicine.disease, Androgen receptor, Disease Models, Animal, MicroRNAs, Squalene Monooxygenase, chemistry, Drug Resistance, Neoplasm, Cancer research, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6faf70310bba7f4f1c068812b8cc48b
https://doaj.org/article/11b1a821ae93404d9aff913722f3970e

المؤلفون: Otavia L Caballero, Qi Zhao, Donata Rimoldi, Brian J Stevenson, Suzanne Svobodová, Sylvie Devalle, Ute F Röhrig, Anna Pagotto, Olivier Michielin, Daniel Speiser, Jedd D Wolchok, Cailian Liu, Tanja Pejovic, Kunle Odunsi, Francis Brasseur, Benoit J Van den Eynde, Lloyd J Old, Xin Lu, Jonathan Cebon, Robert L Strausberg, Andrew J Simpson

المصدر: PLoS ONE, Vol 5, Iss 9, Pp 3307-3314 (2010)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC2940856?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/37fef53b5d7742bab7456b57d26a4314

المؤلفون: Marta A. S. Perez, Michel A. Cuendet, Ute F. Röhrig, Olivier Michielin, Vincent Zoete

المصدر: Methods in Molecular Biology ISBN: 9781071618547

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::86d6539da59199bf64dda04f8e1cbf2f
https://doi.org/10.1007/978-1-0716-1855-4_13

المؤلفون: Somi Reddy Majjigapu, Ute F. Röhrig, Florence Pojer, Vincent Zoete, Aline Reynaud, Pierre Vogel

المصدر: Journal of Medicinal Chemistry. 62:8784-8795

مصطلحات موضوعية: Kynurenine pathway, Molecular Conformation, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, Oxidoreductase, Immunity, Oximes, Drug Discovery, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Density Functional Theory, 030304 developmental biology, chemistry.chemical_classification, Sulfonamides, 0303 health sciences, Quinones, Temperature, Triazoles, Tryptophan Metabolism, Recombinant Proteins, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Biochemistry, Molecular Medicine, Function (biology), Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b6903d1c9a5a9df7200b9467e8e918
https://doi.org/10.1021/acs.jmedchem.9b00942

المؤلفون: Antoine Daina, Vincent Zoete, Ute F. Röhrig

المصدر: Systems Medicine

مصطلحات موضوعية: Drug, medicine.medical_specialty, business.industry, media_common.quotation_subject, Computer-aided, Cancer therapy, medicine, Medical physics, business, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6ea03b2192b969c227a04b44adc26fa6
https://doi.org/10.1016/b978-0-12-801238-3.11670-8

المؤلفون: Ellen A. A. Nollen, Michael Platten, Ute F. Röhrig, Christiane A. Opitz, Francesca Fallarino

المصدر: Nature Reviews Drug Discovery

مصطلحات موضوعية: 0301 basic medicine, Kynurenine pathway, medicine.medical_treatment, Antineoplastic Agents, Disease, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cancer immunotherapy, Animals, Clinical Trials as Topic, Humans, Metabolic Networks and Pathways, Neoplasms, Neurodegenerative Diseases, Tryptophan, Drug Discovery, medicine, business.industry, Drug discovery, Neurodegeneration, Cancer, General Medicine, medicine.disease, 3. Good health, 030104 developmental biology, chemistry, Drug development, 030220 oncology & carcinogenesis, business, Kynurenine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0450baacbc937d0e254e705d2d4a1ab2
https://doi.org/10.1038/s41573-019-0016-5

المؤلفون: Qi Wang, Laura J Byrnes, Bo Shui, Ute F Röhrig, Avtar Singh, Dmitriy M Chudakov, Sergey Lukyanov, Warren R Zipfel, Michael I Kotlikoff, Holger Sondermann

المصدر: PLoS ONE, Vol 6, Iss 8, p e23513 (2011)

مصطلحات موضوعية: Medicine, Science

Relation: http://europepmc.org/articles/PMC3161743?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/eaf6abd054c74006af0981c4e88e0a13

الاتاحة: https://doi.org/10.1371/journal.pone.0023513
https://doaj.org/article/eaf6abd054c74006af0981c4e88e0a13

المؤلفون: Otavia L. Caballero, Qi Zhao, Donata Rimoldi, Brian J. Stevenson, Suzanne Svobodová, Sylvie Devalle, Ute F. Röhrig, Anna Pagotto, Olivier Michielin, Daniel Speiser, Jedd D. Wolchok, Cailian Liu, Tanja Pejovic, Kunle Odunsi, Francis Brasseur, Benoit J. Van den Eynde, Lloyd J. Old, Xin Lu, Jonathan Cebon, Robert L. Strausberg, Andrew J. Simpson

المصدر: PLoS ONE, Vol 5, Iss 11 (2010)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3007588; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/0f9beb27778e421b8151de1aca4d0eb8

المؤلفون: Marc-Etienne Moret, Enrico Tapavicza, Leonardo Guidoni, Ute F. Röhrig, Marialore Sulpizi, Ivano Tavernelli, Ursula Rothlisberger

المصدر: CHIMIA, Vol 59, Iss 7-8 (2005)

مصطلحات موضوعية: Car-parrinello first-principles molecular dynamics, Excited states, Photoactive proteins, Qm/mm simulations, Time-dependent density functional theory, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://chimia.ch/chimia/article/view/4021; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424

URL الوصول: https://doaj.org/article/bc3255bc23b04e818cb1528ab5a3194a

المؤلفون: George T. Duncan, Stephen F. Roehrig

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.niss.org/dgii/TR/roehrig-markov.pdf.

مصطلحات موضوعية: Statistical Disclosure Limitation, Confidentiality, Cell Suppression

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.100.393; http://www.niss.org/dgii/TR/roehrig-markov.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.100.393
http://www.niss.org/dgii/TR/roehrig-markov.pdf

المؤلفون: George T. Duncan, Stephen E. Fienberg, Ramayya Krishnan, Rema Padman, Stephen F. Roehrig

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.niss.org/dg/./TR/duncan-lanechapter.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.6.8595; http://www.niss.org/dg/./TR/duncan-lanechapter.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.6.8595
http://www.niss.org/dg/./TR/duncan-lanechapter.pdf

المؤلفون: Daniela Caldelari, Olivier Michielin, Somi Reddy Majjigapu, Nahzli Dilek, George Coukos, Pierre Vogel, Ute F. Röhrig, Kelly Ascencao, Patrick Reichenbach, Vincent Zoete, Melita Irving

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4330-4333

مصطلحات موضوعية: 0301 basic medicine, Molecular model, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, 03 medical and health sciences, Cancer immunotherapy, Catalytic Domain, Drug Discovery, medicine, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Molecular Biology, chemistry.chemical_classification, Organic Chemistry, Immune escape, Triazoles, Tryptophan Metabolism, Enzyme Activation, Molecular Weight, 030104 developmental biology, Enzyme, chemistry, Drug Design, Molecular Medicine, Molecular probe

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753aa427a0274a2f50a8cb98df0c4571
https://doi.org/10.1016/j.bmcl.2016.07.031

المؤلفون: Daan M. F. van Aalten, Vladimir S. Borodkin, Vincent Zoete, Ute F. Röhrig, Fabienne Lammers, Patrice Waridel, Winship Herr, Vaibhav Kapuria

المصدر: The Journal of biological chemistry, vol. 293, no. 46, pp. 17754-17768

مصطلحات موضوعية: 0301 basic medicine, Host cell factor C1, Glycosylation, 010304 chemical physics, medicine.diagnostic_test, Chemistry, Glycobiology, Proteolysis, Cell Biology, Cleavage (embryo), 01 natural sciences, Biochemistry, Cell biology, Serine, carbohydrates (lipids), 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0103 physical sciences, medicine, Threonine, Molecular Biology, Peptide sequence, Amino Acid Motifs, Amino Acid Sequence, Endopeptidases/genetics, Endopeptidases/metabolism, Host Cell Factor C1/genetics, Host Cell Factor C1/metabolism, Humans, Molecular Dynamics Simulation, Multifunctional Enzymes/genetics, Multifunctional Enzymes/metabolism, Mutation, N-Acetylglucosaminyltransferases/genetics, N-Acetylglucosaminyltransferases/metabolism, Stereoisomerism, Substrate Specificity, Uridine Diphosphate N-Acetylglucosamine/analogs & derivatives, Uridine Diphosphate N-Acetylglucosamine/metabolism, O-GlcNAcylation, O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT), enzyme mechanism, glycobiology, host-cell factor-1, post-translational modification (PTM)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ed876b3531baab7bad629e97b6180b
https://serval.unil.ch/resource/serval:BIB_2C5B11AB86FD.P001/REF.pdf

المؤلفون: Vaibhav, Kapuria, Ute F, Röhrig, Patrice, Waridel, Fabienne, Lammers, Vladimir S, Borodkin, Daan M F, van Aalten, Vincent, Zoete, Winship, Herr

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Glycosylation, Uridine Diphosphate N-Acetylglucosamine, post-translational modification (PTM), host-cell factor-1, Amino Acid Motifs, Glycobiology and Extracellular Matrices, Stereoisomerism, Molecular Dynamics Simulation, N-Acetylglucosaminyltransferases, O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT), Multifunctional Enzymes, Substrate Specificity, carbohydrates (lipids), O-GlcNAcylation, glycobiology, Endopeptidases, Mutation, Proteolysis, Humans, enzyme mechanism, Amino Acid Sequence, Host Cell Factor C1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f2e8bdc17e96103033e3b35a198aae7f
https://pubmed.ncbi.nlm.nih.gov/30224358

المؤلفون: Olivier Michielin, Ute F. Röhrig, Vincent Zoete

المصدر: Biochemistry. 56(33)

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Plasma protein binding, Heme, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Molecular mechanics, Molecular Docking Simulation, Cofactor, 03 medical and health sciences, chemistry.chemical_compound, Oximes, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Indoleamine 2,3-dioxygenase, Sulfonamides, biology, 010405 organic chemistry, 0104 chemical sciences, 030104 developmental biology, chemistry, Docking (molecular), biology.protein, Pharmacophore, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54962d6d9dc0de5b6632b48b81a603f0
https://pubmed.ncbi.nlm.nih.gov/28731684

المؤلفون: F. Röhrig, Hubert Kübler, B. Kneitz, A. Rosenwald, E. Hartmann, Markus Krebs, Mathias T. Rosenfeldt, Charis Kalogirou, W. Schmitz, Almut Schulze

المصدر: European Urology Supplements. 18:e1340

مصطلحات موضوعية: Prostate cancer, business.industry, Urology, medicine, Druggability, Cancer research, Regulator, medicine.disease, business, Cholesterol biosynthesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c468abd06cec5b0387a703c15cc0d9a6
https://doi.org/10.1016/s1569-9056(19)30968-6

المؤلفون: Pablo Campomanes, Ute F. Röhrig, Ivano Tavernelli, Bruno A. C. Horta, Ursula Rothlisberger, Stefano Vanni, Marilisa Neri

المصدر: Journal of the American Chemical Society. 136:3842-3851

مصطلحات موضوعية: Models, Molecular, Rhodopsin, biology, Chemistry, Hydrogen bond, Static Electricity, Hydrogen Bonding, General Chemistry, Chromophore, Photochemical Processes, Biochemistry, Catalysis, Optical spectra, Dipole, Crystallography, Colloid and Surface Chemistry, Spectrophotometry, biology.protein, ZINDO, Amino Acid Sequence, Absorption (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb6edacfcb8aa94c3f21353ae38a222
https://doi.org/10.1021/ja411303v