المؤلفون: Margarita Stampelou, Graham Ladds, Antonios Kolocouris

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Immunology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, rank candidate drugs, produce accurate results, mean unsigned error, inactive human adenosine, extracellular loop 2, 56 kcal mol, relative residence times, multistate alphafold 2, longer residence times, thermodynamic binding calculations, improved drug molecules, blocked ligand ’, af )- derived, 3 , 2 , three homology models, thermodynamic data (<, kinetic binding data, thermodynamic integration coupled, stronger binding affinities, ramd method showed, md calculations produced

Relation: https://figshare.com/articles/journal_contribution/Computational_Workflow_for_Refining_AlphaFold_Models_in_Drug_Design_Using_Kinetic_and_Thermodynamic_Binding_Calculations_A_Case_Study_for_the_Unresolved_Inactive_Human_Adenosine_A_sub_3_sub_Receptor/25021296

الاتاحة: https://doi.org/10.1021/acs.jpcb.3c05986.s001
https://figshare.com/articles/journal_contribution/Computational_Workflow_for_Refining_AlphaFold_Models_in_Drug_Design_Using_Kinetic_and_Thermodynamic_Binding_Calculations_A_Case_Study_for_the_Unresolved_Inactive_Human_Adenosine_A_sub_3_sub_Receptor/25021296

المؤلفون: Gaete, Pablo S, Contreras, Jorge E

مصطلحات موضوعية: Medical Physiology, Biomedical and Clinical Sciences, Connexins, Cryoelectron Microscopy, atp release, carbenoxolone, extracellular loop, heptemeric channel, human, ion selectivity, molecular biophysics, neuroscience, pannexin, structural biology, xenopus, Biochemistry and Cell Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5738653z
https://escholarship.org/content/qt5738653z/qt5738653z.pdf

المؤلفون: Haruki Yamane, Takashi Ishida

المصدر: Frontiers in Bioinformatics, Vol 3 (2023)

مصطلحات موضوعية: compound-protein interaction, class A GPCR, deep learning, ligand binding site, transmembrane region, extracellular loop, Computer applications to medicine. Medical informatics, R858-859.7

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbinf.2023.1193025/full; https://doaj.org/toc/2673-7647

URL الوصول: https://doaj.org/article/0945d9aa9021456f9bbd26e1a5099f94

المؤلفون: Simões, André Faria Pita

مصطلحات موضوعية: canal-túnel TolC, Gram-negativas, sistemas de efluxo, regiões de loops extracelulares, TolC channel-tunnel, Gram-negatives, efflux system, extracellular loop regions

الاتاحة: https://hdl.handle.net/10316/97928

المؤلفون: Marcel M. Wygas, Jeannette M. Laugwitz, Peter Schmidt, Matthias Elgeti, Anette Kaiser

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 15; Pages: 12197

مصطلحات موضوعية: peptide G-protein-coupled receptor (GPCR), extracellular loop, conserved disulfide, electron paramagnetic resonance (EPR), functional selectivity, arrestin

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Biology; https://dx.doi.org/10.3390/ijms241512197

الاتاحة: https://doi.org/10.3390/ijms241512197

المؤلفون: Alessandro Nicoli (10379229), Andreas Dunkel (1466371), Toni Giorgino (4332820), Chris de Graaf (8219667), Antonella Di Pizio (120535)

مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, seven main groups, second extracellular loop, highly conserved cysteine, extracellular loop 2, backbone volume overlaps, conformational differences within, high sequence variability, gpcr structural domains, experimental ecl2 structures, structural information, highlighting differences, gpcr subfamilies, analyzed structures, work provides, intramolecular interactions, intramolecular contacts, helices 4, gpcrmd website, g protein, coupled receptors, conformation levels

Relation: https://figshare.com/articles/journal_contribution/Classification_Model_for_the_Second_Extracellular_Loop_of_Class_A_GPCRs/19117113

الاتاحة: https://doi.org/10.1021/acs.jcim.1c01056.s001

المؤلفون: Kristina N. Delgado, Jairo M. Montezuma-Rusca, Isabel C. Orbe, Melissa J. Caimano, Carson J. La Vake, Amit Luthra, Christopher M. Hennelly, Fredrick N. Nindo, Jacob W. Meyer, Letitia D. Jones, Jonathan B. Parr, Juan C. Salazar, M. Anthony Moody, Justin D. Radolf, Kelly L. Hawley

المصدر: mBio, Vol 13, Iss 4 (2022)

مصطلحات موضوعية: Treponema pallidum, syphilis, outer membrane protein, extracellular loop, FadL, B cells, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2150-7511

URL الوصول: https://doaj.org/article/a5028a454e21422fb729d7c1f9cd8a9f

المؤلفون: Daniel Ivanusic, Kazimierz Madela, Heidi Burghard, Gudrun Holland, Michael Laue, Norbert Bannert

المصدر: BioTechniques, Vol 70, Iss 1, Pp 21-28 (2021)

مصطلحات موضوعية: 2F5, antibodies, CD20, display system, large extracellular loop, LEL, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

URL الوصول: https://doaj.org/article/2131ad4919a7427aa599963ca23cd72e

المؤلفون: van der Velden, W.J.C., Lindquist, P., Madsen, J.S., Stassen, R.H.M.J., Albrechtsen, N.J.W., Hoist, J.J., Hauser, A.S., Rosenkilde, M.M.

المصدر: van der Velden , W J C , Lindquist , P , Madsen , J S , Stassen , R H M J , Albrechtsen , N J W , Hoist , J J , Hauser , A S & Rosenkilde , M M 2022 , ' Molecular and in vivo phenotyping of missense variants of the human glucagon receptor ' , Journal of Biological Chemistry , vol. 298 , no. 2 , 101413 . https://doi.org/10.1016/j.jbc.2021.101413

مصطلحات موضوعية: GLY40SER POLYMORPHISM, EXTRACELLULAR LOOP, INSULIN-SECRETION, CRYSTAL-STRUCTURE, CELL HYPERPLASIA, GENE GLY40SER, WEIGHT-LOSS, MUTATION, GLUCOSE, BINDING

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/a039cc79-31e2-45a9-ab39-f5bd5d473345
https://doi.org/10.1016/j.jbc.2021.101413

المؤلفون: Gad, Abanoub A, Azimzadeh, Pedram, Balenga, Nariman

المصدر: 11 ; 1 ; 14060 ; United States ; England

مصطلحات موضوعية: ADGRG2, conserved residues, Stachel sequence, extracellular loop 2 (ECL2), Receptors, G-Protein-Coupled

Relation: Scientific Reports; http://hdl.handle.net/10713/16160

الاتاحة: http://hdl.handle.net/10713/16160
https://doi.org/10.1038/s41598-021-93577-y

المؤلفون: Mengrong Li (11361642), Miaomiao Li (483829), Jingjing Guo (393650)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, transmembrane domain 6, induces conformational changes, extracellular loop 1, e258 – e260, common second messenger, extensive molecular dynamics, underlying allosteric mechanism, 2 +, allosteric regulation mechanism, pth1r allosteric pathway, allosteric regulation, molecular mechanism, allosteric regulator, molecular details, tmd allosterically, still missing, results support, results indicate, results demonstrate

Relation: https://figshare.com/articles/journal_contribution/Molecular_Mechanism_of_Ca_sup_2_sup_in_the_Allosteric_Regulation_of_Human_Parathyroid_Hormone_Receptor_1/16548126

الاتاحة: https://doi.org/10.1021/acs.jcim.1c00471.s001

المؤلفون: Yue Chen (73753), Oliver Fleetwood (8415849), Sergio Pérez-Conesa (4577794), Lucie Delemotte (525893)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Cancer, Science Policy, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, specific subtle differences, results provide insights, involving mainly tm1, dynamic network analysis, conformational changes induced, based drug discovery, intracellular loop 2, biased partial agonist, extracellular loop 2, specific active states, intracellular binding partners, intracellular binding partner, fully active state, transmembrane helix 6, gpcr activation mechanism, intracellular end, fully active, active state, full agonist

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Effect_of_Nanobody_Binding_on_Ligand-Specific_Active_States_of_the_2_Adrenergic_Receptor/17014751

الاتاحة: https://doi.org/10.1021/acs.jcim.1c00826.s001

المؤلفون: Jon Kapla (1296636), Ismael Rodriguez Espigares (10798603), Flavio Ballante (1312488), Jana Selent (147923), Jens Carlsson (584038)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, screening performance, extracellular loop region, crystal structure conformation, D 3 R, transmembrane helix region, GPCR structure prediction, D 3 dopamine receptor, G protein-coupled receptor, MD simulations, accuracy, MD refinement, ligand binding mode, D 3 R crystal structure, model

Relation: https://figshare.com/articles/journal_contribution/Supporting_information_for_MD_simulations_and_molecular_docking_calculations_/14593057

الاتاحة: https://doi.org/10.1371/journal.pcbi.1008936.s001

المؤلفون: Ying Li (38224), Han Gong (4764102), Rui Zhan (572279), Shushan Ouyang (10654993), Kyung-Tae Park (10654996), Joe Lutkenhaus (606941), Shishen Du (606940)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, FtsW E 289G, septal peptidoglycan synthase FtsWI, 269I, other, class B penicillin binding proteins, mutation, RodA-PBP 2 structure, activation mechanism, FtsQLB, PG, substitution, interaction, pedestal domain, extracellular loop 4, ECL, Escherichia coli FtsN switches FtsA, transpeptidases PBP 2, SEDS-bPBP complexes SEDS family pep., FtsN-triggered activation signal, FtsI K 211I, analysis

Relation: https://figshare.com/articles/journal_contribution/Plasmids_used_in_this_study_/14427877

الاتاحة: https://doi.org/10.1371/journal.pgen.1009366.s003

المؤلفون: Ying Li (38224), Han Gong (4764102), Rui Zhan (572279), Shushan Ouyang (10654993), Kyung-Tae Park (10654996), Joe Lutkenhaus (606941), Shishen Du (606940)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, FtsW E 289G, septal peptidoglycan synthase FtsWI, 269I, other, class B penicillin binding proteins, mutation, RodA-PBP 2 structure, activation mechanism, FtsQLB, PG, substitution, interaction, pedestal domain, extracellular loop 4, ECL, Escherichia coli FtsN switches FtsA, transpeptidases PBP 2, SEDS-bPBP complexes SEDS family pep., FtsN-triggered activation signal, FtsI K 211I, analysis

Relation: https://figshare.com/articles/journal_contribution/Bacterial_strains_used_in_this_study_/14427874

الاتاحة: https://doi.org/10.1371/journal.pgen.1009366.s002

المؤلفون: Ying Li (38224), Han Gong (4764102), Rui Zhan (572279), Shushan Ouyang (10654993), Kyung-Tae Park (10654996), Joe Lutkenhaus (606941), Shishen Du (606940)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, FtsW E 289G, septal peptidoglycan synthase FtsWI, 269I, other, class B penicillin binding proteins, mutation, RodA-PBP 2 structure, activation mechanism, FtsQLB, PG, substitution, interaction, pedestal domain, extracellular loop 4, ECL, Escherichia coli FtsN switches FtsA, transpeptidases PBP 2, SEDS-bPBP complexes SEDS family pep., FtsN-triggered activation signal, FtsI K 211I, analysis

Relation: https://figshare.com/articles/journal_contribution/Construction_of_strains_and_plasmids_/14427871

الاتاحة: https://doi.org/10.1371/journal.pgen.1009366.s001

المؤلفون: Aida Shahraki (10018147), Ali Işbilir (9746762), Berna Dogan (5762903), Martin J. Lohse (250713), Serdar Durdagi (626227), Necla Birgul-Iyison (10018150)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Biotechnology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Next-Generation Pest Control Agents., pest control agents, allatostatin receptor type C, β- arrestin recruitment, dynamics simulation studies, importance, Q 271 6.55, extracellular loop 2, G protein-dependent activation, Thaumetopoea pityocampa, G protein-coupled receptor, AST-C, AstR-C, resonance energy transfer-based methods

Relation: https://figshare.com/articles/journal_contribution/Structural_and_Functional_Characterization_of_Allatostatin_Receptor_Type_C_of_Thaumetopoea_pityocampa_a_Potential_Target_for_Next-Generation_Pest_Control_Agents/13623946

الاتاحة: https://doi.org/10.1021/acs.jcim.0c00985.s001

المؤلفون: Daniela Rodrigues-Amorim, Marta Iglesias-Martínez-Almeida, Tania Rivera-Baltanás, Patricia Fernández-Palleiro, Luis Freiría-Martínez, Cynthia Rodríguez-Jamardo, María Comís-Tuche, María del Carmen Vallejo-Curto, María Álvarez-Ariza, Marta López-García, Elena de las Heras, Alejandro García-Caballero, Jose Manuel Olivares, Carlos Spuch

المصدر: International Journal of Molecular Sciences, Vol 22, Iss 8499, p 8499 (2021)

مصطلحات موضوعية: schizophrenia, neurotrophin-3, second extracellular loop of NET, tropomyosin receptor kinase C, T cells, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/22/16/8499; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/e72e1af18076496db9d9e91084c3c1c6

الاتاحة: https://doi.org/10.3390/ijms22168499
https://doaj.org/article/e72e1af18076496db9d9e91084c3c1c6

المؤلفون: Pablo S Gaete, Jorge E Contreras

المصدر: eLife, Vol 9 (2020)

مصطلحات موضوعية: pannexin, heptemeric channel, atp release, extracellular loop, ion selectivity, carbenoxolone, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/56114; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/5e738984a93348b4bbb0f1433bbed370

المؤلفون: Kevin Michalski, Johanna L Syrjanen, Erik Henze, Julia Kumpf, Hiro Furukawa, Toshimitsu Kawate

المصدر: eLife, Vol 9 (2020)

مصطلحات موضوعية: pannexin, heptameric channel, ATP release, extracellular loop, ion selectivity, carbenoxolone, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/54670; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/b24aaca1c58e4fbd8868508790a0ca72