المؤلفون: Britta Nubbemeyer (11966262), Ajay Abisheck Paul George (5805008), Toni Kühl (1923214), Anna Pepanian (11966265), Maximilian Steve Beck (11966268), Rahma Maghraby (11966271), Maryam Shetab Boushehri (11966274), Maximilian Muehlhaupt (11966277), Eva Marie Pfeil (9378913), Suvi Katariina Annala (11966280), Hermann Ammer (290430), Diana Imhof (1697893), Dehua Pei (357696)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Inorganic Chemistry, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, peptide library screening, penetrating peptide rendered, nucleotide exchange modulator, novel chemical probe, dynamic simulations revealed, selective peptidyl gαi, developing direct gαi, investigating g protein, mediated cell signaling, investigating cell signaling, targeting gαi, peptides cell, study demonstrates, specifically modulate, molecular docking, molecular basis, gdp binding, g proteins, biologically active

Relation: https://figshare.com/articles/journal_contribution/Targeting_G_i_s_Proteins_with_Peptidyl_Nucleotide_Exchange_Modulators/18665808

الاتاحة: https://doi.org/10.1021/acschembio.1c00929.s001

المؤلفون: Britta Nubbemeyer, Ajay Abisheck Paul George, Toni Kühl, Anna Pepanian, Maximilian Steve Beck, Rahma Maghraby, Maryam Shetab Boushehri, Maximilian Muehlhaupt, Eva Marie Pfeil, Suvi Katariina Annala, Hermann Ammer, Diana Imhof, Dehua Pei

المصدر: ACS Chemical Biology. 17:463-473

مصطلحات موضوعية: Molecular Docking Simulation, Nucleotides, Molecular Medicine, General Medicine, Peptides, Heterotrimeric GTP-Binding Proteins, Biochemistry, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a955ac768369ef3b2d6a0ea1f1609b
https://doi.org/10.1021/acschembio.1c00929

المؤلفون: Matthias Irmen, Janine Holze, Michael Kauk, Marcel Bermudez, Marco De Amici, Clelia Dallanoce, Klaus Mohr, Theresa Bödefeld, Gabriele M. König, Andreas Bock, Eva Marie Pfeil, Carsten Hoffmann, Gerhard Wolber, Carlo Matera, Ulrike Holzgrabe, Evi Kostenis, Ramona Schrage, Christian Tränkle

المصدر: ACS Pharmacol Transl Sci

مصطلحات موضوعية: Pharmacology, Coupling (electronics), Chemistry, Allosteric regulation, Biophysics, Extracellular, Pharmacology (medical), Muscarinic acetylcholine receptor M1, Receptor, Intracellular, G Protein-Coupled Receptor Signaling, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b5f203c7b3b178ef34fa4414d35cba
https://doi.org/10.1021/acsptsci.0c00069

المؤلفون: Evi, Kostenis, Eva Marie, Pfeil, Suvi, Annala

المصدر: The Journal of biological chemistry. 295(16)

مصطلحات موضوعية: Oncogene Proteins, Depsipeptides, JBC Reviews, Drug Discovery, Animals, GTP-Binding Protein alpha Subunits, Gq-G11, Humans, Antineoplastic Agents, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::534a7570a1afbd6f4b6042ddb564ded3
https://pubmed.ncbi.nlm.nih.gov/32122969

المؤلفون: Michael Gütschow, Eva Marie Pfeil, Katharina Simon, Manuel Grundmann, Oscar M Bautista-Aguilera, C. David Weaver, Felix Häberlein, Katrin M Krebs, Evi Kostenis, Bernd K. Fleischmann

المصدر: ACS Omega
ACS Omega, Vol 3, Iss 11, Pp 14814-14823 (2018)

مصطلحات موضوعية: 0301 basic medicine, Chemistry, Inward-rectifier potassium ion channel, G protein, Activator (genetics), urogenital system, General Chemical Engineering, General Chemistry, Article, lcsh:Chemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, lcsh:QD1-999, Biophysics, Channel blocker, G protein-coupled inwardly-rectifying potassium channel, Cytoskeleton, 030217 neurology & neurosurgery, Intracellular, Actin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dae0fb6ee7eee303c5fb0eda41c323a
http://europepmc.org/articles/PMC6289404

المؤلفون: Junken Aoki, Evi Kostenis, Daniela Wenzel, Nicole Merten, Nina Heycke, Maddalena Vescovo, Bernd K. Fleischmann, Ina Maria Albrecht, Katharina Simon, Alexander Pfeifer, Michaela Matthey, Gabriele M. König, Stephanie Hennen, Francois Marie Ngako Kadji, Felix Häberlein, Bernhard Nieswandt, Timo Vögtle, Kouki Kawakami, Julian Brands, Suzune Hiratsuka, Jaspal Garg, Asuka Inoue, Eva Marie Pfeil, Akos Heinemann, Marie Lise Jobin, Yuki Ono, Kerstin Seier, Davide Calebiro, Ulrike Rick

مصطلحات موضوعية: Ca, 2+, signaling, FR900359, Gi, GPCR, GPR17, Gq, heterotrimeric G protein, phospholipase Cβ, PTX, real-time BRET-based IP, 3, biosensor, Calcium, Calcium Signaling, Cytosol, GTP-Binding Protein alpha Subunits, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, HEK293 Cells, Heterotrimeric GTP-Binding Proteins, Humans, Phospholipase C beta, Protein Binding, Receptors, G-Protein-Coupled, Signal Transduction, G protein, Phospholipase, 03 medical and health sciences, G-Protein-Coupled, 0302 clinical medicine, Heterotrimeric G protein, Receptors, Receptor, Molecular Biology, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, biology, Active site, Cell Biology, Cell biology, Gq alpha subunit, biology.protein, Heterotrimeric G Protein Subunit, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67b365bfcd1d76a4cd31c504e9faee2
http://hdl.handle.net/11390/1205646

المؤلفون: Xiaodong Feng, Stefania Monteleone, Felix Häberlein, Julian Patt, José Vázquez-Prado, Ramona Schrage, Funda Eryilmaz, Gabriele M. König, Moritz Bünemann, Asuka Inoue, Evelyna Gaffal, Sandra Engel, Tanja Slodczyk, Naveen Shridhar, Peter Kolb, J. Silvio Gutkind, Nina Heycke, Ulrike Rick, Evi Kostenis, Ju Hee Yang, Suvi Annala, Eva Marie Pfeil, Stefan Kehraus, Raphael Reher, Rodolfo Daniel Cervantes-Villagrana, Alexander Pfeifer, Thomas Tüting

المصدر: Science Signaling. 12

مصطلحات موضوعية: 0303 health sciences, GTP', biology, G protein, Chemistry, Effector, Cell Biology, Guanosine triphosphate, Biochemistry, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Gq alpha subunit, 030220 oncology & carcinogenesis, Heterotrimeric G protein, Cancer cell, biology.protein, Molecular Biology, GNAQ, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5181b7d3d2f3064a199ecc3e58308bec
https://doi.org/10.1126/scisignal.aau5948

المؤلفون: Evi Kostenis, Nicole Merten, Max Crüsemann, Julian Patt, Nina Heycke, Uli Rick, Eva Marie Pfeil, Gabriele M. König, Funda Eryilmaz, Stefan Kehraus, Jan H. Voss, Xavier Deupi, Christa E. Müller, Asuka Inoue, Judith Alenfelder

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, loss-of-function mutagenesis, Biochemistry, G protein inhibitor, Adenylyl cyclase, chemistry.chemical_compound, FR900359, label-free biosensor, Arg60, arginine 60, SRE, serum response element, Depsipeptides, Heterotrimeric G protein, HBSS, Hanks' buffered salt solution, RTK, receptor tyrosine kinases, AC, adenylyl cyclase, HTRF, homogeneous time resolved fluorescence, biology, G proteins, guanine nucleotide-binding proteins, DMR, dynamic mass redistribution, Heterotrimeric GTP-Binding Proteins, GTP-Binding Protein alpha Subunits, Cell biology, Gq alpha subunit, PTX, pertussis toxin, FR, FR900359, Signal transduction, Signal Transduction, Research Article, heterotrimeric G protein, CCh, carbachol, G protein, UBO-QIC, YM-254890, YM, YM-254890, Peptides, Cyclic, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, PLC, phospholipase C, PDB, Protein Data Bank, Humans, Gαq, dynamic mass redistribution (DMR), Molecular Biology, G protein-coupled receptor, IP1, inositol monophosphate, 030102 biochemistry & molecular biology, Phospholipase C, HEK 293 cells, Cell Biology, HEK293 Cells, 030104 developmental biology, chemistry, biology.protein, GTP-Binding Protein alpha Subunits, Gq-G11, GPCR, G protein–coupled receptor, FCS, fetal calf serum, HA, hemagglutinin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad14382365f90e4057dbc24db130542
https://doi.org/10.1016/j.jbc.2021.100472