المؤلفون: Glogen Clinical Research Pvt. Ltd

المصدر: An Open-Label, Balanced, Randomized, Single Dose, Two-Treatment, Two-Sequence, Two-Period ,Two-Way Crossover Oral Bioavailability Study of CreNeuroSTM CNS Fish Oil Plus Softgels [Eicosapentaenoic Acid (as Ethyl Ester) 342 mg; L-5-methyltetrahydrofolate 1.875 mg; Other Vitamins and Minerals] (Test Product) Compared With Co-administration of Icosapent Ethyl 1000 mg Capsules (Reference Product-1) and L-methylfolate Calcium 7.5 mg Capsules (Reference Product-2) in Healthy Human Adult Subjects Under Fasting Conditions
Rusca A, Di Stefano AF, Doig MV, Scarsi C, Perucca E. Relative bioavailability and pharmacokinetics of two oral formulations of docosahexaenoic acid/eicosapentaenoic acid after multiple-dose administration in healthy volunteers. Eur J Clin Pharmacol. 2009 May;65(5):503-10. doi: 10.1007/s00228-008-0605-4. Epub 2009 Jan 16.

المؤلفون: InCor Heart Institute

المساهمون: Inar Castro Erger, Professor

المصدر: Effect of Icosapent-ethyl Ester (IPE) to Reduce the Residual Risk in Patients Undergoing Secondary Prevention for Cardiovascular Disease.
Cartolano FC, Dias GD, Miyamoto S, Damasceno NRT. Omega-3 Fatty Acids Improve Functionality of High-Density Lipoprotein in Individuals With High Cardiovascular Risk: A Randomized, Parallel, Controlled and Double-Blind Clinical Trial. Front Nutr. 2022 Feb 23;8:767535. doi: 10.3389/fnut.2021.767535. eCollection 2021.
Atar D, Jukema JW, Molemans B, Taub PR, Goto S, Mach F, CerezoOlmos C, Underberg J, Keech A, Tokgozoglu L, Bonaca MP. New cardiovascular prevention guidelines: How to optimally manage dyslipidaemia and cardiovascular risk in 2021 in patients needing secondary prevention? Atherosclerosis. 2021 Feb;319:51-61. doi: 10.1016/j.atherosclerosis.2020.12.013. Epub 2021 Jan 18.
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT Jr, Juliano RA, Jiao L, Granowitz C, Tardif JC, Ballantyne CM; REDUCE-IT Investigators. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med. 2019 Jan 3;380(1):11-22. doi: 10.1056/NEJMoa1812792. Epub 2018 Nov 10.

المؤلفون: National Cancer Institute (NCI), Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard School of Public Health (HSPH), University of Bradford

المساهمون: Mark A Hull, PhD FRCP, Professor of Gastroenterology

المصدر: Biospecimen Collection for:Prebiotic Effect of Eicosapentaenoic Acid Treatment for Colorectal Cancer Liver Metastases

المصدر: Targeting Vascular INflammation in Patients with Community-Acquired Pneumonia (TIN_CAP): a Multi-centre, Prospective, Randomized Control Trial

المؤلفون: University of Wisconsin, Madison

المصدر: Impact of Icosapent Ethyl on Alzheimers Disease Biomarkers in Preclinical Adults

المصدر: Phase Ib/II Study of EPA-Based EphA2 Targeted Therapy for Patients With Metastatic Triple-Negative Inflammatory Breast Cancer

Other URLs: https://grants.nih.gov/policy/sharing.htm

المؤلفون: Sumitomo Pharma (Suzhou) Co., Ltd.

المصدر: A Multi-center, Randomized, Double-blind, Parallel-group, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ethyl Icosapentate in Patients With Severe Hypertriglyceridemia

المساهمون: Matthijs Boekholdt, Dr.

المصدر: IcoSApent ethyL to Slow Down Aortic VAlve Stenosis proGrEssion

المؤلفون: Christiane Schön, Antje Micka, Vishnupriya Gourineni, Roberta Bosi

المصدر: Food & Nutrition Research, Vol 68, Pp 1-9 (2024)

مصطلحات موضوعية: omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, bioavailability, pharmacokinetic, lysine, ethyl ester, triglyceride, Nutrition. Foods and food supply, TX341-641

وصف الملف: electronic resource

Relation: https://foodandnutritionresearch.net/index.php/fnr/article/view/11028/18564; https://doaj.org/toc/1654-661X

URL الوصول: https://doaj.org/article/c8a7c160ff894e31929e071e4abdd37d

المساهمون: Dinesh Kalra, MD, Professor, MD

المصدر: Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP)

المؤلفون: National Institutes of Health (NIH)

المساهمون: Mingyang Song, Principal Investigator

المصدر: PREPARE: PRevention Using EPA Against coloREctal Cancer

المؤلفون: HLS Therapeutics, Inc, Unity Health Toronto, Western University, Canada

المصدر: The Icosapent Ethyl and Prevention of Vascular Regenerative Cell Exhaustion Study
Mechanick JI, Farkouh ME, Newman JD, Garvey WT. Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Feb 11;75(5):525-538. doi: 10.1016/j.jacc.2019.11.044.
Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003 Jun;9(6):653-60. doi: 10.1038/nm0603-653.
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, Doyle RT Jr, Juliano RA, Jiao L, Granowitz C, Tardif JC, Ballantyne CM; REDUCE-IT Investigators. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med. 2019 Jan 3;380(1):11-22. doi: 10.1056/NEJMoa1812792. Epub 2018 Nov 10.
Isner JM, Asahara T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J Clin Invest. 1999 May;103(9):1231-6. doi: 10.1172/JCI6889. No abstract available.
Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L, Moore MA, Rafii S. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood. 2000 Feb 1;95(3):952-8.
Takamura M, Kurokawa K, Ootsuji H, Inoue O, Okada H, Nomura A, Kaneko S, Usui S. Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization. J Am Heart Assoc. 2017 Feb 21;6(2):e004560. doi: 10.1161/JAHA.116.004560.
Devaraj S, Chien A, Rao B, Chen X, Jialal I. Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. Atherosclerosis. 2013 May;228(1):94-7. doi: 10.1016/j.atherosclerosis.2013.02.036. Epub 2013 Mar 13.
Morishita T, Uzui H, Ikeda H, Amaya N, Kaseno K, Ishida K, Fukuoka Y, Lee JD, Tada H. Association of CD34/CD133/VEGFR2-Positive Cell Numbers with Eicosapentaenoic Acid and Postprandial Hyperglycemia in Patients with Coronary Artery Disease. Int J Cardiol. 2016 Oct 15;221:1039-42. doi: 10.1016/j.ijcard.2016.07.079. Epub 2016 Jul 5.
Capoccia BJ, Robson DL, Levac KD, Maxwell DJ, Hohm SA, Neelamkavil MJ, Bell GI, Xenocostas A, Link DC, Piwnica-Worms D, Nolta JA, Hess DA. Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood. 2009 May 21;113(21):5340-51. doi: 10.1182/blood-2008-04-154567. Epub 2009 Mar 26.
Putman DM, Liu KY, Broughton HC, Bell GI, Hess DA. Umbilical cord blood-derived aldehyde dehydrogenase-expressing progenitor cells promote recovery from acute ischemic injury. Stem Cells. 2012 Oct;30(10):2248-60. doi: 10.1002/stem.1206.
Terenzi DC, Al-Omran M, Quan A, Teoh H, Verma S, Hess DA. Circulating Pro-Vascular Progenitor Cell Depletion During Type 2 Diabetes: Translational Insights Into the Prevention of Ischemic Complications in Diabetes. JACC Basic Transl Sci. 2018 Nov 5;4(1):98-112. doi: 10.1016/j.jacbts.2018.10.005. eCollection 2019 Feb.
Hess DA, Terenzi DC, Trac JZ, Quan A, Mason T, Al-Omran M, Bhatt DL, Dhingra N, Rotstein OD, Leiter LA, Zinman B, Sabongui S, Yan AT, Teoh H, Mazer CD, Connelly KA, Verma S. SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus. Cell Metab. 2019 Oct 1;30(4):609-613. doi: 10.1016/j.cmet.2019.08.015. Epub 2019 Aug 30.
Balber AE. Concise review: aldehyde dehydrogenase bright stem and progenitor cell populations from normal tissues: characteristics, activities, and emerging uses in regenerative medicine. Stem Cells. 2011 Apr;29(4):570-5. doi: 10.1002/stem.613.
Gentry T, Foster S, Winstead L, Deibert E, Fiordalisi M, Balber A. Simultaneous isolation of human BM hematopoietic, endothelial and mesenchymal progenitor cells by flow sorting based on aldehyde dehydrogenase activity: implications for cell therapy. Cytotherapy. 2007;9(3):259-74. doi: 10.1080/14653240701218516.
Shoulars K, Noldner P, Troy JD, Cheatham L, Parrish A, Page K, Gentry T, Balber AE, Kurtzberg J. Development and validation of a rapid, aldehyde dehydrogenase bright-based cord blood potency assay. Blood. 2016 May 12;127(19):2346-54. doi: 10.1182/blood-2015-08-666990. Epub 2016 Mar 11.
Bakbak E, Krishnaraj A, Bhatt DL, Quan A, Park B, Bakbak AI, Bari B, Terenzi KA, Pan Y, Fry EJ, Terenzi DC, Puar P, Khan TS, Rotstein OD, Mazer CD, Leiter LA, Teoh H, Hess DA, Verma S. Icosapent ethyl modulates circulating vascular regenerative cell content: The IPE-PREVENTION CardioLink-14 trial. Med. 2024 Jul 12;5(7):718-734.e4. doi: 10.1016/j.medj.2024.03.009. Epub 2024 Mar 28.

المؤلفون: Yorkshire Cancer Research, Amarin Pharma Inc.

المساهمون: Mark A Hull, PhD FRCP, Prof Mark Hull

المصدر: A Randomised Placebo-controlled Phase III Trial of the Effect of the Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) on Colorectal Cancer Recurrence and Survival After Surgery for Resectable Liver Metastases

المؤلفون: Kendra I. McGlothen, Rochelle M. Hines, Dustin J. Hines

المصدر: Frontiers in Cellular Neuroscience, Vol 18 (2024)

مصطلحات موضوعية: microglia, mitochondrial membrane potential, lipopolysaccharide, emapunil, tetramethylrhodamine ethyl ester, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2024.1430448/full; https://doaj.org/toc/1662-5102

URL الوصول: https://doaj.org/article/942c63ec6e27462fb44179ca5832a6e9

المؤلفون: Amarin Corporation

المصدر: A Pragmatic Randomized Trial of Icosapent Ethyl for High-Cardiovascular Risk Adults (MITIGATE)

المؤلفون: James N. Bates, Santhosh M. Baby, Paulina M. Getsy, Gregory A. Coffee, Yee-Hsee Hsieh, Zackery T. Knauss, Albert Dahan, Jason A. Bubier, Peter M. MacFarlane, Devin Mueller, Stephen J. Lewis

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

مصطلحات موضوعية: Fentanyl, Physical dependence, N-acetyl-L-cysteine, N-acetyl-L-cysteine ethyl ester, Naloxone, Withdrawal phenomena, Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/7cf134f1aa4b40f786d4d28221785b6e

المؤلفون: Jennifer McDonough, Naveen K. Singhal, Paulina M. Getsy, Katherine Knies, Zackery T. Knauss, Devin Mueller, James N. Bates, Derek S. Damron, Stephen J. Lewis

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: morphine, addiction, dependence, D-cysteine ethyl ester, betaine, human SH-SY5Y cells, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1416701/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/b770ebd95e5f4062957719f54007718e

المؤلفون: Seyed Mehrdad Mirsalami, Mahsa Mirsalami

المصدر: Results in Engineering, Vol 22, Iss , Pp 102138- (2024)

مصطلحات موضوعية: Biofuel production, Catalysts, Lipases, Mesoporous silica particles, Ethyl ester synthesis, Co-precipitation method, Technology

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S259012302400392X; https://doaj.org/toc/2590-1230

URL الوصول: https://doaj.org/article/ade241780e6e47dcb66894013f487c85

المؤلفون: Intermountain Research and Medical Foundation

المساهمون: Matthew J. Budoff, Principal Investigator

المصدر: Effect of Vascepa on Progression of Coronary Atherosclerosis in Persons With Elevated Triglycerides (200-499) on Statin Therapy

المؤلفون: Nattee Akkarawatkhoosith, Thapanee Bangjang, Amaraporn Kaewchada, Attasak Jaree

المصدر: Energy Reports, Vol 9, Iss , Pp 5299-5305 (2023)

مصطلحات موضوعية: Biodiesel, Rice bran oil fatty acid distillate, Microreactor, Fatty acid ethyl ester, Supercritical conditions, Electrical engineering. Electronics. Nuclear engineering, TK1-9971

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352484723007126; https://doaj.org/toc/2352-4847

URL الوصول: https://doaj.org/article/29d9c8c831c749dd9b38319fe1b790e7