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المؤلفون: Eric L. Kaijzel, Jens van Wijngaarden, Victor W.M. van Hinsbergh, Clemens W.G.M. Löwik, Ermond van Beek, Thomas J. A. Snoeks, Henny Bloys
المساهمون: Physiology, ICaR - Ischemia and repair
المصدر: van Wijngaarden, J, Snoeks, T J A, van Beek, E, Bloys, H, Kaijzel, E L, van Hinsbergh, V W M & Lowik, C W G M 2010, ' An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: Actions of TNP-470, marimastat and the tubulin-binding agent Ang-510 ', Biochemical and Biophysical Research Communications, vol. 391, no. 2, pp. 1161-1165 . https://doi.org/10.1016/j.bbrc.2009.11.097
Biochemical and Biophysical Research Communications, 391(2), 1161-1165. Academic Press Inc.
Biochemical and Biophysical Research Communications, 391(2), 1161-1165مصطلحات موضوعية: Endothelium, Angiogenesis, Biophysics, Neovascularization, Physiologic, Angiogenesis Inhibitors, Pharmacology, Biology, In Vitro Techniques, Hydroxamic Acids, Biochemistry, Tubulin binding, Neovascularization, Mice, Organophosphorus Compounds, Angiogenesis In vitro assay Vascular disruption Tubulin binding combretastatin a4 phosphate endothelial-cell growth tumor blood-vessels disrupting agents matrix metalloproteinases cancer-therapy inhibition strategy disease vivo, Cyclohexanes, medicine, Benzene Derivatives, Animals, Fumagillin, Enzyme Inhibitors, Molecular Biology, O-(Chloroacetylcarbamoyl)fumagillol, Neovascularization, Pathologic, Cell Biology, In vitro, Tubulin Modulators, Capillaries, Disease Models, Animal, medicine.anatomical_structure, Tubulin Binding Agent, Cancer research, Endothelium, Vascular, medicine.symptom, Sesquiterpenes, Marimastat, medicine.drug
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المؤلفون: Marieke A. Stammes, Ermond van Beek, Vicky T. Knol-Blankevoort, Alan Chan, Thomas J. A. Snoeks, Ivo Que, Clemens W.G.M. Löwik, Luis J. Cruz, Eric L. Kaijzel
المصدر: Journal of Controlled Release, 223, 31-41
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Necrosis, Indoles, Traumatic brain injury, Pharmaceutical Science, 02 engineering and technology, Contrast agents, Imaging, 03 medical and health sciences, chemistry.chemical_compound, Mice, Polylactic Acid-Polyglycolic Acid Copolymer, Cell Line, Tumor, PEG ratio, medicine, Animals, Tissue Distribution, Lactic Acid, Particle Size, Brain injury, Neuroinflammation, Fluorescent Dyes, Drug Carriers, Mice, Inbred BALB C, Targeting, Benzenesulfonates, technology, industry, and agriculture, Brain, PLGA, Penetration (firestop), 021001 nanoscience & nanotechnology, medicine.disease, Imaging agent, Surgery, 030104 developmental biology, chemistry, Brain Injuries, Biophysics, Nanoparticles, Female, medicine.symptom, 0210 nano-technology, Drug carrier, Polyglycolic Acid
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المؤلفون: Victor W.M. van Hinsbergh, Clemens W.G.M. Löwik, Klaas Hoekman, Gerda van Rossum, Jens van Wijngaarden, Marjolein A. van der Pol, Chris van der Bent, Ermond van Beek, Henk J. Broxterman, Gabri van der Pluijm
المصدر: European Journal of Cancer. 43:433-442
مصطلحات موضوعية: Cancer Research, Breast Neoplasms, Biology, Pharmacology, Mice, In vivo, Cell Line, Tumor, polycyclic compounds, medicine, Animals, Humans, Doxorubicin, skin and connective tissue diseases, Cytotoxicity, Cell Proliferation, Mice, Inbred BALB C, Sulfonamides, Antibiotics, Antineoplastic, Dose-Response Relationship, Drug, Cell growth, organic chemicals, Anti-Inflammatory Agents, Non-Steroidal, NF-kappa B, In vitro, Oncology, Celecoxib, Enzyme inhibitor, biology.protein, Pyrazoles, ATP-Binding Cassette Transporters, Female, Cell Division, Intracellular, medicine.drug
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المؤلفون: Ermond van Beek, Thomas J. A. Snoeks, Vicky T. Knol-Blankevoort, Maria Siebes, Alan Chan, Bangwen Xie, Ivo Que, Eric L. Kaijzel, Pieter B A A van Driel, Marieke A. Stammes, Martijn A.M. Löwik, Daniel Razansky, Richard W. Horobin, Vasilis Ntziachristos, Stijn Keereweer, Luis J. Cruz, Laura Mezzanotte, Mathias Hoehn, Clemens W.G.M. Löwik, Sven Gottschalk, Jeroen P. H. M. van den Wijngaard
المساهمون: Biomedical Engineering and Physics, ACS - Amsterdam Cardiovascular Sciences
المصدر: Oncotarget, 6(36), 39036-39049
Oncotarget 6, 39036-39049 (2015)
Oncotarget, 6(36), 39036-39049. Impact Journals
Oncotargetمصطلحات موضوعية: Programmed cell death, Pathology, medicine.medical_specialty, Necrosis, Lymphoma, Mice, Nude, Quantitative Structure-Activity Relationship, Mice, Random Allocation, In vivo, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, cancer, Avidity, Fluorescent Dyes, Mice, Inbred BALB C, Microscopy, Confocal, cyanines, business.industry, Mammary Neoplasms, Experimental, Cancer, imaging, Cell Death, Cyanines, Imaging, Necrosis Avid Contrast Agents, Carbocyanines, medicine.disease, In vitro, 3. Good health, necrosis avid contrast agents, Disease Models, Animal, cell death, Oncology, Female, Tumor necrosis factor alpha, medicine.symptom, business, Research Paper
وصف الملف: application/pdf
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المصدر: Bone. 38:167-171
مصطلحات موضوعية: Histology, Geranylgeranyl pyrophosphate, Receptors, Retinoic Acid, Physiology, Endocrinology, Diabetes and Metabolism, Protein Prenylation, Retinoic acid, Farnesyl pyrophosphate, Mevalonic Acid, Osteoclasts, Biology, Bone and Bones, Bone resorption, Mice, chemistry.chemical_compound, Polyisoprenyl Phosphates, Prenylation, Pregnancy, Animals, Bone Resorption, Ibandronic Acid, Bone Density Conservation Agents, Diphosphonates, Dose-Response Relationship, Drug, Drug Synergism, Cell biology, Retinoic acid receptor, chemistry, Biochemistry, Protein prenylation, Calcium, Female, Mevalonate pathway, Diterpenes
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المؤلفون: Yongcheng Song, Christine A. Schwerdtfeger, Sarah Odeh, Ermond van Beek, Thomas Kosztowski, Gary A. Meints, Yonghui Zhang, Craig T. Morita, Ryan M. Flessner, Aurora Ortiz Gomez, Eric Oldfield, John M. Sanders, Samuel Jennings, Evangelia Kotsikorou, Hong Wang, Julian M. W. Chan, Amy M. Raker, Socrates E. Papapoulos, Dolores González-Pacanowska
المصدر: Journal of Medicinal Chemistry. 48:2957-2963
مصطلحات موضوعية: Models, Molecular, Quantitative Structure-Activity Relationship, Antineoplastic Agents, Pyridinium Compounds, In Vitro Techniques, Bone resorption, Mice, chemistry.chemical_compound, Farnesyl diphosphate synthase, Drug Discovery, Animals, Humans, Dictyostelium, Bone Resorption, Metatarsal Bones, Leishmania major, Alkyl and Aryl Transferases, Diphosphonates, biology, Geranyltranstransferase, Receptors, Antigen, T-Cell, gamma-delta, Trypanocidal Agents, In vitro, Resorption, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Calcium, Growth inhibition, Pharmacophore
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المؤلفون: Hans Bernsen, Ermond van Beek, Jens van Wijngaarden, Karien E. de Rooij, Ivo Que, Victor W.M. van Hinsbergh, Clemens W.G.M. Löwik
المصدر: Laboratory Investigation. 84:1472-1483
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Mice, Nude, Angiogenesis Inhibitors, Antineoplastic Agents, Breast Neoplasms, Core Binding Factor Alpha 1 Subunit, macromolecular substances, Biology, Core binding factor, Pathology and Forensic Medicine, Mice, Cell Line, Tumor, Gene expression, medicine, Animals, Humans, Pimonidazole, Carcinoma, Renal Cell, Molecular Biology, Transcription factor, Gene, Mice, Knockout, Mice, Inbred BALB C, Neovascularization, Pathologic, Core Binding Factors, Cancer, Cell Biology, medicine.disease, Kidney Neoplasms, Endostatins, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, cardiovascular system, Cancer research, Immunohistochemistry, Endostatin, Neoplasm Transplantation, Granulocytes, Transcription Factors
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المؤلفون: Elsbet J. Pieterman, Clemens W.G.M. Löwik, Louis A. Cohen, Ermond van Beek, Socrates E. Papapoulos
المصدر: Biochemical and Biophysical Research Communications. 255:491-494
مصطلحات موضوعية: Geranylgeranyl Transferase, Nitrogen, Biophysics, Farnesyl pyrophosphate, Isopentenyl pyrophosphate, Pamidronate, Isomerase, Biochemistry, Mice, chemistry.chemical_compound, Hemiterpenes, Multienzyme Complexes, Animals, Bone Resorption, Enzyme Inhibitors, Mode of action, Ibandronic Acid, Molecular Biology, chemistry.chemical_classification, Diphosphonates, Dose-Response Relationship, Drug, ATP synthase, biology, Chemistry, Brain, Cell Biology, Carbon-Carbon Double Bond Isomerases, Dimethylallyltranstransferase, Enzyme Activation, Enzyme, biology.protein, Cattle, Mevalonate pathway, Clodronic Acid
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المؤلفون: Eric L. Kaijzel, Erin L. Cole, Bryan A. Smith, Vicky Blankevoort, Bradley D. Smith, Ivo Que, Clemens W.G.M. Löwik, Mathias Hoehn, Shuzhang Xiao, Bangwen Xie, Ermond van Beek
المصدر: ACS Chemical Neuroscience, 3(7), 530-537
مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Fluorescence-lifetime imaging microscopy, Programmed cell death, Physiology, Traumatic brain injury, Cognitive Neuroscience, medicine.medical_treatment, multicolor fluorescence imaging, Mice, Nude, Biology, Blood–brain barrier, Biochemistry, Imaging data, Cryosurgery, blood-brain-barrier, Mice, medicine, Animals, Mice, Hairless, Optical Imaging, Cell Biology, General Medicine, medicine.disease, cell death imaging, annexin V, Disease Models, Animal, medicine.anatomical_structure, Brain Injuries, zinc(II)-dipicolylamine, Molecular imaging, Ex vivo
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المؤلفون: Alan Chan, Isabel M. Mol, Eric L. Kaijzel, Ivo Que, Clemens W.G.M. Löwik, Ermond van Beek, Thomas J. A. Snoeks, Bangwen Xie, Stijn Keereweer
المساهمون: Otorhinolaryngology and Head and Neck Surgery
المصدر: PLoS ONE, Vol 7, Iss 2, p e31875 (2012)
PLoS ONE, 7(2)
PLoS ONE, 7(2), e31875
PLoS One (print), 7(2). Public Library of Science
PLoS ONEمصطلحات موضوعية: Diagnostic Imaging, Fluorescence-lifetime imaging microscopy, Pathology, medicine.medical_specialty, Indoles, lcsh:Medicine, Biochemistry, Mice, Model Organisms, SDG 3 - Good Health and Well-being, In vivo, Molecular Cell Biology, Basic Cancer Research, Medical imaging, Animals, Bioluminescence imaging, Bioluminescence, Medicine, lcsh:Science, Biology, Fluorescent Dyes, Multidisciplinary, business.industry, Physics, Benzenesulfonates, fungi, lcsh:R, Obstetrics and Gynecology, Cancers and Neoplasms, Mammary Neoplasms, Experimental, Animal Models, Fluorescence, Disease Models, Animal, Oncology, Tumor progression, Luminescent Measurements, Disease Progression, lcsh:Q, Physical Laws and Principles, business, Preclinical imaging, Research Article
وصف الملف: application/pdf
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المصدر: Methods in molecular biology (Clifton, N.J.). 816
مصطلحات موضوعية: Diagnostic Imaging, Mice, Neoplasms, Luminescent Measurements, Animals, Neoplasm Metastasis, Bone and Bones
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المصدر: Methods in Molecular Biology ISBN: 9781617794148
مصطلحات موضوعية: Fluorescence-lifetime imaging microscopy, Optical imaging, genetic structures, business.industry, medicine, Bioluminescence imaging, Cancer, Bone metastasis, medicine.disease, business, eye diseases, Biomedical engineering, Imaging modalities
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المؤلفون: Joo Hwan No, Yonghui Zhang, Rey-Ting Guo, Mitsuo Ochi, Yongcheng Song, Rong Cao, Dushyant Mukkamala, Lauren M. Cass, Socrates E. Papapoulos, Sujoy Mukherjee, Tadahiko Kubo, Michael P. Hudock, Fu Yang Lin, Annette Leon, Howard Robinson, Andrew H.-J. Wang, Kilannin Krysiak, Fenglin Yin, Yi Gui Gao, Kyle Bergan, Ermond van Beek, Eric Oldfield, Ting Kai Chang, Amanda Goddard
المصدر: Journal of the American Chemical Society. 131(14)
مصطلحات موضوعية: Geranylgeranyl Transferase, Saccharomyces cerevisiae Proteins, Stereochemistry, Trypanosoma brucei brucei, Protozoan Proteins, Mice, Nude, Saccharomyces cerevisiae, Crystallography, X-Ray, Biochemistry, Catalysis, Article, Mice, Colloid and Surface Chemistry, Geranylgeranylation, Farnesyl diphosphate synthase, Cell Line, Tumor, Transferase, Animals, Farnesyltranstransferase, Humans, Neoplasm Invasiveness, Nuclear Magnetic Resonance, Biomolecular, Cell Proliferation, chemistry.chemical_classification, biology, Diphosphonates, Chemistry, Cell growth, Geranyltranstransferase, General Chemistry, Lipids, Enzyme, biology.protein
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المؤلفون: Marcel Karperien, Clemens W.G.M. Löwik, Hetty Farih-Sips, Ermond van Beek, Jan M. Wit, Jakomijn Hoogendam
المصدر: Hormone research. 67(4)
مصطلحات موضوعية: musculoskeletal diseases, Endocrinology, Diabetes and Metabolism, Biology, Polymerase Chain Reaction, Chondrocyte, Cell Line, Mice, Endocrinology, Chondrocytes, Downregulation and upregulation, medicine, Transcriptional regulation, Animals, Metatarsal Bones, Oligonucleotide Array Sequence Analysis, Regulation of gene expression, Messenger RNA, Osteoblasts, Microarray analysis techniques, Parathyroid Hormone-Related Protein, Gene Expression Regulation, Developmental, Cell Differentiation, Mesenchymal Stem Cells, Chondrogenesis, Molecular biology, medicine.anatomical_structure, Cell culture, Pediatrics, Perinatology and Child Health, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Lianne van der Wee-Pals, Marco G. Cecchini, Gabri van der Pluijm, Antoinette Wetterwald, Martine Deckers, Ermond van Beek, Socrates E. Papapoulos, Clemens W.G.M. Löwik
المصدر: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 17(6)
مصطلحات موضوعية: musculoskeletal diseases, Tail, Bone disease, Angiogenesis, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Neovascularization, Physiologic, Osteoclasts, Bone resorption, Mice, Osteoclast, Bone cell, medicine, Animals, Orthopedics and Sports Medicine, Endothelium, Bone Resorption, Bone Development, Ossification, business.industry, Anatomy, Bisphosphonate, medicine.disease, Alkaline Phosphatase, Immunohistochemistry, Mice, Mutant Strains, Resorption, medicine.anatomical_structure, Animals, Newborn, Osteopetrosis, Cancer research, medicine.symptom, business
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المصدر: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14(5)
مصطلحات موضوعية: medicine.medical_specialty, Nitrogen, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Protein Prenylation, Mevalonic Acid, Pharmacology, Biology, Bone resorption, Bone and Bones, chemistry.chemical_compound, Mice, Prenylation, Geranylgeraniol, Osteoclast, Pregnancy, Internal medicine, Culture Techniques, medicine, Animals, Orthopedics and Sports Medicine, Lovastatin, Bone Resorption, Ibandronic Acid, Diphosphonates, Dose-Response Relationship, Drug, Bisphosphonate, Resorption, Endocrinology, medicine.anatomical_structure, chemistry, Models, Chemical, Protein prenylation, Female, Mevalonate pathway
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المؤلفون: C. P. A. T. Klein, Jolanda De Blieck, Theo van den Bos, Arnold van den Hooff, Harry W. Denissen, Ermond van Beek
المصدر: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 12(2)
مصطلحات موضوعية: Surface Properties, Endocrinology, Diabetes and Metabolism, Dentistry, Bone resorption, Bone and Bones, Absorption, chemistry.chemical_compound, Mice, Osteoclast, medicine, Animals, Orthopedics and Sports Medicine, Dental alveolus, Dental Implants, Diphosphonates, Dose-Response Relationship, Drug, business.industry, Histocytochemistry, Osteoblast, Drug Synergism, Phosphate, Alkaline Phosphatase, Resorption, medicine.anatomical_structure, Durapatite, chemistry, Delayed-Action Preparations, Alkaline phosphatase, Implant, business, Nuclear chemistry
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المؤلفون: Socrates E. Papapoulos, Ivo Que, Ermond van Beek, Clemens W.G.M. Löwik
المصدر: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 11(10)
مصطلحات موضوعية: Stereochemistry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Bone Matrix, Pamidronate, Dissociation (chemistry), Mice, Structure-Activity Relationship, In vivo, Pregnancy, Side chain, medicine, Moiety, Animals, Orthopedics and Sports Medicine, Amines, Bone Resorption, Bone mineral, Analysis of Variance, Binding Sites, Calcium Oxalate, Diphosphonates, Chemistry, Etidronic Acid, Bisphosphonate, In vitro, Resorption, Biochemistry, Female, Crystallization
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المؤلفون: Clemens W.G.M. Löwik, Socrates E. Papapoulos, Monique Hoekstra, Marjan van De Ruit, Ermond van Beek
المصدر: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 9(12)
مصطلحات موضوعية: medicine.medical_specialty, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Long bone, chemistry.chemical_element, Bone Matrix, Ulna, Calcium, Bone resorption, Mice, Structure-Activity Relationship, In vivo, Internal medicine, medicine, Animals, Orthopedics and Sports Medicine, Bone Resorption, Bone mineral, Diphosphonates, Bisphosphonate, medicine.disease, Resorption, Radius, medicine.anatomical_structure, Endocrinology, chemistry, Calcification
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المؤلفون: Lianne J. A. van der Wee-Pals, Socrates E. Papapoulos, Marjan van De Ruit, Clemens W.G.M. Löwik, Ermond van Beek, Peter J. Nijweide
المصدر: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 8(2)
مصطلحات موضوعية: endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Acid Phosphatase, Osteoclasts, Biology, Leukemia Inhibitory Factor, Bone and Bones, Bone remodeling, Mice, Calcification, Physiologic, Calcitriol, Osteoclast, Osteogenesis, Pregnancy, Internal medicine, Culture Techniques, medicine, Animals, Orthopedics and Sports Medicine, Bone Resorption, reproductive and urinary physiology, Lymphokines, Bone Development, Interleukin-6, Cartilage, Metacarpal Bones, medicine.disease, Alkaline Phosphatase, Growth Inhibitors, Resorption, Leukemia, medicine.anatomical_structure, Cytokine, Endocrinology, Parathyroid Hormone, embryonic structures, Alkaline phosphatase, Calcium, Female, Leukemia inhibitory factor, hormones, hormone substitutes, and hormone antagonists