المؤلفون: Fang-Tsao Hong, Jian Jiang, Brian A. Lanman, Victor J. Cee, Liping H. Pettus, Paul E. Hughes, Nancy Zhang, Douglas A. Whittington, Tisha San Miguel, Anthony B. Reed, Ling Wang, Erin L. Mullady, Kristin L. Andrews, John D. McCarter, Andrew Tasker, Leeanne Zalameda, Mark H. Norman, Tian Wu, Ryan Wurz, Raju Subramanian

المصدر: Bioorganic & Medicinal Chemistry Letters. 24:5630-5634

مصطلحات موضوعية: Male, Pyridines, Clinical Biochemistry, Molecular Conformation, Mice, Nude, Pharmaceutical Science, Alcohol, Biochemistry, Piperazines, Rats, Sprague-Dawley, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Piperazine, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Sulfonamides, Phosphoinositide 3-kinase, biology, Triazines, TOR Serine-Threonine Kinases, Organic Chemistry, In vitro, Rats, Sulfonamide, Liver, chemistry, Alcohols, biology.protein, Molecular Medicine, Phosphorylation, Female, Hepatocyte growth factor, Proto-Oncogene Proteins c-akt, Half-Life, Protein Binding, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac5698d5fbf21b4947041fb8e3a9326
https://doi.org/10.1016/j.bmcl.2014.10.085

المؤلفون: Zihao Hua, Bryan Egge, Erin L. Mullady, Hakan Gunaydin, John L. Buchanan, Steve Schneider, Xin Huang, Yohannes Teffera, Renee Emkey, Howard Bregman, Randy Serafino, Mary K. Stanton, Erin F. DiMauro, Jingzhou Liu, Virginia Berry, Douglas Saffran, Angel Guzman-Perez, Jennifer Dovey, Liyue Huang, Craig A. Strathdee, Susan M. Turci, Yan Gu, Paul S. Andrews, John Newcomb, Cindy Wilson, Ankita Mishra, Lisa Acquaviva, Nagasree Chakka

المصدر: Journal of Medicinal Chemistry. 56:10003-10015

مصطلحات موضوعية: Models, Molecular, Tankyrases, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Drug discovery, Poly ADP ribose polymerase, Wnt signaling pathway, Administration, Oral, Biological Availability, Structure-Activity Relationship, Biochemistry, Drug Discovery, biology.protein, Humans, Molecular Medicine, Structure–activity relationship, Enzyme Inhibitors, Pharmacophore, Axin Protein, Polymerase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba595497eee0272affa9da310eb1804
https://doi.org/10.1021/jm401317z

المؤلفون: Angel Guzman-Perez, Erin L. Mullady, Randy Serafino, Erin F. DiMauro, Hakan Gunaydin, Xin Huang, Liyue Huang, Jingzhou Liu, Virginia Berry, Bryan Egge, Nagasree Chakka, Cindy Wilson, Steve Schneider, John Newcomb, Yan Gu, Yohannes Teffera, Susan M. Turci, Ankita Mishra, Paul S. Andrews, Howard Bregman, Craig A. Strathdee

المصدر: Journal of Medicinal Chemistry. 56:4320-4342

مصطلحات موضوعية: Models, Molecular, Molecular model, Poly ADP ribose polymerase, Administration, Oral, Biological Availability, In Vitro Techniques, Pharmacology, medicine.disease_cause, Mice, Structure-Activity Relationship, Pharmacokinetics, Transcription (biology), Drug Discovery, medicine, Animals, Axin Protein, Oxazolidinones, Tankyrases, Binding Sites, Oncogene, Chemistry, Stereoisomerism, Rats, Bioavailability, Biochemistry, Microsomes, Liver, Molecular Medicine, Benzimidazoles, Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21eb09a2b123ca06a4a37ee2b8c466a
https://doi.org/10.1021/jm4000038

المؤلفون: Yunxin Bo, Tisha San Miguel, Nobuko Nishimura, Jian Jiang, Douglas A. Whittington, Paul E. Hughes, Sean Caenepeel, Mark H. Norman, John D. McCarter, Erin L. Mullady, Daniel J. Freeman, Kevin Yang, Ryan Wurz, Longbin Liu, Raju Subramanian, Kristin L. Andrews, Ling Wang, Liping H. Pettus, Nancy Zhang

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5714-5720

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphorylation, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Sulfonamides, Binding Sites, Phosphoinositide 3-kinase, biology, Triazines, Akt/PKB signaling pathway, Chemistry, TOR Serine-Threonine Kinases, Cellular Assay, Organic Chemistry, Rats, Molecular Docking Simulation, biology.protein, Molecular Medicine, Female, Proto-Oncogene Proteins c-akt, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62866028e9510797810acdca23680ada
https://doi.org/10.1016/j.bmcl.2012.06.078

المؤلفون: Bradley J. Herberich, Tian Wu, Paul E. Hughes, Claire L. M. Jackson, Nobuko Nishimura, Nancy Zhang, Ryan Wurz, Douglas A. Whittington, Shon Booker, Sean Caenepeel, Tisha San Miguel, Jian Jiang, Anthony B. Reed, Adrian L. Smith, Seifu Tadesse, Brian A. Lanman, Andrew Tasker, Erin L. Mullady, John D. McCarter, Fang-Tsao Hong, Liping H. Pettus, Divesh Aidasani, Victor J. Cee, Ling Wang, Bin Wu, Mark H. Norman, Daniel J. Freeman, Kevin Yang, Longbin Liu, Leeanne Zalameda, Yunxin Y. Bo, Xiaochun Zhu, Kristin L. Andrews, Markian Stec, Nuria A. Tamayo, Raju Subramanian, Noel D'angelo

المصدر: Journal of Medicinal Chemistry. 55:7796-7816

مصطلحات موضوعية: Models, Molecular, Phosphoinositide 3-kinase, biology, Triazines, Chemistry, Cell growth, Pharmacology, Crystallography, X-Ray, medicine.disease, chemistry.chemical_compound, In vivo, Glioma, Drug Discovery, Second messenger system, medicine, biology.protein, Molecular Medicine, Phosphorylation, Phosphatidylinositol, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7379e5002efb24d810fb0e1f33a3641
https://doi.org/10.1021/jm300846z

المؤلفون: Yunxin Y. Bo, Leeanne Zalameda, Kevin Yang, Fang-Tsao Hong, Longbin Liu, Anthony B. Reed, Kristin L. Andrews, Tisha San Miguel, Brian A. Lanman, Paul E. Hughes, Noel D'angelo, Brad Herberich, Jian Jiang, Victor J. Cee, Claire L. M. Jackson, Ryan Wurz, Nobuko Nishimura, Raju Subramanian, Seifu Tadesse, Nancy Zhang, John D. McCarter, Daniel J. Freeman, Ling Wang, Nuria A. Tamayo, Erin L. Mullady, Mark H. Norman, Liping H. Pettus, Tian Wu, Douglas A. Whittington, Sean Caenepeel, Adrian L. Smith, Shon Booker

المصدر: Journal of Medicinal Chemistry. 55:5188-5219

مصطلحات موضوعية: Models, Molecular, Indazoles, Class I Phosphatidylinositol 3-Kinases, Pyridines, Biological Availability, Mice, Nude, Crystallography, X-Ray, Piperazines, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Sulfones, Phosphatidylinositol, PI3K/AKT/mTOR pathway, Sulfonamides, Triazines, Akt/PKB signaling pathway, Chemistry, Kinase, TOR Serine-Threonine Kinases, Xenograft Model Antitumor Assays, Rats, Cell biology, Pyrimidines, Biochemistry, Purines, Drug Design, Microsomes, Liver, Pyrazoles, Molecular Medicine, Female, Signal transduction, Proto-Oncogene Proteins c-akt, Signal Transduction, Phosphoinositide-dependent kinase-1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e14c947647f0ff5c20164ffa4566dd
https://doi.org/10.1021/jm300184s

المؤلفون: Kristin L. Andrews, Kevin Yang, Markian Stec, Tisha San Miguel, Ling Wang, John McCarter, Mark H. Norman, Shon Booker, Jian Jiang, Nan Zhang, Daniel J. Freeman, Erin L. Mullady, Hongyu Liao, Paul E. Hughes, Leeanne Zalameda, Sean Caenepeel, Raju Subramanian, Nuria A. Tamayo

المصدر: Journal of Medicinal Chemistry. 54:5174-5184

مصطلحات موضوعية: Models, Molecular, Pyridines, Metabolite, Transplantation, Heterologous, Mice, Nude, Antineoplastic Agents, Pharmacology, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Oxazoles, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Sulfonamides, Phosphoinositide 3-kinase, biology, Chemistry, TOR Serine-Threonine Kinases, Imidazoles, In vitro, Rats, Pyridazines, Thiazoles, medicine.anatomical_structure, Biochemistry, Benzothiazole, Acetylation, Hepatocyte, Hepatocytes, biology.protein, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a9feddc793ad895a56aaf047e435fd
https://doi.org/10.1021/jm2004442

المؤلفون: Ling Wang, Leeanne Zalameda, Hongyu Liao, Kristin L. Andrews, Yunxin Bo, Nobuko Nishimura, Paul E. Hughes, John D. McCarter, Erin L. Mullady, Tisha San Miguel, Douglas A. Whittington, Sean Caenepeel, Nancy Zhang, Daniel J. Freeman, Mark H. Norman, Shon Booker, Aaron C. Siegmund, Nuria A. Tamayo, Marian C. Bryan, Raju Subramanian, Kevin Yang, Longbin Liu

المصدر: Journal of Medicinal Chemistry. 54:4735-4751

مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Biological Availability, In Vitro Techniques, Pharmacology, Crystallography, X-Ray, PI3K signaling, Rats, Sprague-Dawley, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Quinoxaline, In vivo, Quinoxalines, Drug Discovery, medicine, Animals, Humans, Phosphorylation, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Kinase, Chemistry, TOR Serine-Threonine Kinases, Quinoline, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Rats, Liver, Quinolines, Molecular Medicine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d51bb8cdaf63d264b7bb9e0cbc6de70
https://doi.org/10.1021/jm200386s

المؤلفون: Alan C. Cheng, Ti Cai, Barbara Grubinska, Daniel S. La, Tammy L. Bush, Yohannes Teffera, Joseph L. Kim, Christiane Boezio, Michele Potashman, Russell Graceffa, Erin L. Mullady, Paul S. Andrews, James R. Coats, Katrina W. Copeland, Alessandro Boezio, Emily A. Peterson, Richard T. Lewis, John Stellwagen, Jingzhou Liu, Deborah Choquette, Karina Romero, Adria E. Colletti, Shuyan Yi, Mary K. Stanton, Paul L. Shaffer, Michelle DuPont

المصدر: Bioorganicmedicinal chemistry letters. 22(15)

مصطلحات موضوعية: Male, Cell signaling, Imidazopyridine, Pyridines, Clinical Biochemistry, Regulator, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Binding, Competitive, Rats, Sprague-Dawley, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, In vivo, Drug Discovery, Structure–activity relationship, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Binding Sites, Chemistry, TOR Serine-Threonine Kinases, Organic Chemistry, Imidazoles, Protein Structure, Tertiary, Pyridazines, Drug Design, Microsomes, Liver, Molecular Medicine, Benzimidazoles, Signal transduction, Half-Life, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b4513ddf80e3dd0091b6571268da1c
https://pubmed.ncbi.nlm.nih.gov/22765895

المؤلفون: Yang Xu, Leeanne Zalameda, Raju Subramanian, Erin L. Mullady, Michael Schrag, Kevin Yang, Daniel J. Freeman, Jian Jiang, Longbin Liu, Tian Wu, Derin C. D'amico, John D. McCarter, Noel D'angelo, Sean Caenepeel, Peter Yakowec, Ling Wang, Mark H. Norman, Robert C. Wahl, Tisha San Miguel, Jin Tang, Douglas A. Whittington, Paul E. Hughes, Shon Booker, Ning Xi, Tae-Seong Kim, Kui Chen, Nancy Zhang, Kristin L. Andrews

المصدر: Journal of medicinal chemistry. 54(6)

مصطلحات موضوعية: Models, Molecular, Transplantation, Heterologous, Biological Availability, Mice, Nude, Antineoplastic Agents, Crystallography, X-Ray, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Humans, Benzothiazoles, Phosphorylation, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Sulfonamides, Phosphoinositide 3-kinase, Binding Sites, biology, Drug discovery, Chemistry, Kinase, TOR Serine-Threonine Kinases, In vitro, Rats, Transplantation, Biochemistry, Benzothiazole, Liver, biology.protein, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Proto-Oncogene Proteins c-akt, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef766c5554069d71d128a5c63ff879f
https://pubmed.ncbi.nlm.nih.gov/21332118

المؤلفون: Philip R. Olivieri, Barbara Grubinska, Alan C. Cheng, Alessandro Boezio, Katrina W. Copeland, Yohannes Teffera, Daniel S. La, Xuhai Be, James R. Coats, Paul S. Andrews, Jean-Christophe Harmange, Joseph L. Kim, Ti Cai, Emily A. Peterson, Michelle DuPont, Douglas A. Whittington, Laurie B. Schenkel, Adria E. Colletti, Mary K. Stanton, Tammy L. Bush, Russell Graceffa, Erin L. Mullady

المصدر: Bioorganicmedicinal chemistry letters. 21(7)

مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, mTORC2, Inhibitory Concentration 50, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Humans, Kinase activity, Molecular Biology, PI3K/AKT/mTOR pathway, Chemistry, Cell growth, Kinase, Drug discovery, Triazines, TOR Serine-Threonine Kinases, Organic Chemistry, RPTOR, Hydrogen Bonding, Cancer research, Molecular Medicine, Benzimidazoles, Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7455263dc4eb0802f5be9fd3b94ee6c6
https://pubmed.ncbi.nlm.nih.gov/21376583

المؤلفون: Pierceall William, Erin L. Mullady, William Millett, Dallas Hughes, Dennis Ditullio, Jianxin Chen, Victoria Knight-Connoni, Andrew Weiskopf, Hye-Dong Yoo

المصدر: Journal of natural products. 67(12)

مصطلحات موضوعية: Pharmaceutical Science, Antineoplastic Agents, Protein Serine-Threonine Kinases, Analytical Chemistry, Phthalide, chemistry.chemical_compound, Proto-Oncogene Proteins, Drug Discovery, Tumor Cells, Cultured, Humans, Nuclear Magnetic Resonance, Biomolecular, Benzofurans, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Fungi, Biological activity, Biochemical Activity, Oidiodendron, Complementary and alternative medicine, Biochemistry, Polyphenol, Cell culture, Molecular Medicine, Fermentation, Growth inhibition, Drug Screening Assays, Antitumor, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62da8bb394c4ef0ec24f9a3d730d4fe1
https://pubmed.ncbi.nlm.nih.gov/15620258

المؤلفون: Mark H. Norman, Kristin L. Andrews, Yunxin Y. Bo, Shon K. Booker, Sean Caenepeel, Victor J. Cee, Noel D. D’Angelo, Daniel J. Freeman, Bradley J. Herberich, Fang-Tsao Hong, Claire L. M. Jackson, Jian Jiang, Brian A. Lanman, Longbin Liu, John D. McCarter, Erin L. Mullady, Nobuko Nishimura, Liping H. Pettus, Anthony B. Reed, Tisha San Miguel, Adrian L. Smith, Markian M. Stec, Seifu Tadesse, Andrew Tasker, Divesh Aidasani, Xiaochun Zhu, Raju Subramanian, Nuria A. Tamayo, Ling Wang, Douglas A. Whittington, Bin Wu, Tian Wu, Ryan P. Wurz, Kevin Yang, Leeanne Zalameda, Nancy Zhang, Paul E. Hughes

المصدر: Journal of Medicinal Chemistry. 55:8975-8975

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::66fee0b326baeef0668bab8fc892abb9
https://doi.org/10.1021/jm301439j

المؤلفون: Markian M. Stec, Kristin L. Andrews, Shon K. Booker, Sean Caenepeel, Daniel J. Freeman, Jian Jiang, Hongyu Liao, John McCarter, Erin L. Mullady, Tisha San Miguel, Raju Subramanian, Nuria Tamayo, Ling Wang, Kevin Yang, Leeanne P. Zalameda, Nancy Zhang, Paul E. Hughes, Mark H. Norman

المصدر: Journal of Medicinal Chemistry; Jul2011, Vol. 54 Issue 14, p5174-5184, 11p

المؤلفون: Noel D. D’Angelo, Tae-Seong Kim, Kristin Andrews, Shon K. Booker, Sean Caenepeel, Kui Chen, Derin D’Amico, Dan Freeman, Jian Jiang, Longbin Liu, John D. McCarter, Tisha San Miguel, Erin L. Mullady, Michael Schrag, Raju Subramanian, Jin Tang, Robert C. Wahl, Ling Wang, Douglas A. Whittington, Tian Wu

المصدر: Journal of Medicinal Chemistry; Mar2011, Vol. 54 Issue 6, p1789-1811, 23p