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1
المؤلفون: Eric S. Marr, Simone Sciabola, Robin T. Nelson, Anabella Villalobos, Xiaomin Chen, Stefan Doerr, Yaozhong Zou, Michelle Vanase-Frawley, Noelia Ferruz, Gianni De Fabritiis, Travis T. Wager, Xinjun Hou, Bethany L. Kormos
المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-4 (2019)
مصطلحات موضوعية: Multidisciplinary, Chemistry, Dopamine receptor D3, lcsh:R, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Antagonist, lcsh:Medicine, lcsh:Q, Pharmacology, lcsh:Science, G protein-coupled receptor
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2
المؤلفون: Robin T. Nelson, Xinjun Hou, Bethany L. Kormos, Michelle Vanase-Frawley, Gianni De Fabritiis, Anabella Villalobos, Xiaomin Chen, Noelia Ferruz, Eric S. Marr, Travis T. Wager, Yaozhong Zou, Stefan Doerr, Simone Sciabola
المصدر: Scientific Reports
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)مصطلحات موضوعية: 0301 basic medicine, lcsh:Medicine, Plasma protein binding, Computational biology, Molecular Dynamics Simulation, Molecular dynamics, Crystallography, X-Ray, Ligands, 01 natural sciences, Molecular Docking Simulation, Article, Cell Line, Receptors, G-Protein-Coupled, 03 medical and health sciences, Dopamine D3 receptor, Eticlopride, Markov state models, Dopamine receptor D3, 0103 physical sciences, Salicylamides, Sf9 Cells, Animals, Humans, Binding site, lcsh:Science, Author Correction, G protein-coupled receptor, Multidisciplinary, Binding Sites, 010304 chemical physics, Drug discovery, Chemistry, lcsh:R, Receptors, Dopamine D3, 030104 developmental biology, G-protein coupled receptors, Docking (molecular), Mutagenesis, Site-Directed, lcsh:Q, Protein Binding
وصف الملف: application/pdf
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3
المؤلفون: Raymond S. Hurst, Mihály Hajós, Dennis J. Hoover, William E. Hoffmann, Nandini Chaturbhai Patel, Christopher L. Shaffer, Xinjun J. Hou, Christopher J. O’Donnell, Dina McGinnis, Jayvardhan Pandit, Eric S. Marr, Randall James Gallaschun, Dianne K. Bryce, John T. Lazzaro, Longfei Xie, Jacob Bradley Schwarz, Fliri Anton F J, Justin L Gazard, Ashley N. Hanks, Renato J. Scialis
المصدر: Journal of Medicinal Chemistry. 56:9180-9191
مصطلحات موضوعية: Male, Models, Molecular, Stereochemistry, Allosteric regulation, AMPA receptor, Absorption, Mice, Structure-Activity Relationship, Allosteric Regulation, Drug Discovery, Animals, Humans, Structure–activity relationship, Receptors, AMPA, Receptor, ADME, Drug discovery, Chemistry, Isoxazoles, Potentiator, Ligand (biochemistry), High-Throughput Screening Assays, Protein Structure, Tertiary, Rats, nervous system, Biochemistry, Molecular Medicine
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4
المؤلفون: Rose Barham, Thuy Hoang, Jeremy T. Starr, Jennifer A. Young, M. Megan Lemmon, Joseph Penzien, Mark J. Mitton-Fry, Thomas M. Harris, Antonia A. Nikitenko, Brian S. Gerstenberger, Sandra P. McCurdy, Veerabahu Shanmugasundaram, Lisa Mullins, Joel R. Hardink, Jeffrey M. Casavant, Eric S. Marr, Jian Lin, Seungil Han, Joel T. Arcari, John P. Mueller, Brandon P. Schuff, Mark S. Plummer, Craig J. McPherson, Michael D. Huband, Mark C. Noe, Manjinder S. Lall, Richard P. Zaniewski, Chao Li, Matthew Frank Brown, Jianmin Sun, Eric B. McElroy, Andrew P. Tomaras
المصدر: Journal of Medicinal Chemistry. 56:5541-5552
مصطلحات موضوعية: Male, Gram-negative bacteria, Pyridones, Klebsiella pneumoniae, Microbial Sensitivity Tests, Plasma protein binding, medicine.disease_cause, Microbiology, Inhibitory Concentration 50, Gram-Negative Bacteria, Drug Discovery, Escherichia coli, medicine, Animals, Monobactam, Rats, Wistar, Molecular Structure, biology, Pseudomonas aeruginosa, Chemistry, biology.organism_classification, In vitro, Anti-Bacterial Agents, Rats, Biochemistry, Molecular Medicine, Antibacterial activity, Monobactams, medicine.drug
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5
المؤلفون: Veerabahu Shanmugasundaram, Michael D. Huband, Jinshan Michael Chen, Thuy-Trinh Nguyen, Eric S. Marr, Karl Granskog, Bruce A. Maguire, Sandra P. McCurdy, Timothy A. Subashi, Seungil Han, Magee Thomas Victor
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1727-1731
مصطلحات موضوعية: Carbamate, Pyrrolidines, Staphylococcus, medicine.medical_treatment, Clinical Biochemistry, Substituent, Pharmaceutical Science, Erythromycin, Microbial Sensitivity Tests, Ribosome Subunits, Large, Bacterial, Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Pyrrolidine, Microbiology, chemistry.chemical_compound, Antibiotic resistance, Drug Resistance, Bacterial, Drug Discovery, Escherichia coli, medicine, Molecular Biology, Methylurea Compounds, Binding Sites, biology, Organic Chemistry, Streptococcus, Deinococcus radiodurans, biology.organism_classification, Anti-Bacterial Agents, Protein Structure, Tertiary, chemistry, Linezolid, Molecular Medicine, Deinococcus, medicine.drug
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6
المؤلفون: Carol B. Fox, Spiros Liras, Douglas S. Chapin, Frederick R. Nelson, Jayvardhan Pandit, Xinjun Hou, Christopher John Helal, John M. Humphrey, Christopher J. Schmidt, Thomas Allen Chappie, Kimberly F. Fennell, Frank S. Menniti, Zhijun Kang, Julia Cianfrogna, Judith A. Siuciak, Mary C. MacDougall, Kari R. Fonseca, Rebecca E. O’Connor, Lois K. Chenard, Eric S. Marr, Lorraine A. Lebel, Laura McDowell, Robert D. Williams
المصدر: Journal of Medicinal Chemistry. 54:4536-4547
مصطلحات موضوعية: Models, Molecular, Databases, Factual, Phosphodiesterase Inhibitors, Protein Conformation, In Vitro Techniques, Crystallography, X-Ray, Cocrystal, Permeability, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Avoidance Learning, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Binding site, Cyclic GMP, ADME, Mice, Knockout, Binding Sites, Phosphoric Diester Hydrolases, Chemistry, Rational design, Phosphodiesterase, Corpus Striatum, Biochemistry, Blood-Brain Barrier, Drug Design, Microsomes, Liver, Schizophrenia, Molecular Medicine, Structure based, PDE10A, Antipsychotic Agents
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المؤلفون: Artem G. Evdokimov, Veerabahu Shanmugasundaram, Seungil Han, J. Richard Miller, Eric S. Marr, Brian M. Lacey, Richard P. Zaniewski, Andrew P. Tomaras
المصدر: Proceedings of the National Academy of Sciences. 107:22002-22007
مصطلحات موضوعية: Models, Molecular, Conformational change, Penicillin binding proteins, Siderophores, Aztreonam, Biology, Crystallography, X-Ray, beta-Lactams, medicine.disease_cause, Acylation, Amino Acids, Aromatic, chemistry.chemical_compound, medicine, Humans, Penicillin-Binding Proteins, Monobactam, Pseudomonas Infections, chemistry.chemical_classification, Cross Infection, Multidisciplinary, Pseudomonas aeruginosa, Pseudomonas, biology.organism_classification, Anti-Bacterial Agents, Protein Structure, Tertiary, Enzyme, Biochemistry, chemistry, Physical Sciences, medicine.drug
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8
المؤلفون: Ing-Kae Wang, Zuoyu Xu, Richard P. Zaniewski, Samuel P. Simons, Timothy A. Subashi, Thomas J. Dougherty, Thomas J. McLellan, Charlene R. Desbonnet, Peter K. LeMotte, Bruce A. Maguire, Paul A. Aeed, Eric S. Marr, Lillian M. Wondrack
المصدر: Analytical Biochemistry. 395:77-85
مصطلحات موضوعية: Ribosomal Proteins, Spectrometry, Mass, Electrospray Ionization, Recombinant Fusion Proteins, Magnesium Chloride, Biophysics, Gene Expression, Ribosome Subunits, Small, Bacterial, Ribosome Subunits, Large, Bacterial, Biochemistry, Ribosome, Chromatography, Affinity, Bacterial Proteins, Affinity chromatography, Tandem Mass Spectrometry, Large ribosomal subunit, Centrifugation, Density Gradient, 30S, Cloning, Molecular, Databases, Protein, Molecular Biology, Chromatography, High Pressure Liquid, 50S, biology, RNA, Deinococcus radiodurans, Cell Biology, biology.organism_classification, Peptide Fragments, RNA, Bacterial, RNA, Ribosomal, Ribosome Subunits, Deinococcus, Peptides, Oligopeptides
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المؤلفون: Eric S. Marr, Timothy A. Subashi, Bruce A. Maguire, Seungil Han, Ing-Kae Wang, Lillian M. Wondrack, Thomas J. McLellan, Paul A. Aeed, Zuoyu Xu
المصدر: Acta Crystallographica Section D Biological Crystallography. 65:1270-1282
مصطلحات موضوعية: Models, Molecular, Ribosomal Proteins, Molecular Sequence Data, Ribosome Subunits, Large, Bacterial, Cell Fractionation, Crystallography, X-Ray, Ribosome, law.invention, Bacterial Proteins, Structural Biology, law, Amino Acid Sequence, Crystallization, Protein Structure, Quaternary, 50S, biology, Resolution (electron density), Deinococcus radiodurans, General Medicine, Ribosomal RNA, biology.organism_classification, RNA, Bacterial, Crystallography, Yield (chemistry), Nucleic Acid Conformation, Deinococcus, Single crystal
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10
المؤلفون: Christopher J. Schmidt, Frank S. Menniti, Kari R. Fonseca, Spiros Liras, Robert D. Williams, Michelle Vanase-Frawley, Frederick R. Nelson, Christopher John Helal, Eric S. Marr, Patrick Robert Verhoest, Xinjun Hou, Shenping Liu, Lois K. Chenard, Michael L. Corman, Anne W. Schmidt, Caroline Proulx-Lafrance, Robin J. Kleiman
المصدر: Journal of Medicinal Chemistry. 52:7946-7949
مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Phosphoric Diester Hydrolases, Brain, Hydrogen Bonding, Computational biology, Mice, chemistry.chemical_compound, chemistry, Biochemistry, 3',5'-Cyclic-AMP Phosphodiesterases, In vivo, Drug Discovery, Animals, Humans, Molecular Medicine, Penetrant (biochemical), Cyclic GMP
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المؤلفون: John F. Harms, Christopher J. Schmidt, Anne W. Schmidt, Caroline Proulx-Lafrance, Eric S. Marr, Michael L. Corman, Kari R. Fonseca, Frank S. Menniti, Douglas S. Chapin, Rebecca E. O’Connor, Jayvardhan Pandit, Xinjun Hou, Judith A. Suiciak, Spiros Liras, Frederick R. Nelson, Patrick Robert Verhoest
المصدر: Journal of Medicinal Chemistry. 52:5188-5196
مصطلحات موضوعية: Male, Models, Molecular, PF-2545920, Molecular model, Stereochemistry, In Vitro Techniques, Crystallography, X-Ray, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Avoidance Learning, Animals, Humans, Structure–activity relationship, Mice, Knockout, Binding Sites, Molecular Structure, biology, Phosphoric Diester Hydrolases, Chemistry, Quinoline, Brain, Phosphodiesterase, Hydrogen Bonding, Rats, Macaca fascicularis, Enzyme inhibitor, Microsomes, Liver, Quinolines, Schizophrenia, biology.protein, Pyrazoles, Molecular Medicine, Female, PDE10A, Antipsychotic Agents, Protein Binding
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12
المؤلفون: Patrick Vincent, Joel Morris, Francis Rajamohan, Elisabeth Knauth, Shaughnessy Robinson, Tracey Clark, Liuqing Wei, Merin Troutman, Shefali Kakar, Jayvardhan Pandit, Matthew Corbett, Blaise Lippa, Gonghua Pan, Elsa G. Barbacci-Tobin, Eric S. Marr, Gary Borzillo, Goss Stryker Kauffman, Deborah A. Baker, Ekaterina Kozina, Chao Li
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3359-3363
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, AKT1, Antineoplastic Agents, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Combinatorial Chemistry Techniques, Structure–activity relationship, Potency, Pyrroles, Spiro Compounds, Molecular Biology, Protein kinase B, Molecular Structure, biology, Chemistry, Kinase, Organic Chemistry, Biological activity, Disease Models, Animal, Pyrimidines, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Signal transduction, Proto-Oncogene Proteins c-akt
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المؤلفون: Martin Patrick Allen, Lorraine A. Lebel, Feng V. Yang, Christopher J. Schmidt, Spiros Liras, Kimberly G. Estep, Thomas Allen Chappie, Meihua Tu, Robert D. Williams, Carol B. Fox, Jayvardhan Pandit, John M. Humphrey, Frank S. Menniti, Eric S. Marr
المصدر: Journal of Medicinal Chemistry. 50:182-185
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Phosphodiesterase Inhibitors, Stereochemistry, Ether, Crystallography, X-Ray, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Cyclic GMP, biology, Phosphoric Diester Hydrolases, Chemistry, Aryl, Corpus Striatum, Inhibitory potency, Enzyme inhibitor, Quinazolines, biology.protein, Molecular Medicine, PDE10A, Pharmacophore
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المؤلفون: George A. Karam, Maynard D. Carty, Mark Tardie, Walt Soeller, Ing-Kae Wang, Tracy Brown Phillips, Xiayang Qiu, Eric S. Marr
المصدر: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 62:1058-1060
مصطلحات موضوعية: Models, Molecular, DNA, Complementary, Protein Conformation, Molecular Sequence Data, Restriction Mapping, Biophysics, Crystallography, X-Ray, Fatty Acid-Binding Proteins, Biochemistry, Fatty acid-binding protein, law.invention, chemistry.chemical_compound, Protein structure, Structural Biology, law, Adipocyte, Genetics, Humans, Protein Structure Communications, Amino Acid Sequence, Crystallization, Peptide sequence, chemistry.chemical_classification, food and beverages, Fatty acid, Condensed Matter Physics, chemistry, Intracellular, DNA
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المؤلفون: Matthew C. Griffor, Xi Song, Boris A. Chrunyk, Suman Shanker, Eric S. Marr, Shenping Liu, Lise R. Hoth
المصدر: Nature Communications. 4
مصطلحات موضوعية: Models, Molecular, Receptor complex, Conformational change, Molecular Sequence Data, Allosteric regulation, Interleukin 5 receptor alpha subunit, General Physics and Astronomy, Immune receptor, Biology, Crystallography, X-Ray, Protein Structure, Secondary, General Biochemistry, Genetics and Molecular Biology, Interleukin 10 receptor, alpha subunit, Protein structure, Allosteric Regulation, Humans, Amino Acid Sequence, Receptor, Conserved Sequence, Receptors, Interleukin-17, Multidisciplinary, Interleukin-17, General Chemistry, Surface Plasmon Resonance, Molecular biology, Protein Structure, Tertiary, Cell biology, HEK293 Cells, Mutagenesis, Protein Multimerization, Crystallization, Protein Binding
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المؤلفون: H. James Harwood, R. Kirk McPherson, Susan Tapley, Leanne M. Buzon, Kevin Daniel Freeman-Cook, Steven B. Coffey, Richard L. Elliott, Darcy Kohls, Liang Tong, Felix Vajdos, Meihua Tu, Eliot Sugarman, Shawn D. Doran, Francis Rajamohan, Eric S. Marr, Hailong Zhang, Wei Song, Kenneth J. DiRico, Jeffrey W. Corbett, Janet A. Houser, Sharad B. Murdande, William P. Esler, Martha L. Minich, Christopher J. Jones
المصدر: Bioorganicmedicinal chemistry letters. 20(7)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Isozyme, Small Molecule Libraries, Structure-Activity Relationship, Drug Discovery, Transferase, Animals, Humans, Enzyme Inhibitors, Molecular Biology, biology, Drug discovery, Chemistry, Organic Chemistry, Acetyl-CoA carboxylase, Acetyl-CoA Carboxylase 1, Small molecule, Pyruvate carboxylase, Rats, Isoenzymes, Enzyme inhibitor, biology.protein, Molecular Medicine, Acetyl-CoA Carboxylase
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المؤلفون: Susan Deborah Lagreca, Daniel Tyler Richter, Kevin Coleman, Matt Wessel, John Charles Kath, Catherine Angela Hulford, Martin A. Berliner, Erika Schmitt, Walter Gregory Roberts, Jing Lin, Matt Griffor, Michael Joseph Luzzio, Eric S. Marr, Pamela Whalen, Christofer Autry, Beth Cooper, Jitesh P. Jani, Earling Emerson, Nandini Chaturbhai Patel, Luis Martinez-Alsina, Lili Yao, Marianne J. Lorenzen, Felix Vajdos, Ethan Ung
المصدر: Cancer research. 68(6)
مصطلحات موضوعية: Cancer Research, Indoles, PTK2, Mice, Nude, Antineoplastic Agents, Apoptosis, Biology, Focal adhesion, Mice, In vivo, Cell Line, Tumor, Animals, Humans, Phosphorylation, Protein Kinase Inhibitors, Sulfonamides, Cell adhesion molecule, Kinase, Biological activity, Xenograft Model Antitumor Assays, Oncology, Biochemistry, Models, Chemical, Focal Adhesion Protein-Tyrosine Kinases, Cancer research, Female, Glioblastoma, Tyrosine kinase
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18
المؤلفون: Thomas J. Carty, Weiling Cai, Nancy C. Elliott, Alan J. Dipesa, Seungil Han, David H. Brown Ripin, Francis J. Sweeney, Eric S. Marr, Ellen R. Laird, Mark A. Dombroski, Douglas H. Tan, Santo R. Cortina, Yong Tao, John T. Barberia, Dennis E. Danley, Jayvardhan Pandit, Thomas R Hynes, Mahmoud N. Mansour, Kim F. McClure, Christopher A. Gabel, Kathleen M. Donahue, Peter K. LeMotte, Yuriy A. Abramov, Michael A. Letavic
المصدر: Journal of medicinal chemistry. 48(18)
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Pyridines, Static Electricity, Triazole, Quantitative Structure-Activity Relationship, Crystallography, X-Ray, Chemical synthesis, p38 Mitogen-Activated Protein Kinases, chemistry.chemical_compound, Drug Discovery, Pyridine, Isoxazole, Binding Sites, biology, Molecular Structure, Molecular Mimicry, Active site, Hydrogen Bonding, Triazoles, Acceptor, chemistry, biology.protein, Molecular Medicine, Triazolopyridine, Benzimidazoles, Hydrophobic and Hydrophilic Interactions, Protein Binding
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المؤلفون: Erika S. Roberts, Matt Griffor, Martin A. Berliner, John Charles Kath, Luis Martinez-Alsina, Huiping Xu, Catherine Angela Hulford, Matthew David Wessel, Jing Lin, Lili Yao, Marianne J. Lorenzen, Jitesh P. Jani, Christopher Autry, Pamela Whalen, Vajdos Felix, Nandini Chaturbhai Patel, Daniel Tyler Richter, Ethan Ung, Erling Emerson, Susan Deborah Lagreca, Kevin G. Coleman, Walter Gregory Roberts, Eric S. Marr, Beth C. Vetelino
المصدر: Molecular Cancer Therapeutics. 8:A86-A86
مصطلحات موضوعية: Cancer Research, Cell growth, Kinase, Chemistry, Cell, Cell biology, Focal adhesion, medicine.anatomical_structure, Oncology, Biochemistry, medicine, Phosphorylation, Anoikis, IC50, ADME
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20Academic Journal
المؤلفون: Patrick R. Verhoest, Douglas S. Chapin, Michael Corman, Kari Fonseca, John F. Harms, Xinjun Hou, Eric S. Marr, Frank S. Menniti, Frederick Nelson, Rebecca O’Connor, Jayvardhan Pandit, Caroline Proulx-LaFrance, Anne W. Schmidt, Christopher J. Schmidt, Judith A. Suiciak, Spiros Liras
المصدر: Journal of Medicinal Chemistry; Aug2009, Vol. 52 Issue 16, p5188-5196, 9p