المؤلفون: Kirthana M. V. Sindhe, Wesley Wu, Jenny Legac, Yong-Kang Zhang, Eric E. Easom, Roland A. Cooper, Jacob J. Plattner, Yvonne R. Freund, Joseph L. DeRisi, Philip J. Rosenthal

المصدر: mBio, Vol 11, Iss 1 (2020)

مصطلحات موضوعية: malaria, Plasmodium falciparum, drug, benzoxaborole, resistance, PfPARE, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2150-7511

URL الوصول: https://doaj.org/article/f9067457c1d346e893d1e74840fb86f1

المؤلفون: Robert T. Jacobs, Rianna Stefanakis, Nancy Tricoche, Eric E. Easom, Yvonne Freund, Kee Chong Lim, James H. McKerrow, David S. Carter, Christina A. Bulman, Brian M. Suzuki, Christopher S. Lunde, Pamela Berry, Judy A. Sakanari, Jacob J. Plattner, Chelsea Fischer, Sara Lustigman, Tsutomu Akama, Fernando Rock

المصدر: ACS Infectious Diseases

مصطلحات موضوعية: Boron Compounds, Male, 0301 basic medicine, Benzimidazole, Letter, Ketone, 030106 microbiology, Administration, Oral, Flubendazole, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Onchocerciasis, Ocular, parasitic diseases, medicine, Animals, lymphatic filariasis, chemistry.chemical_classification, flubendazole, organoboron, Blindness, biology, Chemistry, onchocerciasis, Ketones, medicine.disease, biology.organism_classification, Onchocerca volvulus, Disease Models, Animal, Filaricides, 030104 developmental biology, Infectious Diseases, Nematode, tubulin, Benzimidazoles, Female, Gerbillinae, Onchocerciasis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beee7fb4c5ebfd7c32f697f2a5ce9791
https://doi.org/10.1021/acsinfecdis.9b00397

المؤلفون: Rianna Stefanakis, Eric E. Easom, Jacob J. Plattner, Yvonne Freund, Erin E. Stebbins, Melissa S. Love, Pamela Berry, Jiri Gut, Christopher D. Huston, Rajiv S. Jumani, Case W. McNamara, Philip J. Rosenthal, Peter J. Miller, Christopher S. Lunde, Robert T. Jacobs, John W. Barlow, Mahmudul Hasan

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications

مصطلحات موضوعية: Boron Compounds, Male, 0301 basic medicine, Parasitic infection, Phenotypic screening, Science, Antiprotozoal Agents, Drug Evaluation, Preclinical, Cryptosporidiosis, Cryptosporidium, General Physics and Astronomy, Drug development, 02 engineering and technology, Disease, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, medicine, Animals, Humans, lcsh:Science, Multidisciplinary, biology, business.industry, Intracellular parasite, Isoxazoles, General Chemistry, 021001 nanoscience & nanotechnology, biology.organism_classification, Amides, Rats, 3. Good health, Diarrhea, Drug repositioning, 030104 developmental biology, Immunology, Neglected tropical diseases, Female, lcsh:Q, medicine.symptom, 0210 nano-technology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32813dbe54d00c74f148ff27329f781
https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7

المؤلفون: Jacob J. Plattner, Yong-Kang Zhang, Francisco-Javier Gamo, Eric E. Easom, Laura M. Sanz, Philip J. Rosenthal, Yvonne Freund, Robert T. Jacobs, Brice Campo, Denghui Guo, Vic Ciaravino, Jianxin Cao, Pamela Berry, John C. L. Erve

المصدر: Journal of Medicinal Chemistry. 60:5889-5908

مصطلحات موضوعية: Boron Compounds, Male, 0301 basic medicine, Plasmodium berghei, Plasmodium falciparum, Pharmacology, 01 natural sciences, Rats, Sprague-Dawley, Antimalarials, Mice, Structure-Activity Relationship, 03 medical and health sciences, Dogs, In vivo, Chloroquine, parasitic diseases, Drug Discovery, medicine, Animals, Humans, Antimalarial Agent, Malaria, Falciparum, Artemisinin, biology, 010405 organic chemistry, Chemistry, biology.organism_classification, Amides, Malaria, Rats, 0104 chemical sciences, 030104 developmental biology, Pyrimethamine, Micronucleus test, Molecular Medicine, Female, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7593ef9390da411669370e393e82e6
https://doi.org/10.1021/acs.jmedchem.7b00621

المؤلفون: Jacob J. Plattner, Kirthana M. V. Sindhe, Roland A. Cooper, Jenny Legac, Eric E. Easom, Yvonne Freund, Yong-Kang Zhang, Wesley Wu, Philip J. Rosenthal, Joseph L. DeRisi

المساهمون: Wellems, Thomas E

المصدر: mBio, vol 11, iss 1
mBio, Vol 11, Iss 1, p e02640-19 (2020)
mBio
mBio, Vol 11, Iss 1 (2020)

مصطلحات موضوعية: DNA Mutational Analysis, SUMO protein, Protozoan Proteins, Drug Resistance, Drug resistance, Mass Spectrometry, Antimalarial Agent, Malaria, Falciparum, PfPARE, chemistry.chemical_classification, 0303 health sciences, Chromatography, Liquid, Molecular Structure, sumoylation, drug, Single Nucleotide, QR1-502, 3. Good health, Infectious Diseases, 5.1 Pharmaceuticals, HIV/AIDS, Development of treatments and therapeutic interventions, Infection, Research Article, Biotechnology, Falciparum, plasmodium falciparum, Plasmodium falciparum, benzoxaborole, malaria, Biology, ubiquitination, Polymorphism, Single Nucleotide, Microbiology, resistance, 03 medical and health sciences, Antimalarials, Rare Diseases, Virology, Genetics, Humans, Polymorphism, antimalarial agents, IC50, Gene, 030304 developmental biology, 030306 microbiology, pfpare, Therapeutics and Prevention, biology.organism_classification, In vitro, Vector-Borne Diseases, Enzyme, Orphan Drug, chemistry, drug resistance mechanisms, Mutation, drug resistance evolution, Antimicrobial Resistance, Chromatography, Liquid

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8e895585eb102c0d05ce9a1f2565df
https://escholarship.org/uc/item/1mq202tv

المؤلفون: Tsutomu Akama, Yvonne R. Freund, Pamela W. Berry, David S. Carter, Eric E. Easom, Kurt Jarnagin, Christopher S. Lunde, Jacob J. Plattner, Fernando Rock, Rianna Stefanakis, Chelsea Fischer, Christina A. Bulman, Kee Chong Lim, Brian M. Suzuki, Nancy Tricoche, Abdelmoneim Mansour, Utami DiCosty, Scott McCall, Ben Carson, John W. McCall, James McKerrow, Marc P. Hübner, Sabine Specht, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari, Robert T. Jacobs

المصدر: ACS Infectious Diseases

مصطلحات موضوعية: Boron Compounds, Male, flubendazole, Letter, organoboron, onchocerciasis, Amides, Onchocerca volvulus, Infectious Diseases, Filaricides, tubulin, parasitic diseases, Brugia, Animals, Benzimidazoles, Female, Gerbillinae, lymphatic filariasis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cc683f66d1ab3829297dad3581ff3c
https://pubmed.ncbi.nlm.nih.gov/31876154

المؤلفون: Hervé Pelloux, Cristina Sensi, Rose-Laurence Bertini, Philip J. Rosenthal, Eric E. Easom, Véronique Josserand, Yvonne Freund, Alexandre Bougdour, Mohamed-Ali Hakimi, Bastien Touquet, Julien Vollaire, Stephen Cusack, Marie-Pierre Brenier-Pinchart, Andrés Palencia

المصدر: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 9, Iss 3, Pp 385-394 (2017)

مصطلحات موضوعية: 0301 basic medicine, Boron Compounds, Medicine (General), 030106 microbiology, benzoxaborole, Antiprotozoal Agents, Drug Resistance, Toxoplasma gondii, Administration, Oral, CPSF3, Cleavage and polyadenylation specificity factor, QH426-470, Biology, drug discovery, 03 medical and health sciences, Mice, R5-920, Parasitic Sensitivity Tests, parasitic diseases, Genetics, medicine, CRISPR, Animals, Point Mutation, Pharmacology & Drug Discovery, Research Articles, Cas9, Drug discovery, Point mutation, Cleavage And Polyadenylation Specificity Factor, medicine.disease, biology.organism_classification, Virology, Phenotype, Survival Analysis, Toxoplasmosis, Microbiology, Virology & Host Pathogen Interaction, 3. Good health, Disease Models, Animal, 030104 developmental biology, Molecular Medicine, mRNA processing, Toxoplasma, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae553059e910240ea313dbe76d2661b
http://europepmc.org/articles/PMC5331205

المؤلفون: Vincent Hernandez, Liang Liu, M. R. K. Alley, Iñigo Angulo-Barturen, Manisha Mohan, Baojie Wan, Andrés Palencia, Wai Choi, Zhenkun Ma, Lisa Feng, Scott G. Franzblau, Charles Z. Ding, Maliwan Meewan, David Barros, James C. Sacchettini, Joaquín Rullas, Paul Houston, Fernando Rock, Wei Bu, Anne J. Lenaerts, Tanya Parish, Alfonso Mendoza, Xianfeng Li, Lisa K. Woolhiser, Yasheen Zhou, M. Gerard Waters, Christopher B. Cooper, Jacob J. Plattner, Suoming Zhang, Eric E. Easom, Stephen Cusack, Veronica Gruppo, Theresa O’Malley, Holly Sexton, Esther Pérez-Herrán, Thomas R. Ioerger, Yuehong Wang

المصدر: Antimicrobial Agents and Chemotherapy
'Antimicrobial Agents and Chemotherapy ', vol: 60, pages: 6271-6280 (2016)

مصطلحات موضوعية: 0301 basic medicine, Drug, Tuberculosis, media_common.quotation_subject, 030106 microbiology, Mycobacterium smegmatis, Antitubercular Agents, Drug Evaluation, Preclinical, Administration, Oral, Mice, Inbred Strains, Microbial Sensitivity Tests, Pharmacology, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, medicine, Animals, Humans, Pharmacology (medical), Experimental Therapeutics, Vero Cells, media_common, Protein Synthesis Inhibitors, Mice, Inbred BALB C, Protein synthesis inhibitor, biology, Leucyl-tRNA synthetase, Isoniazid, biology.organism_classification, medicine.disease, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Infectious Diseases, chemistry, Streptomycin, Linezolid, Female, Leucine-tRNA Ligase, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ebfe2cf75e49febf18965798c8ef46
http://europepmc.org/articles/PMC5038265

المؤلفون: Yasheen Zhou, Defauw Jean Marie, Terry William Balko, Eric E. Easom, Wuxin Zou, Jianxin Cao, Tsutomu Akama, Yong-Kang Zhang, Joseph Raymond Winkle, Jian Xue, Wei Bu, Jacob J. Plattner, Shenghai Guo, W. Hunter White

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:5589-5593

مصطلحات موضوعية: Boron Compounds, Time Factors, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Ectoparasitic Infestations, Pharmacology, Biochemistry, Toxicology, Single oral dose, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Dog Diseases, Dermacentor variabilis, Molecular Biology, Ctenocephalides, Ectoparasiticide, Molecular Structure, biology, Chemistry, Felis, Organic Chemistry, Isoxazoles, American dog ticks, biology.organism_classification, Bioavailability, Long acting, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d92604251fefa4eb6bb096549743d41
https://doi.org/10.1016/j.bmcl.2015.10.044

المؤلفون: Joaquín Rullas, Manisha Mohan, Wai Choi, David Barros, M. R. K. Alley, Vincent Hernandez, Wuxin Zou, Sabrinia D. Crouch, Weimin Mao, Jacob J. Plattner, Ilaria Giordano, Yasheen Zhou, Iñigo Angulo-Barturen, Fátima Ortega, Carlos Alemparte, Alfonso Mendoza-Losana, Eric E. Easom, Esther Pérez-Herrán, Xianfeng Li, Fernando Rock, Yvonne Mak

المصدر: Journal of medicinal chemistry. 60(19)

مصطلحات موضوعية: 0301 basic medicine, Boron Compounds, 030106 microbiology, Antitubercular Agents, Heterocyclic Compounds, 2-Ring, Substrate Specificity, Mycobacterium tuberculosis, 03 medical and health sciences, Mice, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Mode of action, IC50, chemistry.chemical_classification, biology, Chemistry, Drug discovery, Leucyl-tRNA synthetase, respiratory system, bacterial infections and mycoses, biology.organism_classification, In vitro, Mice, Inbred C57BL, 030104 developmental biology, Enzyme, Biochemistry, Molecular Medicine, Female, Leucine-tRNA Ligase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa731b796b5352b9fff5fb6d6f8f143
https://pubmed.ncbi.nlm.nih.gov/28953378

المؤلفون: Tsutomu, Akama, Yong-Kang, Zhang, Yvonne R, Freund, Pamela, Berry, Joanne, Lee, Eric E, Easom, Robert T, Jacobs, Jacob J, Plattner, Michael J, Witty, Rosemary, Peter, Tim G, Rowan, Kirsten, Gillingwater, Reto, Brun, Bakela, Nare, Luke, Mercer, Musheng, Xu, Jiangong, Wang, Hao, Liang

المصدر: Bioorganic & Medicinal Chemistry Letters

مصطلحات موضوعية: Boron Compounds, Benzoxaborole, Trypanosoma congolense, Antiprotozoal Agents, Valine, Article, Mice, Structure-Activity Relationship, Trypanosomiasis, African, Trypanosomiasis, Protozoan, Animals, Lead optimisation, Cattle, Trypanosoma vivax, ComputingMethodologies_COMPUTERGRAPHICS, SAR

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::fdc55e8753819399ce081720b1e3cc0c
https://pubmed.ncbi.nlm.nih.gov/29169674

المؤلفون: Christopher S. Lunde, Martina Fendler, Xianfeng Li, Joseph D. Turner, Mark J. Taylor, Marianne Koschel, Marc P. Hübner, Alexandra Ehrens, Dominique Struever, Robert T. Jacobs, Franziska Lenz, Stefan J. Frohberger, Achim Hoerauf, Eric E. Easom, Yvonne Freund, Stephen A. Ward, Jacob J. Plattner, Rianna Stefanakis

المصدر: PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007957 (2020)
PLoS Neglected Tropical Diseases

مصطلحات موضوعية: 0301 basic medicine, RC955-962, Onchocerciasis, 0302 clinical medicine, Antibiotics, qx_301, Oral administration, Arctic medicine. Tropical medicine, Medicine and Health Sciences, Oral Administration, Routes of Administration, Lymphatic filariasis, Doxycycline, Mice, Inbred BALB C, Antimicrobials, Pharmaceutics, Drugs, Animal Models, wc_850, Anti-Bacterial Agents, Filariasis, Infectious Diseases, Experimental Organism Systems, Helminth Infections, Female, Wolbachia, Diterpenes, Rifampin, Public aspects of medicine, RA1-1270, Research Article, Neglected Tropical Diseases, medicine.drug, wc_880, 030231 tropical medicine, Mouse Models, Biology, Research and Analysis Methods, wc_885, Microbiology, Antimalarials, 03 medical and health sciences, Model Organisms, Drug Therapy, In vivo, Microbial Control, parasitic diseases, Parasitic Diseases, medicine, Animals, Adults, Polycyclic Compounds, Symbiosis, qw_131, Filarioidea, Boron, Pharmacology, Bacteria, Lymphatic Filariasis, Organisms, Public Health, Environmental and Occupational Health, Biology and Life Sciences, Tropical Diseases, medicine.disease, biology.organism_classification, 030104 developmental biology, Nematode, Age Groups, People and Places, Animal Studies, Population Groupings, Rifampicin

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93bb93720e40d8a7a8b1031df65f76a
https://doi.org/10.1371/journal.pntd.0007957

المؤلفون: Jianzhang Yang, Joseph Raymond Winkle, Jacob J. Plattner, Yong-Kang Zhang, Zhixin Ge, Eric E. Easom, Jianxin Cao, Terry William Balko, Yasheen Zhou, Defauw Jean Marie, W. Hunter White, Tsutomu Akama

المصدر: Bioorganicmedicinal chemistry letters. 26(13)

مصطلحات موضوعية: 0301 basic medicine, Boron Compounds, Stereochemistry, Clinical Biochemistry, Cmax, Pharmaceutical Science, Administration, Oral, Ectoparasitic Infestations, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Parasitic Sensitivity Tests, Drug Discovery, Animals, Dermacentor variabilis, Benzamide, Molecular Biology, Ctenocephalides, Ectoparasiticide, Dermacentor, biology, Antiparasitic Agents, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Isoxazoles, biology.organism_classification, Antiparasitic agent, Amides, 030104 developmental biology, Pharmacodynamics, Cats, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5faf93f91bfd392cc2d3f56f43e76a
https://pubmed.ncbi.nlm.nih.gov/27210432

المؤلفون: Eric E. Easom, Hui-Hong Zhou, Min Ge, Daniel M. Retz, Liang Liu, Yong-Kang Zhang, Jacob J. Plattner

المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 55:201-205

مصطلحات موضوعية: biology, Stereochemistry, Chemistry, Organic Chemistry, Drug Discovery, Radiology, Nuclear Medicine and imaging, Plasmodium falciparum, Antimalarial Agent, biology.organism_classification, Biochemistry, Combinatorial chemistry, Spectroscopy, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4b8a537c3113b12aabc10a48adf5cdc1
https://doi.org/10.1002/jlcr.2926

المؤلفون: Eric E. Easom, Lingchao Li, Min Ge, Zhiya Li, David Waterson, Yong Jian, Jacob J. Plattner, Yong-Kang Zhang

المصدر: Tetrahedron Letters. 52:3909-3911

مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Organic Chemistry, Plasmodium falciparum, medicine.disease, biology.organism_classification, Biochemistry, Chemical synthesis, Drug development, parasitic diseases, Drug Discovery, Organic Boron Compounds, medicine, Antimalarial Agent, Malaria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4453bb189665e3c79f6c1539030766f5
https://doi.org/10.1016/j.tetlet.2011.05.088

المؤلفون: David Waterson, Zhiya Li, Francisco-Javier Gamo, Yasheen Zhou, Long Ye, Eric E. Easom, Jacob J. Plattner, Yvonne Freund, Lingchao Li, Laura M. Sanz, Hailong Wang, Min Ge, Yong-Kang Zhang, Huchen Zhou, Han Cui

المصدر: Bioorganicmedicinal chemistry letters. 22(3)

مصطلحات موضوعية: inorganic chemicals, Boron Compounds, Stereochemistry, Cell Survival, Clinical Biochemistry, Plasmodium falciparum, Substituent, Pharmaceutical Science, Ring (chemistry), Biochemistry, chemistry.chemical_compound, Antimalarials, Inhibitory Concentration 50, Jurkat Cells, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Humans, Antimalarial Agent, Molecular Biology, biology, Molecular Structure, Chemistry, Organic Chemistry, Fluorine, biology.organism_classification, Bridged Bicyclo Compounds, Heterocyclic, Molecular Medicine, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67e201f2806384a4b64b0e6b97ed9ad
https://pubmed.ncbi.nlm.nih.gov/22243961

المؤلفون: Jian Yang, Eric E. Easom, Yasheen Zhou, Yvonne Freund, Lingchao Li, Hailong Wang, Min Ge, Zhiya Li, David Waterson, Iñigo Angulo-Barturen, Jacob J. Plattner, Philip J. Rosenthal, Han Cui, Jiri Gut, Yong Jian, Yong-Kang Zhang, Francisco-Javier Gamo

المصدر: Bioorganicmedicinal chemistry letters. 21(2)

مصطلحات موضوعية: Boron Compounds, Stereochemistry, Cell Survival, Carboxylic acid, Clinical Biochemistry, Plasmodium falciparum, Pharmaceutical Science, Biochemistry, Chemical synthesis, Cell Line, Antimalarials, Structure-Activity Relationship, Parasitic Sensitivity Tests, Drug Discovery, Structure–activity relationship, Potency, Humans, Antimalarial Agent, Malaria, Falciparum, Molecular Biology, chemistry.chemical_classification, biology, Bicyclic molecule, Chemistry, Organic Chemistry, biology.organism_classification, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0cf7e430ad7871f14612701ecd78fd5
https://pubmed.ncbi.nlm.nih.gov/21195617

المؤلفون: Yong-Kang Zhang, JacobJ. Plattner, Eric E. Easom, RobertT. Jacobs, Denghui Guo, Virginia Sanders, Yvonne R. Freund, Brice Campo, Philip J. Rosenthal, Wei Bu, Francisco-Javier Gamo, Laura M. Sanz, Min Ge, Liang Li, Jie Ding, Yin Yang

المصدر: Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 13, p5344-5354, 11p