المؤلفون: Nicolás Leonel González (14279373), Guillermo Moscatelli (567716), Samanta Moroni (340736), Griselda Ballering (567720), Laura Jurado (14279376), Nicolás Falk (14279379), Andrés Bochoeyer (14279382), Alejandro Goldsman (14279385), María Grippo (14279388), Héctor Freilij (3098268), Facundo Garcia Bournissen (14279391), Eric Chatelain (115412), Jaime Altcheh (373341)

مصطلحات موضوعية: Medicine, Biotechnology, Cancer, Infectious Diseases, Virology, Computational Biology, tracking 2d echocardiogram, term cardiology outcomes, negative seroconversion occurred, hour holter monitoring, evaluate cardiac involvement, challenging since features, baseline parasitemia data, 6 years post, 2 &# 8211, considered probably related, 7 %, pediatric ecg trace, trypanosoma cruzi <, cardiological lesions related, 4 %]) patients, long term follow, patients treated early, cardiological lesions, related findings, early treatment, cruzi <, pediatric patients, routine ecg

Time: 95

Relation: https://figshare.com/articles/journal_contribution/STROBE_Statement_/21752670

الاتاحة: https://doi.org/10.1371/journal.pntd.0010968.s001

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/journal_contribution/PRISMA_Checklist_/15175006

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s001

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/journal_contribution/Search_Strategy_and_Eligibility_criteria_/15175009

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s002

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/journal_contribution/Benznidazole_dose_variability_by_age_group_/15175024

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s007

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/journal_contribution/Diagnostic_criteria_used_for_patient_enrolment_by_phase_of_the_disease_/15175021

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s006

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/journal_contribution/Time_point_at_which_parasitological_assessments_were_carried_out_during_follow-up_/15175030

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s009

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/journal_contribution/Total_number_of_parasitological_assessments_during_study_follow-up_/15175027

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s008

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/journal_contribution/Assessment_of_quality_of_a_body_of_evidence_using_GRADE_approach_/15175033

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s010

المؤلفون: Andrew M. Thompson (1621570), Patrick D. O’Connor (2072647), Vanessa Yardley (2179120), Louis Maes (191127), Delphine Launay (2553787), Stephanie Braillard (4019258), Eric Chatelain (115412), Baojie Wan (410986), Scott G. Franzblau (380600), Zhenkun Ma (798844), Christopher B. Cooper (1779883), William A. Denny (1621576)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Pharmacology, Cancer, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Enhanced Solubility Antitubercular 7-, DNDI, development risks, novel amine, vivo efficacy, solubility improvements, side chain ether linkage, leishmaniasi, candidate profiles, urea functionality, Novel Linker Variants, latter groups, antileishmanial potency reduction, carbamate 66, antitrypanosomal activities

Relation: https://figshare.com/articles/journal_contribution/Novel_Linker_Variants_of_Antileishmanial_Antitubercular_7_Substituted_2_Nitroimidazooxazines_Offer_Enhanced_Solubility/13622397

الاتاحة: https://doi.org/10.1021/acsmedchemlett.0c00649.s001

المؤلفون: Nicolás Leonel González (14279373), Guillermo Moscatelli (567716), Samanta Moroni (340736), Griselda Ballering (567720), Laura Jurado (14279376), Nicolás Falk (14279379), Andrés Bochoeyer (14279382), Alejandro Goldsman (14279385), María Grippo (14279388), Héctor Freilij (3098268), Facundo Garcia Bournissen (14279391), Eric Chatelain (115412), Jaime Altcheh (373341)

مصطلحات موضوعية: Medicine, Biotechnology, Cancer, Infectious Diseases, Virology, Computational Biology, tracking 2d echocardiogram, term cardiology outcomes, negative seroconversion occurred, hour holter monitoring, evaluate cardiac involvement, challenging since features, baseline parasitemia data, 6 years post, 2 &# 8211, considered probably related, 7 %, pediatric ecg trace, trypanosoma cruzi <, cardiological lesions related, 4 %]) patients, long term follow, patients treated early, cardiological lesions, related findings, early treatment, cruzi <, pediatric patients, routine ecg

Time: 95

Relation: https://figshare.com/articles/dataset/Description_of_patients_with_ECG_alterations_/21752679

الاتاحة: https://doi.org/10.1371/journal.pntd.0010968.t001

المؤلفون: Nicolás Leonel González (14279373), Guillermo Moscatelli (567716), Samanta Moroni (340736), Griselda Ballering (567720), Laura Jurado (14279376), Nicolás Falk (14279379), Andrés Bochoeyer (14279382), Alejandro Goldsman (14279385), María Grippo (14279388), Héctor Freilij (3098268), Facundo Garcia Bournissen (14279391), Eric Chatelain (115412), Jaime Altcheh (373341)

مصطلحات موضوعية: Medicine, Biotechnology, Cancer, Infectious Diseases, Virology, Computational Biology, tracking 2d echocardiogram, term cardiology outcomes, negative seroconversion occurred, hour holter monitoring, evaluate cardiac involvement, challenging since features, baseline parasitemia data, 6 years post, 2 &# 8211, considered probably related, 7 %, pediatric ecg trace, trypanosoma cruzi <, cardiological lesions related, 4 %]) patients, long term follow, patients treated early, cardiological lesions, related findings, early treatment, cruzi <, pediatric patients, routine ecg

Time: 95

Relation: https://figshare.com/articles/figure/Flow_chart_of_patient_enrollment_in_the_study_/21752673

الاتاحة: https://doi.org/10.1371/journal.pntd.0010968.g001

المؤلفون: Nicolás Leonel González (14279373), Guillermo Moscatelli (567716), Samanta Moroni (340736), Griselda Ballering (567720), Laura Jurado (14279376), Nicolás Falk (14279379), Andrés Bochoeyer (14279382), Alejandro Goldsman (14279385), María Grippo (14279388), Héctor Freilij (3098268), Facundo Garcia Bournissen (14279391), Eric Chatelain (115412), Jaime Altcheh (373341)

مصطلحات موضوعية: Medicine, Biotechnology, Cancer, Infectious Diseases, Virology, Computational Biology, tracking 2d echocardiogram, term cardiology outcomes, negative seroconversion occurred, hour holter monitoring, evaluate cardiac involvement, challenging since features, baseline parasitemia data, 6 years post, 2 &# 8211, considered probably related, 7 %, pediatric ecg trace, trypanosoma cruzi <, cardiological lesions related, 4 %]) patients, long term follow, patients treated early, cardiological lesions, related findings, early treatment, cruzi <, pediatric patients, routine ecg

Time: 95

Relation: https://figshare.com/articles/figure/Serological_seroconversion_by_ELISA_and_IHA_profile_in_234_treated_patients_Kaplan-Meier_/21752676

الاتاحة: https://doi.org/10.1371/journal.pntd.0010968.g002

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/dataset/Source_data_supporting_the_systematic_review_of_Chagas_disease_trypanocidal_treatment_studies_/15175018

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s005

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/dataset/REDCap_data_dictionary_and_variable_dictionary_for_data_collection_/15175012

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s003

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/dataset/Search_Results_/15175015

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.s004

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/figure/Preferred_Reporting_Items_for_Systematic_Reviews_and_Meta-Analyses_PRISMA_flow_diagram_of_publications_screened_/15175036

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.g001

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/figure/Sites_where_the_studies_included_were_conducted_/15175039

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.g002

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/figure/Number_of_cohorts_and_participants_size_stratified_by_country_/15175045

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.g004

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/figure/Temporal_distribution_of_cohort_endemicity_/15175042

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.g003

المؤلفون: Brittany J. Maguire (10492519), Prabin Dahal (3628118), Sumayyah Rashan (10492525), Roland Ngu (10492516), Anca Boon (11278873), Colin Forsyth (7434155), Nathalie Strub-Wourgaft (356578), Eric Chatelain (115412), Fabiana Barreira (9248928), Sergio Sosa-Estani (664057), Philippe J. Guérin (8919389)

مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, trypanosoma cruzi <, following electronic databases, efforts would enable, efficacy varied largely, 6 %), itraconazole, 18 &# 8211, studies could support, parasitological efficacy relied, 9 %), allopurinol, 6 %) studies, 0 %), microscopy, 2 %), parasitological, cd ), caused, 60 &# 8211, 4 %), nifurtimox, 1 used molecular, 9 %) studies

Time: 3

Relation: https://figshare.com/articles/dataset/Diagnostic_criteria_used_for_patient_enrolment_/15175054

الاتاحة: https://doi.org/10.1371/journal.pntd.0009697.t001