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    المصدر: Genes; Volume 14; Issue 7; Pages: 1467

    مصطلحات موضوعية: colorectal cancer, MGMT, ERCC1, methylation, relapse, FOLFOX response

    جغرافية الموضوع: agris

    وصف الملف: application/pdf

    Relation: Human Genomics and Genetic Diseases; https://dx.doi.org/10.3390/genes14071467

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    المساهمون: The work was conducted with the support of Russian Science Foundation Grant No. 20-75-10158 – Pharmacogenetic and pharmacokinetic approaches to gastrointestinal cancer chemotherapy based on total body composition., Работа проводилась при поддержке гранта Российского научного фонда №20-75-10158 «Фармакогенетические и фармакокинетические подходы к химиотерапии опухолей желудочно-кишечного тракта на основе анализа состава тела».

    المصدر: Meditsinskiy sovet = Medical Council; № 18 (2023); 175-184 ; Медицинский Совет; № 18 (2023); 175-184 ; 2658-5790 ; 2079-701X

    وصف الملف: application/pdf

    Relation: https://www.med-sovet.pro/jour/article/view/7850/6971; Каприн АД, Старинский ВВ, Петрова ГВ (ред.). Состояние онкологической помощи населению России в 2018 году. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России; 2019. 236 с. Режим доступа: https://oncology-association.ru/wp-content/uploads/2020/09/sostoyanie_2018.pdf?ysclid=lnis28yzzl945263948.; Tournigand C, André T, Achille E, Lledo G, Flesh M, Mery-Mignar D et al. FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study. J Clin Oncol. 2004;22(2):229–237. https://doi.org/10.1200/JCO.2004.05.113.; De Vita F, Orditura M, Matano E, Bianco R, Carlomagno C, Infusino S et al. A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients. Br J Cancer. 2005;92(9):1644–1649. https://doi.org/10.1038/sj.bjc.6602573.; Onakpoya IJ, Heneghan CJ, Aronson JK. Worldwide withdrawal of medicinal products because of adverse drug reactions: a systematic review and analysis. Crit Rev Toxicol. 2016;46(6):477–489. https://doi.org/10.3109/10408444.2016.1149452.; Shahnam A, Ridha Z, Wiese MD, Kichenadasse G, Sorich MJ. Pharmacogenetic and ethnicity influence on oxaliplatin therapy for colorectal cancer: a meta-analysis. Pharmacogenomics. 2016;17(15):1725–1732. https://doi.org/10.2217/pgs-2016-0102.; Meulendijks D, Henricks LM, Sonke GS, Deenen MJ, Froehlich TK, Amstutz U et al. Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data. Lancet Oncol. 2015;16(16):1639–1650. https://doi.org/10.1016/S1470-2045(15)00286-7.; Wigle TJ, Medwid S, Ross C, Schwarz UI, Kim RB. DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation. Curr Oncol. 2023;30(1):663–672. https://doi.org/10.3390/curroncol30010051.; Khalil KA, Musallam HS, Hassan MA, Mahmoud IA. Triplet (FOLFOXIRI) Versus Doublet (FOLFOX or FOLFIRI) Regimen as First Line Treatment in Metastatic Colorectal Carcinoma, a Prospective Phase II, Randomized Controlled Trial. Asian Pac J Cancer Prev. 2022;23(10):3421–3429. https://doi.org/10.31557/APJCP.2022.23.10.3421.; Morel A, Boisdron-Celle M, Fey L, Soulie P, Craipeau MC, Traore S, Gamelin E. Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance. Mol Cancer Ther. 2006;5(11):2895–904. https://doi.org/10.1158/1535-7163.MCT-06-0327.; Sissung TM, Cordes L, Peer CJ, Gandhy S, Redman J, Strauss J, Figg WD. Case report: severe toxicity in an African-American patient receiving FOLFOX carrying uncommon allelic variants in DPYD. Pharmacogenomics. 2021;22(2):81–85. https://doi.org/10.2217/pgs-2020-0120.; Božina N, Bilić I, Ganoci L, Šimičević L, Pleština S, Lešnjaković L, Trkulja V. DPYD polymorphisms c.496A>G, c.2194G>A and c.85T>C and risk of severe adverse drug reactions in patients treated with fluoropyrimidine-based protocols. Br J Clin Pharmacol. 2022;88(5):2190–2202. https://doi.org/10.1111/bcp.15144.; Medwid S, Wigle TJ, Kim RB. Fluoropyrimidine-associated toxicity and DPYD variants c.85T>C, c.496A>G, and c.1236G>A: impact of haplotype. Cancer Chemother Pharmacol. 2023;91(1):97–102. https://doi.org/10.1007/s00280-022-04491-7.; Glewis S, Alexander M, Khabib MNH, Brennan A, Lazarakis S, Martin J et al. A systematic review and meta-analysis of toxicity and treatment outcomes with pharmacogenetic-guided dosing compared to standard of care BSA-based fluoropyrimidine dosing. Br J Cancer. 2022;127(1):126–136. https://doi.org/10.1038/s41416-022-01779-6.; Федянин МЮ, Мамедли ЗЗ, Гордеев СС, Ачкасов СИ, Болотина ЛВ, Гладков ОА и др. Злокачественное новообразование ободочной кишки: клинические рекомендации. 2022. Режим доступа: https://cr.minzdrav.gov.ru/schema/396_3.; Van Triest B, Peters GJ. Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer. Oncology. 1999;57(3):179–194. https://doi.org/10.1159/000012030.; Kawakami K, Omura K, Kanehira E, Watanabe Y. Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res. 1999;19(4B):3249–3252. Available at: https://pubmed.ncbi.nlm.nih.gov/10652619.; Schwab M, Zanger UM, Marx C, Schaeffeler E, Klein K, Dippon J et al. Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group. J Clin Oncol. 2008;26(13):2131–2138. https://doi.org/10.1200/JCO.2006.10.4182.; Sohn KJ, Croxford R, Yates Z, Lucock M, Kim YI. Effect of the Methylenetetrahydrofolate Reductase C677T Polymorphism on Chemosensitivity of Colon and Breast Cancer Cells to 5-Fluorouracil and Methotrexate. J Natl Cancer Inst. 2004;96(2):134–144. https://doi.org/10.1093/jnci/djh015.; Ramos-Esquivel A, Chinchilla R, Valle M. Association of C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine-induced Toxicity in Mestizo Patients With Metastatic Colorectal Cancer. Anticancer Res. 2020;40(8):4263–4270. https://doi.org/10.21873/anticanres.14428.; Xie C, Zhao J, Hua W, Tan P, Chen Y, Rui J et al. Effect of XPC polymorphisms on the response to platinum-based chemotherapy: a meta-analysis. Onco Targets Ther. 2019;12:3839–3848. https://doi.org/10.2147/OTT.S202617.; Ban N, Takahashi Y, Takayama T, Kura T, Katahira T, Sakamaki S et al. Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide. Cancer Res. 1996;56(15):3577–3582. Available at: https://pubmed.ncbi.nlm.nih.gov/8758929.; Puerta-García E, Urbano-Pérez D, Carrasco-Campos MI, Pérez-Ramírez C, Segura-Pérez A, Calleja-Hernández et al. Effect of DPYD, MTHFR, ABCB1, XRCC1, ERCC1 and GSTP1 on chemotherapy related toxicity in colorectal carcinoma. Surg Oncol. 2020;35:388–398. https://doi.org/10.1016/j.suronc.2020.09.016.; Huang MY, Huang ML, Chen MJ, Lu CY, Chen CF, Tsai PC et al. Multiple genetic polymorphisms in the prediction of clinical outcome of metastatic colorectal cancer patients treated with first-line FOLFOX-4 chemotherapy. Pharmacogenet Genomics. 2011;21(1):18–25. https://doi.org/10.1097/FPC.0b013e3283415124.; Keam B, Im SA, Han SW, Ham HS, Kim MA, Oh DY et al. Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker. BMC Cancer. 2008;8:148. https://doi.org/10.1186/1471-2407-8-148.; Badary DM, Elkabsh MM, Mady HH, Gabr A, Kroosh SS. Prognostic and Predictive Role of Excision Repair Cross-complementation Group 1 and Thymidylate Synthase in Colorectal Carcinoma Patients Received FOLFOX Chemotherapy: An Immunohistochemical Study. Appl Immunohistochem Mol Morphol. 2020;28(10):741–747. https://doi.org/10.1097/PAI.0000000000000841.; https://www.med-sovet.pro/jour/article/view/7850

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